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Volumn 3, Issue DEC, 2012, Pages

Glucose: An energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator

Author keywords

Articular cartilage; Bone; Extracellular signaling; Glucose; Glucose transport; Glucosensing; Hexokinase; Osteocalcin

Indexed keywords


EID: 84874403269     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2012.00153     Document Type: Review
Times cited : (59)

References (105)
  • 2
    • 0025005270 scopus 로고
    • Inter-leukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters
    • Bird, T. A., Davies, A., Baldwin, S. A., and Saklatvala, J. (1990). Inter-leukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters. J. Biol. Chem. 265, 13578-13583.
    • (1990) J. Biol. Chem. , vol.265 , pp. 13578-13583
    • Bird, T.A.1    Davies, A.2    Baldwin, S.A.3    Saklatvala, J.4
  • 4
    • 84868510906 scopus 로고    scopus 로고
    • Bone remodelling in osteoarthritis
    • Burr, D. B., and Gallant, M. A. (2012). Bone remodelling in osteoarthritis. Nat. Rev. Rheumatol. 8, 665-673.
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 665-673
    • Burr, D.B.1    Gallant, M.A.2
  • 5
    • 0031969977 scopus 로고    scopus 로고
    • GLUT1 glucose transporter: a highly sensitive marker of malignancy in body cavity effusions
    • Burstein, D. E., Reder, I., Weiser, K., Tong, T., Pritsker, A., and Haber, R. S. (1998). GLUT1 glucose transporter: a highly sensitive marker of malignancy in body cavity effusions. Mod. Pathol. 11, 392-396.
    • (1998) Mod. Pathol. , vol.11 , pp. 392-396
    • Burstein, D.E.1    Reder, I.2    Weiser, K.3    Tong, T.4    Pritsker, A.5    Haber, R.S.6
  • 6
    • 1842419225 scopus 로고
    • A glucose transport protein expressed predominately in insulin-responsive tissues
    • Charron, M. J., Brosius, F. C., III, Alper, S. L., and Lodish, H. F. (1989). A glucose transport protein expressed predominately in insulin-responsive tissues. Proc. Natl. Acad. Sci. U.S.A. 86, 2535-2539.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 2535-2539
    • Charron, M.J.1    Brosius III, F.C.2    Alper, S.L.3    Lodish, H.F.4
  • 7
    • 79952717399 scopus 로고    scopus 로고
    • Insulin regulates GLUT1-mediated glucose transport inMG-63 human osteosar-coma cells
    • Cifuentes, M., Garcia, M. A., Arra-bal, P. M., Martinez, F., Yanez, M. J., Jara, N., et al. (2011). Insulin regulates GLUT1-mediated glucose transport inMG-63 human osteosar-coma cells. J. Cell. Physiol. 226, 1425- 1432.
    • (2011) J. Cell. Physiol. , vol.226 , pp. 1425-1432
    • Cifuentes, M.1    Garcia, M.A.2    Arra-bal, P.M.3    Martinez, F.4    Yanez, M.J.5    Jara, N.6
  • 8
    • 0036167350 scopus 로고    scopus 로고
    • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants
    • Clark, A. G., Rohrbaugh, A. L., Otter-ness, I., and Kraus, V. B. (2002). The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biol. 21, 175-184.
    • (2002) Matrix Biol , vol.21 , pp. 175-184
    • Clark, A.G.1    Rohrbaugh, A.L.2    Otter-ness, I.3    Kraus, V.B.4
  • 9
    • 79953038259 scopus 로고    scopus 로고
    • The osteoblast: an insulin target cell controlling glucose homeostasis
    • Clemens, T. L., and Karsenty, G. (2011). The osteoblast: an insulin target cell controlling glucose homeostasis. J. Bone Miner. Res. 26, 677-680.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 677-680
    • Clemens, T.L.1    Karsenty, G.2
  • 10
    • 79958753138 scopus 로고    scopus 로고
    • Bone: from a reservoir of minerals to a regulator of energy metabolism
    • Confavreux, C. B. (2011). Bone: from a reservoir of minerals to a regulator of energy metabolism. Kidney Int. Suppl. S121, S14-S19.
    • (2011) Kidney Int. Suppl. , vol.S121
    • Confavreux, C.B.1
  • 12
    • 84883571269 scopus 로고    scopus 로고
    • Bone cells and the mechanisms of bone remodelling
    • Del Fattore, A., Teti, A., and Rucci, N. (2012). Bone cells and the mechanisms of bone remodelling. Front. Biosci. (Elite Ed.) 4, 2302-2321.
    • (2012) Front. Biosci. (Elite Ed.) , vol.4 , pp. 2302-2321
    • Del Fattore, A.1    Teti, A.2    Rucci, N.3
  • 13
    • 0028173313 scopus 로고
    • The pancreatic beta-cell glucose sensor
    • Efrat, S., Tal, M., and Lodish, H. F. (1994). The pancreatic beta-cell glucose sensor. Trends Biochem. Sci. 19, 535-538.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 535-538
    • Efrat, S.1    Tal, M.2    Lodish, H.F.3
  • 14
    • 77958176814 scopus 로고    scopus 로고
    • Glucose transporter protein 1-targeted RNA interference inhibits growth and invasion of the osteosarcoma cell line MG63 in vitro
    • Fan, J., Zhou, J. Q., Yu, G. R., and Lu, D. D. (2010). Glucose transporter protein 1-targeted RNA interference inhibits growth and invasion of the osteosarcoma cell line MG63 in vitro. Cancer Biother. Radiopharm. 25, 521-527.
