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Volumn 5, Issue 1, 2013, Pages 13-26

Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death

Author keywords

Axonopathies; CD4 T cell; CD8 T cell; Multiple sclerosis; Neurodegeneration; NK cells

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BLOOD BRAIN BARRIER; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CONTACT; CELL GRANULE; CELL INTERACTION; CELL TYPE; CONTROLLED STUDY; DENDRITE; EMBRYO; IMMUNOPATHOGENESIS; INTRACELLULAR SIGNALING; LYMPHOCYTOTOXICITY; MICROTUBULE AXONAL DESTABILIZATION; MOUSE; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPATHY; NONHUMAN; TH1 CELL; TH17 CELL;

EID: 84874861806     PISSN: 17590914     EISSN: None     Source Type: Journal    
DOI: 10.1042/AN20120087     Document Type: Article
Times cited : (15)

References (98)
  • 1
    • 33646890625 scopus 로고    scopus 로고
    • Transient axonal injury in the absence of demyelination: A correlate of clinical disease in acute experimental autoimmune encephalomyelitis
    • Aboul-Enein F., Weiser P, Hoftberger R, Lassmann H, Bradl M (2006) Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis. Acta Neuropathol 111:539-547.
    • (2006) Acta Neuropathol , vol.111 , pp. 539-547
    • Aboul-Enein, F.1    Weiser, P.2    Hoftberger, R.3    Lassmann, H.4    Bradl, M.5
  • 3
    • 72949105157 scopus 로고    scopus 로고
    • Splenic natural killer cell activity in two models of experimental neurodegenerative diseases
    • Al-Falahi Y., Sand KL, Knudsen E, Damaj BB, Rolin J, Maghazachi AA (2009) Splenic natural killer cell activity in two models of experimental neurodegenerative diseases. J Cell Mol Med 13:2693-2703.
    • (2009) J Cell Mol Med , vol.13 , pp. 2693-2703
    • Al-Falahi, Y.1    Sand, K.L.2    Knudsen, E.3    Damaj, B.B.4    Rolin, J.5    Maghazachi, A.A.6
  • 6
    • 0033136695 scopus 로고    scopus 로고
    • NF-κB-inducing kinase is a common mediator of IL-17-, TNF-α-, and IL-1β-induced chemokine promoter activation in intestinal epithelial cells
    • Awane M., Andres PG, Li DJ, Reinecker HC (1999) NF-κB-inducing kinase is a common mediator of IL-17-, TNF-α-, and IL-1β-induced chemokine promoter activation in intestinal epithelial cells. J Immunol 162:5337-5344.
    • (1999) J Immunol , vol.162 , pp. 5337-5344
    • Awane, M.1    Andres, P.G.2    Li, D.J.3    Reinecker, H.C.4
  • 11
    • 0037441487 scopus 로고    scopus 로고
    • Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
    • Bjartmar C., Wujek JR, Trapp BD (2003) Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 206:165-171.
    • (2003) J Neurol Sci , vol.206 , pp. 165-171
    • Bjartmar, C.1    Wujek, J.R.2    Trapp, B.D.3
  • 12
    • 33846441246 scopus 로고    scopus 로고
    • Ankyrin-dependent and-independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule
    • Boiko T., Vakulenko M, Ewers H, Yap CC, Norden C, Winckler B (2007) Ankyrin-dependent and-independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule. J Neurosci 27:590-603.
    • (2007) J Neurosci , vol.27 , pp. 590-603
    • Boiko, T.1    Vakulenko, M.2    Ewers, H.3    Yap, C.C.4    Norden, C.5    Winckler, B.6
  • 13
    • 0020540731 scopus 로고
    • Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: Translocation during activation
    • Borregaard N., Heiple JM, Simons ER, Clark RA (1983) Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation. J Cell Bio 97:52-61.
    • (1983) J Cell Bio , vol.97 , pp. 52-61
    • Borregaard, N.1    Heiple, J.M.2    Simons, E.R.3    Clark, R.A.4
  • 17
    • 20444372657 scopus 로고    scopus 로고
    • Neuroprotective strategies in MS: Lessons from C57BL/Wld(S) mice
    • Coleman MP., Adalbert R, Beirowski B (2005) Neuroprotective strategies in MS: lessons from C57BL/Wld(S) mice. J Neurol Sci 233:133-138.
