Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment

Aging Cell

Volumn 10, Issue 2, 2011, Pages 338-348

  Gu, Bai Wei ^a,b   Fan, Jian Meng ^a,b   Bessler, Monica ^a,b   Mason, Philip J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Dyskeratosis congenita; N acetyl cysteine; Oxidative stress; Reactive oxygen species; Stem cell aging; Telomerase

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; DYSKERIN; REACTIVE OXYGEN METABOLITE; TELOMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL AGING; CELL GROWTH; CELL MUTANT; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DYSKERATOSIS CONGENITA; EMBRYO; FEMALE; FIBROBLAST; GENE MUTATION; GROWTH INHIBITION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; SEX LINKAGE;

ANIMALS; ANTIOXIDANTS; CELL AGING; CELL CYCLE PROTEINS; CELLS, CULTURED; DYSKERATOSIS CONGENITA; FEMALE; FIBROBLASTS; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; TELOMERASE; TELOMERE;

MUS;

EID: 79952584997     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00674.x     Document Type: Article

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