Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhoea

Acta Paediatrica, International Journal of Paediatrics

Volumn 88, Issue 2, 1999, Pages 154-160

  Faruque, A S G ^b   Mahalanabis, D ^a   Haque, S S ^b   Fuchs, G J ^b   Habte, D ^b  

^a SOCIETY FOR APPLIED STUDIES   (India)

^b NONE

Author keywords

Acute diarrhoea; Therapy; Vitamin A; Zinc

Indexed keywords

RETINOL; ZINC;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEHYDRATION; DEVELOPING COUNTRY; DIARRHEA; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ACUTE DISEASE; AGE FACTORS; CHILD, PRESCHOOL; DIARRHEA; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; TIME FACTORS; VITAMIN A; ZINC;

EID: 0038091393     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1080/08035259950170312     Document Type: Article

References (34)

1. 1. Moyenahan EJ. Acrodermatitis enteopathica: a lethal inherited human zinc-deficiency disorder (Letter). Lancet 1974; ii: 399-400
2. 2. Kay RG, Tasman-Jones C. Zinc deficiency and intravenous feeding (Letter). Lancet 1975; ii: 605-6
3. 3. Roy SK. Impact of zinc supplementation of Bangladeshi children suffering from acute and persistent diarrhoea (Thesis). London: London School of Hygiene and Tropical Medicine, 1990
4. 4. Sachdev HP, Mittal NK, Mittal SK, Yadav HS. A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhoea in infants. J Pediatr Gastroenterol Nutr 1988; 7: 877-81
5. 5. Sazawal S, Black RE, Bhan MK, Bhandari N, Sinha A, Jalla S. Zinc supplementation in young children with acute diarrhoea in India. N Engl J Med 1995; 333: 839-44
6. 6. Roy SK, Tomkins AM, Akramuzzaman SM, Behrens RH, Haider R, Mahalanabis D, et al. Randomized controlled trial of zinc supplementation in malnourished Bangladeshi children with acute diarrhoea. Arch Dis Child 1997; 77: 196-200
7. 7. Castillo-Duran C, Vial P, Uauy R. Trace mineral balance during acute diarrhoea in infants. J Pediatr 1988; 113: 452-7
8. 8. Valle BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev 1993; 73: 79-118
9. 9. William RPJ. An introduction to the biochemistry of zinc. In: Mills DF, editor. Zinc in human biology. Berlin: Springer, 1989; 15-31
10. 10. Bhan MK, Arora NK, Ghai OP, Ramachandran K, Khoshoo V, Bhandari N. Major factors in diarrhoea related mortality among rural children. Ind J Med Res 1986; 83: 3-12
11. 11. Bhandari N, Bhan MK, Sazawal S. Mortality associated with acute watery diarrhoea, dysentery and persistent diarrhoea in rural North India. Acta Paediatr 1992; 81 (381 Suppl): 3-6
12. 12. Fauveau V, Yunus M, Zaman K, Chakraborty J, Sarder AM. Diarrhoea mortality in rural Bangladeshi children. J Trop Pediatr 1991; 37: 31-6
13. 13. Baqui AH, Sack RB, Black RE, Chowdhury HR, Yunus M, Siddique AK. Cell-mediated immune deficiency and malnutrition are independent risk factors for persistent diarrhoea in Bangladeshi children. Am J Clin Nutr 1993; 58: 543-8
14. 14. Baqui AH, Black RE, Sack RB, Chowdhury HR, Yunus M, Siddique AK. Malnutrition, cell-mediated immune deficiency, and diarrhoea: a community-based longitudinal study in rural Bangladeshi children. Am J Epidemiol 1993; 137: 355-65
15. 15. Mahalanabis D, Alam AN, Rahman N, Hasnat A. Prognostic indicators and risk factors for increased duration of acute diarrhoea and for persistent diarrhoea in children. Int J Epidemiol 1991; 20: 1064-72
