A function for the RING finger domain in the allosteric control of MDM2 conformation and activity

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11517-11530

  Wawrzynow, Bartosz ^a   Pettersson, Susanne ^a   Zylicz, Alicja ^a   Bramham, Janice ^b   Worrall, Erin ^a   Hupp, Ted R ^a   Ball, Kathryn L ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC CONTROL; ALLOSTERIC MODEL; ANTICANCER DRUG; ATP BINDING; BINDING AFFINITIES; COMPLEX RELATIONSHIPS; DIFFERENT DOMAINS; DNA BINDING DOMAIN; DOMAIN STRUCTURE; FUNCTIONAL DOMAINS; HYDROPHOBIC POCKETS; MOLECULAR CHAPERONES; ONCOPROTEIN; PROTEIN CONFORMATION; RING FINGER; TRANSACTIVATION DOMAIN; TRANSREPRESSION; UBIQUITINATION; WILD TYPES;

BINDING ENERGY; COORDINATION REACTIONS; ENZYMES; GENE EXPRESSION; LAWS AND LEGISLATION; NUCLEIC ACIDS; PROTEINS; ZINC;

HYDROPHOBICITY;

ADENOSINE TRIPHOSPHATE; MUTANT PROTEIN; PROTEIN MDM2; PROTEIN P53; ANTINEOPLASTIC AGENT; CHAPERONE; IMIDAZOLE DERIVATIVE; MDM2 PROTEIN, HUMAN; NUTLIN 1; PIPERAZINE DERIVATIVE; TP53 PROTEIN, HUMAN; UBIQUITIN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE ACTIVITY; GENE MUTATION; GENE REPRESSION; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; RING FINGER MOTIF; TRANSACTIVATION; WILD TYPE; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 66449094959     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809294200     Document Type: Article

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