메뉴 건너뛰기




Volumn 76, Issue 1-2, 2013, Pages 4-12

Interchanging functionality among homologous elongation factors using signatures of heterotachy

Author keywords

Covarion; Functional divergence; Heterotachy

Indexed keywords

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 84874656977     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-013-9540-9     Document Type: Article
Times cited : (7)

References (47)
  • 1
    • 33745626732 scopus 로고    scopus 로고
    • Prediction of function divergence in protein families using the substitution rate variation parameter alpha
    • 16672285 10.1093/molbev/msl002 1:CAS:528:DC%2BD28XmsVOkuro%3D
    • Abhiman S, Daub CO, Sonnhammer ELL (2006) Prediction of function divergence in protein families using the substitution rate variation parameter alpha. Mol Biol Evol 23:1406-1413
    • (2006) Mol Biol Evol , vol.23 , pp. 1406-1413
    • Abhiman, S.1    Daub, C.O.2    Sonnhammer, E.L.L.3
  • 2
    • 0033638335 scopus 로고    scopus 로고
    • Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha
    • 11106763 10.1016/S1097-2765(00)00122-2 1:CAS:528:DC%2BD3cXosV2mt7c%3D
    • Andersen GR, Pedersen L, Valente L, Chatterjee I, Kinzy TG, Kjeldgaard M, Nyborg J (2000) Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha. Mol Cell 6:1261-1266
    • (2000) Mol Cell , vol.6 , pp. 1261-1266
    • Andersen, G.R.1    Pedersen, L.2    Valente, L.3    Chatterjee, I.4    Kinzy, T.G.5    Kjeldgaard, M.6    Nyborg, J.7
  • 3
    • 0035399575 scopus 로고    scopus 로고
    • Evolution, language and analogy in functional genomics
    • 11418223 10.1016/S0168-9525(01)02320-4 1:CAS:528:DC%2BD3MXksVyntLc%3D
    • Benner SA, Gaucher EA (2001) Evolution, language and analogy in functional genomics. Trends Genet 17:414-418
    • (2001) Trends Genet , vol.17 , pp. 414-418
    • Benner, S.A.1    Gaucher, E.A.2
  • 4
    • 54149114377 scopus 로고    scopus 로고
    • Ohno's model revisited: Measuring the frequency of potentially adaptive mutations under various mutational drifts
    • 18687656 10.1093/molbev/msn174 1:CAS:528:DC%2BD1cXhtlyqsbrM
    • Bershtein S, Tawfik DS (2008) Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts. Mol Biol Evol 25:2311-2318
    • (2008) Mol Biol Evol , vol.25 , pp. 2311-2318
    • Bershtein, S.1    Tawfik, D.S.2
  • 5
    • 47249122561 scopus 로고    scopus 로고
    • A site- and time-heterogeneous model of amino acid replacement
    • 18234708 10.1093/molbev/msn018 1:CAS:528:DC%2BD1cXlvVKhur0%3D
    • Blanquart S, Lartillot N (2008) A site- and time-heterogeneous model of amino acid replacement. Mol Biol Evol 25:842-858
    • (2008) Mol Biol Evol , vol.25 , pp. 842-858
    • Blanquart, S.1    Lartillot, N.2
  • 6
    • 79953326533 scopus 로고    scopus 로고
    • Exploiting models of molecular evolution to efficiently direct protein engineering
    • 21132281 10.1007/s00239-010-9415-2 1:CAS:528:DC%2BC3MXjvVSksb4%3D
    • Cole MF, Gaucher EA (2011a) Exploiting models of molecular evolution to efficiently direct protein engineering. J Mol Evol 72:193-203
    • (2011) J Mol Evol , vol.72 , pp. 193-203
    • Cole, M.F.1    Gaucher, E.A.2
  • 7
    • 79958011043 scopus 로고    scopus 로고
    • Utilizing natural diversity to evolve protein function: Applications towards thermostability
