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Volumn 3, Issue JUL, 2012, Pages

Microtubule-organizing center polarity and the immunological synapse: Protein kinase C and beyond

Author keywords

Cell polarity; Cytoskeleton; Lymphocyte; Protein kinase C; Signal transduction,T cell

Indexed keywords


EID: 84871757840     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00235     Document Type: Review
Times cited : (53)

References (85)
  • 1
    • 34249085248 scopus 로고    scopus 로고
    • CCR7ligandscontrolbasal T cell motility within lymph node slicesinaphosphoinositide3-kinase-independent manner
    • Asperti-Boursin,F.,Real,E.,Bismuth, G., Trautmann, A., and Donnadieu, E. (2007).CCR7ligandscontrolbasal T cell motility within lymph node slicesinaphosphoinositide3-kinase-independent manner. J. Exp. Med. 204, 1167-1179.
    • (2007) J. Exp. Med. , vol.204 , pp. 1167-1179
    • Asperti-Boursin, F.1    Real, E.2    Bismuth, G.3    Trautmann, A.4    Donnadieu, E.5
  • 2
    • 64149122243 scopus 로고    scopus 로고
    • PKC inhibitors: potential in T cell-dependent immune diseases
    • Baier, G., and Wagner, J. (2009). PKC inhibitors: potential in T cell-dependent immune diseases. Curr. Opin. Cell Biol. 21,262-267.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 262-267
    • Baier, G.1    Wagner, J.2
  • 3
    • 70349751654 scopus 로고    scopus 로고
    • Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain
    • Beal, A. M., Anikeeva, N., Varma, R., Cameron, T. O.,Vasiliver-Shamis, G., Norris, P. J., Dustin, M. L., and Sykulev, Y. (2009). Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity 31, 632-642.
    • (2009) Immunity , vol.31 , pp. 632-642
    • Beal, A.M.1    Anikeeva, N.2    Varma, R.3    Cameron, T.O.4    Vasiliver-Shamis, G.5    Norris, P.J.6    Dustin, M.L.7    Sykulev, Y.8
  • 4
    • 78049386951 scopus 로고    scopus 로고
    • Activa-tion of the ancestral polarity regu-lator protein kinase C zeta at the immunological synapse drives polar-ization of Th cell secretory machin-ery toward APCs
    • Bertrand, F., Esquerre, M., Petit, A. E., Rodrigues, M., Duchez, S., Delon, J., and Valitutti, S. (2010). Activa-tion of the ancestral polarity regu-lator protein kinase C zeta at the immunological synapse drives polar-ization of Th cell secretory machin-ery toward APCs. J. Immunol. 185, 2887-2894.
    • (2010) J. Immunol. , vol.185 , pp. 2887-2894
    • Bertrand, F.1    Esquerre, M.2    Petit, A.E.3    Rodrigues, M.4    Duchez, S.5    Delon, J.6    Valitutti, S.7
  • 5
    • 4644317252 scopus 로고    scopus 로고
    • Immunological synapse formation licenses CD40-CD40LaccumulationsatT-APCcon-tact sites
    • Boisvert, J., Edmondson, S., and Krum-mel, M. F. (2004). Immunological synapse formation licenses CD40-CD40LaccumulationsatT-APCcon-tact sites. J. Immunol. 173, 3647-3652.
    • (2004) J. Immunol. , vol.173 , pp. 3647-3652
    • Boisvert, J.1    Edmondson, S.2    Krum-Mel, M.F.3
  • 6
    • 41849105805 scopus 로고    scopus 로고
    • +hotonimag-ingofintratumoralCD8 Tcellcyto-toxic activity during adoptive T cell therapy in mice
    • +hotonimag-ingofintratumoralCD8 Tcellcyto-toxic activity during adoptive T cell therapy in mice. J. Clin. Invest. 118, 1390-1397.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1390-1397
    • Breart, B.1    Lemaitre, F.2    Celli, S.3    Bousso, P.4
  • 7
    • 80053325995 scopus 로고    scopus 로고
    • Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapsesrevealedbysuper-resolution microscopy
    • doi: 10.1371/journal.pbio.1001152
    • Brown, A. C., Oddos, S., Dobbie, I. M., Alakoskela, J. M., Parton, R. M., Eissmann, P., Neil, M. A., Dunsby, C., French, P. M., Davis, I., and Davis, D. M. (2011). Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapsesrevealedbysuper-resolution microscopy. PLoS Biol. 9, e1001152. doi: 10.1371/journal.pbio.1001152
    • (2011) PLoS Biol , vol.9
    • Brown, A.C.1    Oddos, S.2    Dobbie, I.M.3    Alakoskela, J.M.4    Parton, R.M.5    Eissmann, P.6    Neil, M.A.7    Dunsby, C.8    French, P.M.9    Davis, I.10    Davis, D.M.11
  • 9
    • 0024328679 scopus 로고
    • Mechanisms of T cell activation by the calcium ionophore ionomycin
    • Chatila, T., Silverman, L., Miller, R., and Geha, R. (1989). Mechanisms of T cell activation by the calcium ionophore ionomycin. J. Immunol. 143,1283-1289.