    • (2010) Cancer Biother. Radiopharm. , vol.25 , pp. 521-527
    • Fan, J.1    Zhou, J.Q.2    Yu, G.R.3    Lu, D.D.4
  • 15
    • 77955035304 scopus 로고    scopus 로고
    • Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    • Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., et al. (2010). Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142, 296-308.
    • (2010) Cell , vol.142 , pp. 296-308
    • Ferron, M.1    Wei, J.2    Yoshizawa, T.3    Del Fattore, A.4    DePinho, R.A.5    Teti, A.6
  • 16
    • 0023143672 scopus 로고
    • Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man
    • Flier, J. S., Mueckler, M., McCall, A. L., and Lodish, H. F. (1987a). Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. J. Clin. Invest. 79, 657-661.
    • (1987) J. Clin. Invest. , vol.79 , pp. 657-661
    • Flier, J.S.1    Mueckler, M.2    McCall, A.L.3    Lodish, H.F.4
  • 17
    • 0023158728 scopus 로고
    • Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
    • Flier, J. S., Mueckler, M. M., Usher, P., and Lodish, H. F. (1987b). Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235, 1492-1495.
    • (1987) Science , vol.235 , pp. 1492-1495
    • Flier, J.S.1    Mueckler, M.M.2    Usher, P.3    Lodish, H.F.4
  • 18
    • 0034799351 scopus 로고    scopus 로고
    • Sensors of extracellular nutrients in Saccharomyces cerevisiae
    • Forsberg, H., and Ljungdahl, P. O. (2001). Sensors of extracellular nutrients in Saccharomyces cerevisiae. Curr. Genet. 40, 91-109.
    • (2001) Curr. Genet. , vol.40 , pp. 91-109
    • Forsberg, H.1    Ljungdahl, P.O.2
  • 20
    • 84855864159 scopus 로고    scopus 로고
    • Novel functions for insulin in bone
    • Fulzele, K., and Clemens, T. L. (2012). Novel functions for insulin in bone. Bone 50, 452-456.
    • (2012) Bone , vol.50 , pp. 452-456
    • Fulzele, K.1    Clemens, T.L.2
  • 21
    • 77955082747 scopus 로고    scopus 로고
    • Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
    • Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., et al. (2010). Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142, 309-319.
    • (2010) Cell , vol.142 , pp. 309-319
    • Fulzele, K.1    Riddle, R.C.2    DiGirolamo, D.J.3    Cao, X.4    Wan, C.5    Chen, D.6
  • 22
    • 0026100550 scopus 로고
    • Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system
    • Gerstenfeld, L. C., and Landis, W. J. (1991). Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system. J. Cell Biol. 112, 501-513.
    • (1991) J. Cell Biol. , vol.112 , pp. 501-513
    • Gerstenfeld, L.C.1    Landis, W.J.2
  • 23
    • 0043246710 scopus 로고    scopus 로고
    • Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm
    • Gilmore, K. S., Srinivas, P., Akins, D. R., Hatter, K. L., and Gilmore, M. S. (2003). Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm. Infect. Immun. 71, 4759-4766.
    • (2003) Infect. Immun. , vol.71 , pp. 4759-4766
    • Gilmore, K.S.1    Srinivas, P.2    Akins, D.R.3    Hatter, K.L.4    Gilmore, M.S.5
  • 25
    • 78650484306 scopus 로고    scopus 로고
    • Nutrigenomics
    • Grayson, M. (2010). Nutrigenomics. Nature 468, S1.
    • (2010) Nature , vol.468
    • Grayson, M.1
  • 26
    • 0141532690 scopus 로고    scopus 로고
    • A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line
    • Gribble, F. M., Williams, L., Simpson, A. K., and Reimann, F. (2003). A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes 52, 1147-1154.
    • (2003) Diabetes , vol.52 , pp. 1147-1154
    • Gribble, F.M.1    Williams, L.2    Simpson, A.K.3    Reimann, F.4
  • 27
    • 0028323263 scopus 로고
    • Expression and cellular localization of glucose transporters (GLUT1, GLUT3 GLUT4) during differentiation of myogenic cells isolated from rat foetuses
    • Guillet-Deniau, I., Leturque, A., and Girard, J. (1994). Expression and cellular localization of glucose transporters (GLUT1, GLUT3, GLUT4) during differentiation of myogenic cells isolated from rat foetuses. J. Cell Sci. 107(Pt 3), 487-496.
    • (1994) J. Cell Sci. , vol.107 , Issue.PART 3 , pp. 487-496
    • Guillet-Deniau, I.1    Leturque, A.2    Girard, J.3
  • 28
    • 0026604486 scopus 로고
    • IL-1 beta, a strong mediator for glucose uptake by rheumatoid and non-rheumatoid cultured human synoviocytes
    • Hernvann, A., Aussel, C., Cynober, L., Moatti, N., and Ekindjian, O. G. (1992). IL-1 beta, a strong mediator for glucose uptake by rheumatoid and non-rheumatoid cultured human synoviocytes. FEBS Lett. 303, 77-80.
