Oral zinc for treating diarrhoea in children

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 1, 2013, Pages

  Lazzerini, Marzia ^a   Ronfani, Luca ^a  

^a INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; ZINC; TRACE ELEMENT;

ACUTE DIARRHEA; CHILD; CLINICAL OUTCOME; COMPARATIVE STUDY; DEATH; DEVELOPING COUNTRY; DIARRHEA; DIET SUPPLEMENTATION; DISEASE CONTROL; DISEASE DURATION; DISEASE SEVERITY; DYSENTERY; EPIGASTRIC PAIN; EVIDENCE BASED MEDICINE; FATIGUE; GASTROENTERITIS; HOSPITALIZATION; HUMAN; LETHARGY; MALNUTRITION; METALLIC TASTE; MORTALITY; NONHUMAN; ORAL REHYDRATION THERAPY; PERSISTENT DIARRHEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; VOMITING; ZINC DEFICIENCY; ACUTE DISEASE; AGE; INFANT; INFANTILE DIARRHEA; META ANALYSIS; PRESCHOOL CHILD; TIME;

ACUTE DISEASE; AGE FACTORS; CHILD, PRESCHOOL; DEVELOPING COUNTRIES; DIARRHEA; DIARRHEA, INFANTILE; HUMANS; INFANT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TIME FACTORS; TRACE ELEMENTS; ZINC;

MLCS; MLOWN;

EID: 84874799744     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD005436.pub4     Document Type: Review

References (210)

1. Al-Sonboli N, Gurgel RQ, Shenkin A, Hart CA, Cuevas LE. Zinc supplementation in Brazilian children with acute diarrhoea. Annals of Tropical Paediatrics 2003;23(1):3-8.
2. Cuevas LE, Al Sonboli NN, Gurgel RQ, Shenkins A, Hart CA. Impact of zinc on duration of acute diarrhoea in children [Abstract]. Journal of Infection 2000;40:A29.
3. Bahl R, Bhandari N, Saksena M, Strand T, Kumar GT, Bhan MK, et al.Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea. Journal of Pediatrics 2002;141(5):677-82.
4. Bhatnagar S, Bahl R, Sharma PK, Kumar GT, Saxena SK, Bhan MK. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2004;38(1):34-40.
5. Bhutta ZA, Nizami SQ, Isani Z. Zinc supplementation in malnourished children with persistent diarrhea in Pakistan. Pediatrics 1999;103(4):e42.
6. Brooks WA, Santosham M, Roy SK, Faruque AS, Wahed MA, Nahar K, et al.Efficacy of zinc in young infants with acute watery diarrhea. American Journal of Clinical Nutrition 2005;82(3):605-10.
7. See Brooks 2005a.
8. See Brooks 2005a.
9. Dalgic N, Sancar M, Bayraktar B, Pullu M, Hasim O. Probiotic, zinc andlactose-free formula in children with rotavirus diarrhea: are they effective?. Pediatrics International 2011;53(5):677-82.
10. Dutta P, Mitra U, Datta A, Niyogi SK, Dutta S, Manna B, et al.Impact of zinc supplementation in malnourished children with acute watery diarrhoea. Journal of Tropical Pediatrics 2000;46(5):259-63.
11. Dutta P, Mitra U, Dutta S, Naik TN, Rajendran K, Chatterjee MK. Zinc, vitamin A, and micronutrient supplementation in children with diarrhea: a randomized controlled clinical trial of combination therapy versus monotherapy. Journal of Pediatrics 2011;159(4):633-7.
12. Fajolu IB, Emokpae A, Oduwole AO, Silva BO, Abidoye RO, Renner JK. Zinc supplementation in children with acute diarrhoea. Nigerian Quarterly Journal of Hospital Medicine. Nigerian Quarterly Journal of Hospital Medicine. 2008;18(2):101-3.
13. Faruque AS, Mahalanabis D, Haque SS, Fuchs GJ, Habte D. Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhoea. Acta Paediatrica 1999;88(2):154-60.
14. Fischer Walker CL, Bhutta ZA, Bhandari N, Teka T, Shahid F, Taneja S, et al.Zinc supplementation for the treatment of diarrhea in infants in Pakistan, India and Ethiopia. Journal of Pediatric Gastroenterology and Nutrition 2006;43(3):357-63.
15. See Fischer Walker 2006.
16. See Fischer Walker 2006.
17. See Fischer Walker 2006.
18. Khatun UH, Malek MA, Black RE, Sarkar NR, Wahed MA, Fuchs G, et al.A randomized controlled clinical trial of zinc, vitamin A or both in undernourished children with persistent diarrhea in Bangladesh. Acta Paediatrica 2001;90(4):376-80.
19. Roy SK. A randomized four cell clinical trial of zinc and vitamin A in undernourished children with persistent diarrhoea in Bangladesh. Journal of Pediatric Gastroenterology and Nutrition 1998;26(5):595.
20. Larson CP, Hoque AB, Larson CP, Khan AM, Saha UR. Initiation of zinc treatment for acute childhood diarrhoea and risk for vomiting or regurgitation: a randomized, double-blind, placebo-controlled trial. Journal of Health, Population, and Nutrition 2005;23(4):311-9.
21. Patel A, Dibley MJ, Mamtani M, Badhoniya N, Kulkarni H. Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. BMC Medicine 2009;5(7):22.
22. Patel A, Dibley MJ, Mamtani M, Badhoniya N, Kulkarni H. Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. BMC Medicine 2009;5(7):22.
23. Patel A, Dibley MJ, Mamtani M, Badhoniya N, Kulkarni H. Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. BMC Medicine 2009;5(7):22.
24. Patro B, Szymanski H, Szajewska H. Oral zinc for the treatment of acute gastroenteritis in polish children: a randomized, double-blind, placebo-controlled trial. Journal of Pediatrics 2010;157(6):984-8.