    • (1989) J. Immunol. , vol.143 , pp. 1283-1289
    • Chatila, T.1    Silverman, L.2    Miller, R.3    Geha, R.4
  • 10
    • 33748764383 scopus 로고    scopus 로고
    • C1domainsexposed:from diacylglycerol binding to protein-protein interactions
    • Colon-Gonzalez, F., and Kazanietz, M. G. (2006).C1domainsexposed:from diacylglycerol binding to protein-protein interactions. Biochim. Bio-phys. Acta 1761,827-837.
    • (2006) Biochim. Bio-phys. Acta , vol.1761 , pp. 827-837
    • Colon-Gonzalez, F.1    Kazanietz, M.G.2
  • 13
    • 0037743735 scopus 로고    scopus 로고
    • Eukaryotic chemotaxis: dis-tinctions between directional sensing and polarization
    • Devreotes, P., and Janetopoulos, C. (2003). Eukaryotic chemotaxis: dis-tinctions between directional sensing and polarization. J. Biol. Chem. 278, 20445-20448.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20445-20448
    • Devreotes, P.1    Janetopoulos, C.2
  • 15
    • 77951689563 scopus 로고    scopus 로고
    • Cytotoxic immunological synapses
    • Dustin, M. L., and Long, E. O. (2010). Cytotoxic immunological synapses. Immunol. Rev. 235, 24-34.
    • (2010) Immunol. Rev. , vol.235 , pp. 24-34
    • Dustin, M.L.1    Long, E.O.2
  • 16
    • 0037222950 scopus 로고    scopus 로고
    • Cell polarity: Par6,aPKC and cytoskeletal crosstalk
    • Etienne-Manneville, S., and Hall, A. (2003). Cell polarity: Par6,aPKC and cytoskeletal crosstalk. Curr. Opin. Cell Biol. 15, 67-72.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 67-72
    • Etienne-Manneville, S.1    Hall, A.2
  • 18
    • 0020365635 scopus 로고
    • Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lym-phocytes and target cells
    • Geiger, B., Rosen, D., and Berke, G. (1982). Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lym-phocytes and target cells. J. Cell Biol. 95, 137-143.
    • (1982) J. Cell Biol. , vol.95 , pp. 137-143
    • Geiger, B.1    Rosen, D.2    Berke, G.3
  • 19
    • 17844379382 scopus 로고    scopus 로고
    • Nuclearmovementreg-ulatedbyCdc42,MRCK,myosin,and actin flow establishes MTOC polar-ization in migrating cells
    • Gomes, E. R., Jani, S., and Gundersen, G.G. (2005).Nuclearmovementreg-ulatedbyCdc42,MRCK,myosin,and actin flow establishes MTOC polar-ization in migrating cells. Cell 121, 451-463.
    • (2005) Cell , vol.121 , pp. 451-463
    • Gomes, E.R.1    Jani, S.2    Gundersen, G.G.3
  • 20
    • 44049096985 scopus 로고    scopus 로고
    • T cell activation and the cytoskeleton: you can't have one without the other
    • Gomez, T. S., and Billadeau, D. D. (2008). T cell activation and the cytoskeleton: you can't have one without the other. Adv. Immunol. 97, 1-64.
    • (2008) Adv. Immunol. , vol.97 , pp. 1-64
    • Gomez, T.S.1    Billadeau, D.D.2
  • 21
    • 33847311403 scopus 로고    scopus 로고
    • Formins regulate the actin-related protein 2/3 complex-independent polariza-tion of the centrosome to the immunological synapse
    • Gomez, T. S., Kumar, K., Medeiros, R. B., Shimizu, Y., Leibson, P. J., and Billadeau, D. D. (2007). Formins regulate the actin-related protein 2/3 complex-independent polariza-tion of the centrosome to the immunological synapse. Immunity 26,177-190.