    • (1992) FEBS Lett , vol.303 , pp. 77-80
    • Hernvann, A.1    Aussel, C.2    Cynober, L.3    Moatti, N.4    Ekindjian, O.G.5
  • 30
    • 0034464652 scopus 로고    scopus 로고
    • Facilitative glucose transporters in livestock species
    • Hocquette, J. F., and Abe, H. (2000). Facilitative glucose transporters in livestock species. Reprod. Nutr. Dev. 40, 517-533.
    • (2000) Reprod. Nutr. Dev. , vol.40 , pp. 517-533
    • Hocquette, J.F.1    Abe, H.2
  • 31
    • 0023882706 scopus 로고
    • Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein
    • James, D. E., Brown, R., Navarro, J., and Pilch, P. F. (1988). Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature 333, 183-185.
    • (1988) Nature , vol.333 , pp. 183-185
    • James, D.E.1    Brown, R.2    Navarro, J.3    Pilch, P.F.4
  • 32
    • 0028101926 scopus 로고
    • Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neu-roendocrine cells in the brain and gut
    • Jetton, T. L., Liang, Y., Pettepher, C. C., Zimmerman, E. C., Cox, F. G., Horvath, K., et al. (1994). Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neu-roendocrine cells in the brain and gut. J. Biol. Chem. 269, 3641-3654.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3641-3654
    • Jetton, T.L.1    Liang, Y.2    Pettepher, C.C.3    Zimmerman, E.C.4    Cox, F.G.5    Horvath, K.6
  • 34
    • 0035685698 scopus 로고    scopus 로고
    • The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
    • Joost, H. G., and Thorens, B. (2001). The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Mol. Membr. Biol. 18, 247-256.
    • (2001) Mol. Membr. Biol. , vol.18 , pp. 247-256
    • Joost, H.G.1    Thorens, B.2
  • 35
    • 35848940094 scopus 로고    scopus 로고
    • Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-stimulated osteoclast differentiation
    • Kim, J. M., Jeong, D., Kang, H. K., Jung, S. Y., Kang, S. S., and Min, B. M. (2007). Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-stimulated osteoclast differentiation. Cell. Phys-iol. Biochem. 20, 935-946.
    • (2007) Cell. Physiol. Biochem. , vol.20 , pp. 935-946
    • Kim, J.M.1    Jeong, D.2    Kang, H.K.3    Jung, S.Y.4    Kang, S.S.5    Min, B.M.6
  • 36
    • 33644688772 scopus 로고    scopus 로고
    • Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection
    • Koster, J. C., Permutt, M. A., and Nichols, C. G. (2005). Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection. Diabetes 54, 3065-3072.
    • (2005) Diabetes , vol.54 , pp. 3065-3072
    • Koster, J.C.1    Permutt, M.A.2    Nichols, C.G.3
  • 37
    • 35848967006 scopus 로고    scopus 로고
    • Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism
    • Le Gall, M., Tobin, V., Stolarczyk, E., Dalet, V., Leturque, A., and Brot-Laroche, E. (2007). Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism. J. Cell. Physiol. 213, 834-843.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 834-843
    • Le Gall, M.1    Tobin, V.2    Stolarczyk, E.3    Dalet, V.4    Leturque, A.5    Brot-Laroche, E.6
  • 38
    • 0141675976 scopus 로고    scopus 로고
    • Regulation of root ion transporters by photosynthesis: functional importance and relation with hexokinase
    • Lejay, L., Gansel, X., Cerezo, M., Tillard, P., Muller, C., Krapp, A., et al. (2003). Regulation of root ion transporters by photosynthesis: functional importance and relation with hexokinase. Plant Cell 15, 2218-2232.
    • (2003) Plant Cell , vol.15 , pp. 2218-2232
    • Lejay, L.1    Gansel, X.2    Cerezo, M.3    Tillard, P.4    Muller, C.5    Krapp, A.6
  • 39
    • 34347236558 scopus 로고    scopus 로고
    • Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
    • Mace, O. J., Affleck, J., Patel, N., and Kel-lett, G. L. (2007). Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J. Physiol. 582, 379-392.
    • (2007) J. Physiol. , vol.582 , pp. 379-392
    • Mace, O.J.1    Affleck, J.2    Patel, N.3    Kel-Lett, G.L.4
  • 40
    • 0034463846 scopus 로고    scopus 로고
    • Localization of glucokinase-like immunoreactivity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms
    • Maekawa, F., Toyoda, Y., Torii, N., Miwa, I., Thompson, R. C., Foster, D. L., et al. (2000). Localization of glucokinase-like immunoreactiv-ity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms. Endocrinology 141, 375-384.
    • (2000) Endocrinology , vol.141 , pp. 375-384
    • Maekawa, F.1    Toyoda, Y.2    Torii, N.3    Miwa, I.4    Thompson, R.C.5    Foster, D.L.6
  • 41
    • 0033028690 scopus 로고    scopus 로고
    • The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor
    • Maor, G., and Karnieli, E. (1999). The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor. Endocrinology 140, 1841-1851.