    • 21470898 10.1016/j.cbpa.2011.03.005 1:CAS:528:DC%2BC3MXntV2lurc%3D
    • Cole MF, Gaucher EA (2011b) Utilizing natural diversity to evolve protein function: applications towards thermostability. Curr Opin Chem Biol 15:399-406
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 399-406
    • Cole, M.F.1    Gaucher, E.A.2
  • 9
    • 0030034795 scopus 로고    scopus 로고
    • A Hidden Markov Model approach to variation among sites in rate of evolution
    • 8583911 10.1093/oxfordjournals.molbev.a025575 1:CAS:528: DyaK28XhtVylur0%3D
    • Felsenstein J, Churchill GA (1996) A Hidden Markov Model approach to variation among sites in rate of evolution. Mol Biol Evol 13:93-104
    • (1996) Mol Biol Evol , vol.13 , pp. 93-104
    • Felsenstein, J.1    Churchill, G.A.2
  • 10
    • 0015162378 scopus 로고
    • Rate of change of concomitantly variable codons
    • 4377447 10.1007/BF01659396 1:CAS:528:DyaE38XmvFahuw%3D%3D
    • Fitch WM (1971) Rate of change of concomitantly variable codons. J Mol Evol 1:84-96
    • (1971) J Mol Evol , vol.1 , pp. 84-96
    • Fitch, W.M.1
  • 11
    • 0014860857 scopus 로고
    • An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution
    • 5489762 10.1007/BF00486096 1:CAS:528:DyaE3MXjsVc%3D
    • Fitch WM, Markowitz E (1970) An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution. Biochem Genet 4:579-593
    • (1970) Biochem Genet , vol.4 , pp. 579-593
    • Fitch, W.M.1    Markowitz, E.2
  • 12
    • 26444556992 scopus 로고    scopus 로고
    • A call for likelihood phylogenetics even when the process of sequence evolution is heterogeneous
    • 16291095 10.1016/j.ympev.2005.03.027
    • Gaucher EA, Miyamoto MM (2005) A call for likelihood phylogenetics even when the process of sequence evolution is heterogeneous. Mol Phylogenet Evol 37:928-931
    • (2005) Mol Phylogenet Evol , vol.37 , pp. 928-931
    • Gaucher, E.A.1    Miyamoto, M.M.2
  • 13
    • 0035895207 scopus 로고    scopus 로고
    • Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors
    • 11209054 10.1073/pnas.98.2.548 1:CAS:528:DC%2BD3MXnslKgsA%3D%3D
    • Gaucher EA, Miyamoto MM, Benner SA (2001) Function-structure analysis of proteins using covarion-based evolutionary approaches: elongation factors. Proc Natl Acad Sci U S A 98:548-552
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 548-552
    • Gaucher, E.A.1    Miyamoto, M.M.2    Benner, S.A.3
  • 14
    • 0036218655 scopus 로고    scopus 로고
    • The crystal structure of eEF1A refines the functional predictions of an evolutionary analysis of rate changes among elongation factors
    • 11919299 10.1093/oxfordjournals.molbev.a004113 1:CAS:528: DC%2BD38XivV2gur8%3D
    • Gaucher EA, Das UK, Miyamoto MM, Benner SA (2002a) The crystal structure of eEF1A refines the functional predictions of an evolutionary analysis of rate changes among elongation factors. Mol Biol Evol 19:569-573
    • (2002) Mol Biol Evol , vol.19 , pp. 569-573
    • Gaucher, E.A.1    Das, U.K.2    Miyamoto, M.M.3    Benner, S.A.4
  • 15
    • 0036606898 scopus 로고    scopus 로고
    • Predicting functional divergence in protein evolution by site-specific rate shifts
    • 12069792 10.1016/S0968-0004(02)02094-7 1:CAS:528:DC%2BD38XksFOjurc%3D