25. Penny ME, Peerson JM, Marin RM, Duran A, Lanata CF, Lonnerdal B, et al.Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru. Journal of Pediatrics 1999;135(2 Pt 1):208-17.
26. Polat TB, Uysalol M, Cetinkaya F. Efficacy of zinc supplementation on the severity and duration of diarrhea in malnourished Turkish children. Pediatrics International 2003;45(5):555-9.
27. Polat TB, Uysalol M, Cetinkaya F. Efficacy of zinc supplementation on the severity and duration of diarrhea in malnourished Turkish children. Pediatrics International 2003;45(5):555-9.
28. Polat TB, Uysalol M, Cetinkaya F. Efficacy of zinc supplementation on the severity and duration of diarrhea in malnourished Turkish children. Pediatrics International 2003;45(5):555-9.
29. Roy SK. Effect of zinc supplementation in patients with acute and persistent diarrhoea. Glimpse 1991;13(3):2.
30. Roy SK, Tomkins AM, Akramuzzaman SM, Behrens RH, Haider R, Mahalanabis D, et al.Randomised controlled trial of zinc supplementation in malnourished Bangladeshi children with acute diarrhoea. Archives of Disease in Childhood 1997;77(3):196-200.
31. Roy SK. Effect of zinc supplementation in patients with acute and persistent diarrhoea. Glimpse 1991;13(3):2.
32. Roy SK, Tomkins AM, Mahalanabis D, Akramuzzaman SM, Haider R, Behrens RH, et al.Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children. Acta Paediatrica 1998;87(12):1235-9.
33. Roy SK, Raqib R, Khatun W, Azim T, Chowdhury R, Fuchs GJ, et al.Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. European Journal of Clinical Nutrition 2008;62(7):849-55.
34. Sachdev HP, Mittal NK, Mittal SK, Yadav HS. A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants. Journal of Pediatric Gastroenterology and Nutrition 1988;7(6):877-81.
35. Sachdev HP, Mittal NK, Yadav HS. Oral zinc supplementation in persistent diarrhoea in infants. Annals of Tropical Paediatrics 1990;10(1):63-9.
36. Darmon N, Briend A, Desjeux JF. Zinc in the treatment of diarrhea. Journal of Pediatric Gastroenterology and Nutrition 1997;25(3):363-5.
37. Folwaczny C. Role of zinc in treatment of acute diarrhea. Zeitschrift für Gastroenterologie 1996;34(4):260-2.
38. Sazawal S, Black RE, Bhan MK, Bhandari N, Sinha A, Jalla S. Zinc supplementation in young children with acute diarrhea in India. New England Journal of Medicine 1995;333(13):839-44.
39. Strand TA, Chandyo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, et al.Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics 2002;109(5):898-903.
40. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: Effects on growth and motor development. American Journal of Clinical Nutrition 2007;86(2):412-20.
41. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. The American journal of clinical nutrition 2008;87(4):929-38.
42. Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics 2007;119(6):1120-30.
43. Agustina R, Lukito W, Firmansyah A, Suhardjo HN, Murniati D, Bindels J. The effect of early nutritional supplementation with a mixture of probiotic, prebiotic, fiber and micronutrients in infants with acute diarrhea in Indonesia. Asia Pacific Journal of Clinical Nutrition 2007;16(3):435-42.
44. Alam DS, Yunus M, El Arifeen S, Chowdury HR, Larson CP, Sack DA, Baqui AH, Black RE. Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children. Journal of Nutrition 2010;141(2):312-5.
45. Alarcon K, Kolsteren PW, Prada AM, Chian AM, Velarde RE, Pecho IL, et al.Effects of separate delivery of zinc or zinc and vitamin A on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anemia. American Journal of Clinical Nutrition 2004;80(5):1276-82.
46. Awasthi S, INCLEN Childnet Zinc Effectiveness for Diarrhea (IC-ZED) Group. Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications: a randomized trial in five countries. Journal of Pediatric Gastroenterology and Nutrition 2006;42(3):300-5.
47. Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, et al.Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ 2002;325(7372):1059-64.
48. Baqui AH, Black RE, El Arifeen S, Yunus M, Zaman K, Begum N, et al.Zinc therapy for diarrhoea increased the use of oral rehydration therapy and reduced the use of antibiotics in Bangladeshi children. Journal of Health, Population, and Nutrition 2004;22(4):440-2.
49. Baqui AH, Zaman K, Persson LA, El Arifeen S, Yunus M, Begum N, et al.Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladeshi infants. Journal of Nutrition 2003;133(12):4150-7.
50. Baqui AH, Black RE, Fischer Walker CL, Arifeen S, Zaman K, Yunus M, et al.Zinc supplementation and serum zinc during diarrhea. Indian Journal of Pediatrics 2006;73(6):493-7.
51. Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 2010;50(12):1653-60.
52. Behrens RH, Tomkins AM, Roy SK. Zinc supplementation during diarrhoea, a fortification against malnutrition?. Lancet 1990;336(8712):442-3.
53. Bhandari N, Bahl R, Taneja S, Strand T, Molbak K, Ulvik RJ, et al.Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children. Pediatrics 2002;109(6):e86.
54. Bhandari N, Mazumder S, Taneja S, Dube B, Black RE, Fontaine O, et al.A pilot test of the addition of zinc to the current case management package of diarrhea in a primary health care setting. Journal of Pediatric Gastroenterology and Nutrition 2005;41(5):685-7.
55. Bhandari N, Taneja S, Mazumder S, Bahl R, Fontaine O, Bhan MK. Adding zinc to supplemental iron and folic acid does not affect mortality and severe morbidity in young children. Journal of Nutrition 2007;137(1):112-7.
