-
1
-
-
75149161903
-
PKC and the control of localized signal dynamics
-
Rosse, C., Linch, M., Kermorgant, S., Cameron, A. J., Boeckeler, K., Parker, P. J. (2010) PKC and the control of localized signal dynamics. Nat. Rev. Mol. Cell. Biol. 11, 103-112.
-
(2010)
Nat. Rev. Mol. Cell. Biol.
, vol.11
, pp. 103-112
-
-
Rosse, C.1
Linch, M.2
Kermorgant, S.3
Cameron, A.J.4
Boeckeler, K.5
Parker, P.J.6
-
2
-
-
83555176323
-
Allosteric regulation of PKCθ: Understanding multistep phosphorylation and priming by ligands in AGC kinases
-
Seco, J., Ferrer-Costa, C., Campanera, J. M., Soliva, R., Barril, X. (2012) Allosteric regulation of PKCθ: understanding multistep phosphorylation and priming by ligands in AGC kinases. Proteins 80, 269-280.
-
(2012)
Proteins
, vol.80
, pp. 269-280
-
-
Seco, J.1
Ferrer-Costa, C.2
Campanera, J.M.3
Soliva, R.4
Barril, X.5
-
3
-
-
55949109631
-
Structural basis of protein kinase C isoform function
-
Steinberg, S. F. (2008) Structural basis of protein kinase C isoform function. Physiol. Rev. 88, 1341-1378.
-
(2008)
Physiol. Rev.
, vol.88
, pp. 1341-1378
-
-
Steinberg, S.F.1
-
4
-
-
63849136153
-
Protein kinase C isoforms: Multi-functional regulators of cell life and death
-
Reyland, M. E. (2009) Protein kinase C isoforms: multi-functional regulators of cell life and death. Front. Biosci. 14, 2386-2399.
-
(2009)
Front. Biosci.
, vol.14
, pp. 2386-2399
-
-
Reyland, M.E.1
-
5
-
-
0027418818
-
Molecular cloning and characterization of PKC θ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
-
Baier, G., Telford, D., Giampa, L., Coggeshall, K. M., Baier-Bitterlich, G., Isakov, N., Altman, A. (1993) Molecular cloning and characterization of PKC θ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268, 4997-5004.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4997-5004
-
-
Baier, G.1
Telford, D.2
Giampa, L.3
Coggeshall, K.M.4
Baier-Bitterlich, G.5
Isakov, N.6
Altman, A.7
-
6
-
-
0031012266
-
Selective modulation of protein kinase C-θ during T-cell activation
-
Monks, C. R., Kupfer, H., Tamir, I., Barlow, A., Kupfer, A. (1997) Selective modulation of protein kinase C-θ during T-cell activation. Nature 385, 83-86.
-
(1997)
Nature
, vol.385
, pp. 83-86
-
-
Monks, C.R.1
Kupfer, H.2
Tamir, I.3
Barlow, A.4
Kupfer, A.5
-
7
-
-
63849163448
-
Impaired activation of platelets lacking protein kinase C-θ isoform
-
Nagy Jr., B., Bhavaraju, K., Getz, T., Bynagari, Y. S., Kim, S., Kunapuli, S. P. (2009) Impaired activation of platelets lacking protein kinase C-θ isoform. Blood 113, 2557-2567.
-
(2009)
Blood
, vol.113
, pp. 2557-2567
-
-
Nagy Jr, B.1
Bhavaraju, K.2
Getz, T.3
Bynagari, Y.S.4
Kim, S.5
Kunapuli, S.P.6
-
8
-
-
54349086262
-
Differential requirement of PKC-θ in the development and function of natural regulatory T cells
-
Gupta, S., Manicassamy, S., Vasu, C., Kumar, A., Shang, W., Sun, Z. (2008) Differential requirement of PKC-θ in the development and function of natural regulatory T cells. Mol. Immunol. 46, 213-224.
-
(2008)
Mol. Immunol.
, vol.46
, pp. 213-224
-
-
Gupta, S.1
Manicassamy, S.2
Vasu, C.3
Kumar, A.4
Shang, W.5
Sun, Z.6
-
9
-
-
0026665459
-
A new member of the protein kinase C family, nPKCθ, predominantly expressed in skeletal muscle
-
Osada, S., Mizuno, K., Saido, T. C., Suzuki, K., Kuroki, T., Ohno, S. (1992) A new member of the protein kinase C family, nPKCθ, predominantly expressed in skeletal muscle. Mol. Cell. Biol. 12, 3930-3938.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 3930-3938
-
-
Osada, S.1
Mizuno, K.2
Saido, T.C.3
Suzuki, K.4
Kuroki, T.5
Ohno, S.6
-
10
-
-
0027153592
-
Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets
-
Chang, J. D., Xu, Y., Raychowdhury, M. K., Ware, J. A. (1993) Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. J. Biol. Chem. 268, 14208-14214.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14208-14214
-
-
Chang, J.D.1
Xu, Y.2
Raychowdhury, M.K.3
Ware, J.A.4
-
11
-
-
0028893595
-
Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction
-
Hilgenberg, L., Miles, K. (1995) Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction. J. Cell Sci. 108, 51-61.
-
(1995)
J. Cell Sci.
, vol.108
, pp. 51-61
-
-
Hilgenberg, L.1
Miles, K.2
-
12
-
-
0033615968
-
Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel β 5 integrinmodulating, PKC θ-dependent protein
-
Tang, S., Gao, Y., Ware, J. A. (1999) Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel β 5 integrinmodulating, PKC θ-dependent protein. J. Cell Biol. 147, 1073-1084.
-
(1999)
J. Cell Biol.
, vol.147
, pp. 1073-1084
-
-
Tang, S.1
Gao, Y.2
Ware, J.A.3
-
13
-
-
43349093880
-
Stromal cell-derived factor 1-α (SDF)-induced human T cell chemotaxis becomes phosphoinositide 3-kinase (PI3K)-independent: Role of PKC-θ
-
Shahabi, N. A., McAllen, K., Sharp, B. M. (2008) Stromal cell-derived factor 1-α (SDF)-induced human T cell chemotaxis becomes phosphoinositide 3-kinase (PI3K)-independent: role of PKC-θ. J. Leukoc. Biol. 83, 663-671.
-
(2008)
J. Leukoc. Biol.
, vol.83
, pp. 663-671
-
-
Shahabi, N.A.1
McAllen, K.2
Sharp, B.M.3
-
14
-
-
0029070256
-
Insulin increases mRNA levels of protein kinase C-α and-β in rat adipocytes and protein kinase C-α,-β and-θ in rat skeletal muscle
-
Avignon, A., Standaert, M. L., Yamada, K., Mischak, H., Spencer, B., Farese, R. V. (1995) Insulin increases mRNA levels of protein kinase C-α and-β in rat adipocytes and protein kinase C-α,-β and-θ in rat skeletal muscle. Biochem. J. 308, 181-187.
-
(1995)
Biochem. J.
