-
1
-
-
0036663016
-
mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization
-
Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, and Williams JT (2002) mu-Opioid receptors: ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci 22:5769-5776.
-
(2002)
J Neurosci
, vol.22
, pp. 5769-5776
-
-
Alvarez, V.A.1
Arttamangkul, S.2
Dang, V.3
Salem, A.4
Whistler, J.L.5
Von Zastrow, M.6
Grandy, D.K.7
Williams, J.T.8
-
2
-
-
33646084606
-
Separation of mu opioid receptor desensitization and internalizations. Endogenous receptors in primary neuronal cultures
-
Arttamangkul S, Torrecilla M, Kobayashi K, Okano H, and Williams JT (2006) Separation of mu opioid receptor desensitization and internalizations. Endogenous receptors in primary neuronal cultures. J Neurosci 26:4118-4125.
-
(2006)
J Neurosci
, vol.26
, pp. 4118-4125
-
-
Arttamangkul, S.1
Torrecilla, M.2
Kobayashi, K.3
Okano, H.4
Williams, J.T.5
-
3
-
-
0031046190
-
Opiate-induced adenylyl cyclase superactivation is isozyme-specific
-
Avidor-Reiss T, Nevo I, Saya D, Bayewitch M, and Vogel Z (1997) Opiate-induced adenylyl cyclase superactivation is isozyme-specific. J Biol Chem 272:5040-5047.
-
(1997)
J Biol Chem
, vol.272
, pp. 5040-5047
-
-
Avidor-Reiss, T.1
Nevo, I.2
Saya, D.3
Bayewitch, M.4
Vogel, Z.5
-
4
-
-
12344271040
-
Opioids: Cellular mechanisms of tolerance and physical dependence
-
Bailey CP and Connor M (2005) Opioids: cellular mechanisms of tolerance and physical dependence. Curr Opin Pharmacol 5:60-68.
-
(2005)
Curr Opin Pharmacol
, vol.5
, pp. 60-68
-
-
Bailey, C.P.1
Connor, M.2
-
5
-
-
0034619796
-
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
-
Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, and Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-723.
-
(2000)
Nature
, vol.408
, pp. 720-723
-
-
Bohn, L.M.1
Gainetdinov, R.R.2
Lin, F.T.3
Lefkowitz, R.J.4
Caron, M.G.5
-
6
-
-
0037805628
-
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors
-
Borgland SL, Connor M, Osborne PB, Furness JB, and Christie MJ (2003) Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors. J Biol Chem 278:18776-18784.
-
(2003)
J Biol Chem
, vol.278
, pp. 18776-18784
-
-
Borgland, S.L.1
Connor, M.2
Osborne, P.B.3
Furness, J.B.4
Christie, M.J.5
-
7
-
-
1342265799
-
Distinct domains of the μ-opioid receptor control uncoupling and internalization
-
Celver J, Xu M, Jin W, Lowe J, and Chavkin C (2004) Distinct domains of the μ-opioid receptor control uncoupling and internalization. Mol Pharmacol 65:528-537.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 528-537
-
-
Celver, J.1
Xu, M.2
Jin, W.3
Lowe, J.4
Chavkin, C.5
-
8
-
-
0022830856
-
Tolerance to opioids in single locus coeruleus neurons of the rat
-
Christie MJ, Williams JT, and North RA (1986) Tolerance to opioids in single locus coeruleus neurons of the rat. NIDA Res Monogr 75:591-594.
-
(1986)
NIDA Res Monogr
, vol.75
, pp. 591-594
-
-
Christie, M.J.1
Williams, J.T.2
North, R.A.3
-
9
-
-
10044280635
-
Mu-opioid receptor desensitization: Is morphine different?
-
Connor M, Osborne PB, and Christie MJ (2004) Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol 143:685-696.