    • (2005) J Neurol Sci , vol.233 , pp. 133-138
    • Coleman, M.P.1    Adalbert, R.2    Beirowski, B.3
  • 18
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A., Coles A (2008) Multiple sclerosis. Lancet 372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 19
    • 65249107203 scopus 로고    scopus 로고
    • Microtubule assembly, organization and dynamics in axons and dendrites
    • Conde C., Caceres A (2009) Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 10:319-332.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 319-332
    • Conde, C.1    Caceres, A.2
  • 20
    • 33745115644 scopus 로고    scopus 로고
    • The contribution of demyelination to axonal loss in multiple sclerosis
    • DeLuca GC., Williams K, Evangelou N, Ebers GC, Esiri MM (2006) The contribution of demyelination to axonal loss in multiple sclerosis. Brain 129:1507-1516.
    • (2006) Brain , vol.129 , pp. 1507-1516
    • DeLuca, G.C.1    Williams, K.2    Evangelou, N.3    Ebers, G.C.4    Esiri, M.M.5
  • 21
    • 0033152818 scopus 로고    scopus 로고
    • Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis
    • Dittel BN., Merchant RM, Janeway, Jr., CA (1999) Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol 162:6392-6400.
    • (1999) J Immunol , vol.162 , pp. 6392-6400
    • Dittel, B.N.1    Merchant, R.M.2    Janeway Jr., C.A.3
  • 22
    • 0031135533 scopus 로고    scopus 로고
    • Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-γ in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR
    • Dittel BN., Sant'Angelo DB, Janeway, Jr., CA (1997) Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-γ in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR. J Immunol 158:4065-4073.
    • (1997) J Immunol , vol.158 , pp. 4065-4073
    • Dittel, B.N.1    Sant'Angelo, D.B.2    Janeway Jr., C.A.3
  • 25
    • 77954563548 scopus 로고    scopus 로고
    • Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • El-Behi M., Rostami A, Ciric B (2010) Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol 5:189-197.
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 189-197
    • El-Behi, M.1    Rostami, A.2    Ciric, B.3
  • 26
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B., Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120:393-399.
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 28
    • 0037530542 scopus 로고    scopus 로고
    • Vulnerability of human neurons to T cell-mediated cytotoxicity
    • Giuliani F., Goodyer CG, Antel JP, Yong VW (2003) Vulnerability of human neurons to T cell-mediated cytotoxicity. J Immunol 171:368-379.
    • (2003) J Immunol , vol.171 , pp. 368-379
    • Giuliani, F.1    Goodyer, C.G.2    Antel, J.P.3    Yong, V.W.4
  • 30
    • 3142516228 scopus 로고    scopus 로고
    • Microtubule-dependent transport in neurons: Steps towards an understanding of regulation, function and dysfunction
    • Guzik BW., Goldstein LS (2004) Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol 16:443-450.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 443-450
    • Guzik, B.W.1    Goldstein, L.S.2
  • 34
    • 51249090471 scopus 로고    scopus 로고
    • T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
    • Hedegaard CJ., Krakauer M, Bendtzen K, Lund H, Sellebjerg F, Nielsen CH (2008) T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology 125:161-169.
    • (2008) Immunology , vol.125 , pp. 161-169
    • Hedegaard, C.J.1    Krakauer, M.2    Bendtzen, K.3    Lund, H.4    Sellebjerg, F.5    Nielsen, C.H.6
  • 35
    • 77955659717 scopus 로고    scopus 로고
    • Neurodegeneration in autoimmune CNS inflammation
    • Herz J., Zipp F, Siffrin V (2009) Neurodegeneration in autoimmune CNS inflammation. Exp Neurol 225:9-17.
    • (2009) Exp Neurol , vol.225 , pp. 9-17
    • Herz, J.1    Zipp, F.2    Siffrin, V.3
  • 36
    • 78449269612 scopus 로고    scopus 로고
    • Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease
    • Hirokawa N., Niwa S, Tanaka Y (2010) Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 68:610-638.