56. Bhandari N, Mazumder S, Taneja S, Dube B, Agarwal RC, Mahalanabis D, et al.Effectiveness of zinc supplementation plus oral rehydration salts compared with oral rehydration salts alone as a treatment for acute diarrhea in a primary care setting: a cluster randomized trial. Pediatrics 2008;121(5):e1279-85.
57. Bhatnagar S, Natchu UC. Zinc in child health and disease. Indian Journal of Pediatrics 2004;71(11):991-5.
58. Bhutta ZA, Raza F, Nizami SQ, Issani Z. Does zinc supplementation influence appetite in malnourished children with persistent diarrhoea? A randomized controlled trial in Pakistan. Journal of Pediatric Gastroenterology and Nutrition 2000;31 Suppl 2:23.
59. Bilenko N, Belmaker I, Vardi H, Fraser D. Efficacy of multiple micronutrient supplementations on child health: study design and baseline characteristics. The Israel Medical Association journal: IMAJ 2010;12(6):342-7.
60. Black RE, Sazawal S. Zinc and childhood infectious disease morbidity and mortality. British Journal of Nutrition 2001;85 Suppl 2:125-9.
61. Bobat R, Coovadia H, Stephen C, Naidoo KL, McKerrow N, Black RE, et al.Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: a randomised double-blind placebo-controlled trial. Lancet 2005;366(9500):1862-7.
62. Borges Dantas CV, Veiga Black AP, Barroso dos Santos G, Jesus Oliveira EF, Serpa Barbosa RF, Moreira S, et al.Association among serum concentration of minerals, anthropometric indices and diarrhea in low-income children in the metropolitan region of Rio de Janeiro, Brazil [Associação entre concentrações séricas de minerais, índices antropométricos e ocorrência de diarréia entre crianças de baixa renda da região metropolitana do Rio de Janeiro]. Revista de Nutricao 2007;20(2):159-69.
63. Brooks WA, Santosham M, Naheed A, Goswami D, Wahed MA, Diener-West M, et al.Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Lancet 2005;366(9490):999-1004.
64. Brown KH, de Romana DL, Arsenault JE, Peerson JM, Penny ME. Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth morbidity and plasma zinc concentrations of young Peruvian children. American Journal of Clinical Nutrition 2007;85(2):538-47.
65. Brown KH, Lopez de Romana D, Arsenault JE, Peerson JM, Penny ME. Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth, morbidity, and plasma zinc concentrations of young Peruvian children. The American Journal of Clinical Nutrition 2007;85(2):538-47.
66. Carbajal C. Micronutrients: An option in the treatment of acute diarrheal diseases [Micronutrientes: una opción en el tratamiento de las enfermedades diarreicas agudas]. Revista Cubana de Pediatría 2000;72(4):261-6.
67. Carcamo C, Hooton T, Weiss NS, Gilman R, Wener MH, Chavez V, et al.Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. Journal of Acquired Immune Deficiency Syndromes 2006;43(2):197-201.
68. Chandyo RK, Shrestha PS, Valentiner-Branth P, Mathisen M, Basnet S, Ulak M, et al.Two weeks of zinc administration to Nepalese children with pneumonia does not reduce the incidence of pneumonia or diarrhea during the next six months. The Journal of Nutrition 2010;140(9):1677-82.
69. Chang S, El Arifeen S, Bari S, Wahed MA, Rahman KM, Rahman MT, et al.Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. European Journal of Clinical Nutrition 2010;64(2):153-60.
70. Chen K, Zhang X, Li TY, Chen L, Wei XP, Qu P, et al.Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children. Nutrition 2010, June 1;27(4):428-34.
71. Chhagan MK, Van den Broeck J, Luabeya KK, Mpontshane N, Tucker KL, Bennish ML. Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa. European Journal of Clinical Nutrition 2009;63(7):850-7.
72. Chhagan MK, Van den Broeck J, Luabeya KK, Mpontshane N, Tomkins A, Bennish ML. Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months. BMC Public Health 2010;10:145.
73. Christian P, Stewart CP, LeClerq SC, Wu L, Katz J, West KP Jr, et al.Antenatal and postnatal iron supplementation and childhood mortality in rural Nepal: a prospective follow-up in a randomized, controlled community trial. American Journal of Epidemiology 2009;170(9):1127-36.
74. The Chilenje Infant Growth, Nutrition and Infection (CIGNIS) Study Team. Micronutrient fortification to improve growth and health of maternally HIV-unexposed and exposed Zambian infants: a randomised controlled trial. PLoS ONE 2010;5(6):e11165.
75. Cross AJ, Heath AL, Ferguson EL, Gray AR, Szymlek-Gay EA. Rates of common communicable illnesses in non-anaemic 12-24 month old South Island, New Zealand children. The New Zealand Medical Journal 2009;122(1290):24-35.
76. Dhingra U, Hiremath G, Menon VP, Dhingra P, Sarkar A, Sazawal S. Zinc deficiency: descriptive epidemiology and morbidity among preschool children in peri-urban population in Delhi, India. Journal of Health, Population, and Nutrition 2009;27(5):632-9.
77. Doherty CP, Sarkar MA, Shakur MS, Ling SC, Elton RA, Cutting WA. Zinc and rehabilitation from severe protein-energy malnutrition: higher-dose regimens are associated with increased mortality. American Journal of Clinical Nutrition 1998;68(3):742-8.
78. Ebrahimi S, Pormahmodi A, Kamkar A. Study of zinc supplementation on growth of schoolchildren in Yasuj, Southwest of Iran. Pakistan Journal of Nutrition 2006;5(4):341-2.
79. Ellis AA, Winch P, Daou Z, Gilroy KE, Swedberg E. Home management of childhood diarrhoea in southern Mali-Implications for the introduction of zinc treatment. Social Science and Medicine 2007;64(3):701-12.
