Endogenous RGS protein action modulates μ-opioid signaling through Gαo: Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9418-9425

  Clark, Mary J ^a   Harrison, Charlotte ^a   Zhong, Huailing ^a   Neubig, Richard R ^a,b   Traynor, John R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; MUTAGENESIS; SIGNALING; TOXIC MATERIALS;

PROTEIN SIGNALING;

PROTEINS;

ADENYLATE CYCLASE; CALCIUM ION; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MORPHINE; MU OPIATE RECEPTOR; MUTANT PROTEIN; RGS PROTEIN; CALCIUM; CYCLIC AMP; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL LINE; CELL MEMBRANE; CHEMISTRY; DOSE RESPONSE; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; TIME;

ANIMALIA;

ADENYLATE CYCLASE; ANIMALS; CALCIUM; CELL LINE; CELL MEMBRANE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHINE; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN BINDING; RATS; RECEPTORS, OPIOID, MU; RGS PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037984338     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208885200     Document Type: Article

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