Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis

American Journal of Clinical Nutrition

Volumn 81, Issue 2, 2005, Pages 495-502

  Rahman, Muhammad J ^b   Sarker, Protim ^b   Roy, Swapan K ^b   Ahmad, Shaikh M ^b   Chisti, Jobayer ^b   Azim, Tasnim ^b   Mathan, Minnie ^b   Sack, David ^b   Andersson, Jan ^b   Raqib, Rubhana ^a  

^a ICDDRB Laboratory Sciences Division   (Bangladesh)

^b NONE

Author keywords

Adjunct therapy; B cells; Rectum; Serum killing; Shigella; Zinc

Indexed keywords

CALCIUM; CD20 ANTIGEN; CD38 ANTIGEN; NICOTINAMIDE; RETINOL; RIBOFLAVIN; THIAMINE; VITAMIN D; ZINC; ANTIINFECTIVE AGENT; BACTERIUM ANTIBODY; VITAMIN;

ANTIBIOTIC THERAPY; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; INFANT; MALNUTRITION; PLASMA CELL; PRESCHOOL CHILD; SEROCONVERSION; SHIGELLA FLEXNERI; SHIGELLOSIS; SUPPLEMENTATION; TREATMENT OUTCOME; ZINC BLOOD LEVEL; ANALYSIS OF VARIANCE; BLOOD; CELLULAR IMMUNITY; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; INFLAMMATION; MALE; NUTRITIONAL DISORDER; RANDOMIZED CONTROLLED TRIAL; SERUM BACTERICIDAL ACTIVITY;

SHIGELLA; SHIGELLA FLEXNERI;

ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; B-LYMPHOCYTES; BLOOD BACTERICIDAL ACTIVITY; CALCIUM; CHILD NUTRITION DISORDERS; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DYSENTERY, BACILLARY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNITY, CELLULAR; INFANT; INFLAMMATION; MALE; SHIGELLA FLEXNERI; VITAMINS; ZINC;

EID: 14544272856     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn.81.2.495     Document Type: Article

References (49)

