Zinc supplementation for the treatment of diarrhea in infants in Pakistan, India and Ethiopia

Journal of Pediatric Gastroenterology and Nutrition

Volumn 43, Issue 3, 2006, Pages 357-363

  Fischer Walker, Christa L ^a   Bhutta, Zulfiqar A ^b   Bhandari, Nita ^c   Teka, Telahun ^d   Shahid, Farhana ^b   Taneja, Sunita ^c   Black, Robert E ^a   Rasool, Shahid ^b   Nizami, S Qamaruddin ^b   Rongsen, Temsunaro ^e   Suri, Vandna ^e   Lulseged, Sileshi ^f   Tesfaye, Yeshewatsehaye ^f  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b AGA KHAN UNIVERSITY   (Pakistan)

^c Society for Applied Studies   (United States)

^d ADDIS ABABA UNIVERSITY   (Ethiopia)

^e SOCIETY FOR APPLIED STUDIES   (India)

^f ADDIS ABABA UNIVERSITY   (Ethiopia)

Author keywords

Diarrhea; Infants; Randomized controlled trial; Zinc supplementation

Indexed keywords

PLACEBO; ZINC;

ACUTE DIARRHEA; ANTHROPOMETRY; ARTICLE; BREAST FEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE DURATION; DISEASE SEVERITY; ETHIOPIA; FECES ANALYSIS; FEMALE; HUMAN; INDIA; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PAKISTAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOCIOECONOMICS; TREATMENT OUTCOME;

BREAST FEEDING; DIARRHEA; ETHIOPIA; HUMANS; INDIA; INFANT; INFANT, NEWBORN; PAKISTAN; PLACEBOS; TREATMENT OUTCOME; URBAN POPULATION; ZINC;

EID: 33748541957     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpg.0000232018.40907.00     Document Type: Article

References (31)

1. Bryce J, Boschi-Pinto C, Shibuya K, et al. WHO estimates of the causes of death in children. Lancet 2005;365:1147-52.
2. Black RE, Morris SS, Bryce J. Where and why are 10 million children dying every year? Lancet 2003;361:2226-34.
3. Rahaman MM, Aziz KM, Patwari Y, et al. Diarrhoeal mortality in two Bangladeshi villages with and without community-based oral rehydration therapy. Lancet 1979;2:809-12.
4. Zinc Investigators' Collaborative Group. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr 1999;135:689-97.
5. Zinc Investigators' Collaborative Group. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr 2000;72:1516-22.
6. Sazawal S, Black RE, Bhan MK, et al. Zinc supplementation in young children with acute diarrhea in India. N Engl J Med 1995;333:839-44.
7. Sachdev HP, Mittal NK, Yadav HS. Oral zinc supplementation in persistent diarrhoea in infants. Ann Trop Paediatr 1990;10:63-9.
8. Al-Sonboli N, Gurgel RQ, Shenkin A, et al. Zinc supplementation in Brazilian children with acute diarrhoea. Ann Trop Paediatr 2003;23:3-8.
9. Khatun UH, Malek MA, Black RE, et al. A randomized controlled clinical trial of zinc, vitamin A or both in undernourished children with persistent diarrhea in Bangladesh. Acta Paediatr 2001;90:376-80.
10. Dutta P, Mitra U, Datta A, et al. Impact of zinc supplementation in malnourished children with acute watery diarrhoea. J Trop Pediatr 2000;46:259-63.
11. Bhatnagar S, Bahl R, Sharma PK, et al. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. J Pediatr Gastroenterol Nutr 2004;38:34-40.
12. Faruque AS, Mahalanabis D, Haque SS, et al. Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhoea. Acta Paediatr 1999;88:154-60.
13. WHO-UNICEF. Joint Statement: Clinical Management of Acute Diarrhoea. (WHO/FCH/CAH/04.07). Geneva: WHO; 2004.
14. Brooks WA, Santosham M, Roy SK, et al. Efficacy of zinc in young infants with acute watery diarrhoea. Am J Clin Nutr 2005;82:605-10.
15. Krebs NF. Zinc transfer to the breastfed infant. J Mammary Gland Biol Neoplasia 1999;4:259-68.
16. Kelly D, Coutts AG. Early nutrition and the development of immune function in the neonate. Proc Nutr Soc 2000;59:177-85.
17. Ashworth A. Effects of intrauterine growth retardation on mortality and morbidity in infants and young children. Eur J Clin Nutr 1998;52:S34-41. discussion S-2.
18. Victora CG, Kirkwood BR, Ashworth A, et al. Potential interventions for the prevention of childhood pneumonia in developing countries: improving nutrition. Am J Clin Nutr 1999;70:309-20.
19. Pakistan Demographic and Health Survey. Columbia, MD: IRD/Macro International; 1990/91.
20. India Demographic and Health Survey. Columbia, MD: IRD/Macro International; 1998/99.
21. Ethiopia Demographic and Health Survey. Columbia, MD: IRD/Macro International; 2000.
22. WHO. The Treatment of Diarrhoea: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO; 2003.
23. STATA 8.0 Reference Manual. College Station, TX: STATA Corporation; 2003.
24. Labbok M, Krasovec K. Toward consistency in breastfeeding definitions. Stud Fam Plann 1990;21:226-30.
25. National Nutrition Survey. New York: UNICEF/Government of Pakistan; 2001-2; 2003.
26. Sazawal S, Black RE, Menon VP, et al. Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Pediatrics 2001;108:1280-6.
27. Umeta M, West CE, Haidar J, et al. Zinc supplementation and stunted infants in Ethiopia: a randomised controlled trial. Lancet 2000;355:2021-6.
28. Brown KH, Rivera JA, Bhutta Z, et al. Assessment of the risk of zinc deficiency in populations. Food Nutr Bull 2004;25:S130-62.
29. Krebs NF, Reidinger CJ, Hartley S, et al. Zinc supplementation during lactation: effects on maternal status and milk zinc concentrations. Am J Clin Nutr 1995;61:1030-6.
30. Okolo SN, Onwuanaku C, Okonji M, et al. Concentration of eight trace minerals in milk and sera of mother-infant pairs in northern Nigeria. J Trop Pediatr 2000;46:160-2.
31. Canani RB, Cirillo P, Buccigrossi V, et al. Zinc inhibits cholera toxin-induced, but not Escherichia coli heat-stable enterotoxin-induced, ion secretion in human enterocytes. JID 2005;191:1072-7.