    • (2010) Neuron , vol.68 , pp. 610-638
    • Hirokawa, N.1    Niwa, S.2    Tanaka, Y.3
  • 41
    • 7444266728 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase
    • Jana A., Pahan K (2004) Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. J Neurosci 24:9531-9540.
    • (2004) J Neurosci , vol.24 , pp. 9531-9540
    • Jana, A.1    Pahan, K.2
  • 42
    • 77957191723 scopus 로고    scopus 로고
    • Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: Implications for Alzheimer's disease
    • Jana A., Pahan K (2010) Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease. J Neurosci 30:12676-12689.
    • (2010) J Neurosci , vol.30 , pp. 12676-12689
    • Jana, A.1    Pahan, K.2
  • 44
    • 12344323961 scopus 로고    scopus 로고
    • Tau phosphorylation in neuronal cell function and dysfunction
    • Johnson GV., Stoothoff WH (2004) Tau phosphorylation in neuronal cell function and dysfunction. J Cell Sci 117:5721-5729.
    • (2004) J Cell Sci , vol.117 , pp. 5721-5729
    • Johnson, G.V.1    Stoothoff, W.H.2
  • 45
    • 34548864370 scopus 로고    scopus 로고
    • Culturing hippocampal neurons
    • Kaech S., Banker G (2006) Culturing hippocampal neurons. Nat Protoc 1:2406-2415.
    • (2006) Nat Protoc , vol.1 , pp. 2406-2415
    • Kaech, S.1    Banker, G.2
  • 46
    • 0028838142 scopus 로고
    • Sorting mechanisms of tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding
    • Kanai Y., Hirokawa N (1995) Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding. Neuron 14:421-432.
    • (1995) Neuron , vol.14 , pp. 421-432
    • Kanai, Y.1    Hirokawa, N.2
  • 49
    • 84874875434 scopus 로고    scopus 로고
    • Natural killer cells and their receptors in multiple sclerosis
    • doi: 10.1093/brain/aws159
    • Kaur G., Trowsdale J, Fugger L (2012) Natural killer cells and their receptors in multiple sclerosis. Brain doi: 10.1093/brain/aws159.
    • (2012) Brain
    • Kaur, G.1    Trowsdale, J.2    Fugger, L.3
  • 51
    • 0028829010 scopus 로고
    • Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells
    • Khoruts A., Miller SD, Jenkins MK (1995) Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J Immunol 155:5011-5017.
    • (1995) J Immunol , vol.155 , pp. 5011-5017
    • Khoruts, A.1    Miller, S.D.2    Jenkins, M.K.3
  • 52
    • 0028985712 scopus 로고
    • Ankyrin G. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvie
    • Kordeli E., Lambert S, Bennett V (1995) Ankyrin G. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem 270:2352-2359.
    • (1995) J Biol Chem , vol.270 , pp. 2352-2359
    • Kordeli, E.1    Lambert, S.2    Bennett, V.3
  • 53
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek B., Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H (2000) Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 157:267-276.
    • (2000) Am J Pathol , vol.157 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6    Linington, C.7    Schmidbauer, M.8    Lassmann, H.9
  • 54
    • 0023434104 scopus 로고
    • MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: An immunocytochemical study of cultured rat cerebrum
    • Kosik KS., Finch EA (1987) MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum. J Neurosci 7:3142-3153.
    • (1987) J Neurosci , vol.7 , pp. 3142-3153
    • Kosik, K.S.1    Finch, E.A.2
  • 55
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • Kuhlmann T., Lingfeld G, Bitsch A, Schuchardt J, Bruck W (2002) Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 125:2202-2212.
    • (2002) Brain , vol.125 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, G.2    Bitsch, A.3    Schuchardt, J.4    Bruck, W.5
  • 56
    • 77955656367 scopus 로고    scopus 로고
    • Axonal and neuronal pathology in multiple sclerosis: What have we learnt from animal models
    • Lassmann H (2010) Axonal and neuronal pathology in multiple sclerosis: what have we learnt from animal models. Exp Neurol 225:2-8.
    • (2010) Exp Neurol , vol.225 , pp. 2-8
    • Lassmann, H.1
  • 58
    • 78650178184 scopus 로고    scopus 로고
    • Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?