-
(2004)
Br J Pharmacol
, vol.143
, pp. 685-696
-
-
Connor, M.1
Osborne, P.B.2
Christie, M.J.3
-
10
-
-
4444236554
-
Chronic morphine treatment reduces recovery from opioid desensitization
-
Dang VC and Williams JT (2004) Chronic morphine treatment reduces recovery from opioid desensitization. J Neurosci 24:7699-7706.
-
(2004)
J Neurosci
, vol.24
, pp. 7699-7706
-
-
Dang, V.C.1
Williams, J.T.2
-
11
-
-
25144435574
-
Morphine-induced μ-opioid receptor desensitization
-
Dang VC and Williams JT (2005) Morphine-induced μ-opioid receptor desensitization. Mol Pharmacol 68:1127-1132.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1127-1132
-
-
Dang, V.C.1
Williams, J.T.2
-
12
-
-
0029865249
-
Opioid desensitization: Interactions with Gprotein-coupled receptors in the locus coeruleus
-
Fiorillo CD and Williams JT (1996) Opioid desensitization: interactions with Gprotein-coupled receptors in the locus coeruleus. J Neurosci 16:1479-1485.
-
(1996)
J Neurosci
, vol.16
, pp. 1479-1485
-
-
Fiorillo, C.D.1
Williams, J.T.2
-
13
-
-
33646540454
-
Development of tolerance and sensitization to different opioid agonists in rats
-
Grecksch G, Bartzsch K, Widera A, Becker A, Hollt V, and Koch T (2006) Development of tolerance and sensitization to different opioid agonists in rats. Psychopharmacology (Berl) 186:177-184.
-
(2006)
Psychopharmacology (Berl)
, vol.186
, pp. 177-184
-
-
Grecksch, G.1
Bartzsch, K.2
Widera, A.3
Becker, A.4
Hollt, V.5
Koch, T.6
-
14
-
-
0025938571
-
Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neurons
-
Harris GC and Williams JT (1991) Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neurons. J Neurosci 11:2574-2581.
-
(1991)
J Neurosci
, vol.11
, pp. 2574-2581
-
-
Harris, G.C.1
Williams, J.T.2
-
15
-
-
33746265800
-
Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells
-
Johnson EA, Oldfield S, Braksator E, Gonzalez-Cuello A, Couch D, Hall KJ, Mundell SJ, Bailey CP, Kelly E, and Henderson G (2006) Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells. Mol Pharmacol 70:676-685.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 676-685
-
-
Johnson, E.A.1
Oldfield, S.2
Braksator, E.3
Gonzalez-Cuello, A.4
Couch, D.5
Hall, K.J.6
Mundell, S.J.7
Bailey, C.P.8
Kelly, E.9
Henderson, G.10
-
16
-
-
18544411827
-
mu-Opioid receptor internalization: Opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain
-
Keith DE, Anton B, Murray SR, Zaki PA, Chu PC, Lissin DV, Monteillet-Agius G, Stewart PL, Evans CJ, and von Zastrow M (1998) mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain. Mol Pharmacol 53:377-384.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 377-384
-
-
Keith, D.E.1
Anton, B.2
Murray, S.R.3
Zaki, P.A.4
Chu, P.C.5
Lissin, D.V.6
Monteillet-Agius, G.7
Stewart, P.L.8
Evans, C.J.9
von Zastrow, M.10
-
17
-
-
0942287665
-
Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization
-
Koch T, Brandenburg LO, Liang Y, Schulz S, Beyer A, Schroder H, and Hollt V (2004) Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization. J Neurochem 88:680-688.
