Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: Community randomised trial

British Medical Journal

Volumn 325, Issue 7372, 2002, Pages 1059-1062

  Baqui, Abdullah H ^a   Black, Robert E ^a   El Arifeen, Shams ^b   Yunus, Mohammad ^b   Chakraborty, Joysnamoy ^b   Ahmed, Saifuddin ^a   Vaughan, J Patrick ^c  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b ICDDR B Centre for Health and Population Research   (Bangladesh)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC;

ARTICLE; BANGLADESH; CHILDHOOD MORTALITY; CLINICAL TRIAL; CLUSTER ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; HUMAN; INFANT; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MORBIDITY; MORTALITY; ORAL REHYDRATION THERAPY; OUTCOMES RESEARCH; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; ZINC DEFICIENCY;

ANTIDIARRHEALS; BANGLADESH; CLUSTER ANALYSIS; DIARRHEA, INFANTILE; DYSENTERY; FLUID THERAPY; HUMANS; INCIDENCE; INFANT; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SURVIVAL RATE; ZINC;

EID: 0037049025     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sandstead HH. Zinc deficiency: A public health problem? Am J Dis Child 1991;145:853-9.
2. Castillo-Duran C, Vial P, Uauy R. Trace mineral balance during acute diarrhoea in infants. J Pediatr 1988;113:452-7.
3. Zinc Ivestigators' Collaborative Group. Therapeutic effects of oral zinc in acute and persistent diarrhoea in children in developing countries: Pooled analysis of randomized controlled trials. Am J Clin Nutr 2000;72:1516-22.
4. Zinc Investigators' Collaborative Group. Prevention of diarrhoea and pneumonia by zinc supplementation in children in developing countries: Pooled analysis of randomized controlled trials. J Pediatr 1999;135:689-97.
5. Health and Demographic Surveillance System Matlab. Registration of Demographic Events and Contraceptive Use 1998. Bangladesh: International Center for Diarrhoeal Disease Research, 2000. (ICDDR,B Scientific Report No. 87.)
6. Baqui AH, Black RE, Arifeen SE, Hill K, Mitra SN, Sabir AA. Causes of childhood deaths in Bangladesh: Results of a nationwide verbal autopsy study. Bull World Health Org 1998;76:161-71.
7. Sazawal S, Black RE, Bhan MK, Bhandari N, Sinha A, Jalla S. Zinc supplementation in young children with acute diarrhoea in India. N Engl J Med 1995;333:839-44.
8. Roy SK, Tomkins AM, Akramuzzaman SM, Behrens RH, Mahalanabis D, Fuchs G. Randomised controlled trial of zinc supplementation in malnourished Bangladeshi children with acute diarrhoea. Arch Dis Child 1997;77:196-200.
9. Golden BE, Golden MHN. Zinc, sodium and potassium losses in the diarrhoeas of malnutrition and zinc deficiency. In: Mills CF, Bremner I, Chesters JK, eds. Trace Elements in Man and Animals TEMA 5. Aberdeen: Rowett Research Institute, 1985:228-32.
10. Bettger WJ, O'Dell BL. A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 1981;28:1425-38.
11. Gebhard RL, Karouani R, Prigge WF, McClain CJ. Effect of severe zinc deficiency on activity of intestinal disaccharidases and 3-hydroxy-3-methyl-glutaryl coenzyme A reductase in the rat. J Nutr 1983;113:855-9.
12. Shanker AH, Prasad AS. Zinc and immune function: The biological basis of altered resistance to infection. Am J Clin Nutr 1998;68(suppl 2):447-65S.
13. Fenwick PK, Agget PJ, McDonald D, Huber C, Wakelin D. Zinc deficiency and zinc repletion: Effect on the response of rats to infection with Strongyloids ratti. Am J Clin Nutr 1990;52:166-72.
14. Sazawal S, Black RE, Bhan MK, Jalla S, Sinha A, Bhandari N, Efficacy of zinc supplementation in reducing the incidence and prevalence of acute diarrhoea - A community-based, double-blind, controlled trial. Am J Clin Nutr 1997;66:413-18.
15. Rosado JL, Lopez P, Munoz E, Martinez H, Allen LH. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. Am J Clin Nutr 1997;65:13-9.
16. Ruel MT, Rivera JA, Santizo MC, Lonnerdal B, Brown KH, Impact of zinc supplementation on morbidity from diarrhoea and respiratory infections among rural Guatemalan children. Pediatrics 1997;99:808-13.
17. Sazawal S, Black RE, Jalla S, Mazumdar S, Sinha A. Bhan MK. Zinc supplementation reduces the incidence of acute lower respiratory infection in infants and preschool children: A double-blind controlled trial. Pediatrics 1998;102:1-5.