    • (1999) Endocrinology , vol.140 , pp. 1841-1851
    • Maor, G.1    Karnieli, E.2
  • 43
    • 14644415944 scopus 로고    scopus 로고
    • Nutrient sensing in pancreatic beta cells suppresses mitochondrial superoxide generation and its contribution to apoptosis
    • Martens, G., Cai, Y., Hinke, S., Stange, G., Van de Casteele, M., and Pipeleers, D. (2005). Nutrient sensing in pancreatic beta cells suppresses mitochondrial superoxide generation and its contribution to apoptosis. Biochem. Soc. Trans. 33, 300-301.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 300-301
    • Martens, G.1    Cai, Y.2    Hinke, S.3    Stange, G.4    Van de Casteele, M.5    Pipeleers, D.6
  • 44
    • 0030067124 scopus 로고    scopus 로고
    • Banting Lecture 1995 A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky, F. M. (1996). Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45, 223-241.
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 45
    • 0014429630 scopus 로고
    • Metabolism of glucose in the islets of Langerhans
    • Matschinsky, F. M., and Ellerman, J. E. (1968). Metabolism of glucose in the islets of Langerhans. J. Biol. Chem. 243, 2730-2736.
    • (1968) J. Biol. Chem. , vol.243 , pp. 2730-2736
    • Matschinsky, F.M.1    Ellerman, J.E.2
  • 46
    • 32544461628 scopus 로고    scopus 로고
    • Nutraceuti-cals: do they work and when should we use them?
    • McAlindon, T. E. (2006). Nutraceuti-cals: do they work and when should we use them? Best Pract. Res. Clin. Rheumatol. 20, 99-115.
    • (2006) Best Pract. Res. Clin. Rheumatol. , vol.20 , pp. 99-115
    • McAlindon, T.E.1
  • 47
    • 20444395796 scopus 로고    scopus 로고
    • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2
    • McNulty, A. L., Vail, T. P., and Kraus, V. B. (2005). Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. Biochim. Biophys. Acta 1712, 212-221.
    • (2005) Biochim. Biophys. Acta , vol.1712 , pp. 212-221
    • McNulty, A.L.1    Vail, T.P.2    Kraus, V.B.3
  • 48
    • 0028280535 scopus 로고
    • Expression of glucose transporters in head-and-neck tumors
    • Mellanen, P., Minn, H., Grenman, R., and Harkonen, P. (1994). Expression of glucose transporters in head-and-neck tumors. Int. J. Cancer 56, 622-629.
    • (1994) Int. J. Cancer , vol.56 , pp. 622-629
    • Mellanen, P.1    Minn, H.2    Grenman, R.3    Harkonen, P.4
  • 49
    • 58149170369 scopus 로고    scopus 로고
    • Facilita-tive glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines
    • 1 p following vi
    • Mobasheri, A., Bondy, C. A., Moley, K., Mendes, A. F., Rosa, S. C., Richardson, S. M., et al. (2008). Facilita-tive glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines. Adv. Anat. Embryol. Cell Biol. 200, 1 p following vi, 1-84.
    • (2008) Adv. Anat. Embryol. Cell Biol. , vol.200 , pp. 1-84
    • Mobasheri, A.1    Bondy, C.A.2    Moley, K.3    Mendes, A.F.4    Rosa, S.C.5    Richardson, S.M.6
  • 50
    • 0036182992 scopus 로고    scopus 로고
    • Integrins and stretch activated ion channels; putative components of functional cell surface mechanore-ceptors in articular chondrocytes
    • Mobasheri, A., Carter, S. D., Martin-Vasallo, P., and Shakibaei, M. (2002a). Integrins and stretch activated ion channels; putative components of functional cell surface mechanore-ceptors in articular chondrocytes. Cell Biol. Int. 26, 1-18.
    • (2002) Cell Biol. Int. , vol.26 , pp. 1-18
    • Mobasheri, A.1    Carter, S.D.2    Martin-Vasallo, P.3    Shakibaei, M.4
  • 51
    • 0036388628 scopus 로고    scopus 로고
    • Human articular chondro-cytes express three facilitative glucose transporter isoforms: GLUT1
    • Mobasheri, A., Neama, G., Bell, S., Richardson, S., and Carter, S. D. (2002b). Human articular chondro-cytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol. Int. 26, 297-300.
    • (2002) GLUT3 and GLUT9. Cell Biol. Int. , vol.26 , pp. 297-300
    • Mobasheri, A.1    Neama, G.2    Bell, S.3    Richardson, S.4    Carter, S.D.5
  • 52
    • 18644371961 scopus 로고    scopus 로고
    • Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis
    • Mobasheri, A., Vannucci, S. J., Bondy, C. A., Carter, S. D., Innes, J. F., Arteaga, M. F., et al. (2002c). Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis. Histol. Histopathol. 17, 1239-1267.