80. Ferraz IS, Daneluzzi JC, Vannucchi H, Jordão Jr AA, Ricco RG, Del Ciampo LA, Martinelli CE Jr, Engelberg AA, Bonilha LR, Custódio VI. Zinc serum levels and their association with vitamin A deficiency in preschool children [Nível sérico de zinco e sua associação com deficiência de vitamina A em crianças pré-escolares]. Jornal de Pediatria (Rio J) 2007;83(6):512-17.
81. Ferrufino B, Sagrario A. Acceptability of mothers of zinc sulphate supplementation in children under 5 years in the municipality of Jinotega. November 2006 to March 2007. [Aceptabilidad de las madres de la suplementación del sulfato de zinc en el manejo de las enfermedades diarreicas en menores de 5 años, municipio de Jinotega. Noviembre del año 2006 a marzo del año 2007]. Thesis, Universidad Nacional Autónoma de Nicaragua, Managua, 2007.
82. Fischer Walker CL, Black RE, Baqui AH. Does age affect the response to zinc therapy for diarrhoea in Bangladeshi infants?. Journal of Health, Population, and Nutrition 2008;26(1):105-9.
83. Gardner JM, Powell CA, Baker-Henningham H, Walker SP, Cole TJ, Grantham-McGregor SM. Zinc supplementation and psychosocial stimulation: effects on the development of undernourished Jamaican children. American Journal of Clinical Nutrition 2005;82(2):399-405.
84. Garenne M, Becher H, Ye Y, Kouyate B, Muller O. Sex-specific responses to zinc supplementation in Nouna, Burkina Faso. Journal of Pediatric Gastroenterology and Nutrition 2007;44(5):619-28.
85. Gregorio GV, Dans LF, Cordero CP, Panelo CA. Zinc supplementation reduced cost and duration of acute diarrhea in children. Journal of Clinical Epidemiology 2007;60(6):560-6.
86. Gupta DN, Mondal SK, Ghosh S, Rajendran K, Sur D, Manna B. Impact of zinc supplementation on diarrhoeal morbidity in rural children of West Bengal, India. Acta Paediatrica 2003;92(5):531-6.
87. Gupta DN, Rajendran K, Mondal SK, Ghosh S, Bhattacharya SK. Operational feasibility of implementing community-based zinc supplementation:impact on childhood diarrheal morbidity. Pediatric Infectious Disease Journal 2007;26(4):306-10.
88. Habib MA, Soofi SB, Bhutta ZA. Effect of zinc in tablet and suspension formulations in the treatment of acute diarrhoea among young children in an emergency setting of earthquake affected region of Pakistan. Journal of College of Physicians and Surgeons Pakistan 2010;20(12):837-8.
89. Heinig MJ, Brown KH, Lonnerdal B, Dewey KG. Zinc supplementation does not affect growth morbidity or motor development of US term breastfed infants at 4-10 mo of age. American Journal of Clinical Nutrition 2006;84(3):594-601.
90. Hettiarachchi M, Liyanage C, Wickremasinghe R, Hilmers DC, Abrams SA. The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka. European Journal of Clinical Nutrition 2008;62(7):856-65.
91. Hidayat A, Achadi A, Sunoto, Soedarmo SP. The effect of zinc supplementation in children under three years of age with acute diarrhea in Indonesia. Medical Journal of Indonesia 1998;7:237-41.
92. Hoque KM, Binder HJ. Zinc in the treatment of acute diarrhea: current status and assessment. Gastroenterology 2006;130(1):2201-5.
93. Hyder SM, Haseen F, Khan M, Schaetzel T, Jalal CS, Rahman M, et al.A multiple-micronutrient-fortified beverage affects hemoglobin, iron, and vitamin A status and growth in adolescent girls in rural Bangladesh. The Journal of Nutrition 2007;137(9):2147-53.
94. Iannotti LL, Zavaleta N, Leon Z, Huasquiche C, Shankar AH, Caulfield LE. Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants. Journal of Pediatrics 2010;156(6):960-4, 964.e1-2.
95. Islam MN, Chowdhury MA, Siddika M, Qurishi SB, Bhuiyan MK, Hoque MM, et al.Effect of oral zinc supplementation on the growth of preterm infants. Indian Pediatrics 2010;47(10):845-9.
96. Jimenez R, Sagaro E, Lafita Y. How growth infants supplemented with zinc sulfate after an episode of persistent diarrhea. Journal of Pediatric Gastroenterology and Nutrition 2000;31 Suppl 2:26.
97. Kelly P, Musonda R, Kafwembe E, Kaetano L, Keane E, Farthing M. Micronutrient supplementation in the AIDS diarrhoea-wasting syndrome in Zambia: a randomized controlled trial. AIDS 1999;13(4):495-500.
98. Kelly P, Shawa T, Mwanamakondo S, Soko R, Smith G, Barclay GR, et al.Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial. BMC Gastroenterology 2010;10:72.
99. Larson CP, Nasrin D, Saha A, Chowdhury MI, Qadri F. The added benefit of zinc supplementation after zinc treatment of acute childhood diarrhoea: a randomized, double-blind field trial. Tropical Medicine and International Health 2010;15(6):754-61.
100. Lin CA, Manary MJ, Maleta K, Briend A, Ashorn P. An energy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 6-18 months. Journal of Nutrition 2008;138(3):593-8.
101. Lind T, Lonnerdal B, Stenlund H, Gamayanti IL, Ismail D, Seswandhana R, et al.A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. American Journal of Clinical Nutrition 2004;80(3):729-36.
102. Lind T, Seswandhana R, Persson LA, Lonnerdal B. Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age. Acta paediatrica 2008;97(6):770-5.
103. Lira PI, Ashworth A, Morris SS. Effect of zinc supplementation on the morbidity, immune function, and growth of low-birth-weight, full-term infants in northeast Brazil. American Journal of Clinical Nutrition 1998;68 Suppl 2:418s-24s.