, vol.308
, pp. 181-187
-
-
Avignon, A.1
Standaert, M.L.2
Yamada, K.3
Mischak, H.4
Spencer, B.5
Farese, R.V.6
-
15
-
-
0030914330
-
Alterations in the expression and cellular localization of protein kinase C isozymes ∈ and θ are associated with insulin resistance in skeletal muscle of the high-fatfed rat
-
Schmitz-Peiffer, C., Browne, C. L., Oakes, N. D., Watkinson, A., Chisholm, D. J., Kraegen, E. W., Biden, T. J. (1997) Alterations in the expression and cellular localization of protein kinase C isozymes ∈ and θ are associated with insulin resistance in skeletal muscle of the high-fatfed rat. Diabetes 46, 169-178.
-
(1997)
Diabetes
, vol.46
, pp. 169-178
-
-
Schmitz-Peiffer, C.1
Browne, C.L.2
Oakes, N.D.3
Watkinson, A.4
Chisholm, D.J.5
Kraegen, E.W.6
Biden, T.J.7
-
16
-
-
0037608687
-
Transgenic mice with dominant negative PKC-θ in skeletal muscle: A new model of insulin resistance and obesity
-
Serra, C., Federici, M., Buongiorno, A., Senni, M. I., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., Lauro, R., Molinaro, M., Giaccari, A., Bouche, M. (2003) Transgenic mice with dominant negative PKC-θ in skeletal muscle: a new model of insulin resistance and obesity. J. Cell. Physiol. 196, 89-97.
-
(2003)
J. Cell. Physiol.
, vol.196
, pp. 89-97
-
-
Serra, C.1
Federici, M.2
Buongiorno, A.3
Senni, M.I.4
Morelli, S.5
Segratella, E.6
Pascuccio, M.7
Tiveron, C.8
Mattei, E.9
Tatangelo, L.10
Lauro, R.11
Molinaro, M.12
Giaccari, A.13
Bouche, M.14
-
17
-
-
8544244084
-
PKC-θ knockout mice are protected from fat-induced insulin resistance
-
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D. W., Liu, Z. X., Soos, T. J., Cline, G. W., O'Brien, W. R., Littman, D. R., Shulman, G. I. (2004) PKC-θ knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114, 823-827.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
Fillmore, J.J.2
Sunshine, M.J.3
Albrecht, B.4
Higashimori, T.5
Kim, D.W.6
Liu, Z.X.7
Soos, T.J.8
Cline, G.W.9
O'Brien, W.R.10
Littman, D.R.11
Shulman, G.I.12
-
18
-
-
0242721945
-
Increased skeletal muscle expression of PKC-θ but not PKC-θ mRNA in type 2 diabetes: Inverse relationship with in-vivo insulin sensitivity
-
Gray, S., Idris, I., Davis, K. R., Donnelly, R. (2003) Increased skeletal muscle expression of PKC-θ but not PKC-θ mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity. Eur. J. Clin. Invest. 33, 983-987.
-
(2003)
Eur. J. Clin. Invest.
, vol.33
, pp. 983-987
-
-
Gray, S.1
Idris, I.2
Davis, K.R.3
Donnelly, R.4
-
19
-
-
0141891204
-
A p53-independent G1 cell cycle checkpoint induced by the suppression of protein kinase C α and θ isoforms
-
Deeds, L., Teodorescu, S., Chu, M., Yu, Q., Chen, C. Y. (2003) A p53-independent G1 cell cycle checkpoint induced by the suppression of protein kinase C α and θ isoforms. J. Biol. Chem. 278, 39782-39793.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39782-39793
-
-
Deeds, L.1
Teodorescu, S.2
Chu, M.3
Yu, Q.4
Chen, C.Y.5
-
20
-
-
0032906666
-
Protein kinase C-θ is specifically localized on centrosomes and kinetochores in mitotic cells
-
Passalacqua, M., Patrone, M., Sparatore, B., Melloni, E., Pontremoli, S. (1999) Protein kinase C-θ is specifically localized on centrosomes and kinetochores in mitotic cells. Biochem. J. 337, 113-118.
-
(1999)
Biochem. J.
, vol.337
, pp. 113-118
-
-
Passalacqua, M.1
Patrone, M.2
Sparatore, B.3
Melloni, E.4
Pontremoli, S.5
-
21
-
-
0034724201
-
NF-κ B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ
-
Coudronniere, N., Villalba, M., Englund, N., Altman, A. (2000) NF-κ B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ. Proc. Natl. Acad. Sci. USA 97, 3394-3399.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3394-3399
-
-
Coudronniere, N.1
Villalba, M.2
Englund, N.3
Altman, A.4
-
22
-
-
0037047136
-
CD28 plays a critical role in the segregation of PKC θ within the immunologic synapse
-
Huang, J., Lo, P. F., Zal, T., Gascoigne, N. R., Smith, B. A., Levin, S. D., Grey, H. M. (2002) CD28 plays a critical role in the segregation of PKC θ within the immunologic synapse. Proc. Natl. Acad. Sci. USA 99, 9369-9373.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9369-9373
-
-
Huang, J.1
Lo, P.F.2
Zal, T.3
Gascoigne, N.R.4
Smith, B.A.5
Levin, S.D.6
Grey, H.M.7
-
23
-
-
0035873711
-
Protein kinase C-θ mediates a selective T cell survival signal via phosphorylation of BAD
-
Villalba, M., Bushway, P., Altman, A. (2001) Protein kinase C-θ mediates a selective T cell survival signal via phosphorylation of BAD. J. Immunol. 166, 5955-5963.
-
(2001)
J. Immunol.
, vol.166
, pp. 5955-5963
-
-
Villalba, M.1
Bushway, P.2
Altman, A.3
-
24
-
-
0034711239
-
Protein kinase C θ and ∈ promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD
-
Bertolotto, C., Maulon, L., Filippa, N., Baier, G., Auberger, P. (2000) Protein kinase C θ and ∈ promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD. J. Biol. Chem. 275, 37246-37250.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37246-37250
-
-
Bertolotto, C.1
Maulon, L.2
Filippa, N.3
Baier, G.4
Auberger, P.5
-
25
-
-
33646877319
-
Protein kinase C-θ-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL
-
Manicassamy, S., Gupta, S., Huang, Z., Sun, Z. (2006) Protein kinase C-θ-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL. J. Immunol. 176, 6709-6716.
-
(2006)
J. Immunol.
, vol.176
, pp. 6709-6716
-
-
Manicassamy, S.1
Gupta, S.2
Huang, Z.3
Sun, Z.4
-
26
-
-
33845921462
-
The critical role of protein kinase C-θ in Fas/Fas ligand-mediated apoptosis
-
Manicassamy, S., Sun, Z. (2007) The critical role of protein kinase C-θ in Fas/Fas ligand-mediated apoptosis. J. Immunol. 178, 312-319.