    • (2007) Immunity , vol.26 , pp. 177-190
    • Gomez, T.S.1    Kumar, K.2    Medeiros, R.B.3    Shimizu, Y.4    Leibson, P.J.5    Billadeau, D.D.6
  • 23
    • 77952295580 scopus 로고    scopus 로고
    • Early events in B cell acti-vation
    • Harwood, N. E., and Batista, F. D. (2010). Early events in B cell acti-vation. Annu. Rev. Immunol. 28, 185-210.
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 185-210
    • Harwood, N.E.1    Batista, F.D.2
  • 24
    • 79959332816 scopus 로고    scopus 로고
    • Dynein-driven transport of T cell receptor microclusters reg-ulates immune synapse formation and T cell activation
    • Hashimoto-Tane, A., Yokosuka, T., Sakata-Sogawa,K.,Sakuma,M.,Ishi-Hara, C., Tokunaga, M., and Saito, T. (2011). Dynein-driven transport of T cell receptor microclusters reg-ulates immune synapse formation and T cell activation. Immunity 34, 919-931.
    • (2011) Immunity , vol.34 , pp. 919-931
    • Hashimoto-Tane, A.1    Yokosuka, T.2    Sakata-Sogawa, K.3    Sakuma, M.4    Ishi-Hara, C.5    Tokunaga, M.6    Saito, T.7
  • 25
    • 34447647655 scopus 로고    scopus 로고
    • Spatial and temporal dynamics of T cell receptor signaling with a pho-toactivatable agonist
    • Huse, M., Klein, L. O., Girvin, A. T., Faraj, J. M., Li, Q. J., Kuhns, M. S., and Davis, M. M. (2007). Spatial and temporal dynamics of T cell receptor signaling with a pho-toactivatable agonist. Immunity 27, 76-88.
    • (2007) Immunity , vol.27 , pp. 76-88
    • Huse, M.1    Klein, L.O.2    Girvin, A.T.3    Faraj, J.M.4    Li, Q.J.5    Kuhns, M.S.6    Davis, M.M.7
  • 26
    • 33344458030 scopus 로고    scopus 로고
    • T cells use two directionally distinct pathways for cytokine secretion
    • Huse,M.,Lillemeier,B.F.,Kuhns,M.S., Chen,D.S.,and Davis,M.M. (2006). T cells use two directionally distinct pathways for cytokine secretion. Nat. Immunol. 7,247-255.
    • (2006) Nat. Immunol. , vol.7 , pp. 247-255
    • Huse, M.1    Lillemeier, B.F.2    Kuhns, M.S.3    Chen, D.S.4    Davis, M.M.5
  • 27
    • 52649128664 scopus 로고    scopus 로고
    • Shouts, whispers, and the kiss of death: directional secre-tion in T cells
    • Huse, M., Quann, E. J., and Davis, M. M. (2008). Shouts, whispers, and the kiss of death: directional secre-tion in T cells. Nat. Immunol. 9, 1105-1111.
    • (2008) Nat. Immunol. , vol.9 , pp. 1105-1111
    • Huse, M.1    Quann, E.J.2    Davis, M.M.3
  • 28
    • 0037459076 scopus 로고    scopus 로고
    • Membrane fusion
    • Jahn, R., Lang, T., and Sudhof, T. C. (2003). Membrane fusion. Cell 112, 519-533.
    • (2003) Cell , vol.112 , pp. 519-533
    • Jahn, R.1    Lang, T.2    Sudhof, T.C.3
  • 29
    • 70450228589 scopus 로고    scopus 로고
    • Regulators of the cytoplasmic dynein motor
    • Kardon, J. R., and Vale, R. D. (2009). Regulators of the cytoplasmic dynein motor. Nat. Rev. Mol. Cell Biol. 10, 854-865.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 854-865
    • Kardon, J.R.1    Vale, R.D.2
  • 30
    • 0037124093 scopus 로고    scopus 로고
    • Importance of C1B domain for lipid messenger-induced targeting of pro-tein kinase C
    • Kashiwagi, K., Shirai, Y., Kuriyama, M., Sakai, N., and Saito, N. (2002). Importance of C1B domain for lipid messenger-induced targeting of pro-tein kinase C. J. Biol. Chem. 277, 18037-18045.