104. Long KZ, Montoya Y, Hertzmark E, Santos JI, Rosado JL. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mexico. American Journal of Clinical Nutrition 2006;83(3):693-700.
105. Long KZ, Rosado JL, Montoya Y, de Lourdes Solano M, Hertzmark E, DuPont HL, et al.Effect of vitamin A and zinc supplementation on gastrointestinal parasitic infections among Mexican children. Pediatrics 2007;120(4):e846-55.
106. Lopez de Romana G, Cusirramos S, Lopez de Romana D, Gross R. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants. Journal of Nutrition 2005;135(3):646-52.
107. Luabeya KK, Mpontshane N, Mackay M, Ward H, Elson I, Chhagan M, et al.Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: a randomized controlled trial. PLoS ONE 2007;2(6):e541.
108. Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008;121(2):326-36.
109. Makonnen B, Venter A, Joubert G. A randomized controlled study of the impact of dietary zinc supplementation in the management of children with protein-energy malnutrition in Lesotho. I: Mortality and morbidity. Journal of Tropical Pediatrics 2003;49(6):340-52.
110. Makonnen B, Venter A, Joubert G. A randomized controlled study of the impact of dietary zinc supplementation in the management of children with protein-energy malnutrition in Lesotho. II: Special investigations. Journal of Tropical Pediatrics 2003;49(6):353-60.
111. Manger MS, McKenzie JE, Winichagoon P, Gray A, Chavasit V, Pongcharoen T, et al.A micronutrient-fortified seasoning powder reduces morbidity and improves short-term cognitive function, but has no effect on anthropometric measures in primary school children in northeast Thailand: a randomized controlled trial. The American Journal of Clinical Nutrition 2008;87(6):1715-22.
112. Mazariegos M, Hambidge KM, Westcott JE, Solomons NW, Raboy V, Das A, et al.Neither a zinc supplement nor phytate-reduced maize nor their combination enhance growth of 6- to 12-month-old Guatemalan infants. The Journal of Nutrition 2010;140(5):1041-8.
113. Mazumder S, Taneja S, Bhandari N, Dube B, Agarwal RC, Mahalanabis D, et al.Effectiveness of zinc supplementation plus oral rehydration salts for diarrhoea in infants aged less than 6 months in Haryana state, India. Bulletin of the World Health Organization 2010;88(10):754-60.
114. Mda S, van Raaij JM, de Villiers FP, MacIntyre UE, Kok FJ. Short-term micronutrient supplementation reduces the duration of pneumonia and diarrheal episodes in HIV-infected children. The Journal of Nutrition 2010;140(5):969-74.
115. Meeks Gardner J, Witter MM, Ramdath DD. Zinc supplementation: effects on the growth and morbidity of undernourished Jamaican children. European Journal of Clinical Nutrition 1998;52(1):34-9.
116. Müller O, Becher H, van Zweeden AB, Ye Y, Diallo DA, Konate AT, et al.Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial. BMJ 2001;322(7302):1567.
117. Naheed A, Walker Fischer CL, Mondal D, Ahmed S, Arifeen SE, Yunus M, et al.Zinc therapy for diarrhoea improves growth among Bangladeshi infants 6 to 11 months of age. Journal of Pediatric Gastroenterology and Nutrition 2009;48(1):89-93.
118. Nasrin D, Larson CP, Sultana S, Khan TU. Acceptability of and adherence to dispersible zinc tablet in the treatment of acute childhood diarrhoea. Journal of Health, Population, and Nutrition 2005;23(3):215-21.
119. Nga TT, Winichagoon P, Dijkhuizen MA, Khan NC, Wasantwisut E, Furr H, et al.Multi-micronutrient-fortified biscuits decreased prevalence of anemia and improved micronutrient status and effectiveness of deworming in rural Vietnamese school children. The Journal of Nutrition 2009;139(5):1013-21.
120. Osendarp SJ, Santosham M, Black RE, Wahed MA, van Raaij JM, Fuchs GJ. Effect of zinc supplementation between 1 and 6 mo of life on growth and morbidity of Bangladeshi infants in urban slums. American Journal of Clinical Nutrition 2002;76(6):1401-8.
121. Ouedraogo HZ, Dramaix-Wilmet M, Zeba AN, Hennart P, Donnen P. Effect of iron or multiple micronutrient supplements on the prevalence of anaemia among anaemic young children of a malaria-endemic area: a randomized double-blind trial. Tropical Medicine and International Health 2008;13(10):1257-66.
122. Passariello A, Terrin G, De Marco G, Cecere G, Ruotolo S, Marino A, et al.Efficacy of a New Hypotonic Oral Rehydration Solution Containing Zinc and Prebiotics in the Treatment of Childhood Acute Diarrhea: A Randomized Controlled Trial. The Journal of Pediatrics 2011;158(2):288-92.e1.
123. Patel AB, Dhande LA, Rawat MS. Therapeutic evaluation of zinc and copper supplementation in acute diarrhea in children: double blind randomized trial. Indian Pediatrics 2005;42(5):433-42.
124. Patel AB, Dibley MJ, Mamtani M, Badhoniya N, Kulkarni H. Influence of zinc supplementation in acute diarrhea differs by the isolated organism. International Journal of Pediatrics 2010;2010:671587.
125. Patel A, Mamtani M, Dibley MJ, Badhoniya N, Kulkarni H. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. PLoS ONE 2010;5(4):e10386.
126. Patro B, Golicki D, Szajewska H. Meta-analysis: zinc supplementation for acute gastroenteritis in children. Alimentary Pharmacology and Therapeutics 2008;28(6):713-23.