-
(2007)
J. Immunol.
, vol.178
, pp. 312-319
-
-
Manicassamy, S.1
Sun, Z.2
-
27
-
-
0030689728
-
Requirement for protein kinase C θ for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells
-
Tang, S., Morgan, K. G., Parker, C., Ware, J. A. (1997) Requirement for protein kinase C θ for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells. J. Biol. Chem. 272, 28704-28711.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28704-28711
-
-
Tang, S.1
Morgan, K.G.2
Parker, C.3
Ware, J.A.4
-
28
-
-
0032571406
-
Protein kinase C-θ phosphorylation of moesin in the actin-binding sequence
-
Pietromonaco, S. F., Simons, P. C., Altman, A., Elias, L. (1998) Protein kinase C-θ phosphorylation of moesin in the actin-binding sequence. J. Biol. Chem. 273, 7594-7603.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7594-7603
-
-
Pietromonaco, S.F.1
Simons, P.C.2
Altman, A.3
Elias, L.4
-
29
-
-
0035652354
-
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
-
Delon, J., Kaibuchi, K., Germain, R. N. (2001) Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 15, 691-701.
-
(2001)
Immunity
, vol.15
, pp. 691-701
-
-
Delon, J.1
Kaibuchi, K.2
Germain, R.N.3
-
30
-
-
0037092038
-
Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K-and Vav-dependent pathway, but does not absolutely require phospholipase C
-
Villalba, M., Bi, K., Hu, J., Altman, Y., Bushway, P., Reits, E., Neefjes, J., Baier, G., Abraham, R. T., Altman, A. (2002) Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K-and Vav-dependent pathway, but does not absolutely require phospholipase C. J. Cell Biol. 157, 253-263.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 253-263
-
-
Villalba, M.1
Bi, K.2
Hu, J.3
Altman, Y.4
Bushway, P.5
Reits, E.6
Neefjes, J.7
Baier, G.8
Abraham, R.T.9
Altman, A.10
-
31
-
-
0037351084
-
Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse
-
Ardouin, L., Bracke, M., Mathiot, A., Pagakis, S. N., Norton, T., Hogg, N., Tybulewicz, V. L. (2003) Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur. J. Immunol. 33, 790-797.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 790-797
-
-
Ardouin, L.1
Bracke, M.2
Mathiot, A.3
Pagakis, S.N.4
Norton, T.5
Hogg, N.6
Tybulewicz, V.L.7
-
32
-
-
0037564513
-
Vav1: A key signal transducer downstream of the TCR
-
Tybulewicz, V. L., Ardouin, L., Prisco, A., Reynolds, L. F. (2003) Vav1: a key signal transducer downstream of the TCR. Immunol. Rev. 192, 42-52.
-
(2003)
Immunol. Rev.
, vol.192
, pp. 42-52
-
-
Tybulewicz, V.L.1
Ardouin, L.2
Prisco, A.3
Reynolds, L.F.4
-
33
-
-
34548259213
-
WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse
-
Nolz, J. C., Medeiros, R. B., Mitchell, J. S., Zhu, P., Freedman, B. D., Shimizu, Y., Billadeau, D. D. (2007) WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol. Cell. Biol. 27, 5986-6000.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 5986-6000
-
-
Nolz, J.C.1
Medeiros, R.B.2
Mitchell, J.S.3
Zhu, P.4
Freedman, B.D.5
Shimizu, Y.6
Billadeau, D.D.7
-
34
-
-
0035851918
-
Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
-
Villalba, M., Bi, K., Rodriguez, F., Tanaka, Y., Schoenberger, S., Altman, A. (2001) Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J. Cell Biol. 155, 331-338.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 331-338
-
-
Villalba, M.1
Bi, K.2
Rodriguez, F.3
Tanaka, Y.4
Schoenberger, S.5
Altman, A.6
-
35
-
-
0038362705
-
Cytoskeletal remodeling in lymphocyte activation
-
Miletic, A. V., Swat, M., Fujikawa, K., Swat, W. (2003) Cytoskeletal remodeling in lymphocyte activation. Curr. Opin. Immunol. 15, 261-268.
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 261-268
-
-
Miletic, A.V.1
Swat, M.2
Fujikawa, K.3
Swat, W.4
-
36
-
-
30044438580
-
Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling
-
Zipfel, P. A., Bunnell, S. C., Witherow, D. S., Gu, J. J., Chislock, E. M., Ring, C., Pendergast, A. M. (2006) Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. Curr. Biol. 16, 35-46.
-
(2006)
Curr. Biol.
, vol.16
, pp. 35-46
-
-
Zipfel, P.A.1
Bunnell, S.C.2
Witherow, D.S.3
Gu, J.J.4
Chislock, E.M.5
Ring, C.6
Pendergast, A.M.7
-
37
-
-
35648969165
-
Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses
-
Dustin, M. L. (2007) Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses. Curr. Opin Cell. Biol. 19, 529-533.
-
(2007)
Curr. Opin Cell. Biol.
, vol.19
, pp. 529-533
-
-
Dustin, M.L.1
-
38
-
-
77957272682
-
Modular design of immunological synapses and kinapses
-
Dustin, M. L. (2009) Modular design of immunological synapses and kinapses. Cold Spring Harb. Perspect. Biol. 1, a002873.
-
(2009)
Cold Spring Harb. Perspect. Biol.
, vol.1
-
-
Dustin, M.L.1
-
39
-
-
79952201000
-
Understanding the structure and function of the immunological synapse
-
Dustin, M. L., Chakraborty, A. K., Shaw, A. S. (2010) Understanding the structure and function of the immunological synapse. Cold Spring Harb. Perspect. Biol. 2, a002311.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
-
-
Dustin, M.L.1
Chakraborty, A.K.2
Shaw, A.S.3
-
40
-
-
77953545815
-
The synapse and cytolytic machinery of cytotoxic T cells
-
Jenkins, M. R., Griffiths, G. M. (2010) The synapse and cytolytic machinery of cytotoxic T cells. Curr. Opin. Immunol. 22, 308-313.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 308-313
-
-
Jenkins, M.R.1
Griffiths, G.M.2
-
41
-
-
80053130680
-
New insights into the T cell synapse from single molecule techniques
-
Dustin, M. L., Depoil, D. (2011) New insights into the T cell synapse from single molecule techniques. Nat. Rev. Immunol. 11, 672-684.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 672-684
-
-
Dustin, M.L.1
Depoil, D.2
-
42
-
-
77951620965
-
Spatial organization and signal transduction at intercellular junctions
-
Manz, B. N., Groves, J. T. (2010) Spatial organization and signal transduction at intercellular junctions. Nat. Rev. Mol. Cell. Biol. 11, 342-352.
-
(2010)
Nat. Rev. Mol. Cell. Biol.
, vol.11
, pp. 342-352
-
-
Manz, B.N.1
Groves, J.T.2
-
43
-
-
34848927902
-
The many faces of actin: Matching assembly factors with cellular structures
-
Chhabra, E. S., Higgs, H. N. (2007) The many faces of actin: matching assembly factors with cellular structures. Nat. Cell. Biol. 9, 1110-1121.