    • (2002) J. Biol. Chem. , vol.277 , pp. 18037-18045
    • Kashiwagi, K.1    Shirai, Y.2    Kuriyama, M.3    Sakai, N.4    Saito, N.5
  • 31
    • 0036166541 scopus 로고    scopus 로고
    • Dynamic polarization of the micro-tubule cytoskeleton during CTL-mediated killing
    • Kuhn, J. R., and Poenie, M. (2002). Dynamic polarization of the micro-tubule cytoskeleton during CTL-mediated killing. Immunity 16, 111-121.
    • (2002) Immunity , vol.16 , pp. 111-121
    • Kuhn, J.R.1    Poenie, M.2
  • 32
    • 0038445896 scopus 로고    scopus 로고
    • Linker for acti-vation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
    • Kuhne, M. R., Lin, J., Yablonski, D., Mollenauer, M. N., Ehrlich, L. I., Huppa, J., Davis, M. M., and Weiss, A. (2003). Linker for acti-vation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J. Immunol. 171, 860-866.
    • (2003) J. Immunol. , vol.171 , pp. 860-866
    • Kuhne, M.R.1    Lin, J.2    Yablonski, D.3    Mollenauer, M.N.4    Ehrlich, L.I.5    Huppa, J.6    Davis, M.M.7    Weiss, A.8
  • 33
    • 0344006229 scopus 로고
    • Polarization of the Golgi apparatus and the microtubule-organizing center within cloned nat-uralkillercellsboundtotheirtargets
    • Kupfer, A., Dennert, G., and Singer, S. J. (1983). Polarization of the Golgi apparatus and the microtubule-organizing center within cloned nat-uralkillercellsboundtotheirtargets. Proc. Natl. Acad. Sci. U.S.A. 80, 7224-7228.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 7224-7228
    • Kupfer, A.1    Dennert, G.2    Singer, S.J.3
  • 34
    • 0025978984 scopus 로고
    • Polarized expres-sion of cytokines in cell conjugates of helper T cells and splenic B cells
    • Kupfer, A., Mosmann, T. R., and Kupfer, H. (1991). Polarized expres-sion of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl. Acad. Sci. U.S.A. 88, 775-779.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 775-779
    • Kupfer, A.1    Mosmann, T.R.2    Kupfer, H.3
  • 35
    • 0022592627 scopus 로고
    • On the mechanism of unidirectional killing in mix-tures of two cytotoxic T lympho-cytes Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell
    • Kupfer, A., Singer, S. J., and Den-nert, G. (1986). On the mechanism of unidirectional killing in mix-tures of two cytotoxic T lympho-cytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell. J. Exp. Med. 163, 489-498.
    • (1986) J. Exp. Med. , vol.163 , pp. 489-498
    • Kupfer, A.1    Singer, S.J.2    Den-Nert, G.3
  • 36
    • 0028354216 scopus 로고
    • Small splenic B cells that bindtoantigen-specificThelper(Th) cells and face the site of cytokine production in the Th cells selec-tively proliferate: immunofluores-cence microscopic studies of Th-B antigen-presenting cell interactions
    • Kupfer, H., Monks, C. R., and Kupfer, A. (1994). Small splenic B cells that bindtoantigen-specificThelper(Th) cells and face the site of cytokine production in the Th cells selec-tively proliferate: immunofluores-cence microscopic studies of Th-B antigen-presenting cell interactions. J. Exp. Med. 179,1507-1515.
    • (1994) J. Exp. Med. , vol.179 , pp. 1507-1515
    • Kupfer, H.1    Monks, C.R.2    Kupfer, A.3
  • 37
    • 0017348632 scopus 로고
    • Studies on the mechanism of lymphocyte-mediated cytolysis IX. Relationshipsbetweenantigenrecog-nition and lytic expression in killer T cells
    • Kuppers, R. C., and Henney, C. S. (1977). Studies on the mechanism of lymphocyte-mediated cytolysis. IX. Relationshipsbetweenantigenrecog-nition and lytic expression in killer T cells. J. Immunol. 118,71-76.
    • (1977) J. Immunol. , vol.118 , pp. 71-76
    • Kuppers, R.C.1    Henney, C.S.2
  • 38
    • 0022620429 scopus 로고
    • Is the T-cell receptor involved in T-cell killing?
    • Lanzavecchia, A. (1986). Is the T-cell receptor involved in T-cell killing? Nature 319,778-780.