    • Lovett-Racke AE, Yang Y, Racke MK (2011) Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis? Biochim Biophys Acta 1812:246-251.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 246-251
    • Lovett-Racke, A.E.1    Yang, Y.2    Racke, M.K.3
  • 60
    • 0022253052 scopus 로고
    • Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes
    • Masson D., Tschopp J (1985) Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes. J Biol Chem 260:9069-9072.
    • (1985) J Biol Chem , vol.260 , pp. 9069-9072
    • Masson, D.1    Tschopp, J.2
  • 63
    • 84858079448 scopus 로고    scopus 로고
    • Regulation of CCL20 expression in astrocytes by IL-6 and IL-17
    • Meares GP., Ma X, Qin H, Benveniste EN (2012) Regulation of CCL20 expression in astrocytes by IL-6 and IL-17. Glia 60:771-781.
    • (2012) Glia , vol.60 , pp. 771-781
    • Meares, G.P.1    Ma, X.2    Qin, H.3    Benveniste, E.N.4
  • 64
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • Medana I., Martinic MA, Wekerle H, Neumann H (2001) Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am J Pathol 159:809-815.
    • (2001) Am J Pathol , vol.159 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 66
    • 84859540194 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Miller E (2012) Multiple sclerosis. Adv Exp Med Biol 724:222-238.
    • (2012) Adv Exp Med Biol , vol.724 , pp. 222-238
    • Miller, E.1
  • 70
    • 0038459134 scopus 로고    scopus 로고
    • Molecular mechanisms of axonal damage in inflammatory central nervous system diseases
    • Neumann H (2003) Molecular mechanisms of axonal damage in inflammatory central nervous system diseases. Curr Opin Neurol. 16:267-273.
    • (2003) Curr Opin Neurol. , vol.16 , pp. 267-273
    • Neumann, H.1
  • 73
    • 0021270576 scopus 로고
    • Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization
    • Podack ER., Konigsberg PJ (1984) Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization. J Exp Med 160:695-710.
    • (1984) J Exp Med , vol.160 , pp. 695-710
    • Podack, E.R.1    Konigsberg, P.J.2
  • 74
    • 33846018916 scopus 로고    scopus 로고
    • GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
    • Ponomarev ED., Shriver LP, Maresz K, Pedras-Vasconcelos J, Verthelyi D, Dittel BN (2007) GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J Immunol 178:39-48.
    • (2007) J Immunol , vol.178 , pp. 39-48
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Pedras-Vasconcelos, J.4    Verthelyi, D.5    Dittel, B.N.6
  • 75
    • 0017669602 scopus 로고
    • Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties
    • Ransom BR., Neale E, Henkart M, Bullock PN, Nelson PG (1977) Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties. J Neurophysiol 40:1132-1150.
    • (1977) J Neurophysiol , vol.40 , pp. 1132-1150
    • Ransom, B.R.1    Neale, E.2    Henkart, M.3    Bullock, P.N.4    Nelson, P.G.5
  • 76
    • 84859376769 scopus 로고    scopus 로고
    • A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand
    • Ray A., Basu S, Williams CB, Salzman NH, Dittel BN (2012) A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol 188:3188-3198.
    • (2012) J Immunol , vol.188 , pp. 3188-3198
    • Ray, A.1    Basu, S.2    Williams, C.B.3    Salzman, N.H.4    Dittel, B.N.5
  • 77
    • 11144236862 scopus 로고    scopus 로고
    • NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors
    • Regunathan J., Chen Y, Wang D, Malarkannan S (2005) NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Blood 105:233-240.
    • (2005) Blood , vol.105 , pp. 233-240
    • Regunathan, J.1    Chen, Y.2    Wang, D.3    Malarkannan, S.4
  • 78
    • 0018701573 scopus 로고
    • The beige mutation in the mouse. II. Selectivity of the natural killer (NK) cell defect
    • Roder JC., Lohmann-Matthes ML, Domzig W, Wigzell H (1979) The beige mutation in the mouse. II. Selectivity of the natural killer (NK) cell defect. J Immunol 123:2174-2181.