-
(2007)
Nat. Cell. Biol.
, vol.9
, pp. 1110-1121
-
-
Chhabra, E.S.1
Higgs, H.N.2
-
44
-
-
80054895503
-
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
-
Kong, K. F., Yokosuka, T., Canonigo-Balancio, A. J., Isakov, N., Saito, T., Altman, A. (2011) A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat. Immunol. 12, 1105-1112.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1105-1112
-
-
Kong, K.F.1
Yokosuka, T.2
Canonigo-Balancio, A.J.3
Isakov, N.4
Saito, T.5
Altman, A.6
-
45
-
-
41149167494
-
T-cell fate and function: PKC-θ and beyond
-
Marsland, B. J., Kopf, M. (2008) T-cell fate and function: PKC-θ and beyond. Trends Immunol. 29, 179-185.
-
(2008)
Trends Immunol.
, vol.29
, pp. 179-185
-
-
Marsland, B.J.1
Kopf, M.2
-
46
-
-
84870545526
-
PKC-θ-mediated signal delivery from the TCR/CD28 surface receptors
-
Isakov, N., Altman, A. (2012) PKC-θ-mediated signal delivery from the TCR/CD28 surface receptors. Front. Immunol. 3, 273.
-
(2012)
Front. Immunol.
, vol.3
, pp. 273
-
-
Isakov, N.1
Altman, A.2
-
47
-
-
0037902559
-
Protein kinase C-θ (PKCθ): It's all about location, location, location
-
Altman, A., Villalba, M. (2003) Protein kinase C-θ (PKCθ): it's all about location, location, location. Immunol. Rev. 192, 53-63.
-
(2003)
Immunol. Rev.
, vol.192
, pp. 53-63
-
-
Altman, A.1
Villalba, M.2
-
48
-
-
0026050824
-
PLC θ 1, a possible mediator of T cell receptor function
-
Granja, C., Lin, L. L., Yunis, E. J., Relias, V., Dasgupta, J. D. (1991) PLC θ 1, a possible mediator of T cell receptor function. J. Biol. Chem. 266, 16277-16280.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 16277-16280
-
-
Granja, C.1
Lin, L.L.2
Yunis, E.J.3
Relias, V.4
Dasgupta, J.D.5
-
49
-
-
0036604936
-
Protein kinase C-θ: Signaling from the center of the T-cell synapse
-
Arendt, C. W., Albrecht, B., Soos, T. J., Littman, D. R. (2002) Protein kinase C-θ: signaling from the center of the T-cell synapse. Curr. Opin. Immunol. 14, 323-330.
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 323-330
-
-
Arendt, C.W.1
Albrecht, B.2
Soos, T.J.3
Littman, D.R.4
-
50
-
-
0034288906
-
A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation
-
Villalba, M., Coudronniere, N., Deckert, M., Teixeiro, E., Mas, P., Altman, A. (2000) A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation. Immunity 12, 151-160.
-
(2000)
Immunity
, vol.12
, pp. 151-160
-
-
Villalba, M.1
Coudronniere, N.2
Deckert, M.3
Teixeiro, E.4
Mas, P.5
Altman, A.6
-
51
-
-
0033610868
-
Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigenpresenting cells
-
Michel, F., Grimaud, L., Tuosto, L., Acuto, O. (1998) Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigenpresenting cells. J. Biol. Chem. 273, 31932-31938.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31932-31938
-
-
Michel, F.1
Grimaud, L.2
Tuosto, L.3
Acuto, O.4
-
52
-
-
0035339837
-
ZAP-70 and SLP-76 regulate protein kinase C-θ and NF-κ B activation in response to engagement of CD3 and CD28
-
Herndon, T. M., Shan, X. C., Tsokos, G. C., Wange, R. L. (2001) ZAP-70 and SLP-76 regulate protein kinase C-θ and NF-κ B activation in response to engagement of CD3 and CD28. J. Immunol. 166, 5654-5664.
-
(2001)
J. Immunol.
, vol.166
, pp. 5654-5664
-
-
Herndon, T.M.1
Shan, X.C.2
Tsokos, G.C.3
Wange, R.L.4
-
53
-
-
79959396065
-
Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization
-
Pauker, M. H., Reicher, B., Fried, S., Perl, O., Barda-Saad, M. (2011) Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization. Mol. Cell. Biol. 31, 2653-2666.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2653-2666
-
-
Pauker, M.H.1
Reicher, B.2
Fried, S.3
Perl, O.4
Barda-Saad, M.5
-
54
-
-
12344272845
-
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
-
Barda-Saad, M., Braiman, A., Titerence, R., Bunnell, S. C., Barr, V. A., Samelson, L. E. (2005) Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat. Immunol. 6, 80-89.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 80-89
-
-
Barda-Saad, M.1
Braiman, A.2
Titerence, R.3
Bunnell, S.C.4
Barr, V.A.5
Samelson, L.E.6
-
55
-
-
0036928182
-
Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation
-
Sasahara, Y., Rachid, R., Byrne, M. J., de la Fuente, M. A., Abraham, R. T., Ramesh, N., Geha, R. S. (2002) Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol. Cell 10, 1269-1281.
-
(2002)
Mol. Cell
, vol.10
, pp. 1269-1281
-
-
Sasahara, Y.1
Rachid, R.2
Byrne, M.J.3
de la Fuente, M.A.4
Abraham, R.T.5
Ramesh, N.6
Geha, R.S.7
-
56
-
-
0033618287
-
T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins
-
Gelkop, S., Isakov, N. (1999) T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins. J. Biol. Chem. 274, 21519-21527.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21519-21527
-
-
Gelkop, S.1
Isakov, N.2
-
57
-
-
29144441366
-
T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315
-
Gelkop, S., Gish, G. D., Babichev, Y., Pawson, T., Isakov, N. (2005) T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315. J. Immunol. 175, 8123-8132.
-
(2005)
J. Immunol.
, vol.175
, pp. 8123-8132
-
-
Gelkop, S.1
Gish, G.D.2
Babichev, Y.3
Pawson, T.4
Isakov, N.5
-
58
-
-
0036696174
-
The immunological synapse: Integrins take the stage
-
Sims, T. N., Dustin, M. L. (2002) The immunological synapse: integrins take the stage. Immunol. Rev. 186, 100-117.
-
(2002)
Immunol. Rev.
, vol.186
, pp. 100-117
-
-
Sims, T.N.1
Dustin, M.L.2
-
59
-
-
58149393273
-
PKC-θ selectively controls the adhesionstimulating molecule Rap1
-
Letschka, T., Kollmann, V., Pfeifhofer-Obermair, C., Lutz-Nicoladoni, C., Obermair, G. J., Fresser, F., Leitges, M., Hermann-Kleiter, N., Kaminski, S., Baier, G. (2008) PKC-θ selectively controls the adhesionstimulating molecule Rap1. Blood 112, 4617-4627.
