Randomized controlled trial of the effect of daily supplementation with zinc or multiple micronutrients on the morbidity, growth, and micronutrient status of young Peruvian children

American Journal of Clinical Nutrition

Volumn 79, Issue 3, 2004, Pages 457-465

  Penny, Mary E ^a   Marin, R Margot ^a   Duran, Augusto ^a   Peerson, Janet M ^b   Lanata, Claudio F ^a   Lönnerdal, Bo ^b   Black, Robert E ^c   Brown, Kenneth H ^b  

^a INSTITUTO DE INVESTIGACIÓN NUTRICIONAL   (Peru)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Diarrhea; Growth; Respiratory infection; Zinc deficiency; Zinc supplementation

Indexed keywords

MINERAL; TRACE ELEMENT; VITAMIN; ZINC;

ARTICLE; BODY HEIGHT; BODY WEIGHT; CHILD GROWTH; CHRONIC DIARRHEA; CONTROLLED STUDY; COUGHING; DIET SUPPLEMENTATION; DYSENTERY; FEVER; HUMAN; INFANT; MAJOR CLINICAL STUDY; MORBIDITY; NUTRITIONAL STATUS; PRESCHOOL CHILD; PREVALENCE; RESPIRATORY TRACT DISEASE; VITAMIN SUPPLEMENTATION; ZINC BLOOD LEVEL; ANTHROPOMETRY; CHILD DEVELOPMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; MALE; MORTALITY; PERU; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ANTHROPOMETRY; CHILD DEVELOPMENT; CHILD, PRESCHOOL; COUGH; DIARRHEA; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FEVER; HUMANS; INFANT; MALE; MICRONUTRIENTS; MINERALS; MORBIDITY; NUTRITIONAL STATUS; PERU; PREVALENCE; TREATMENT OUTCOME; ZINC;

EID: 1642315347     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/79.3.457     Document Type: Article

References (36)