127. Penny ME, Marin RM, Duran A, Peerson JM, Lanata CF, Lonnerdal B, et al.Randomized controlled trial of the effect of daily supplementation with zinc or multiple micronutrients on the morbidity, growth, and micronutrient status of young Peruvian children. American Journal of Clinical Nutrition 2004;79(3):457-65.
128. Penny ME, Black RE, Brown KH, Lönnerdal B. Reply to RJ Walden [Letter to the Editor]. American Journal of Clinical Nutrition 2004;80(4):1084-5.
129. Polat TB, Uysalol M, Cetinkaya F. Impact of zinc supplementation in children with acute diarrhoea in Turkey. Archives of Disease in Childhood 2006;91(4):296-9.
130. Rahman MM, Vermund SH, Wahed MA, Fuchs GJ, Baqui AH, Alvarez JO. Simultaneous zinc and vitamin A supplementation in Bangladeshi children: randomised double blind controlled trial. BMJ 2001;323(7308):314-8.
131. Rahman MJ, Sarker P, Roy SK, Ahmad SM, Chisti J, Azim T, et al.Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis. American Journal of Clinical Nutrition 2005;81(2):495-502.
132. Raqib R, Roy SK, Rahman MJ, Azim T, Ameer SS, Chisti J, et al.Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. American Journal of Clinical Nutrition 2004;79(3):444-50.
133. Richard SA, Zavaleta N, Caulfield LE, Black RE, Witzig RS, Shankar AH. Zinc and iron supplementation and malaria, diarrhea, and respiratory infections in children in the Peruvian Amazon. American Journal of Tropical Medicine and Hygiene 2006;75(1):126-32.
134. Rollins NC, van den Broeck J, Kindra G, Pent M, Kasambira T, Bennish ML. The effect of nutritional support on weight gain of HIV-infected children with prolonged diarrhoea. Acta Paediatrica 2007;96(1):62-8.
135. Rosado JL, Lopez P, Munoz E, Martinez H, Allen LH. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. American Journal of Clinical Nutrition 1997;65(1):13-9.
136. Rosado JL. Zinc deficiency and its functional implications [Deficiencia de zinc y sus implicaciones funcionales]. Salud Pública de México 1998;40(2):181-8.
137. Rosado JL, Caamano MC, Montoya YA, de Lourdes Solano M, Santos JI, Long KZ. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. European Journal of Clinical Nutrition 2009;63(10):1176-84.
138. Roy SK, Akramuzzaman SM, Haider R, Mahalanabis D, Behrens RH, Wahed MA, et al.Zinc supplementation in diarrhoea: Nutritional implication on clinical recovery and intestinal permeability [Abstract]. Journal of Gastroenterology and Hepatology 1994;9(6):A166.
139. Roy SK, Behrens RH, Haider R, Akramuzzaman SM, Mahalanabis D, Wahed MA, et al.Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhoea and persistent diarrhoea syndrome. Journal of Pediatric Gastroenterology and Nutrition 1992;15(3):289-96.
140. Roy SK, Tomkins AM, Haider R, Behren RH, Akramuzzaman SM, Mahalanabis D, et al.Impact of zinc supplementation on subsequent growth and morbidity in Bangladeshi children with acute diarrhoea. European Journal of Clinical Nutrition 1999;53(7):529-34.
141. Roy SK, Tomkins AM, Akramuzzaman SM, Chakraborty B, Ara G, Biswas R, et al.Impact of zinc supplementation on subsequent morbidity and growth in Bangladeshi children with persistent diarrhoea. Journal of Health, Population, and Nutrition 2007;25(1):67-74.
142. Roy SK, Hossain MJ, Khatun W, Chakraborty B, Chowdhury S, Begum A, et al.Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial. BMJ 2008;336(7638):266-8.
143. Ruel MT, Rivera JA, Santizo MC, Lonnerdal B, Brown KH. Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among rural Guatemalan children. Pediatrics 1997;99(6):808-13.
144. Sabatier García FJ, Izquierdo Estévez A, León García RE, Díaz Fernández L. Benefits of zinc in the treatment of infants presenting with diarrhea [Beneficios del cinc en el tratamiento de niños con diarrea]. Revista Cubana de Pediatría 1997;69(3/4):197-200.
145. Samuel MJ. Paediatrics Forum. Acute diarrhoea. Africa Health 1995;17(5):27, 29-30.
146. Sancho Martinez A, Saenz De Pipaon Marcos M, Quero Jimenez J. Effects of supplementation with zinc in the first year of life [Efectos de la suplementacion con cinc en el primer ano de vida]. Revista Espanola De Pediatria 2007;63(6):464-82.
147. Sazawal S, Black RE, Bhan MK, Jalla S, Bhandari N, Sinha A, et al.Zinc supplementation reduces the incidence of persistent diarrhea and dysentery among low socio-economic children in India. Journal of Nutrition 1996;126(2):443-50.
148. Sazawal S, Black RE, Bhan MK, Jalla S, Sinha A, Bhandari N. Efficacy of zinc supplementation in reducing the incidence and prevalence of acute diarrhea - a community-based, double-blind, controlled trial. American Journal of Clinical Nutrition 1997;66(2):413-8.
149. Sazawal S, Marwah D, Sazawal S, Black RE, Deb S, Dhingra U, et al.Efficacy of zinc and iron fortification of milk in prevention of anemia, diarrhea pneumonia, and iron deficiency- a community based double masked randomized trial. Journal of Pediatric Gastroenterology and Nutrition 2004;39 Suppl 1:417-8.
150. Sazawal S, Dhingra U, Dhingra P, Hiremath G, Kumar J, Sarkar A, et al.Effects of fortified milk on morbidity in young children in north India: community based randomised double masked placebo controlled trial. BMJ 2007;334(7585):140.
151. Sazawal S, Dhingra U, Deb S, Bhan MK, Menon VP, Black RE. Effect of zinc added to multi-vitamin supplementation containing low-dose vitamin A on plasma retinol level in children--a double-blind randomized, controlled trial. Journal of Health, Population, and Nutrition 2007;25(1):62-6.