    • (2002) Histol. Histopathol. , vol.17 , pp. 1239-1267
    • Mobasheri, A.1    Vannucci, S.J.2    Bondy, C.A.3    Carter, S.D.4    Innes, J.F.5    Arteaga, M.F.6
  • 53
    • 23944493709 scopus 로고    scopus 로고
    • Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondro-cytes in ovine articular cartilage
    • Mobasheri, A., Dobson, H., Mason, S. L., Cullingham, F., Shakibaei, M., Moley, J. F., et al. (2005). Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondro-cytes in ovine articular cartilage. Cell Biol. Int. 29, 249-260.
    • (2005) Cell Biol. Int. , vol.29 , pp. 249-260
    • Mobasheri, A.1    Dobson, H.2    Mason, S.L.3    Cullingham, F.4    Shakibaei, M.5    Moley, J.F.6
  • 54
    • 33947584687 scopus 로고    scopus 로고
    • Regulation of 2-deoxy-D-glucose transport, lactate metabolism, andMMP-2secretionby the hypoxia mimetic cobalt chloride in articular chondrocytes
    • Mobasheri, A., Platt, N., Thorpe, C., and Shakibaei, M. (2006a). Regulation of 2-deoxy-D-glucose transport, lactate metabolism, andMMP-2secretionby the hypoxia mimetic cobalt chloride in articular chondrocytes. Ann. N. Y. Acad. Sci. 1091, 83-93.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1091 , pp. 83-93
    • Mobasheri, A.1    Platt, N.2    Thorpe, C.3    Shakibaei, M.4
  • 55
    • 33745921754 scopus 로고    scopus 로고
    • Glucose sensing in chondrocytes via GLUT1 and GLUT3: implications for articular cartilage and intervertebral disc metabolism
    • Mobasheri, A., Shakibaei, M., Mobash-eri, R., Richardson, S. M., and Hoyland, J. A. (2006b). Glucose sensing in chondrocytes via GLUT1 and GLUT3: implications for articular cartilage and intervertebral disc metabolism. Curr. Rheumatol. Rev. 2, 109-121.
    • (2006) Curr. Rheumatol. Rev. , vol.2 , pp. 109-121
    • Mobasheri, A.1    Shakibaei, M.2    Mobash-eri, R.3    Richardson, S.M.4    Hoyland, J.A.5
  • 56
    • 0037432789 scopus 로고    scopus 로고
    • Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling
    • Moore, B., Zhou, L., Rolland, F., Hall, Q., Cheng, W. H., Liu, Y. X., et al. (2003). Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling. Science 300, 332-336.
    • (2003) Science , vol.300 , pp. 332-336
    • Moore, B.1    Zhou, L.2    Rolland, F.3    Hall, Q.4    Cheng, W.H.5    Liu, Y.X.6
  • 58
    • 0027483861 scopus 로고
    • Expression of facilitative glucose transporter isoforms in human brain tumors
    • Nagamatsu, S., Sawa, H., Wakizaka, A., and Hoshino, T. (1993). Expression of facilitative glucose transporter isoforms in human brain tumors. J. Neurochem. 61, 2048-2053.
    • (1993) J. Neurochem. , vol.61 , pp. 2048-2053
    • Nagamatsu, S.1    Sawa, H.2    Wakizaka, A.3    Hoshino, T.4
  • 59
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto, S., Fergusson, M. M., and Finkel, T. (2004). Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306, 2105-2108.
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 60
    • 79960155579 scopus 로고    scopus 로고
    • Regulation of glucose metabolism and the skeleton
    • Ng, K. W. (2011). Regulation of glucose metabolism and the skeleton. Clin. Endocrinol. (Oxf.) 75, 147-155.
    • (2011) Clin. Endocrinol. (Oxf.) , vol.75 , pp. 147-155
    • Ng, K.W.1
  • 61
    • 0034750409 scopus 로고    scopus 로고
    • Immunocy-tochemical demonstration of glucose transporters in epiphyseal growth plate chondrocytes of young rats in correlation with autoradiographic distribution of 2-deoxyglucose in chondrocytes of mice
    • Ohara, H., Tamayama, T., Maemura, K., Kanbara, K., Hayasaki, H., Abe, M., et al. (2001). Immunocy-tochemical demonstration of glucose transporters in epiphyseal growth plate chondrocytes of young rats in correlation with autoradiographic distribution of 2-deoxyglucose in chondrocytes of mice. Acta His-tochem. 103, 365-378.
    • (2001) Acta His-tochem , vol.103 , pp. 365-378
    • Ohara, H.1    Tamayama, T.2    Maemura, K.3    Kanbara, K.4    Hayasaki, H.5    Abe, M.6
  • 62
    • 0242582374 scopus 로고    scopus 로고
    • A novel type of chloro-plast stromal hexokinase is the major glucose-phosphorylating enzyme in the moss Physcomitrella patens
    • Olsson, T., Thelander, M., and Ronne, H. (2003). A novel type of chloro-plast stromal hexokinase is the major glucose-phosphorylating enzyme in the moss Physcomitrella patens. J. Biol. Chem. 278, 44439-44447.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44439-44447
    • Olsson, T.1    Thelander, M.2    Ronne, H.3
  • 63
    • 0025947255 scopus 로고
    • Basic cell metabolism of articular cartilage Manometric studies
    • Otte, P. (1991). Basic cell metabolism of articular cartilage. Manometric studies. Z. Rheumatol. 50, 304-312.