    • (1986) Nature , vol.319 , pp. 778-780
    • Lanzavecchia, A.1
  • 39
    • 27844539756 scopus 로고    scopus 로고
    • ProteinkinaseCand the regulation of the actin cytoskele-ton
    • Larsson,C. (2006).ProteinkinaseCand the regulation of the actin cytoskele-ton. Cell. Signal. 18,276-284.
    • (2006) Cell. Signal. , vol.18 , pp. 276-284
    • Larsson, C.1
  • 40
    • 54549102288 scopus 로고    scopus 로고
    • Beyond polymer polarity: how the cytoskeleton builds a polarized cell
    • Li, R., and Gundersen, G. G. (2008). Beyond polymer polarity: how the cytoskeleton builds a polarized cell. Nat. Rev. Mol. Cell Biol. 9, 860-873.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 860-873
    • Li, R.1    Gundersen, G.G.2
  • 41
    • 70249114140 scopus 로고    scopus 로고
    • The polar-ity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization
    • Lin, J., Hou, K. K., Piwnica-Worms, H., and Shaw, A. S. (2009). The polar-ity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. J. Immunol. 183, 1215-1221.
    • (2009) J. Immunol. , vol.183 , pp. 1215-1221
    • Lin, J.1    Hou, K.K.2    Piwnica-Worms, H.3    Shaw, A.S.4
  • 42
    • 34548029399 scopus 로고    scopus 로고
    • Leuko-cyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leuko-cyte recruitment in vivo
    • Liu, L., Puri, K. D., Penninger, J. M., and Kubes, P. (2007). Leuko-cyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leuko-cyte recruitment in vivo. Blood 110, 1191-1198.
    • (2007) Blood , vol.110 , pp. 1191-1198
    • Liu, L.1    Puri, K.D.2    Penninger, J.M.3    Kubes, P.4
  • 43
    • 0032559586 scopus 로고    scopus 로고
    • Cytoskeletal polar-ization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mecha-nism
    • Lowin-Kropf, B., Shapiro, V. S., and Weiss, A. (1998). Cytoskeletal polar-ization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mecha-nism. J. Cell Biol. 140,861-871.
    • (1998) J. Cell Biol. , vol.140 , pp. 861-871
    • Lowin-Kropf, B.1    Shapiro, V.S.2    Weiss, A.3
  • 45
    • 58149300245 scopus 로고    scopus 로고
    • Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly medi-ates TCR signals leading to granule exocytosis-mediated cytotoxicity
    • Ma, J. S., Haydar, T. F., and Radoja, S. (2008). Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly medi-ates TCR signals leading to granule exocytosis-mediated cytotoxicity. J. Immunol. 181,4716-4722.
    • (2008) J. Immunol. , vol.181 , pp. 4716-4722
    • Ma, J.S.1    Haydar, T.F.2    Radoja, S.3
  • 47
    • 33947097707 scopus 로고    scopus 로고
    • Selective function of PKC-theta in T cells
    • Manicassamy, S., Gupta, S., and Sun, Z. (2006). Selective function of PKC-theta in T cells. Cell. Mol. Immunol. 3,263-270.
    • (2006) Cell. Mol. Immunol. , vol.3 , pp. 263-270
    • Manicassamy, S.1    Gupta, S.2    Sun, Z.3
  • 48
    • 41149167494 scopus 로고    scopus 로고
    • T-cell fate and function: PKC-theta and beyond
    • Marsland, B. J., and Kopf, M. (2008). T-cell fate and function: PKC-theta and beyond. Trends Immunol. 29, 179-185.
    • (2008) Trends Immunol , vol.29 , pp. 179-185
    • Marsland, B.J.1    Kopf, M.2
  • 50
    • 34547118860 scopus 로고    scopus 로고
    • Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase C theta
    • Melowic, H. R., Stahelin, R. V., Blatner, N. R., Tian, W., Hayashi, K., Altman, A., and Cho, W. (2007). Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase C theta. J. Biol. Chem. 282, 21467-21476.
    • (2007) J. Biol. Chem. , vol.282 , pp. 21467-21476
    • Melowic, H.R.1    Stahelin, R.V.2    Blatner, N.R.3    Tian, W.4    Hayashi, K.5    Altman, A.6    Cho, W.7
  • 51
    • 77954197189 scopus 로고    scopus 로고
    • Rapid lytic granule conver-gence to the MTOC in natural killer cellsisdependentondyneinbutnot cytolyticcommitment
    • Mentlik, A. N., Sanborn, K. B., Holzbaur, E. L., and Orange, J. S. (2010). Rapid lytic granule conver-gence to the MTOC in natural killer cellsisdependentondyneinbutnot cytolyticcommitment.Mol.Biol.Cell 21,2241-2256.