-
(2004)
J Neurochem
, vol.88
, pp. 680-688
-
-
Koch, T.1
Brandenburg, L.O.2
Liang, Y.3
Schulz, S.4
Beyer, A.5
Schroder, H.6
Hollt, V.7
-
18
-
-
11244344642
-
Receptor endocytosis counteracts the development of opioid tolerance
-
Koch T, Widera A, Bartzsch K, Schulz S, Brandenburg LO, Wundrack N, Beyer A, Grecksch G, and Hollt V (2005) Receptor endocytosis counteracts the development of opioid tolerance. Mol Pharmacol 67:280-287.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 280-287
-
-
Koch, T.1
Widera, A.2
Bartzsch, K.3
Schulz, S.4
Brandenburg, L.O.5
Wundrack, N.6
Beyer, A.7
Grecksch, G.8
Hollt, V.9
-
19
-
-
0033930091
-
Receptor density and recycling affect the rate of agonist-induced desensitization of μ-opioid receptor
-
Law PY, Erickson LJ, El-Kouhen R, Dicker L, Solberg J, Wang W, Miller E, Burd AL, and Loh HH (2000) Receptor density and recycling affect the rate of agonist-induced desensitization of μ-opioid receptor. Mol Pharmacol 58:388-398.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 388-398
-
-
Law, P.Y.1
Erickson, L.J.2
El-Kouhen, R.3
Dicker, L.4
Solberg, J.5
Wang, W.6
Miller, E.7
Burd, A.L.8
Loh, H.H.9
-
20
-
-
33749175958
-
Antinociception by spinal and systemic oxycodone: Why does the route make a difference? In vitro and in vivo studies in rats
-
Lemberg KK, Kontinen VK, Siiskonen AO, Viljakka KM, Yli-Kauhaluoma JT, Korpi ER, and Kalso EA (2006) Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats. Anesthesiology 105:801-812.
-
(2006)
Anesthesiology
, vol.105
, pp. 801-812
-
-
Lemberg, K.K.1
Kontinen, V.K.2
Siiskonen, A.O.3
Viljakka, K.M.4
Yli-Kauhaluoma, J.T.5
Korpi, E.R.6
Kalso, E.A.7
-
21
-
-
0029088229
-
Characterization of acute homologous desensitization of mu-opioid receptor-induced currents in locus coeruleus neurones
-
Osborne PB and Williams JT (1995) Characterization of acute homologous desensitization of mu-opioid receptor-induced currents in locus coeruleus neurones. Br J Pharmacol 115:925-932.
-
(1995)
Br J Pharmacol
, vol.115
, pp. 925-932
-
-
Osborne, P.B.1
Williams, J.T.2
-
22
-
-
0036892880
-
Opioid agonists differentially regulate μ-opioid receptors and trafficking proteins in vivo
-
Patel MB, Patel CN, Rajashekara V, and Yoburn BC (2002) Opioid agonists differentially regulate μ-opioid receptors and trafficking proteins in vivo. Mol Pharmacol 62:1464-1470.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1464-1470
-
-
Patel, M.B.1
Patel, C.N.2
Rajashekara, V.3
Yoburn, B.C.4
-
23
-
-
34247169145
-
Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2
-
Pawar M, Kumar P, Sunkaraneni S, Sirohi S, Walker EA, and Yoburn BC (2007) Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2. Eur J Pharmacol 563:92-101.
-
(2007)
Eur J Pharmacol
, vol.563
, pp. 92-101
-
-
Pawar, M.1
Kumar, P.2
Sunkaraneni, S.3
Sirohi, S.4
Walker, E.A.5
Yoburn, B.C.6
-
24
-
-
33644756719
-
Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats
-
Peckham EM and Traynor JR (2006) Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats. J Pharmacol Exp Ther 316:1195-1201.
-
(2006)
J Pharmacol Exp Ther
, vol.316
, pp. 1195-1201
-
-
Peckham, E.M.1
Traynor, J.R.2
-
25
-
-
4444311166
-
Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375
-
Schulz S, Mayer D, Pfeiffer M, Stumm R, Koch T, and Hollt V (2004) Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J 23:3282-3289.
-
(2004)
EMBO J
, vol.23
, pp. 3282-3289
-
-
Schulz, S.1
Mayer, D.2
Pfeiffer, M.3
Stumm, R.4
Koch, T.5
Hollt, V.6
-
26
-
-
0034979543
-
mu-Opioid receptor down-regulation contributes to opioid tolerance in vivo
-
Stafford K, Gomes AB, Shen J, and Yoburn BC (2001) mu-Opioid receptor down-regulation contributes to opioid tolerance in vivo. Pharmacol Biochem Behav 69:233-237.