    • (1991) Z. Rheumatol. , vol.50 , pp. 304-312
    • Otte, P.1
  • 64
    • 63349105399 scopus 로고    scopus 로고
    • Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo
    • Peansukmanee, S., Vaughan-Thomas, A., Carter, S. D., Clegg, P. D., Taylor, S., Redmond, C., et al. (2009). Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo. J. Orthop. Res. 27, 529-535.
    • (2009) J. Orthop. Res. , vol.27 , pp. 529-535
    • Peansukmanee, S.1    Vaughan-Thomas, A.2    Carter, S.D.3    Clegg, P.D.4    Taylor, S.5    Redmond, C.6
  • 65
    • 14044268899 scopus 로고    scopus 로고
    • Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes
    • Phillips, T., Ferraz, I., Bell, S., Clegg, P. D., Carter, S. D., and Mobasheri, A. (2005). Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes. Vet. J. 169, 216-222.
    • (2005) Vet. J. , vol.169 , pp. 216-222
    • Phillips, T.1    Ferraz, I.2    Bell, S.3    Clegg, P.D.4    Carter, S.D.5    Mobasheri, A.6
  • 66
    • 77955871810 scopus 로고    scopus 로고
    • Gustation genetics: sweet gustducin! Chem
    • Reed, D. R., and Margolskee, R. F. (2010). Gustation genetics: sweet gustducin! Chem. Senses 35, 549-550.
    • (2010) Senses , vol.35 , pp. 549-550
    • Reed, D.R.1    Margolskee, R.F.2
  • 67
    • 72449180982 scopus 로고    scopus 로고
    • Sweet taste signaling functions as a hypothalamic glucose sensor
    • doi: 10.3389/neuro.07.012.2009
    • Ren, X., Zhou, L., Terwilliger, R., Newton, S. S., and de Araujo, I. E. (2009). Sweet taste signaling functions as a hypothalamic glucose sensor. Front. Integr. Neurosci. 3:12. doi: 10.3389/neuro.07.012.2009
    • (2009) Front. Integr. Neurosci. , vol.3 , pp. 12
    • Ren, X.1    Zhou, L.2    Terwilliger, R.3    Newton, S.S.4    de Araujo, I.E.5
  • 68
    • 0037321673 scopus 로고    scopus 로고
    • Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation
    • Richardson, S., Neama, G., Phillips, T., Bell, S., Carter, S. D., Moley, K. H., et al. (2003). Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage 11, 92-101.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 92-101
    • Richardson, S.1    Neama, G.2    Phillips, T.3    Bell, S.4    Carter, S.D.5    Moley, K.H.6
  • 69
    • 41049084437 scopus 로고    scopus 로고
    • Expression of glucose transporters GLUT-1, GLUT-3 GLUT-9 and HIF-1alpha in normal and degenerate human interverte-bral disc
    • Richardson, S. M., Knowles, R., Tyler, J., Mobasheri, A., and Hoyland, J. A. (2008). Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1alpha in normal and degenerate human interverte-bral disc. Histochem. Cell Biol. 129, 503-511.
    • (2008) Histochem. Cell Biol. , vol.129 , pp. 503-511
    • Richardson, S.M.1    Knowles, R.2    Tyler, J.3    Mobasheri, A.4    Hoyland, J.A.5
  • 70
    • 0036276818 scopus 로고    scopus 로고
    • Sugar sensing and signaling in plants
    • Rolland, F., Moore, B., and Sheen, J. (2002). Sugar sensing and signaling in plants. Plant Cell 14(Suppl.), S185-S205.
    • (2002) Plant Cell , vol.14 , Issue.SUPPL.
    • Rolland, F.1    Moore, B.2    Sheen, J.3
  • 71
    • 14644392199 scopus 로고    scopus 로고
    • Sugar sensing and signalling networks in plants
    • Rolland, F., and Sheen, J. (2005). Sugar sensing and signalling networks in plants. Biochem. Soc. Trans. 33, 269-271.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 269-271
    • Rolland, F.1    Sheen, J.2
  • 73
    • 67649439168 scopus 로고    scopus 로고
    • Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage
    • Rosa, S. C., Goncalves, J., Judas, F., Mobasheri, A., Lopes, C., and Mendes, A. F. (2009). Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Res. Ther. 11, R80.
    • (2009) Arthritis Res. Ther. , vol.11
    • Rosa, S.C.1    Goncalves, J.2    Judas, F.3    Mobasheri, A.4    Lopes, C.5    Mendes, A.F.6
  • 74
    • 80053207223 scopus 로고    scopus 로고
    • Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondro-cytes
    • Rosa, S. C., Rufino, A. T., Judas, F. M., Tenreiro, C. M., Lopes, M. C., and Mendes, A. F. (2011). Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondro-cytes. J. Cell. Biochem. 112, 2813- 2824.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 2813-2824
    • Rosa, S.C.1    Rufino, A.T.2    Judas, F.M.3    Tenreiro, C.M.4    Lopes, M.C.5    Mendes, A.F.6
  • 76
    • 77955034753 scopus 로고    scopus 로고
    • No bones about it: insulin modulates skeletal remodeling
    • Rosen, C. J., and Motyl, K. J. (2010). No bones about it: insulin modulates skeletal remodeling. Cell 142, 198-200.