152. Sazawal S, Black RE, Ramsan M, Chwaya HM, Dutta A, Dhingra U, et al.Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial. Lancet 2007;369(9565):927-34.
153. Shamir R, Makhoul IR, Etzioni A, Shehadeh N. Evaluation of a diet containing probiotics and zinc for the treatment of mild diarrheal illness in children younger than one year of age. Journal of the American College of Nutrition 2005;24(5):370-5.
154. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. American Journal Clinical Nutrition 1998;68 Suppl 2:447-63.
155. Sharieff W, Bhutta Z, Schauer C, Tomlinson G, Zlotkin S. Micronutrients (including zinc) reduce diarrhoea in children: the Pakistan Sprinkles Diarrhoea Study. Archives of Disease in Childhood 2006;91(7):573-9.
156. Sheikh A, Shamsuzzaman S, Ahmad SM, Nasrin D, Nahar S, Alam MM, et al.Zinc influences innate immune responses in children with enterotoxigenic Escherichia coli-induced diarrhea. Journal of Nutrition 2010;140(5):1049-56.
157. Sur D, Gupta DN, Mondal SK, Ghosh S, Manna B, Rajendran K, et al.Impact of zinc supplementation on diarrheal morbidity and growth pattern of low birth weight infants in Kolkata, India: a randomized, double-blind, placebo-controlled, community-based study. Pediatrics 2003;112(6 Pt 1):1327-32.
158. Taneja S, Bhandari N, Rongsen-Chandola T, Mahalanabis D, Fontaine O, Bhan MK. Effect of zinc supplementation on morbidity and growth in hospital-born, low-birth-weight infants. American Journal of Clinical Nutrition 2009;90(2):385-91.
159. Taneja S, Strand TA, Sommerfelt H, Bahl R, Bhandari N. Zinc supplementation for four months does not affect growth in young north Indian children. The Journal of Nutrition 2010;140(3):630-4.
160. Tielsch JM, Khatry SK, Stoltzfus RJ, Katz J, LeClerq SC, Adhikari R, et al.Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. Lancet 2006;367(9505):144-52.
161. Tielsch JM, Khatry SK, Stoltzfus RJ, Katz J, LeClerq SC, Adhikari R, et al.Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based, cluster randomised, placebo-controlled trial. Lancet 2007;370(9594):1230-9.
162. Umeta M, West CE, Haidar J, Deurenberg P, Hautvast JG. Zinc supplementation and stunted infants in Ethiopia: a randomised controlled trial. Lancet 2000;355(9220):2021-6.
163. Untoro J, Karyadi E, Wibowo L, Erhardt MW, Gross R. Multiple micronutrient supplements improve micronutrient status and anemia but not growth and morbidity of Indonesian infants: a randomized, double-blind, placebo-controlled trial. Journal of Nutrition 2005;135 Suppl(3):639-45.
164. Valery PC, Torzillo PJ, Boyce NC, White AV, Stewart PA, Wheaton GR, et al.Zinc and vitamin A supplementation in Australian Indigenous children with acute diarrhoea: a randomised controlled trial. Medical Journal of Australia 2005;182(10):530-5.
165. Veenemans J, Mank T, Ottenhof M, Baidjoe A, Mbugi EV, Demir AY, et al.Protection against diarrhea associated with Giardiaintestinalis Is lost with multi-nutrient supplementation: a study in Tanzanian children. PLoS Negleted Tropical Diseases 2011;5(6):e1158.
166. Wadhwa N, Natchu UC, Sommerfelt H, Strand TA, Kapoor V, Saini S, et al.ORS containing zinc does not reduce duration or stool volume of acute diarrhea in hospitalized children. Journal of Pediatric Gastroenterology and Nutrition 2011;53(2):161-7.
167. Walden RJ. Supplementation with zinc and other minerals. American Journal of Clinical Nutrition 2004;80(4):1084.
168. Walker CL, Bhutta ZA, Bhandari N, Teka T, Shahid F, Taneja S, et al.Zinc during and in convalescence from diarrhea has no demonstrable effect on subsequent morbidity and anthropometric status among infants <6 mo of age. American Journal of Clinical Nutrition 2007;85(3):887-94.
169. Wieringa FT, Dijkhuizen MA, Muhilal, Van der Meer JW. Maternal micronutrient supplementation with zinc and beta-carotene affects morbidity and immune function of infants during the first 6 months of life. European Journal of Clinical Nutrition 2010;64(10):1072-9.
170. Winch PJ, Gilroy KE, Doumbia S, Patterson AE, Daou Z, Coulibaly S, et al.Prescription and administration of a 14-day regimen of zinc treatment for childhood diarrhea in Mali. American Journal of Tropical Medicine and Hygiene 2006;74(5):880-3.
171. Winch PJ, Gilroy KE, Doumbia S, Patterson AE, Daou Z, Diawara A, et al.Operational issues and trends associated with the pilot introduction of zinc for childhood diarrhoea in Bougouni district, Mali. Journal of Health, Population, and Nutrition 2008;26(2):151-62.
172. Wuehler SE, Sempertegui F, Brown KH. Dose-response trial of prophylactic zinc supplements, with or without copper, in young Ecuadorian children at risk of zinc deficiency. American Journal of Clinical Nutrition 2008;87(3):723-33.
173. Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute diarrhoea in Children. Ongoing study July 2010 (not yet recruiting in December 2010).
174. A Double Blind Randomized Placebo Controlled Trial of Oral Zinc for Children With Acute diarrhoea in a Developed Nation. Ongoing study September 2010.
