Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 11, 2002, Pages 1382-1394

  Yaswen, Paul ^a   Stampfer, Martha R ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Immortality; p16INK4a; p57KIP2; Telomerase; TGF

Indexed keywords

PROTEIN P16; PROTEIN P53; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA;

BREAST EPITHELIUM; CARCINOGENESIS; CATALYSIS; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TRANSFORMATION; CELL VIABILITY; CHROMOSOME ABERRATION; ENZYME ACTIVATION; ENZYME REACTIVATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE;

BREAST; CELL AGING; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P57; EPITHELIAL CELLS; GENES, MYC; HUMANS; NUCLEAR PROTEINS; TELOMERASE; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036829333     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(02)00047-X     Document Type: Review

References (52)

1. DePinho R.A. The age of cancer. Nature. 408:2000;248-254.
2. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636.
3. Stampfer M., Yaswen R.P. Culture models of human mammary epithelial cell transformation. J. Mam. Gland Bio. Neo. 5:2000;365-378.
4. Dimri G.P.et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 92:1995;9363-9367.
5. Stampfer M.R., Bartley J.C. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene. Proc. Natl. Acad. Sci. U.S.A. 82:1985;2394-2398.
6. Hammond S.L., Ham R.G., Stampfer M.R. Serum-free growth of human mammary epthelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc. Natl. Acad. Sci. U.S.A. 81:1984;5435-5439.
7. INK4a expression with onset of senescence of human mammary epithelial cells and extended growth capacity with inactivation. Oncogene. 17:1998;199-205.
8. INK4a inactivation and telomerase activity are required to immortalize human epithelial cell. Nature. 396:1998;84-88.
9. INK4 expression by methylation is associated with life span extension of human mammary epithelial cells. Cancer Res. 58:1998;3508-3512.
10. Brenner A.J., Aldaz C.M. Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res. 55:1995;2892-2895.
11. INK4 (-) human mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 98:2001;4498-4503.
12. Garbe J., Wong M., Wigington D., Yaswen P., Stampfer M.R. Viral oncogenes accelerate conversion to immortality of cultured human mammary epithelial cells. Oncogene. 18:1999;2169-2180.
13. Chen Q.M. Replicative senescence and oxidant-induced premature senescence: beyond the control of cell cycle checkpoints. Ann. New York Acad. Sci. 908:2000;111-125.
14. Toussaint O., Medrano E.E., von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 35:2000;927-945.
15. Ramirez R.D., Morales C.P., Herbert B.S., Rohde J.M., Passons C., Shay J.W., Wright W.E. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15:2001;398-403.
16. INK4a expression during cellular senescence. Nature. 409:2001;1067-1070.
17. Herman J.G., Merlo A., Mao L., Lapidus R.G., Issa J.-P.J., Davidson N.E., Sidransky D., Baylin S.B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylaton in all common human cancers. Cancer Res. 55:1995;4525-4530.
18. INK4a is an early event in lung cancer and a potential biomarker for early diagnosis. Proc. Natl. Acad. Sci. U.S.A. 95:1998;11891-11896.
19. Romanov S., Kozakiewicz K., Holst C., Stampfer M.R., Haupt L.M., Tlsty T. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature. 409:2001;633-637.
20. Tlsty T.D., Romanov S.R., Kozakiewicz B.K., Holst C.R., Haupt L.M., Crawford Y.G. Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence. J. Mam. Gland Biol. Neoplasia. 6:2001;235-243.
21. Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., de Lange T. Mammalian telomeres end in a large duplex loop. Cell. 97:1999;503-514.
22. Vaziri H., West M.D., Allsopp R.C., Davison T.S., Wu Y.S., Arrowsmith C.H., Poirier G.G., Benchimol S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16:1997;6018-6033.
23. Walen K., Stampfer M.R. Chromosome analyses of human mammary epithelial cells at stages of chemically-induced transformation progression to immortality. Cancer Gen. Cyto. 37:1989;249-261.
24. INK4b/cdk4 complexes and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. Mol. Cell Biol. 17:1997;2458-2467.
25. Lehman T.et al. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis. 14:1993;833-839.