    • Gaucher EA, Gu X, Miyamoto MM, Benner SA (2002b) Predicting functional divergence in protein evolution by site-specific rate shifts. Trends Biochem Sci 27:315-321
    • (2002) Trends Biochem Sci , vol.27 , pp. 315-321
    • Gaucher, E.A.1    Gu, X.2    Miyamoto, M.M.3    Benner, S.A.4
  • 16
    • 0035061686 scopus 로고    scopus 로고
    • Maximum-likelihood approach for gene family evolution under functional divergence
    • 11264396 10.1093/oxfordjournals.molbev.a003824 1:CAS:528: DC%2BD3MXis1eisL4%3D
    • Gu X (2001) Maximum-likelihood approach for gene family evolution under functional divergence. Mol Biol Evol 18:453-464
    • (2001) Mol Biol Evol , vol.18 , pp. 453-464
    • Gu, X.1
  • 17
    • 0036205440 scopus 로고    scopus 로고
    • DIVERGE: Phylogeny-based analysis for functional-structural divergence of a protein family
    • 11934757 10.1093/bioinformatics/18.3.500 1:CAS:528:DC%2BD38XivFKrsLw%3D
    • Gu X, Vander Velden K (2002) DIVERGE: phylogeny-based analysis for functional-structural divergence of a protein family. Bioinformatics 18:500-501
    • (2002) Bioinformatics , vol.18 , pp. 500-501
    • Gu, X.1    Vander Velden, K.2
  • 18
    • 0026534986 scopus 로고
    • Experimental phylogenetics: Generation of a known phylogeny
    • 1736360 10.1126/science.1736360 1:CAS:528:DyaK38Xht1als7Y%3D
    • Hillis DM, Bull JJ, White ME, Badgett MR, Molineux IJ (1992) Experimental phylogenetics: generation of a known phylogeny. Science 255:589-592
    • (1992) Science , vol.255 , pp. 589-592
    • Hillis, D.M.1    Bull, J.J.2    White, M.E.3    Badgett, M.R.4    Molineux, I.J.5
  • 19
    • 0036097894 scopus 로고    scopus 로고
    • Testing a covariotide model of DNA substitution
    • 11961103 10.1093/oxfordjournals.molbev.a004128 1:CAS:528: DC%2BD38XjsFaku78%3D
    • Huelsenbeck JP (2002) Testing a covariotide model of DNA substitution. Mol Biol Evol 19:698-707
    • (2002) Mol Biol Evol , vol.19 , pp. 698-707
    • Huelsenbeck, J.P.1
  • 20
    • 0030025671 scopus 로고    scopus 로고
    • The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution
    • 8596629 10.1038/379511a0 1:CAS:528:DyaK28XhtVWhsLg%3D
    • Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R (1996) The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature 379:511-518
    • (1996) Nature , vol.379 , pp. 511-518
    • Kawashima, T.1    Berthet-Colominas, C.2    Wulff, M.3    Cusack, S.4    Leberman, R.5
  • 21
    • 7244221755 scopus 로고    scopus 로고
    • Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous
    • 15496922 10.1038/nature02917 1:CAS:528:DC%2BD2cXoslSltrw%3D
    • Kolaczkowski B, Thornton JW (2004) Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous. Nature 431:980-984
    • (2004) Nature , vol.431 , pp. 980-984
    • Kolaczkowski, B.1    Thornton, J.W.2
  • 22
    • 44649184070 scopus 로고    scopus 로고
    • A mixed branch length model of heterotachy improves phylogenetic accuracy
    • 18319244 10.1093/molbev/msn042 1:CAS:528:DC%2BD1cXntlWlsbc%3D
    • Kolaczkowski B, Thornton JW (2008) A mixed branch length model of heterotachy improves phylogenetic accuracy. Mol Biol Evol 25:1054-1066
    • (2008) Mol Biol Evol , vol.25 , pp. 1054-1066
    • Kolaczkowski, B.1    Thornton, J.W.2
  • 23