    • (2010) Cell , vol.142 , pp. 198-200
    • Rosen, C.J.1    Motyl, K.J.2
  • 79
    • 33645130011 scopus 로고    scopus 로고
    • Glucose signaling in Saccharomyces cerevisiae
    • Santangelo, G. M. (2006). Glucose signaling in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 70, 253-282.
    • (2006) Microbiol. Mol. Biol. Rev. , vol.70 , pp. 253-282
    • Santangelo, G.M.1
  • 80
    • 0017722709 scopus 로고
    • Effect of ascorbic acid on arylsul-fatase activities and sulfated proteo-glycan metabolism in chondrocyte cultures
    • Schwartz, E. R., and Adamy, L. (1977). Effect of ascorbic acid on arylsul-fatase activities and sulfated proteo-glycan metabolism in chondrocyte cultures. J. Clin. Invest. 60, 96-106.
    • (1977) J. Clin. Invest. , vol.60 , pp. 96-106
    • Schwartz, E.R.1    Adamy, L.2
  • 81
    • 0019865016 scopus 로고
    • Experimentally induced osteoarthritis in guinea pigs: metabolic responses in articular cartilage to developing pathology
    • Schwartz, E. R., Oh, W. H., and Leveille, C. R. (1981). Experimentally induced osteoarthritis in guinea pigs: metabolic responses in articular cartilage to developing pathology. Arthritis Rheum. 24, 1345-1355.
    • (1981) Arthritis Rheum , vol.24 , pp. 1345-1355
    • Schwartz, E.R.1    Oh, W.H.2    Leveille, C.R.3
  • 82
    • 84862744882 scopus 로고    scopus 로고
    • The endocrine role of the skeleton: background and clinical evidence
    • Schwetz, V., Pieber, T., and Obermayer-Pietsch, B. (2012). The endocrine role of the skeleton: background and clinical evidence. Eur. J. Endocrinol. 166, 959-967.
    • (2012) Eur. J. Endocrinol. , vol.166 , pp. 959-967
    • Schwetz, V.1    Pieber, T.2    Obermayer-Pietsch, B.3
  • 85
    • 84874416791 scopus 로고    scopus 로고
    • "A matter of taste. Nutrient sensing through the plasma membrane of eukary-otic cells,"
    • held at the Royal Agricultural College, Cirences-ter, 25-29 September 2004, Biochemist
    • Shirazi-Beechey, S. P. (2005). "A matter of taste. Nutrient sensing through the plasma membrane of eukary-otic cells," in A Biochemical Society Focused Meeting, held at the Royal Agricultural College, Cirences-ter, 25-29 September 2004, Biochemist, 35-38.
    • (2005) A Biochemical Society Focused Meeting , pp. 35-38
    • Shirazi-Beechey, S.P.1
  • 86
    • 0025027463 scopus 로고
    • Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats
    • Tal, M., Schneider, D. L., Thorens, B., and Lodish, H. F. (1990). Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose. J. Clin. Invest. 86, 986-992.
    • (1990) Modulation by glucose. J. Clin. Invest. , vol.86 , pp. 986-992
    • Tal, M.1    Schneider, D.L.2    Thorens, B.3    Lodish, H.F.4
  • 87
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorp-tion by osteoclasts
    • Teitelbaum, S. L. (2000). Bone resorp-tion by osteoclasts. Science 289, 1504- 1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 88
    • 0032835137 scopus 로고    scopus 로고
    • Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccha-romyces cerevisiae
    • Thevelein, J. M., and de Winde, J. H. (1999). Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccha-romyces cerevisiae. Mol. Microbiol. 33, 904-918.
    • (1999) Mol. Microbiol. , vol.33 , pp. 904-918
    • Thevelein, J.M.1    De Winde, J.H.2
  • 89
    • 0029739378 scopus 로고    scopus 로고
    • Dexam-ethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter GLUT 1 in UMR 106-01, a clonal osteogenic sarcoma cell line
    • Thomas, D. M., Rogers, S. D., Ng, K. W., and Best, J. D. (1996). Dexam-ethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter GLUT 1 in UMR 106-01, a clonal osteogenic sarcoma cell line. J. Mol. Endocrinol. 17, 7-17.
    • (1996) J. Mol. Endocrinol. , vol.17 , pp. 7-17
    • Thomas, D.M.1    Rogers, S.D.2    Ng, K.W.3    Best, J.D.4
  • 90
    • 0029938022 scopus 로고    scopus 로고
    • Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes
    • Thorens, B. (1996). Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am. J. Physiol. 270, G541-G553.
    • (1996) Am. J. Physiol. , vol.270
    • Thorens, B.1
  • 91
    • 0025087552 scopus 로고
    • Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells
    • Thorens, B., Cheng, Z. Q., Brown, D., and Lodish, H. F. (1990). Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells. Am. J. Physiol. 259, C279-C285.
    • (1990) Am. J. Physiol. , vol.259
    • Thorens, B.1    Cheng, Z.Q.2    Brown, D.3    Lodish, H.F.4
  • 93
    • 1242317693 scopus 로고    scopus 로고
    • The SLC2 family of facilitated hex-ose and polyol transporters
    • Uldry, M., and Thorens, B. (2004). The SLC2 family of facilitated hex-ose and polyol transporters. Pflugers Arch. 447, 480-489.