26. Stampfer M.R., Bodnar A., Garbe J., Wong M., Pan A., Villeponteau B., Yaswen P. Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells. Mol. Biol. Cell. 8:1997;2391-2405.
27. Nijjar T., Wigington D., Garbe J.C., Waha A., Stampfer M.R., Yaswen P. p57/KIP2 loss of heterozygosity and expression during immortal conversion of human mammary epithelial cells. Cancer Res. 59:1999;5112-5118.
28. KIP2, on chromosome 11p15. Proc. Natl. Acad. Sci. U.S.A. 93:1996;3026-3030.
29. Berns E.M., Klijn J.G., van Stevern K.L., Portengen H., Noordegraaf E., Foekens J.A. Prevalence of amplificatio of the oncogenes c-myc, HER2/neu, and int-2 in 1000 human breast tumors: correlation with steroid receptors. Eur. J. Cancer. 28:1992;697-700.
30. Harada Y., Katagiri T., Ito I., Akiyama F., Sakamoto G., Kasumi F., Nakamura Y., Emi M. Genetic studies of 457 breast cancers. Clinicopathologic parameters compared with genetic alterations. Cancer. 74:1994;2281-2286.
31. Wang J., Xie L.Y., Allan S., Beach D., Hannon G.J. Myc activates telomerase. Genes Dev. 12:1998;1769-1774.
32. Horikawa I., Cable P.L., Afshari C.A., Barrett J.C. Cloning and characterization of the promoter region of human telomerase reverse-transcriptase gene. Cancer Res. 59:1999;826-830.
33. Cong Y.S., Wen J., Bacchetti S. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum. Mol. Genet. 8:1999;137-142.
34. Wu K.-J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., Dalla-Favera R. Direct activation of TERT transcription by c-myc. Nature Genet. 21:1999;220-224.
35. Greenberg R.A.et al. Telomerase reverse-transcriptase gene is a direct target of c-myc but is not functionally equivalent in cellular transformation. Oncogene. 18:1999;1219-1226.
36. Stampfer M.R., Pan C.H., Hosoda J., Bartholomew J., Mendelsohn J., Yaswen P. Blockage of EGF receptor signal transduction causes reversible arrest of normal and transformed human mammary epithelial cells with synchronous reentry into the cell cycle. Exp. Cell Res. 208:1993;175-188.
37. Band V., DeCaprio J., Delmolino L., Kulesa V., Sager R. Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J. Virol. 65:1991;6671-6676.
38. Wazer D.E., Chu Q., Liu X.-L., Gao Q., Safaii H., Band V. Loss of p53 during radiation transformation of primary human mammary epithelial cells. Mol. Cell Biol. 14:1994;2468-2478.
39. Shay J.W., Tomlinson G., Piatyszek M.A., Gollahon L.S. Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Mol. Cell Biol. 15:1995;425-432.
40. Gao Q., Hauser S.H., Liu X.-L., Wazer D.E., Madoc-Jones H., Band V. Mutant p53-induced immortalization of primary human mammary epithelial cells. Cancer Res. 56:1996;3129-3133.
41. his). Oncogene. 12:1996;715-725.
42. Ossovskaya V.S.et al. Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc. Natl. Acad. Sci. U.S.A. 93:1996;10309-10314.
43. Li H., Cao Y., Berndt M.C., Funder J.W., Liu J.-P. Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene. 18:1999;6785-6794.
44. Xu D.et al. Downregulation of telomerase reverse-transcriptase mRNA expression by wild type p53 in human tumor cells. Oncogene. 19:2000;5123-5133.
45. Done S.J., Arneson N.C.R., Özçelik H., Redston M., Andrulis I.L. p53 mutations in mammary ductal carcinoma in situ but not in epithelial hyperplasias. Cancer Res. 58:1998;785-789.
46. Kallioniemi A.et al. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl. Acad. Sci. U.S.A. 91:1994;2156-2160.
47. Werner M., Mattis A., Aubele M., Cummings M., Zitzelsberger H., Hutzler P., Hofler H. 20q13.2 amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast. Virchows Arch. 435:1999;469-472.
48. Collins C.et al. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc. Natl. Acad. Sci. U.S.A. 95:1998;8703-8708.
49. Pieler T., Bellefroid E. Perspectives on zinc finger protein function and evolution-an update. Mol. Biol. Reports. 20:1994;1-8.
50. Nonet G., Stampfer M.R., Chin K., Gray J.W., Collins C.C., Yaswen P. The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells. Cancer Res. 61:2001;1250-1254.
51. Gray J.W., Collins C. Genomic changes and gene expression in human solid tumors. Carcinogenesis. 21:2000;443-452.
52. Bednarek A., Sahin A., Brenner A.J., Johnston D.A., Aldaz C.M. Analysis of telomerase activity in breast cancer: positive detection at the in situ breast carcinoma stage. Clin. Cancer Res. 3:1997;11-16.