175. Albert MJ, Qadri F, Wahed MA, Ahmed T, Rahman AS, Ahmed F, et al.Supplementation with zinc, but not vitamin A, improves seroconversion to vibriocidal antibody in children given an oral cholera vaccine. Journal of Infectious Diseases 2003;187(6):909-13.
176. Berni Canani R, Buccigrossi V, Passariello A. Mechanisms of action of zinc in acute diarrhea. Current Opinion Gastroenterology 2011;1:8-12.
177. Beshgetoor D, Hambidge M. Clinical conditions altering copper metabolism in humans. American Journal of Clinical Nutrition 1998;67(5 Suppl):1017S-21S.
178. Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al.Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. American Journal of Clinical Nutrition 2000;72(6):1516-22.
179. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, Haider BA, Kirkwood B, Morris SS, Sachdev HPS, Shekar M. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371(9610):417-40.
180. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan J, Bassani DB, et al.Global, regional, and national causes of child mortality in2008: a systematic analysis. Lancet 2010;375(9730):1969-87.
181. Brown KH. Diarrhea and malnutrition. Journal of Nutrition 2003;133 Suppl(1):328-32.
182. Dijkhuizen MA, Wieringa FT, West CE, Martuti S, Muhilal. Effects of iron and zinc supplementation in Indonesian infants on micronutrient status and growth. Journal of Nutrition 2001;131(11):2860-5.
183. Fischer Walker C, Kordas K, Stoltzfus RJ, Black RE. Interactive effects of iron and zinc on biochemical and functional outcomes in supplementation trials. American Journal Clinical Nutrition 2005;82(1):5-12.
184. Fontaine O. Effect of zinc supplementation on clinical course of acute diarrhoea. Journal of Health, Population, and Nutrition 2001;19(4):339-46.
185. Garenne M, Becher H, Ye Y, Kouyate B, Muller O. Sex-specific responses to zinc supplementation in Nouna, Burkina Faso. Journal of Pediatric Gastroenterology and Nutrition 2007;44(5):619-28.
186. Jan Brozek, Andrew Oxman, Holger Schünemann. GRADEpro. Version 3.2 for Windows, 2008.
187. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, et al.Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997;388(6641):482-8.
188. Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections:a review of the evidence. Food and Nutrition Bulletin 2009;30:S41-59.
189. Hess SY, Lönnerdal B, Hotz C, Rivera JA, Brown KH. Recent advances in knowledge of zinc nutrition and human health. Food and Nutrition Bulletin 2009;30(Supplement 1):S5-11.
190. Higgins JPT, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]; Appendix 5b. www.cochrane.org/resources/handbook/index.htm (accessed 9 January 2008).
191. Higgins JPT, Altman DG (editors). Chapter 8: Assessing risk of bias in included studies. Cochrane Handbook of Systematic Reviews of Intervention. Version 5.0.0. The Cochrane Collaboration, 2008.
192. Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. American Journal of Physiology, Gastrointestinal and Liver Physiology 2005;288(5):956-63.
193. Hoque KM, Sarker R, Guggino SE, Tse CM. A New Insight into Pathophysiological Mechanisms of Zinc in Diarrhea. Annals of the New York Academy of Sciences 2009;1165:279-84.
194. Iqbal AS, Shahidullah M, Islam MN, Akhter S, Banu S. Serum zinc and copper levels in the maternal blood and cord blood of neonates. Indian Journal of Pediatrics 2001;68(6):523-6.
195. International Zinc Nutrition Consultative Group (IZiNCG), Hotz C, Brown KH, editors. Assessment of the risk of zinc deficiency in population and options for its control [Technical Document]. Food and Nutrition Bulletin 2004;25(1 Suppl 2):94-204.
196. Jüni P, Altman DG, Egger M. Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ 2001;323(7303):42-6.
197. Kordas K, Stoltzfus RJ. New evidence of iron and zinc interplay at the enterocyte and neural tissues. Journal of Nutrition 2004;134(6):1295-8.
198. Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bulletin of the World Health Organization 2003;81(3):197-204.
199. Krebs NF. Zinc transfer to the breastfed infant. Journal of Mammary Gland Biology and Neoplasia 1999;4(3):259-68.
200. MacDonald RS. The Role of Zinc in Growth and Cell Proliferation1, 2. Journal of Nutrition 2000;130:1500S-08S.
201. O'Dell BL. Role of Zinc in Plasma Membrane Function1. Journal of Nutrition 2000;130:1432S-6S.
202. Powell SR. The Antioxidant Properties of Zinc. Journal of Nutrition 2000;130:1447S-54S.
203. Prasad AS. Zinc in Human Health: Effect of Zinc on Immune Cells. Molecular Medicine 2008;14(5-6):353-57.
204. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager 5 (RevMan). 5 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
205. Sazawal S, Jalla S, Mazumder S, Sinha A, Black RE, Bhan MK. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children. Indian Pediatrics 1997;34(7):589-97.
206. Wagstaff A, Bustreo F, Bryce J, Claeson M, WHO-World Bank Child Health and Poverty Working Group. Child health: reaching the poor. American Journal of Public Health 2004;94(5):726-36.
207. World Health Organization. Dept. of Child and Adolescent Health and Development/UNICEF. Clinical management of acute diarrhoea: WHO/UNICEF joint statement [WHO/FCH/CAH/04.7; UNICEF/PD/Diarrhoea/01]. Geneva: World Health Organization, 2004.
208. Zlotkin SH, Cherian MG. Hepatic metallothionein as a source of zinc and cysteine during the first year of life. Pediatric Research 1988;24(3):326-9.
209. Zlotkin S, Arthur P, Schauer C, Antwi KY, Yeung G, Piekarz A. Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children. Journal of Nutrition 2003;133(4):1075-80.
210. Lazzerini M, Ronfani L. Oral zinc for treating diarrhoea in children. Cochrane Database of Systematic Reviews 2005, Issue 3. [DOI: 10.1002/14651858.CD005436]