    • 33751414256 scopus 로고    scopus 로고
    • Tracking the connection between evolutionary and functional shifts using the fungal lipase/feruloyl esterase A family
    • 17092334 10.1186/1471-2148-6-92
    • Levasseur A, Gouret P, Lesage-Meessen L, Asther M, Asther M, Record E, Pontarotti P (2006) Tracking the connection between evolutionary and functional shifts using the fungal lipase/feruloyl esterase A family. Bmc Evol Biol 6:92
    • (2006) Bmc Evol Biol , vol.6 , pp. 92
    • Levasseur, A.1    Gouret, P.2    Lesage-Meessen, L.3    Asther, M.4    Asther, M.5    Record, E.6    Pontarotti, P.7
  • 25
    • 0031852105 scopus 로고    scopus 로고
    • A covariotide model explains apparent phylogenetic structure of oxygenic photosynthetic lineages
    • 9729882 10.1093/oxfordjournals.molbev.a026025 1:CAS:528: DyaK1cXls1Kis7c%3D
    • Lockhart PJ, Steel MA, Barbrook AC, Huson DH, Charleston MA, Howe CJ (1998) A covariotide model explains apparent phylogenetic structure of oxygenic photosynthetic lineages. Mol Biol Evol 15:1183-1188
    • (1998) Mol Biol Evol , vol.15 , pp. 1183-1188
    • Lockhart, P.J.1    Steel, M.A.2    Barbrook, A.C.3    Huson, D.H.4    Charleston, M.A.5    Howe, C.J.6
  • 26
    • 0036134757 scopus 로고    scopus 로고
    • Heterotachy, an important process of protein evolution
    • 11752184 10.1093/oxfordjournals.molbev.a003973 1:CAS:528: DC%2BD38XhtFCjtA%3D%3D
    • Lopez P, Casane D, Philippe H (2002) Heterotachy, an important process of protein evolution. Mol Biol Evol 19:1-7
    • (2002) Mol Biol Evol , vol.19 , pp. 1-7
    • Lopez, P.1    Casane, D.2    Philippe, H.3
  • 27
    • 34547479718 scopus 로고    scopus 로고
    • An empirical test of the concomitantly variable codon hypothesis
    • 17578921 10.1073/pnas.0701900104 1:CAS:528:DC%2BD2sXnsV2lu7Y%3D
    • Merlo LM, Lunzer M, Dean AM (2007) An empirical test of the concomitantly variable codon hypothesis. Proc Natl Acad Sci U S A 104:10938-10943
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10938-10943
    • Merlo, L.M.1    Lunzer, M.2    Dean, A.M.3
  • 28
    • 0028922906 scopus 로고
    • Testing the covarion hypothesis of molecular evolution
    • 7739391 1:CAS:528:DyaK2MXltF2nurw%3D
    • Miyamoto MM, Fitch WM (1995) Testing the covarion hypothesis of molecular evolution. Mol Biol Evol 12:503-513
    • (1995) Mol Biol Evol , vol.12 , pp. 503-513
    • Miyamoto, M.M.1    Fitch, W.M.2
  • 29
    • 57149106289 scopus 로고    scopus 로고
    • Modelling heterotachy in phylogenetic inference by reversible-jump Markov chain Monte Carlo
    • 10.1098/rstb.2008.0178
    • Pagel M, Meade A (2008) Modelling heterotachy in phylogenetic inference by reversible-jump Markov chain Monte Carlo. Philos Transact R Soc B Biol Sci 363:3955-3964
    • (2008) Philos Transact R Soc B Biol Sci , vol.363 , pp. 3955-3964
    • Pagel, M.1    Meade, A.2
  • 31
    • 84861422981 scopus 로고    scopus 로고
    • Amino acid coevolution induces an evolutionary Stokes shift
    • 22547823 10.1073/pnas.1120084109 1:CAS:528:DC%2BC38XosFahs7c%3D
    • Pollock DD, Thiltgen G, Goldstein RA (2012) Amino acid coevolution induces an evolutionary Stokes shift. Proc Natl Acad Sci USA 109:E1352-E1359
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Pollock, D.D.1    Thiltgen, G.2    Goldstein, R.A.3