1. Bennish ML, Wojtyniak BJ. Mortality due to shigellosis: community and hospital data. Rev Infect Dis 1991;13(suppl 4):S245-51.
2. Teka T, Faruque AS, Fuchs GJ. Risk factors for deaths in under-age-five children attending a diarrhoea treatment centre. Acta Paediatr 1996;85: 1070-5.
3. Azim T, Sarker MS, Hamadani J, et al. Effect of nutritional status on the lymphocyte responses in children with Shigella flexneri infection. Immun Infect Dis 1996;6:151-8.
4. Sansonetti PJ. Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. Jpn J Med Sci Biol 1998;51(suppl):S69-80.
5. Sansonetti PJ. Microbes and microbial toxins: paradigms for microbial-mucosal interactions. III. Shigellosis: from symptoms to molecular pathogenesis. Am J Physiol Gastrointest Liver Physiol 2001;280:G319-23.
6. Raqib R, Wretlind B, Andersson J, Lindberg AA. Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma. J Infect Dis 1995;171:376-84.
7. Raqib R, Mia SM, Qadri F, et al. Innate immune responses in children and adults with Shigellosis. Infect Immun 2000;68:3620-9.
8. Bray TM, Bettger WJ. The physiological role of zinc as an antioxidant. Free Radic Biol Med 1990;8:281-91.
9. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998;68(suppl):447S-63S.
10. Cario E, Jung S, Harder D'Heureuse J, et al. Effects of exogenous zinc supplementation on intestinal epithelial repair in vitro. Eur J Clin Invest 2000;30:419-28.
11. Cui L, Takagi Y, Wasa M, Sando K, Khan J, Okada A. Nitric oxide synthase inhibitor attenuates intestinal damage induced by zinc deficiency in rats. J Nutr 1999;129:792-8.
12. Bhutta ZA, Bird SM, Black RE, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr 2000;72:1516-22.
13. Castillo-Duran C, Heresi G, Fisberg M, Uauy R. Controlled trial of zinc supplementation during recovery from malnutrition: effects on growth and immune function. Am J Clin Nutr 1987;45:602-8.
14. Karlsen TH, Sommerfelt H, Klomstad S, et al. Intestinal and systemic immune responses to an oral cholera toxoid B subunit whole-cell vaccine administered during zinc supplementation. Infect Immun 2003;71:3909-13.
15. Albert MJ, Qadri F, Wahed MA, et al. Supplementation with zinc, but not vitamin A, improves seroconversion to vibriocidal antibody in children given an oral cholera vaccine. J Infect Dis 2003;187:909-13.
16. Raqib R, Roy SK, Rahman MJ, et al. Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr 2004;79:444-50.
17. Jackson AA. Severe malnutrition. In: Warrel DA, Cox TM, Firth JD, Benz EJ Jr, eds. Oxford textbook of medicine. 4th ed. Oxford, United Kingdom: Oxford University Press, 2003:1054-61.
18. Pocock SJ. Methods of randomization. In: Pocock SJ, ed. Clinical trials: a practical approach. London: Wiley Medical Publication, 1987:66-89.
19. Food and Nutrition Board, Institute of Medicine. Dietary reference intake for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press, 2001.
20. Hill D, Hassan N, Karim R, Duthie MR, eds. Tables of nutrient composition of Bangladeshi food, English version. Dhaka, Bangladesh: Helen Keller International, 1988.
21. Benenson AS, Saad A, Mosley WH. Serological studies in cholera. 2. The vibriocidal responses of cholera patients determined by microtechnique. Bull World Health Organ 1968;38:277-85.
22. Kotloff KL, Noriega F, Losonsky GA, et al. Safety, immunogenicity, and transmissibility in humans of CVD 1203, alive oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG. Infect Immun 1996;64:4542-8.
23. Barclay AN, Brown MH, Law SKA, et al. The leukocyte antigen facts book. San Diego: Academic Press Inc, 1997.
24. Mathan MM, Mathan VI. Ultrastructural pathology of the rectal mucosa in Shigella dysentery. Am J Pathol 1986;123:25-38.
25. Raqib R, Ekberg C, Sharkar P, et al. Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2. Infect Immun 2002;70:3199-207.
26. Ewing WH, Lindberg AA. Serology of Shigella. London: Academic Press, 1984.
27. Podbielski A, Spahr A, Haller B. Additive antimicrobial activity of calcium hydroxide and chlorhexidine on common endodontic bacterial pathogens. J Endod 2003;29:340-5.
28. Sawai J. Quantitative evaluation of antibacterial activities of metallic oxide powders (ZnO, MgO and CaO) by conductimetric assay. J Microbiol Methods 2003;54:177-82.
29. Brading MG, Cromwell VJ, Jones NM, Baldeck JD, Marquis RE. Antimicrobial efficacy and mode of action studies on a new zinc/Triclosan formulation. Int Dent J 2003;53:363-70.
30. McCarthy TJ, Zeelie JJ, Krause DJ. The antimicrobial action of zinc ion/antioxidant combinations. J Clin Pharm Ther 1992;17:51-4.
31. Sohnle PG, Hahn BL. Effect of zinc-reversible growth-inhibitory activity in human empyema fluid on antibiotic microbicidal activity. Antimicrob Agents Chemother 2000;44:139-42.
32. Cho YH, Lee SJ, Lee JY, et al. Antibacterial effect of intraprostatic zinc injection in a rat model of chronic bacterial prostatitis. Int J Antimicrob Agents 2002;19:576-82.
33. Reed WP. Serum factors capable of opsonizing Shigella for phagocytosis by polymorphonuclear neutrophils. Immunology 1975;28:1051-9.
34. Doroszkiewicz W. Mechanism of antigenic variation in Shigella flexneri bacilli. IV. Role of lipopolysaccharides and their components in the sensitivity of Shigella flexneri 1b and its Lac+ recombinant to killing action of serum. Arch Immunol Ther Exp (Warsz) 1997;45:235-42.
35. Hong M, Payne SM. Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipopolysaccharide genes on invasion and serum resistance. Mol Microbiol 1997;24:779-91.
36. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004;303:1532-5.
37. Islam D, Bandholtz L, Nilsson J, et al. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 2001;7:180-5.
38. Morgan DR, DuPont HL, Gonik B, Kohl S. Cytotoxicity of human peripheral blood and colostral leukocytes against Shigella species. Infect Immun 1984;46:25-33.
39. Ibs KH, Rink L. Zinc-altered immune function. J Nutr 2003;133:1452S-6S.
40. DePasquale-Jardieu P, Fraker PJ. Interference in the development of a secondary immune response in mice by zinc deprivation: persistence of effects. J Nutr 1984;114:1762-9.
41. Shi HN, Scott ME, Stevenson MM, Koski KG. Energy restriction and zinc deficiency impair the functions of murine T cells and antigen-presenting cells during gastrointestinal nematode infection. J Nutr 1998; 128:20-7.
42. Schlesinger L, Arevalo M, Arredondo S, Diaz M, Lonnerdal B, Stekel A. Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants. Am J Clin Nutr 1992;56:491-8.
43. Kreft B, Fischer A, Kruger S, Sack K, Kirchner H, Rink L. The impaired immune response to diphtheria vaccination in elderly chronic hemodialysis patients is related to zinc deficiency. Biogerontology 2000;1: 61-6.
44. Ravaglia G, Forti P, Maioli F, et al. Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >90 y. Am J Clin Nutr 2000;71:590-8.
45. Sazawal S, Jalla S, Mazumder S, Sinha A, Black RE, Bhan MK. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children. Indian Pediatr 1997;34:589-97.
46. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340: 1124-7.
47. Raqib R, Lindberg AA, Wretlind B, Bardhan PK, Andersson U, Andersson J. Persistence of local cytokine production in shigellosis in acute and convalescent stages. Infect Immun 1995;63:289-96.
48. Sunderman FW Jr. The influence of zinc on apoptosis. Ann Clin Lab Sci 1995;25:134-42.
49. Truong-Tran AQ, Ruffin RE, Zalewski PD. Visualization of labile zinc and its role in apoptosis of primary airway epithelial cells and cell lines. Am J Physiol Lung Cell Mol Physiol 2000;279:L1172-83.