-
(2008)
Blood
, vol.112
, pp. 4617-4627
-
-
Letschka, T.1
Kollmann, V.2
Pfeifhofer-Obermair, C.3
Lutz-Nicoladoni, C.4
Obermair, G.J.5
Fresser, F.6
Leitges, M.7
Hermann-Kleiter, N.8
Kaminski, S.9
Baier, G.10
-
60
-
-
1642482866
-
Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-θ1
-
Katagiri, K., Shimonaka, M., Kinashi, T. (2004) Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-θ1. J. Biol. Chem. 279, 11875-11881.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 11875-11881
-
-
Katagiri, K.1
Shimonaka, M.2
Kinashi, T.3
-
61
-
-
33846031421
-
The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation
-
Suzuki, J., Yamasaki, S., Wu, J., Koretzky, G. A., Saito, T. (2007) The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood 109, 168-175.
-
(2007)
Blood
, vol.109
, pp. 168-175
-
-
Suzuki, J.1
Yamasaki, S.2
Wu, J.3
Koretzky, G.A.4
Saito, T.5
-
62
-
-
0026773055
-
Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation
-
Gregorio, C. C., Kubo, R. T., Bankert, R. B., Repasky, E. A. (1992) Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation. Proc. Natl. Acad. Sci. USA 89, 4947-4951.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4947-4951
-
-
Gregorio, C.C.1
Kubo, R.T.2
Bankert, R.B.3
Repasky, E.A.4
-
63
-
-
9944235041
-
Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy
-
Dubielecka, P. M., Jazwiec, B., Potoczek, S., Wrobel, T., Miloszewska, J., Haus, O., Kuliczkowski, K., Sikorski, A. F. (2005) Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy. Biochem. Pharmacol. 69, 73-85.
-
(2005)
Biochem. Pharmacol.
, vol.69
, pp. 73-85
-
-
Dubielecka, P.M.1
Jazwiec, B.2
Potoczek, S.3
Wrobel, T.4
Miloszewska, J.5
Haus, O.6
Kuliczkowski, K.7
Sikorski, A.F.8
-
64
-
-
84856235139
-
Spectrin-based skeleton as an actor in cell signaling
-
Machnicka, B., Grochowalska, R., Boguslawska, D. M., Sikorski, A. F., Lecomte, M. C. (2012) Spectrin-based skeleton as an actor in cell signaling. Cell. Mol. Life Sci. 69, 191-201.
-
(2012)
Cell. Mol. Life Sci.
, vol.69
, pp. 191-201
-
-
McHnicka, B.1
Grochowalska, R.2
Boguslawska, D.M.3
Sikorski, A.F.4
Lecomte, M.C.5
-
65
-
-
0028215576
-
Dynamic properties of ankyrin in T lymphocytes: Colocalization with spectrin and protein kinase C θ
-
Gregorio, C. C., Repasky, E. A., Fowler, V. M., Black, J. D. (1994) Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C θ. J. Cell Biol. 125, 345-358.
-
(1994)
J. Cell Biol.
, vol.125
, pp. 345-358
-
-
Gregorio, C.C.1
Repasky, E.A.2
Fowler, V.M.3
Black, J.D.4
-
66
-
-
0030741077
-
Distribution of HSP70, protein kinase C, and spectrin is altered in lymphocytes during a feverlike hyperthermia exposure
-
Di, Y. P., Repasky, E. A., Subjeck, J. R. (1997) Distribution of HSP70, protein kinase C, and spectrin is altered in lymphocytes during a feverlike hyperthermia exposure. J. Cell. Physiol. 172, 44-54.
-
(1997)
J. Cell. Physiol.
, vol.172
, pp. 44-54
-
-
Di, Y.P.1
Repasky, E.A.2
Subjeck, J.R.3
-
67
-
-
0033559490
-
Effect of fever-like whole-body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity, and uropod formation
-
Wang, X. Y., Ostberg, J. R., Repasky, E. A. (1999) Effect of fever-like whole-body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity, and uropod formation. J. Immunol. 162, 3378-3387.
-
(1999)
J. Immunol.
, vol.162
, pp. 3378-3387
-
-
Wang, X.Y.1
Ostberg, J.R.2
Repasky, E.A.3
-
68
-
-
0344289531
-
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro
-
Rodriguez, M. M., Ron, D., Touhara, K., Chen, C. H., Mochly-Rosen, D. (1999) RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry 38, 13787-13794.
-
(1999)
Biochemistry
, vol.38
, pp. 13787-13794
-
-
Rodriguez, M.M.1
Ron, D.2
Touhara, K.3
Chen, C.H.4
Mochly-Rosen, D.5
-
69
-
-
77952287470
-
Aggregation of spectrin and PKCθ is an early hallmark of fludarabine/mitoxantrone/ dexamethasone-induced apoptosis in Jurkat T and HL60 cells
-
Dubielecka, P. M., Grzybek, M., Kolondra, A., Jazwiec, B., Draga, A., Aleksandrowicz, P., Kolodziejczyk, M., Serwotka, A., Dolinska-Krajewska, B., Warchol, J., Kuliczkowski, K., Sikorski, A. F. (2010) Aggregation of spectrin and PKCθ is an early hallmark of fludarabine/mitoxantrone/ dexamethasone-induced apoptosis in Jurkat T and HL60 cells. Mol. Cell. Biochem. 339, 63-77.
-
(2010)
Mol. Cell. Biochem.
, vol.339
, pp. 63-77
-
-
Dubielecka, P.M.1
Grzybek, M.2
Kolondra, A.3
Jazwiec, B.4
Draga, A.5
Aleksandrowicz, P.6
Kolodziejczyk, M.7
Serwotka, A.8
Dolinska-Krajewska, B.9
Warchol, J.10
Kuliczkowski, K.11
Sikorski, A.F.12
-
70
-
-
84871757840
-
Microtubule-organizing center polarity and the immunological synapse: Protein kinase C and beyond
-
Huse, M. (2012) Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond. Front. Immunol. 3, 235.
-
(2012)
Front. Immunol.
, vol.3
, pp. 235
-
-
Huse, M.1
-
71
-
-
67349243386
-
Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells
-
Quann, E. J., Merino, E., Furuta, T., Huse, M. (2009) Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nat. Immunol. 10, 627-635.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 627-635
-
-
Quann, E.J.1
Merino, E.2
Furuta, T.3
Huse, M.4
-
72
-
-
79959376445
-
A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells
-
Quann, E. J., Liu, X., Altan-Bonnet, G., Huse, M. (2011) A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nat. Immunol. 12, 647-654.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 647-654
-
-
Quann, E.J.1
Liu, X.2
Altan-Bonnet, G.3
Huse, M.4
-
73
-
-
33846626054
-
Regulation of T-cell activation by the cytoskeleton
-
Billadeau, D. D., Nolz, J. C., Gomez, T. S. (2007) Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 7, 131-143.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 131-143
-
-
Billadeau, D.D.1
Nolz, J.C.2
Gomez, T.S.3
-
74
-
-
2542588542
-
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes
-
Ivetic, A., Ridley, A. J. (2004) Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology 112, 165-176.