  • 32
    • 0037036501 scopus 로고    scopus 로고
    • A covarion-based method for detecting molecular adaptation: Application to the evolution of primate mitochondrial genomes
    • 10.1098/rspb.2002.2025 1:CAS:528:DC%2BD38XmsFWntbw%3D
    • Pupko T, Galtier N (2002) A covarion-based method for detecting molecular adaptation: application to the evolution of primate mitochondrial genomes. Proc R Soc Lond Ser B Biol Sci 269:1313-1316
    • (2002) Proc R Soc Lond ser B Biol Sci , vol.269 , pp. 1313-1316
    • Pupko, T.1    Galtier, N.2
  • 33
    • 38849160068 scopus 로고    scopus 로고
    • Accurate gene-tree reconstruction by learning gene- and species-specific substitution rates across multiple complete genomes
    • 17989260 10.1101/gr.7105007 1:CAS:528:DC%2BD2sXhsVGhsLbO
    • Rasmussen MD, Kellis M (2007) Accurate gene-tree reconstruction by learning gene- and species-specific substitution rates across multiple complete genomes. Genome Res 17:1932-1942
    • (2007) Genome Res , vol.17 , pp. 1932-1942
    • Rasmussen, M.D.1    Kellis, M.2
  • 34
    • 78651361594 scopus 로고    scopus 로고
    • Site-specific time heterogeneity of the substitution process and its impact on phylogenetic inference
    • Roure B, Philippe H (2011) Site-specific time heterogeneity of the substitution process and its impact on phylogenetic inference. Bmc Evol Biol 11:17
    • (2011) Bmc Evol Biol , vol.11 , pp. 17
    • Roure, B.1    Philippe, H.2
  • 36
    • 0036313499 scopus 로고    scopus 로고
    • A simple covarion-based approach to analyse nucleotide substitution rates
    • 10.1046/j.1420-9101.2002.00416.x 1:CAS:528:DC%2BD38XlvFOhsro%3D
    • Siltberg J, Liberles DA (2002) A simple covarion-based approach to analyse nucleotide substitution rates. J Evol Biol 15:588-594
    • (2002) J Evol Biol , vol.15 , pp. 588-594
    • Siltberg, J.1    Liberles, D.A.2
  • 37
    • 77958140989 scopus 로고    scopus 로고
    • Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution
    • 20551039 10.1093/molbev/msq149 1:CAS:528:DC%2BC3cXhtlShu7zK
    • Studer RA, Robinson-Rechavi M (2010) Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution. Mol Biol Evol 27:2618-2627
    • (2010) Mol Biol Evol , vol.27 , pp. 2618-2627
    • Studer, R.A.1    Robinson-Rechavi, M.2
  • 38
    • 0031986279 scopus 로고    scopus 로고
    • Modeling the covarion hypothesis of nucleotide substitution
    • 9401352 10.1016/S0025-5564(97)00081-3 1:CAS:528:DyaK2sXnvVOnu70%3D
    • Tuffley C, Steel M (1998) Modeling the covarion hypothesis of nucleotide substitution. Math Biosci 147:63-91
    • (1998) Math Biosci , vol.147 , pp. 63-91
    • Tuffley, C.1    Steel, M.2
  • 39
    • 33845900956 scopus 로고    scopus 로고
    • Testing for covarion-like evolution in protein sequences
    • 17056642 10.1093/molbev/msl155 1:CAS:528:DC%2BD2sXnvFWlsA%3D%3D
    • Wang HC, Spencer M, Susko E, Roger AJ (2007) Testing for covarion-like evolution in protein sequences. Mol Biol Evol 24:294-305
    • (2007) Mol Biol Evol , vol.24 , pp. 294-305
    • Wang, H.C.1    Spencer, M.2    Susko, E.3    Roger, A.J.4
  • 40
    • 79961068835 scopus 로고    scopus 로고
    • Fast statistical tests for detecting heterotachy in Protein Evolution