    • (2010) Mol.Biol.Cell , vol.21 , pp. 2241-2256
    • Mentlik, A.N.1    Sanborn, K.B.2    Holzbaur, E.L.3    Orange, J.S.4
  • 52
    • 0031012266 scopus 로고    scopus 로고
    • Selec-tive modulation of protein kinase C-theta during T-cell activation
    • Monks, C. R., Kupfer, H.,Tamir, I.,Bar-low, A., and Kupfer, A. (1997). Selec-tive modulation of protein kinase C-theta during T-cell activation. Nature 385,83-86.
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.1    Kupfer, H.2    Tamir, I.3    Bar-Low, A.4    Kupfer, A.5
  • 53
    • 84864321408 scopus 로고    scopus 로고
    • CD4 Tcellsrely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
    • doi: 10.1016/j.immuni.2012.05.015 [Epub ahead of print]
    • +, G. F., and Bousso, P. (2012). CD4 Tcellsrely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity. doi: 10.1016/j.immuni.2012.05.015 [Epub ahead of print].
    • (2012) Immunity
    • Muller, A.J.1    Filipe-Santos, O.2    Eberl, G.3    Aebischer, T.4    Spath+, G.F.5    Bousso, P.6
  • 54
    • 79951520024 scopus 로고    scopus 로고
    • Elab-orating polarity: PAR proteins and the cytoskeleton
    • Nance, J., and Zallen, J. A. (2011). Elab-orating polarity: PAR proteins and the cytoskeleton.1; Development 138, 799-809.
    • (2011) Development , vol.138 , pp. 799-809
    • Nance, J.1    Zallen, J.A.2
  • 55
    • 0037452071 scopus 로고    scopus 로고
    • Adaptationof core mechanisms to generate cell polarity
    • Nelson,W.J. (2003).Adaptationof core mechanisms to generate cell polarity. Nature 422,766-774.
    • (2003) Nature , vol.422 , pp. 766-774
    • Nelson, W.J.1
  • 59
    • 0035575616 scopus 로고    scopus 로고
    • Rab GTPases: specifying and deciphering organelle identity and function
    • Pfeffer, S. R. (2001). Rab GTPases: specifying and deciphering organelle identity and function. Trends Cell Biol. 11,487-491.
    • (2001) Trends Cell Biol , vol.11 , pp. 487-491
    • Pfeffer, S.R.1
  • 60
    • 34247577498 scopus 로고    scopus 로고
    • Delivering the kiss of death: progress on understanding how per-forin works
    • Pipkin, M. E., and Lieberman, J. (2007). Delivering the kiss of death: progress on understanding how per-forin works. Curr. Opin. Immunol. 19,301-308.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 301-308
    • Pipkin, M.E.1    Lieberman, J.2
  • 61
    • 0023881127 scopus 로고
    • Receptor-directed focusing of lymphokine release by helper T cells
    • Poo, W. J., Conrad, L., and Janeway, C. A. Jr. (1988). Receptor-directed focusing of lymphokine release by helper T cells. Nature 332, 378-380.
    • (1988) Nature , vol.332 , pp. 378-380
    • Poo, W.J.1    Conrad, L.2    Janeway Jr., C.A.3
  • 62
    • 79959376445 scopus 로고    scopus 로고
    • A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells
    • Quann, E. J., Liu, X., Altan-Bonnet, G., and Huse, M. (2011). A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nat. Immunol. 12, 647-654.
    • (2011) Nat. Immunol. , vol.12 , pp. 647-654
    • Quann, E.J.1    Liu, X.2    Altan-Bonnet, G.3    Huse, M.4
  • 63
    • 67349243386 scopus 로고    scopus 로고
    • Localized diacylglycerol drives the polarization of the microtubule-organizing cen-terinTcells
    • Quann, E. J., Merino, E., Furuta, T., and Huse, M. (2009). Localized diacylglycerol drives the polarization of the microtubule-organizing cen-terinTcells.Nat. Immunol. 10, 627-635.