    • (1979) J Immunol , vol.123 , pp. 2174-2181
    • Roder, J.C.1    Lohmann-Matthes, M.L.2    Domzig, W.3    Wigzell, H.4
  • 81
    • 33747187744 scopus 로고    scopus 로고
    • Regional gray matter atrophy in early primary progressive multiple sclerosis: A voxel-based morphometry study
    • Sepulcre J., Sastre-Garriga J, Cercignani M, Ingle GT, Miller DH, Thompson AJ (2006) Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study. Arch Neurol 63: 1175-1180.
    • (2006) Arch Neurol , vol.63 , pp. 1175-1180
    • Sepulcre, J.1    Sastre-Garriga, J.2    Cercignani, M.3    Ingle, G.T.4    Miller, D.H.5    Thompson, A.J.6
  • 82
    • 35448965261 scopus 로고    scopus 로고
    • +T-cell-mediated control of West Nile virus infection in the central nervous system
    • +T-cell-mediated control of West Nile virus infection in the central nervous system. J Virol 81:11749-11757.
    • (2007) J Virol , vol.81 , pp. 11749-11757
    • Shrestha, B.1    Diamond, M.S.2
  • 83
    • 33748784089 scopus 로고    scopus 로고
    • T-cell-mediated disruption of the neuronal microtubule network: Correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis
    • Shriver LP., Dittel BN (2006) T-cell-mediated disruption of the neuronal microtubule network: correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis. Am J Pathol 169:999-1011.
    • (2006) Am J Pathol , vol.169 , pp. 999-1011
    • Shriver, L.P.1    Dittel, B.N.2
  • 85
    • 77950862182 scopus 로고    scopus 로고
    • Multiple sclerosis-candidate mechanisms underlying CNS atrophy
    • Siffrin V., Vogt J, Radbruch H, Nitsch R, Zipp F (2010b) Multiple sclerosis-candidate mechanisms underlying CNS atrophy. Trends Neurosci 33:202-210.
    • (2010) Trends Neurosci , vol.33 , pp. 202-210
    • Siffrin, V.1    Vogt, J.2    Radbruch, H.3    Nitsch, R.4    Zipp, F.5
  • 87
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M., Martin R (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 88
    • 31144439760 scopus 로고    scopus 로고
    • +T cells in the latently infected trigeminal ganglia
    • +T cells in the latently infected trigeminal ganglia. J Immunol 176:1703-1711.
    • (2006) J Immunol , vol.176 , pp. 1703-1711
    • Suvas, S.1    Azkur, A.K.2    Rouse, B.T.3
  • 89
    • 66549110162 scopus 로고    scopus 로고
    • Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease
    • Tallantyre EC., Bo L, Al-Rawashdeh O, Owens T, Polman CH, Lowe J, Evangelou N (2009) Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease. Brain 132:1190-1199.
    • (2009) Brain , vol.132 , pp. 1190-1199
    • Tallantyre, E.C.1    Bo, L.2    Al-Rawashdeh, O.3    Owens, T.4    Polman, C.H.5    Lowe, J.6    Evangelou, N.7
  • 90
    • 77951688913 scopus 로고    scopus 로고
    • Isolation of cytotoxic T cell and NK granules and purification of their effector proteins
    • 3.37.1-3.37.29
    • Thiery J., Walch M, Jensen DK, Martinvalet D, Lieberman J (2010) Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol 43:3.37.1-3.37.29.
    • (2010) Curr Protoc Cell Biol , vol.43
    • Thiery, J.1    Walch, M.2    Jensen, D.K.3    Martinvalet, D.4    Lieberman, J.5
  • 91
    • 0020676803 scopus 로고
    • Multiple sclerosis: Distribution of T cell subsets within active chronic lesions
    • Traugott U., Reinherz EL, Raine CS (1983) Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science 219:308-310.
    • (1983) Science , vol.219 , pp. 308-310
    • Traugott, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 93
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos JS., Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L (2008) Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 172:146-155.
    • (2008) Am J Pathol , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 98
    • 0030712367 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells
    • Zhang B., Yamamura T, Kondo T, Fujiwara M, Tabira T (1997) Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J Exp Med 186:1677-1687.
    • (1997) J Exp Med , vol.186 , pp. 1677-1687
    • Zhang, B.1    Yamamura, T.2    Kondo, T.3    Fujiwara, M.4    Tabira, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.