16. 16. Arthur P, Kirkwood B, Ross D, Morris S, Gyapong J, Tomkins A, Addy H. Impact of vitamin A supplementation on childhood mortality in northern Ghana (Letter). Lancet 1992; 339: 361-2
17. 17. United Nations Administrative Committee on Coordination - Subcommittee on Nutrition. Micronutrient deficiency - The global situation. SCN News 1993; 9: 11-6
18. 18. Shrimpton R. Zinc deficiency - is it widespread but underrecognized? United Nations Administrative Committee on Coordination - Subcommittee on Nutrition. SCN News 1993; 9: 24-7
19. 19. Pocock SJ. Clinical trials - a practical approach. 1st ed. Chichester: John Wiley, 1983: 123-41
20. 20. World Health Organization. Programme for the Control of Diarrhoeal Diseases. A manual for the treatment of diarrhoea for use by physicians and other health workers (WHO/CDD/SER/ 80.2). Geneva: World Health Organization, 1990
21. 21. Henning B, Stewart Z, Zaman K, Alam AN, Brown KH, Black RE. Lack of therapeutic efficacy of vitamin A for non-cholera watery diarrhoea in Bangladeshi children. Eur J Clin Nutr 1992; 46: 437-43
22. 22. Anke M, Groppel B. Toxic actions of essential trace elements (Mo, Cn, Zn, Fe, Mn). In: Proceedings of the Fourth International Workshop of Trace Element Analytical Chemistry in Medicine and Biology, Neuherberg, 1986. New York: de Gruyter, 1987; 201-36
23. 23. Ghishan FK. Transport of electrolytes, water and glucose in zinc deficiency. J Pediatr Gastroenterol Nutr 1984; 3: 608-12
24. 24. Roy SK. Zinc supplementation in the treatment of childhood diarrhoea. Ind J Pediatr 1995; 62: 181-93
25. 25. Bettger WJ, O'Dell BL. A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 1981; 28: 1425-38
26. 26. Roy SK, Beherens RH, Haider R, Akramuzzaman SM, Mahalanabis D, Wahed MA, Tomkins AM. Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhoea and persistent syndrome. J. Pediatr Gastroenterol Nutr 1992; 15: 289-96
27. 27. Schlesinger L, Arevalo M, Arredondo S, Diaz M, Lonnerdal B, Stekel A. Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants. Am J Clin Nutr 1992; 56: 491-8
28. 28. Cunningham-Rundles C, Cunningham-Rundles S, Garofalo J. Increased T-lymphocyte function and thymopoietin following zinc repletion in man. Fed Proc 1979; 38: 1122
29. 29. Rosado JL, Lopez P, Munoz E, Martinez H, Allen LH. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. Am J Clin Nutr 1997; 65: 13-9
30. 30. Ninh NX, Thissen JP, Collette L, Gerard G, Khoi HH, Ketelslegers JM. Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth-retarded Vietnamese children. Am J Clin Nutr 1996; 63: 515-9
31. 31. Ruel MT, Rivera JA, Santizo MC, Lonnerdal B, Brown KH. Impact of zinc supplementation on morbidity from diarrhoea and respiratory infections among rural Guatemalan children. Pediatrics 1997; 99: 808-13
32. 32. Murphy SP, Beaton GH, Calloway DH. Estimated mineral intakes of toddlers: predicted prevalence of inadequacy in village populations in Egypt, Kenya, and Mexico. Am J Clin Nutr 1992; 56: 565-72
33. 33. Sandström B, Lönnerdal B. Promoters and antagonists of zinc absorption. In: Mills CF, editor. Zinc in human biology. London: International Life Sciences Institute, 1989: 57-78
34. 34. Festa MD, Anderson HL, Dowdy RP, Ellersieck MR. Effect of zinc intake on copper excretion and retention in men. Am J Clin Nutr 1985; 41: 285-92