-
(2001)
Pharmacol Biochem Behav
, vol.69
, pp. 233-237
-
-
Stafford, K.1
Gomes, A.B.2
Shen, J.3
Yoburn, B.C.4
-
27
-
-
4644330576
-
A cell biologist's perspective on physiological adaptation to opiate drugs
-
von Zastrow M (2004) A cell biologist's perspective on physiological adaptation to opiate drugs. Neuropharmacology 47 (Suppl 1):286-292.
-
(2004)
Neuropharmacology
, vol.47
, Issue.SUPPL. 1
, pp. 286-292
-
-
von Zastrow, M.1
-
28
-
-
0035111517
-
Differential tolerance to antinociceptive effects of mu opioids during repeated treatment with etonitazene, morphine, or buprenorphine in rats
-
Walker EA and Young AM (2001) Differential tolerance to antinociceptive effects of mu opioids during repeated treatment with etonitazene, morphine, or buprenorphine in rats. Psychopharmacology (Berl) 154:131-142.
-
(2001)
Psychopharmacology (Berl)
, vol.154
, pp. 131-142
-
-
Walker, E.A.1
Young, A.M.2
-
29
-
-
0033179904
-
Functional dissociation of mu opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
-
Whistler JL, Chuang HH, Chu P, Jan LY, and von Zastrow M (1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23:737-746.
-
(1999)
Neuron
, vol.23
, pp. 737-746
-
-
Whistler, J.L.1
Chuang, H.H.2
Chu, P.3
Jan, L.Y.4
von Zastrow, M.5
-
30
-
-
0032544061
-
Morphine-activated opioid receptors elude desensitization by β-arrestin
-
Whistler JL and von Zastrow M (1998) Morphine-activated opioid receptors elude desensitization by β-arrestin. Proc Natl Acad Sci U S A 95:9914-9919.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 9914-9919
-
-
Whistler, J.L.1
von Zastrow, M.2
-
31
-
-
0035138995
-
Cellular and synaptic adaptations mediating opioid dependence
-
Williams JT, Christie MJ, and Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343.
-
(2001)
Physiol Rev
, vol.81
, pp. 299-343
-
-
Williams, J.T.1
Christie, M.J.2
Manzoni, O.3
-
32
-
-
0021178713
-
Membrane properties of rat locus coeruleus neurones
-
Williams JT, North RA, Shefner SA, Nishi S, and Egan TM (1984) Membrane properties of rat locus coeruleus neurones. Neuroscience 13:137-156.
-
(1984)
Neuroscience
, vol.13
, pp. 137-156
-
-
Williams, J.T.1
North, R.A.2
Shefner, S.A.3
Nishi, S.4
Egan, T.M.5
-
33
-
-
0030691760
-
μ-Opioid receptor phosphorylation, desensitization, and ligand efficacy
-
Yu Y, Zhang L, Yin X, Sun H, Uhl GR, and Wang JB (1997) μ-Opioid receptor phosphorylation, desensitization, and ligand efficacy. J Biol Chem 272:28869-28874.
-
(1997)
J Biol Chem
, vol.272
, pp. 28869-28874
-
-
Yu, Y.1
Zhang, L.2
Yin, X.3
Sun, H.4
Uhl, G.R.5
Wang, J.B.6
-
34
-
-
0031393975
-
Molecular mechanisms of G protein-coupled receptor signaling: Role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization
-
Zhang J, Ferguson SS, Barak LS, Aber MJ, Giros B, Lefkowitz RJ, and Caron MG (1997) Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. Receptors Channels 5:193-199.
-
(1997)
Receptors Channels
, vol.5
, pp. 193-199
-
-
Zhang, J.1
Ferguson, S.S.2
Barak, L.S.3
Aber, M.J.4
Giros, B.5
Lefkowitz, R.J.6
Caron, M.G.7
|