-
(2004)
Immunology
, vol.112
, pp. 165-176
-
-
Ivetic, A.1
Ridley, A.J.2
-
75
-
-
1942521770
-
The role of the θ isoform of protein kinase C (PKC) in activity-dependent synapse elimination: Evidence from the PKC θ knock-out mouse in vivo and in vitro
-
Li, M. X., Jia, M., Yang, L. X., Jiang, H., Lanuza, M. A., Gonzalez, C. M., Nelson, P. G. (2004) The role of the θ isoform of protein kinase C (PKC) in activity-dependent synapse elimination: evidence from the PKC θ knock-out mouse in vivo and in vitro. J. Neurosci. 24, 3762-3769.
-
(2004)
J. Neurosci.
, vol.24
, pp. 3762-3769
-
-
Li, M.X.1
Jia, M.2
Yang, L.X.3
Jiang, H.4
Lanuza, M.A.5
Gonzalez, C.M.6
Nelson, P.G.7
-
76
-
-
58049220350
-
Mechanotransduction in development: A growing role for contractility
-
Wozniak, M. A., Chen, C. S. (2009) Mechanotransduction in development: a growing role for contractility. Nat. Rev. Mol. Cell. Biol. 10, 34-43.
-
(2009)
Nat. Rev. Mol. Cell. Biol.
, vol.10
, pp. 34-43
-
-
Wozniak, M.A.1
Chen, C.S.2
-
77
-
-
84855162727
-
Tropomodulin capping of actin filaments in striated muscle development and physiology
-
Gokhin, D. S., Fowler, V. M. (2011) Tropomodulin capping of actin filaments in striated muscle development and physiology. J. Biomed. Biotechnol. 2011, 103069.
-
(2011)
J. Biomed. Biotechnol.
, vol.2011
, pp. 103069
-
-
Gokhin, D.S.1
Fowler, V.M.2
-
78
-
-
77049114286
-
Nfix regulates fetal-specific transcription in developing skeletal muscle
-
Messina, G., Biressi, S., Monteverde, S., Magli, A., Cassano, M., Perani, L., Roncaglia, E., Tagliafico, E., Starnes, L., Campbell, C. E., Grossi, M., Goldhamer, D. J., Gronostajski, R. M., Cossu, G. (2010) Nfix regulates fetal-specific transcription in developing skeletal muscle. Cell 140, 554-566.
-
(2010)
Cell
, vol.140
, pp. 554-566
-
-
Messina, G.1
Biressi, S.2
Monteverde, S.3
Magli, A.4
Cassano, M.5
Perani, L.6
Roncaglia, E.7
Tagliafico, E.8
Starnes, L.9
Campbell, C.E.10
Grossi, M.11
Goldhamer, D.J.12
Gronostajski, R.M.13
Cossu, G.14
-
79
-
-
0031040997
-
Conventional PKC-θ, novel PKC-θ and PKC-θ, but not atypical PKC-are MARCKS kinases in intact NIH 3T3 fibroblasts
-
Uberall, F., Giselbrecht, S., Hellbert, K., Fresser, F., Bauer, B., Gschwendt, M., Grunicke, H. H., Baier, G. (1997) Conventional PKC-θ, novel PKC-θ and PKC-θ, but not atypical PKC-are MARCKS kinases in intact NIH 3T3 fibroblasts. J. Biol. Chem. 272, 4072-4078.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4072-4078
-
-
Uberall, F.1
Giselbrecht, S.2
Hellbert, K.3
Fresser, F.4
Bauer, B.5
Gschwendt, M.6
Grunicke, H.H.7
Baier, G.8
-
80
-
-
0034176206
-
Involvement of the θ-type protein kinase C in translocation of myristoylated alanine-rich C kinase substrate (MARCKS) during myogenesis of chick embryonic myoblasts
-
Kim, S. S., Kim, J. H., Kim, H. S., Park, D. E., Chung, C. H. (2000) Involvement of the θ-type protein kinase C in translocation of myristoylated alanine-rich C kinase substrate (MARCKS) during myogenesis of chick embryonic myoblasts. Biochem. J. 347, 139-146.
-
(2000)
Biochem. J.
, vol.347
, pp. 139-146
-
-
Kim, S.S.1
Kim, J.H.2
Kim, H.S.3
Park, D.E.4
Chung, C.H.5
-
81
-
-
0037731790
-
Molecular cloning, characterization, and expression of a cDNA encoding the "80-to 87-kDa" myristoylated alanine-rich C kinase substrate: A major cellular substrate for protein kinase C
-
Stumpo, D. J., Graff, J. M., Albert, K. A., Greengard, P., Blackshear, P. J. (1989) Molecular cloning, characterization, and expression of a cDNA encoding the "80-to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc. Natl. Acad. Sci. USA 86, 4012-4016.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 4012-4016
-
-
Stumpo, D.J.1
Graff, J.M.2
Albert, K.A.3
Greengard, P.4
Blackshear, P.J.5
-
82
-
-
0035895882
-
The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate
-
Wang, J., Arbuzova, A., Hangyas-Mihalyne, G., McLaughlin, S. (2001) The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 276, 5012-5019.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5012-5019
-
-
Wang, J.1
Arbuzova, A.2
Hangyas-Mihalyne, G.3
McLaughlin, S.4
-
83
-
-
27744443750
-
The origin of C1A-C2 interdomain interactions in protein kinase Cθ
-
Stahelin, R. V., Wang, J., Blatner, N. R., Rafter, J. D., Murray, D., Cho, W. (2005) The origin of C1A-C2 interdomain interactions in protein kinase Cθ. J. Biol. Chem. 280, 36452-36463.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 36452-36463
-
-
Stahelin, R.V.1
Wang, J.2
Blatner, N.R.3
Rafter, J.D.4
Murray, D.5
Cho, W.6
-
84
-
-
0027328909
-
A new protein kinase C, nPKCθ =, and nPKCθ are expressed in human platelets: Involvement of nPKCθ = and nPKCθ in signal transduction stimulated by PAF
-
Wang, F., Naik, U. P., Ehrlich, Y. H., Freyberg, Z., Osada, S., Ohno, S., Kuroki, T., Suzuki, K., Kornecki, E. (1993) A new protein kinase C, nPKCθ =, and nPKCθ are expressed in human platelets: involvement of nPKCθ = and nPKCθ in signal transduction stimulated by PAF. Biochem. Biophys. Res. Commun. 191, 240-246.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.191
, pp. 240-246
-
-
Wang, F.1
Naik, U.P.2
Ehrlich, Y.H.3
Freyberg, Z.4
Osada, S.5
Ohno, S.6
Kuroki, T.7
Suzuki, K.8
Kornecki, E.9
-
85
-
-
79960894775
-
PKC-θ function at the immunological synapse: Prospects for therapeutic targeting
-
Zanin-Zhorov, A., Dustin, M. L., Blazar, B. R. (2011) PKC-θ function at the immunological synapse: prospects for therapeutic targeting. Trends Immunol. 32, 358-363.