    • (2009) Nat. Immunol. , vol.10 , pp. 627-635
    • Quann, E.J.1    Merino, E.2    Furuta, T.3    Huse, M.4
  • 64
    • 80053321288 scopus 로고    scopus 로고
    • Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse
    • doi: 10.1371/journal.pbio. 1001151e1001151
    • Rak, G. D., Mace, E. M., Banerjee, P. P., Svitkina, T., and Orange, J. S. (2011). Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. PLoS Biol. 9, e1001151. doi: 10.1371/journal.pbio. 1001151
    • (2011) PLoS Biol , vol.9
    • Rak, G.D.1    Mace, E.M.2    Banerjee, P.P.3    Svitkina, T.4    Orange, J.S.5
  • 65
    • 38449108120 scopus 로고    scopus 로고
    • Cut-ting edge: atypical PKCs regulate T lymphocyte polarity and scan-ning behavior
    • Real, E., Faure, S., Donnadieu, E., and Delon, J. (2007). Cut-ting edge: atypical PKCs regulate T lymphocyte polarity and scan-ning behavior. J. Immunol. 179, 5649-5652.
    • (2007) J. Immunol. , vol.179 , pp. 5649-5652
    • Real, E.1    Faure, S.2    Donnadieu, E.3    Delon, J.4
  • 67
    • 4043082729 scopus 로고    scopus 로고
    • Cutting edge: differential roles for phospho-inositide 3-kinases, p110gamma and p110delta,inlymphocytechemotaxis and homing
    • Reif, K., Okkenhaug, K., Sasaki, T., Pen-Ninger, J. M., Vanhaesebroeck, B., and Cyster, J. G. (2004). Cutting edge: differential roles for phospho-inositide 3-kinases, p110gamma and p110delta,inlymphocytechemotaxis and homing. J. Immunol. 173, 2236-2240.
    • (2004) J. Immunol. , vol.173 , pp. 2236-2240
    • Reif, K.1    Okkenhaug, K.2    Sasaki, T.3    Pen-Ninger, J.M.4    Vanhaesebroeck, B.5    Cyster, J.G.6
  • 68
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell, J. H., and Ley, T. J. (2002). Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20,323-370.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 70
    • 0033083257 scopus 로고    scopus 로고
    • TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization
    • Sedwick, C. E., Morgan, M. M., Jusino, L., Cannon, J. L., Miller, J., and Burkhardt, J. K. (1999). TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization. J. Immunol. 162,1367-1375.
    • (1999) J. Immunol. , vol.162 , pp. 1367-1375
    • Sedwick, C.E.1    Morgan, M.M.2    Jusino, L.3    Cannon, J.L.4    Miller, J.5    Burkhardt, J.K.6
  • 71
    • 35148819807 scopus 로고    scopus 로고
    • PI3Kgamma is the dominantisoforminvolvedinmigra-tory responses of human T lym-phocytes: effects of ex vivo mainte-nance and limitations of non-viral delivery of siRNA
    • Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J., and Ward, S. G. (2007). PI3Kgamma is the dominantisoforminvolvedinmigra-tory responses of human T lym-phocytes: effects of ex vivo mainte-nance and limitations of non-viral delivery of siRNA. Cell. Signal. 19, 2528-2539.
    • (2007) Cell. Signal. , vol.19 , pp. 2528-2539
    • Smith, L.D.1    Hickman, E.S.2    Parry, R.V.3    Westwick, J.4    Ward, S.G.5
  • 72
    • 0031725838 scopus 로고    scopus 로고
    • High-level IL-12 production by human dendritic cells requires two signals
    • Snijders,A., Kalinski, P., Hilkens, C. M., and Kapsenberg, M. L. (1998). High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10, 1593-1598.
    • (1998) Int. Immunol. , vol.10 , pp. 1593-1598
    • Snijders, A.1    Kalinski, P.2    Hilkens, C.M.3    Kapsenberg, M.L.4
  • 73
    • 33646560593 scopus 로고    scopus 로고
    • Diacylglyc-erol and protein kinase D localiza-tion during T lymphocyte activation
    • Spitaler, M., Emslie, E., Wood, C. D., and Cantrell, D. (2006). Diacylglyc-erol and protein kinase D localiza-tion during T lymphocyte activation. Immunity 24, 535-546.
    • (2006) Immunity , vol.24 , pp. 535-546
    • Spitaler, M.1    Emslie, E.2    Wood, C.D.3    Cantrell, D.4
  • 74
    • 21244504606 scopus 로고    scopus 로고
    • Diacylglycerol-induced membrane targeting and activation of protein kinase C epsilon: mech-anistic differences between protein kinases C delta and C epsilon
    • Stahelin, R. V., Digman, M. A., Med-Kova, M., Ananthanarayanan, B., Melowic,H.R.,Rafter,J.D.,and Cho, W. (2005). Diacylglycerol-induced membrane targeting and activation of protein kinase C epsilon: mech-anistic differences between protein kinases C delta and C epsilon. J. Biol. Chem. 280,19784-19793.