1. Hambidge M. Human zinc deficiency. J Nutr 2000;130:1344S-9S.
2. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998;68(suppl):447S-63S.
3. Brown KH, Peerson JM, Rivera J, Allen LH. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomised trials. Am J Clin Nutr 2002;75:1062-71.
4. Gibson RS. Zinc nutrition in developing countries. Nutr Res Rev 1994; 7:151-73.
5. Gibson RS, Hotz C. Dietary diversification/modification strategies to enhance micronutrient content and bioavailability of diets in developing countries. Br J Nutr 2001;85(suppl):S159-66.
6. Castillo-Duran C, Vial P, Uauy R. Trace mineral balance during acute diarrhea in infants. J Pediatr 1988;113:452-7.
7. Zinc Investigators' Collaborative Group. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomised controlled trials. J Pediatr 1999; 135:689-97.
8. Gibson RS, Ferguson EL. Assessment of dietary zinc in a population. Am J Clin Nutr 1998;68 (suppl):430S-4S.
9. Bhan MK, Sommerfelt H, Strand T. Micronutrient deficiency in children. Br J Nutr 2001;85(suppl):S199-203.
10. Solomons NW. Competitive interaction of iron and zinc in the diet: consequences for human nutrition. J Nutr 1986;116:927-35.
11. Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr 1998;68:(suppl)442S-6S.
12. Sandström B, Davidsson L, Cederblad A, Lönnerdal B. Oral iron, dietary ligands and zinc absorption. J Nutr 1985;115:411-4.
13. Duggan C, Penny ME, Hibberd P, et al. Oligofructose-supplemented infant cereal: two randomised, blinded, community-based trials in Peruvian infants. Am J Clin Nutr 2003;77:937-42.
14. Black RE, Lopez de Romaña G, Brown KH, Bravo N, Grados Bazalar O, Kanashiro HC. Incidence and etiology of infantile diarrhea and major routes of transmission in Huascar, Peru. Am J Epidemiol 1989;129: 785-99.
15. Brown KH, Lanata CL, Yuen ML, Peerson JM, Butron B, Lönnerdal B. Potential magnitude of the misclassification of a population's trace element status due to infection: example from a survey of young, Peruvian children. Am J Clin Nutr 1993;58:549-54.
16. Penny ME, Peerson JM, Marin RM, et al. Randomised community based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru. J Pediatr 1999;135:208-17.
17. Lanata CF, Black RE, Gilman RH, Lazo F, Del Aguila R. Epidemiologic, clinical and laboratory characteristics of acute vs persistent diarrhea in periurban Lima, Peru. J Pediatr Gastroenterol Nutr 1991;12:82-8.
18. Instituto Nacional de Estadistica y Informatica. Encuesta Nacional Demografíca y Salud. (National demographic and health survey.) Lima, Peru: Instituto Nacional de Estadistica y Informatica, 2001.
19. Lind T, Lönnerdal B, Stenlund H, et al. A community-based, randomized, controlled trial of iron and/or zinc supplementation of Indonesian infants - interactions between iron and zinc. Am J Clin Nutr 2003;77: 883-90.
20. Rossander-Hulthén L, Brune M, Sandström B, Lönnerdal B, Hallberg L. Competitive inhibition of iron absorption by manganese and zinc in humans. Am J Clin Nutr 1991;54:152-6.
21. Sempertegui F, Estrella B, Camaniero V, et al. The beneficial effect of low-dose vitamin A supplementation on acute lower respiratory infections and diarrhea in Ecuadorian children. Pediatrics [serial online] 1999;104:e1. Internet: http://www.pediatrics.org/cgi/content/full/104/1/e1 (accessed 5 December 2003).
22. Ramakrishnan U, Latham MC, Frongillo EA. Vitamin A supplementation and morbidity among pre-school children in South India. Am J Clin Nutr 1995;61:1295-303.
23. Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce the incidence of acute respiratory illness in pre school-age Indonesian children. J Nutr 1996;126:434-42.
24. Stansfield SK, Pierre-Louise M, Lerebours G, Augustin A. Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections. Lancet 1993;342:578-82.
25. Murray MJ, Murray NJ, Murray AB, Murray MB. Refeeding-malaria and hyperferraemia. Lancet 1975;1:653-4.
26. Oppenheimer SJ, Macfarlane SB, Moody JB, Bunari O, Hendrickse RG. Effect of iron prophylaxis on morbidity due to infectious diseases: report on clinical studies in Papua New Guinea. Trans R Soc Trop Med Hyg 1986;80:596-602.
27. Bates CJ, Powers HJ, Lamb WH, Gelman W, Webb E. Effects of supplementary vitamins and iron on malaria indices in rural Gambian children. Trans R Soc Trop Med Hyg 1987;81:286-91.
28. Keusch GT. Micronutrients and susceptibility to infection. Ann N Y Acad Sci 1990;587:181-8.
29. Menendez C, Kahigwa E, Hirt R, et al. Randomized placebo controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 1997; 350:844-50.
30. Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr 2001;131:616S-33S.
31. Mitra AK, Akramuzzaman SM, Fuchs GJ, Rahman MM, Mahalanabis D. Long-term oral supplementation with iron is not harmful for young children in a poor community of Bangladesh. J Nutr 1997;127:1451-5.
32. Brunser O, Espinoza J, Araya M, Pacheco I, Cruchet S. Chronic iron intake and diarrhoeal disease in infants. A field study in a less-developed country. Eur J Clin Nutr 1993;47:317-26.
33. Dewey KG, Domellöf M, Cohen RJ, Landa Rivera L, Hernell O, Lönnerdal B. Iron supplementation affects growth and morbidity of breastfed infants: results of a randomized trial in Sweden and Honduras. J Nutr 2002;132:3249-55.
34. Rosado JL, Lopez P, Muñoz E, Martinez H, Allen LH. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. Am J Clin Nutr 1997;65:13-9.
35. National Research Council. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press, 1989.
36. Srigiridhar K, Nair KM. Iron deficient intestine is more susceptible to peroxidative damage during iron supplementation in rats. Free Radic Biol Med 1998;25:660-5.