-
(2011)
Trends Immunol.
, vol.32
, pp. 358-363
-
-
Zanin-Zhorov, A.1
Dustin, M.L.2
Blazar, B.R.3
-
86
-
-
0035374476
-
Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
-
Bi, K., Tanaka, Y., Coudronniere, N., Sugie, K., Hong, S., van Stipdonk, M. J., Altman, A. (2001) Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation. Nat. Immunol. 2, 556-563.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 556-563
-
-
Bi, K.1
Tanaka, Y.2
Coudronniere, N.3
Sugie, K.4
Hong, S.5
van Stipdonk, M.J.6
Altman, A.7
-
87
-
-
0142246600
-
Role of the kinase activation loop on protein kinase C θ activity and intracellular localisation
-
Sparatore, B., Passalacqua, M., Pedrazzi, M., Ledda, S., Patrone, M., Gaggero, D., Pontremoli, S., Melloni, E. (2003) Role of the kinase activation loop on protein kinase C θ activity and intracellular localisation. FEBS Lett. 554, 35-40.
-
(2003)
FEBS Lett.
, vol.554
, pp. 35-40
-
-
Sparatore, B.1
Passalacqua, M.2
Pedrazzi, M.3
Ledda, S.4
Patrone, M.5
Gaggero, D.6
Pontremoli, S.7
Melloni, E.8
-
88
-
-
15444373874
-
Translocation of diacylglycerol kinase θ from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C
-
Van Baal, J., de Widt, J., Divecha, N., van Blitterswijk, W. J. (2005) Translocation of diacylglycerol kinase θ from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. J. Biol. Chem. 280, 9870-9878.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9870-9878
-
-
van Baal, J.1
de Widt, J.2
Divecha, N.3
van Blitterswijk, W.J.4
-
89
-
-
22244490365
-
Characterization of protein kinase C θ activation loop autophosphorylation and the kinase domain catalytic mechanism
-
Czerwinski, R., Aulabaugh, A., Greco, R. M., Olland, S., Malakian, K., Wolfrom, S., Lin, L., Kriz, R., Stahl, M., Huang, Y., Liu, L., Chaudhary, D. (2005) Characterization of protein kinase C θ activation loop autophosphorylation and the kinase domain catalytic mechanism. Biochemistry 44, 9563-9573.
-
(2005)
Biochemistry
, vol.44
, pp. 9563-9573
-
-
Czerwinski, R.1
Aulabaugh, A.2
Greco, R.M.3
Olland, S.4
Malakian, K.5
Wolfrom, S.6
Lin, L.7
Kriz, R.8
Stahl, M.9
Huang, Y.10
Liu, L.11
Chaudhary, D.12
-
90
-
-
27844439874
-
Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes
-
Thuille, N., Heit, I., Fresser, F., Krumbock, N., Bauer, B., Leuthaeusser, S., Dammeier, S., Graham, C., Copeland, T. D., Shaw, S., Baier, G. (2005) Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes. EMBO J. 24, 3869-3880.
-
(2005)
EMBO J.
, vol.24
, pp. 3869-3880
-
-
Thuille, N.1
Heit, I.2
Fresser, F.3
Krumbock, N.4
Bauer, B.5
Leuthaeusser, S.6
Dammeier, S.7
Graham, C.8
Copeland, T.D.9
Shaw, S.10
Baier, G.11
-
91
-
-
9644264028
-
Catalytic domain crystal structure of protein kinase C-θ (PKCθ)
-
Xu, Z. B., Chaudhary, D., Olland, S., Wolfrom, S., Czerwinski, R., Malakian, K., Lin, L., Stahl, M. L., Joseph-McCarthy, D., Benander, C., Fitz, L., Greco, R., Somers, W. S., Mosyak, L. (2004) Catalytic domain crystal structure of protein kinase C-θ (PKCθ). J. Biol. Chem. 279, 50401-50409.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 50401-50409
-
-
Xu, Z.B.1
Chaudhary, D.2
Olland, S.3
Wolfrom, S.4
Czerwinski, R.5
Malakian, K.6
Lin, L.7
Stahl, M.L.8
Joseph-McCarthy, D.9
Benander, C.10
Fitz, L.11
Greco, R.12
Somers, W.S.13
Mosyak, L.14
-
92
-
-
0030872696
-
Cellular relocalisation of protein kinase C-θ caused by staurosporine and some of its analogues
-
Jones, T., Courage, C., Hubbard, A., Gescher, A. (1997) Cellular relocalisation of protein kinase C-θ caused by staurosporine and some of its analogues. Biochem. Pharmacol. 53, 1413-1418.
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 1413-1418
-
-
Jones, T.1
Courage, C.2
Hubbard, A.3
Gescher, A.4
-
93
-
-
70350128040
-
Small molecule inhibitors of PKCθ as potential antiinflammatory therapeutics
-
Boschelli, D. H. (2009) Small molecule inhibitors of PKCθ as potential antiinflammatory therapeutics. Curr. Topics Med. Chem. 9, 640-654.
-
(2009)
Curr. Topics Med. Chem.
, vol.9
, pp. 640-654
-
-
Boschelli, D.H.1
-
94
-
-
67349125149
-
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity
-
Cameron, A. J., Escribano, C., Saurin, A. T., Kostelecky, B., Parker, P. J. (2009) PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat. Struct. Mol. Biol. 16, 624-630.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 624-630
-
-
Cameron, A.J.1
Escribano, C.2
Saurin, A.T.3
Kostelecky, B.4
Parker, P.J.5
-
95
-
-
67650337799
-
Inhibitor hijacking of Akt activation
-
Okuzumi, T., Fiedler, D., Zhang, C., Gray, D. C., Aizenstein, B., Hoffman, R., Shokat, K. M. (2009) Inhibitor hijacking of Akt activation. Nat. Chem. Biol. 5, 484-493.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 484-493
-
-
Okuzumi, T.1
Fiedler, D.2
Zhang, C.3
Gray, D.C.4
Aizenstein, B.5
Hoffman, R.6
Shokat, K.M.7
-
96
-
-
80054953932
-
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
-
Chuang, H. C., Lan, J. L., Chen, D. Y., Yang, C. Y., Chen, Y. M., Li, J. P., Huang, C. Y., Liu, P. E., Wang, X., Tan, T. H. (2011) The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat. Immunol. 12, 1113-1118.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1113-1118
-
-
Chuang, H.C.1
Lan, J.L.2
Chen, D.Y.3
Yang, C.Y.4
Chen, Y.M.5
Li, J.P.6
Huang, C.Y.7
Liu, P.E.8
Wang, X.9
Tan, T.H.10
-
97
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee, K., Gudapati, P., Dragovic, S., Spencer, C., Joyce, S., Killeen, N., Magnuson, M. A., Boothby, M. (2010) Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32, 743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Magnuson, M.A.7
Boothby, M.8
-
98
-
-
84874219989
-
Regulation of PKC-θ function by phosphorylation in T cell receptor signaling
-
Wang, X., Chuang, H. C., Li, J. P., Tan, T. H. (2012) Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front. Immunol. 3, 197.
