Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

Biochemical Journal

Volumn 450, Issue 3, 2013, Pages 523-536

  Pettersson, Susanne ^a   Sczaniecka, Matylda ^a   McLaren, Lorna ^a   Russell, Fiona ^b   Gladstone, Karen ^a   Hupp, Ted ^b   Wallace, Maura ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Murine double minute 2 (MDM2); Non degradative ubiquitination; Notch1; NUMB; Transcriptional activation

Indexed keywords

NOTCH RECEPTOR; NOTCH1 RECEPTOR; PROTEIN MDM2; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; CANCER CELL; CELL CULTURE; IMMUNOPRECIPITATION; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NEOPLASMS; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84874638103     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121249     Document Type: Article

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