Immortality of cancers: A consequence of inherent karyotypic variations and selections for autonomy

Cell Cycle

Volumn 12, Issue 5, 2013, Pages 783-802

  Duesberg, Peter ^a   McCormack, Amanda ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aneuploidy proximate carcinogen; Clonal and flexible cancer karyotypes; Growth advantages of aneuploidy; Karyotypes of immortal clones of telomerase deficient mice; Karyotypic linkage of immortality and tumorigenicity; Long preneoplastic latency; Low probability of speciation; Muller's ratchet; Selection for cancer specific autonomy; Sub speciation via karyotypic drift

Indexed keywords

TELOMERASE;

ANEUPLOIDY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CLONING; CELL IMMORTALIZATION; CHROMOSOME NUMBER; CLONAL VARIATION; CONTROLLED STUDY; FIBROBLAST; GENE DOSAGE; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; KARYOTYPE; MITOSIS; MOUSE; NONHUMAN; SIMIAN VIRUS 40; SPECIES DIFFERENTIATION;

EID: 84874640598     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.23720     Document Type: Article

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