-
(2012)
Front. Immunol.
, vol.3
, pp. 197
-
-
Wang, X.1
Chuang, H.C.2
Li, J.P.3
Tan, T.H.4
-
99
-
-
33845671162
-
Discovery of potent and selective PKC-θ inhibitors
-
Cywin, C. L., Dahmann, G., Prokopowicz, A. S., 3rd, Young, E. R., Magolda, R. L., Cardozo, M. G., Cogan, D. A., Disalvo, D., Ginn, J. D., Kashem, M. A., Wolak, J. P., Homon, C. A., Farrell, T. M., Grbic, H., Hu, H., Kaplita, P. V., Liu, L. H., Spero, D. M., Jeanfavre, D. D., O'Shea, K. M., White, D. M., Woska J. R., Jr., Brown, M. L. (2007) Discovery of potent and selective PKC-θ inhibitors. Bioorg. Med. Chem. Lett. 17, 225-230.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 225-230
-
-
Cywin, C.L.1
Dahmann, G.2
Prokopowicz III, A.S.3
Young, E.R.4
Magolda, R.L.5
Cardozo, M.G.6
Cogan, D.A.7
Disalvo, D.8
Ginn, J.D.9
Kashem, M.A.10
Wolak, J.P.11
Homon, C.A.12
Farrell, T.M.13
Grbic, H.14
Hu, H.15
Kaplita, P.V.16
Liu, L.H.17
Spero, D.M.18
Jeanfavre, D.D.19
O'Shea, K.M.20
White, D.M.21
Woska Jr., J.R.22
Brown, M.L.23
more..
-
100
-
-
53549089928
-
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C θ (PKCθ) inhibitors
-
Cole, D. C., Asselin, M., Brennan, A., Czerwinski, R., Ellingboe, J. W., Fitz, L., Greco, R., Huang, X., Joseph-McCarthy, D., Kelly, M. F., Kirisits, M., Lee, J., Li, Y., Morgan, P., Stock, J. R., Tsao, D. H., Wissner, A., Yang, X., Chaudhary, D. (2008) Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C θ (PKCθ) inhibitors. J. Med. Chem. 51, 5958-5963.
-
(2008)
J. Med. Chem
, vol.51
, pp. 5958-5963
-
-
Cole, D.C.1
Asselin, M.2
Brennan, A.3
Czerwinski, R.4
Ellingboe, J.W.5
Fitz, L.6
Greco, R.7
Huang, X.8
Joseph-McCarthy, D.9
Kelly, M.F.10
Kirisits, M.11
Lee, J.12
Li, Y.13
Morgan, P.14
Stock, J.R.15
Tsao, D.H.16
Wissner, A.17
Yang, X.18
Chaudhary, D.19
-
101
-
-
33746210212
-
PKC-θ-deficient mice are protected from Th1-dependent antigen-induced arthritis
-
Healy, A. M., Izmailova, E., Fitzgerald, M., Walker, R., Hattersley, M., Silva, M., Siebert, E., Terkelsen, J., Picarella, D., Pickard, M. D., Le-Clair, B., Chandra, S., Jaffee, B. (2006) PKC-θ-deficient mice are protected from Th1-dependent antigen-induced arthritis. J. Immunol. 177, 1886-1893.
-
(2006)
J. Immunol.
, vol.177
, pp. 1886-1893
-
-
Healy, A.M.1
Izmailova, E.2
Fitzgerald, M.3
Walker, R.4
Hattersley, M.5
Silva, M.6
Siebert, E.7
Terkelsen, J.8
Picarella, D.9
Pickard, M.D.10
Le-Clair, B.11
Chandra, S.12
Jaffee, B.13
-
102
-
-
33644512418
-
Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice
-
Tan, S. L., Zhao, J., Bi, C., Chen, X. C., Hepburn, D. L., Wang, J., Sedgwick, J. D., Chintalacharuvu, S. R., Na, S. (2006) Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice. J. Immunol. 176, 2872-2879.
-
(2006)
J. Immunol.
, vol.176
, pp. 2872-2879
-
-
Tan, S.L.1
Zhao, J.2
Bi, C.3
Chen, X.C.4
Hepburn, D.L.5
Wang, J.6
Sedgwick, J.D.7
Chintalacharuvu, S.R.8
Na, S.9
-
103
-
-
47949130474
-
A critical role for protein kinase C-θ-mediated T cell survival in cardiac allograft rejection
-
Manicassamy, S., Yin, D., Zhang, Z., Molinero, L. L., Alegre, M. L., Sun, Z. (2008) A critical role for protein kinase C-θ-mediated T cell survival in cardiac allograft rejection. J. Immunol. 181, 513-520.
-
(2008)
J. Immunol.
, vol.181
, pp. 513-520
-
-
Manicassamy, S.1
Yin, D.2
Zhang, Z.3
Molinero, L.L.4
Alegre, M.L.5
Sun, Z.6
-
104
-
-
33750036982
-
Mice deficient in PKC θ demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases
-
Anderson, K., Fitzgerald, M., Dupont, M., Wang, T., Paz, N., Dorsch, M., Healy, A., Xu, Y., Ocain, T., Schopf, L., Jaffee, B., Picarella, D. (2006) Mice deficient in PKC θ demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases. Autoimmunity 39, 469-478.
-
(2006)
Autoimmunity
, vol.39
, pp. 469-478
-
-
Anderson, K.1
Fitzgerald, M.2
Dupont, M.3
Wang, T.4
Paz, N.5
Dorsch, M.6
Healy, A.7
Xu, Y.8
Ocain, T.9
Schopf, L.10
Jaffee, B.11
Picarella, D.12
-
105
-
-
18844473151
-
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
-
Sun, Z., Arendt, C. W., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P. L., Littman, D. R. (2000) PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404, 402-407.
-
(2000)
Nature
, vol.404
, pp. 402-407
-
-
Sun, Z.1
Arendt, C.W.2
Ellmeier, W.3
Schaeffer, E.M.4
Sunshine, M.J.5
Gandhi, L.6
Annes, J.7
Petrzilka, D.8
Kupfer, A.9
Schwartzberg, P.L.10
Littman, D.R.11
-
106
-
-
0038620475
-
Protein kinase C θ affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
-
Pfeifhofer, C., Kofler, K., Gruber, T., Tabrizi, N. G., Lutz, C., Maly, K., Leitges, M., Baier, G. (2003) Protein kinase C θ affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J. Exp. Med. 197, 1525-1535.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1525-1535
-
-
Pfeifhofer, C.1
Kofler, K.2
Gruber, T.3
Tabrizi, N.G.4
Lutz, C.5
Maly, K.6
Leitges, M.7
Baier, G.8
|