    • (2005) J. Biol. Chem. , vol.280 , pp. 19784-19793
    • Stahelin, R.V.1    Digman, M.A.2    Med-Kova, M.3    Ananthanarayanan, B.4    Melowic, H.R.5    Rafter, J.D.6    Cho, W.7
  • 76
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • Stinchcombe, J. C., Bossi, G., Booth, S., and Griffiths, G. M. (2001). The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751-761.
    • (2001) Immunity , vol.15 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 77
    • 38449096740 scopus 로고    scopus 로고
    • Secretory mecha-nisms in cell-mediated cytotoxicity
    • Stinchcombe, J. C., and Griffiths, G. M. (2007). Secretory mecha-nisms in cell-mediated cytotoxicity. Annu.Rev.CellDev.Biol.23, 495-517.
    • (2007) Annu.Rev.CellDev.Biol. , vol.23 , pp. 495-517
    • Stinchcombe, J.C.1    Griffiths, G.M.2
  • 78
    • 33749185296 scopus 로고    scopus 로고
    • Centrosome polariza-tiondeliverssecretorygranulestothe immunological synapse
    • Stinchcombe, J. C., Majorovits, E., Bossi, G., Fuller, S., and Griffiths, G. M. (2006). Centrosome polariza-tiondeliverssecretorygranulestothe immunological synapse. Nature 443, 462-465.
    • (2006) Nature , vol.443 , pp. 462-465
    • Stinchcombe, J.C.1    Majorovits, E.2    Bossi, G.3    Fuller, S.4    Griffiths, G.M.5
  • 80
    • 78650644637 scopus 로고    scopus 로고
    • T cell polarity at the immunological synapse is required for CD154-dependent IL-12 secretion by dendritic cells
    • Tourret, M., Guegan, S., Chemin, K., Dogniaux, S., Miro, F., Bohineust,A., and Hivroz,C. (2010). T cell polarity at the immunological synapse is required for CD154-dependent IL-12 secretion by dendritic cells. J. Immunol. 185,6809-6818.
    • (2010) J. Immunol. , vol.185 , pp. 6809-6818
    • Tourret, M.1    Guegan, S.2    Chemin, K.3    Dogniaux, S.4    Miro, F.5    Bohineust, A.6    Hivroz, C.7
  • 81
    • 0842333851 scopus 로고    scopus 로고
    • Dynein: an ancient motor pro-tein involved in multiple modes of transport
    • Vallee, R. B., Williams, J. C., Varma, D., and Barnhart, L. E. (2004). Dynein: an ancient motor pro-tein involved in multiple modes of transport. J. Neurobiol. 58, 189-200.
    • (2004) J. Neurobiol. , vol.58 , pp. 189-200
    • Vallee, R.B.1    Williams, J.C.2    Varma, D.3    Barnhart, L.E.4
  • 82
    • 78650419576 scopus 로고    scopus 로고
    • Rab7: role of its protein interaction cascades in endo-lysosomal traffic
    • Wang, T., Ming, Z., Xiaochun, W., and Hong, W. (2011). Rab7: role of its protein interaction cascades in endo-lysosomal traffic. Cell. Signal. 23, 516-521.
    • (2011) Cell. Signal. , vol.23 , pp. 516-521
    • Wang, T.1    Ming, Z.2    Xiaochun, W.3    Hong, W.4
  • 83
    • 59849114020 scopus 로고    scopus 로고
    • Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation
    • Ward, S. G., and Marelli-Berg, F. M. (2009). Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation. Biochem. J. 418, 13-27.
    • (2009) Biochem. J. , vol.418 , pp. 13-27
    • Ward, S.G.1    Marelli-Berg, F.M.2
  • 85
    • 49249109489 scopus 로고    scopus 로고
    • Diacylglycerol kinases in immune cell function and self-tolerance
    • Zhong, X. P., Guo, R., Zhou, H., Liu, C., and Wan,C.K. (2008).Diacylglycerol kinases in immune cell function and self-tolerance. Immunol. Rev. 224, 249-264.
    • (2008) Immunol. Rev. , vol.224 , pp. 249-264
    • Zhong, X.P.1    Guo, R.2    Zhou, H.3    Liu, C.4    Wan, C.K.5


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