    • 21343603 10.1093/molbev/msr050 1:CAS:528:DC%2BC3MXps12lsbs%3D
    • Wang HC, Susko E, Roger AJ (2011) Fast statistical tests for detecting heterotachy in Protein Evolution. Mol Biol Evol 28:2305-2315
    • (2011) Mol Biol Evol , vol.28 , pp. 2305-2315
    • Wang, H.C.1    Susko, E.2    Roger, A.J.3
  • 41
    • 84855876436 scopus 로고    scopus 로고
    • Inconsistencies in estimating the age of HIV-1 subtypes due to heterotachy
    • 22045998 10.1093/molbev/msr266 1:CAS:528:DC%2BC38XosF2kug%3D%3D
    • Wertheim JO, Fourment M, Pond SLK (2012) Inconsistencies in estimating the age of HIV-1 subtypes due to heterotachy. Mol Biol Evol 29:451-456
    • (2012) Mol Biol Evol , vol.29 , pp. 451-456
    • Wertheim, J.O.1    Fourment, M.2    Pond, S.L.K.3
  • 42
    • 0035031966 scopus 로고    scopus 로고
    • A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach
    • 11319253 10.1093/oxfordjournals.molbev.a003851 1:CAS:528: DC%2BD3MXjtFyktr4%3D
    • Whelan S, Goldman N (2001) A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol Biol Evol 18:691-699
    • (2001) Mol Biol Evol , vol.18 , pp. 691-699
    • Whelan, S.1    Goldman, N.2
  • 43
    • 78650494526 scopus 로고    scopus 로고
    • Phylogenetic substitution models for detecting heterotachy during plastid evolution
    • 20724379 10.1093/molbev/msq215 1:CAS:528:DC%2BC3cXhsF2rsLnO
    • Whelan S, Blackburne BP, Spencer M (2011) Phylogenetic substitution models for detecting heterotachy during plastid evolution. Mol Biol Evol 28:449-458
    • (2011) Mol Biol Evol , vol.28 , pp. 449-458
    • Whelan, S.1    Blackburne, B.P.2    Spencer, M.3
  • 44
    • 33745166593 scopus 로고    scopus 로고
    • Tests of parallel molecular evolution in a long-term experiment with Escherichia coli
    • 16751270 10.1073/pnas.0602917103 1:CAS:528:DC%2BD28XmsVWjsLg%3D
    • Woods R, Schneider D, Winkworth CL, Riley MA, Lenski RE (2006) Tests of parallel molecular evolution in a long-term experiment with Escherichia coli. Proc Natl Acad Sci U S A 103:9107-9112
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9107-9112
    • Woods, R.1    Schneider, D.2    Winkworth, C.L.3    Riley, M.A.4    Lenski, R.E.5
  • 45
    • 79955432017 scopus 로고    scopus 로고
    • A test for heterotachy using multiple pairs of sequences
    • 21186190 10.1093/molbev/msq346 1:CAS:528:DC%2BC3MXlt1Gms7k%3D
    • Wu JH, Susko E (2011) A test for heterotachy using multiple pairs of sequences. Mol Biol Evol 28:1661-1673
    • (2011) Mol Biol Evol , vol.28 , pp. 1661-1673
    • Wu, J.H.1    Susko, E.2
  • 46
    • 0028064845 scopus 로고
    • Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: Approximate methods
    • 7932792 10.1007/BF00160154 1:CAS:528:DyaK2cXmt1eit7c%3D
    • Yang Z (1994) Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. J Mol Evol 39:306-314
    • (1994) J Mol Evol , vol.39 , pp. 306-314
    • Yang, Z.1
  • 47
    • 84862814389 scopus 로고    scopus 로고
    • Molecular phylogenetics: Principles and practice
    • 22456349 10.1038/nrg3186 1:CAS:528:DC%2BC38Xks1yktro%3D
    • Yang Z, Rannala B (2012) Molecular phylogenetics: principles and practice. Nat Rev Genet 13:303-314
    • (2012) Nat Rev Genet , vol.13 , pp. 303-314
    • Yang, Z.1    Rannala, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.