    • (2004) Pflugers Arch , vol.447 , pp. 480-489
    • Uldry, M.1    Thorens, B.2
  • 94
    • 0346493196 scopus 로고    scopus 로고
    • Nutrigenomics: exploiting systems biology in the nutrition and health arenas
    • van Ommen, B. (2004). Nutrigenomics: exploiting systems biology in the nutrition and health arenas. Nutrition 20, 4-8.
    • (2004) Nutrition , vol.20 , pp. 4-8
    • Van Ommen, B.1
  • 95
    • 0036812118 scopus 로고    scopus 로고
    • Nutrigenomics: exploiting systems biology in the nutrition and health arena
    • van Ommen, B., and Stierum, R. (2002). Nutrigenomics: exploiting systems biology in the nutrition and health arena. Curr. Opin. Biotechnol. 13, 517-521.
    • (2002) Curr. Opin. Biotechnol. , vol.13 , pp. 517-521
    • Van Ommen, B.1    Stierum, R.2
  • 96
    • 0028807135 scopus 로고
    • A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice
    • Waeber, G., Pedrazzini, T., Bonny, O., Bonny, C., Steinmann, M., Nicod, P., et al. (1995). A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice. Mol. Cell. Endocrinol. 114, 205-215.
    • (1995) Mol. Cell. Endocrinol. , vol.114 , pp. 205-215
    • Waeber, G.1    Pedrazzini, T.2    Bonny, O.3    Bonny, C.4    Steinmann, M.5    Nicod, P.6
  • 97
    • 43149104735 scopus 로고    scopus 로고
    • High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis
    • Wittrant, Y., Gorin, Y., Woodruff, K., Horn, D., Abboud, H. E., Mohan, S., et al. (2008). High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis. Bone 42, 1122- 1130.
    • (2008) Bone , vol.42 , pp. 1122-1130
    • Wittrant, Y.1    Gorin, Y.2    Woodruff, K.3    Horn, D.4    Abboud, H.E.5    Mohan, S.6
  • 98
    • 43449084959 scopus 로고    scopus 로고
    • Energy regulation by the skeleton
    • Wolf, G. (2008). Energy regulation by the skeleton. Nutr. Rev. 66, 229-233.
    • (2008) Nutr. Rev. , vol.66 , pp. 229-233
    • Wolf, G.1
  • 99
    • 0037267005 scopus 로고    scopus 로고
    • Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
    • Wood, I. S., and Trayhurn, P. (2003). Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br. J. Nutr. 89, 3-9.
    • (2003) Br. J. Nutr. , vol.89 , pp. 3-9
    • Wood, I.S.1    Trayhurn, P.2
  • 100
    • 0036939298 scopus 로고    scopus 로고
    • GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms
    • Wu, X., and Freeze, H. H. (2002). GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. Genomics 80, 553-557.
    • (2002) Genomics , vol.80 , pp. 553-557
    • Wu, X.1    Freeze, H.H.2
  • 101
    • 80051969818 scopus 로고    scopus 로고
    • Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism
    • Yoshikawa, Y., Kode, A., Xu, L., Mosialou, I., Silva, B. C., Ferron, M., et al. (2011). Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J. Bone Miner. Res. 26, 2012-2025.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 2012-2025
    • Yoshikawa, Y.1    Kode, A.2    Xu, L.3    Mosialou, I.4    Silva, B.C.5    Ferron, M.6
  • 102
    • 0030023026 scopus 로고    scopus 로고
    • Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers
    • Younes, M., Lechago, L. V., Somoano, J. R., Mosharaf, M., and Lechago, J. (1996). Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res. 56, 1164-1167.
    • (1996) Cancer Res , vol.56 , pp. 1164-1167
    • Younes, M.1    Lechago, L.V.2    Somoano, J.R.3    Mosharaf, M.4    Lechago, J.5
  • 103
    • 84857885423 scopus 로고    scopus 로고
    • T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts
    • Zee, T., Settembre, C., Levine, R. L., and Karsenty, G. (2012). T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts. Mol. Cell. Biol. 32, 1080- 1088.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 1080-1088
    • Zee, T.1    Settembre, C.2    Levine, R.L.3    Karsenty, G.4
  • 104
    • 77956228665 scopus 로고    scopus 로고
    • Metformin reverses the deleterious effects of high glucose on osteoblast function
    • Zhen, D., Chen, Y., and Tang, X. (2010). Metformin reverses the deleterious effects of high glucose on osteoblast function. J. Diabetes Complications 24, 334-344.
    • (2010) J. Diabetes Complications , vol.24 , pp. 334-344
    • Zhen, D.1    Chen, Y.2    Tang, X.3
  • 105
    • 78651284380 scopus 로고    scopus 로고
    • Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulinlike growth factor I
    • Zoidis, E., Ghirlanda-Keller, C., and Schmid, C. (2011). Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulinlike growth factor I. Mol. Cell. Biochem. 348, 33-42.
    • (2011) Mol. Cell. Biochem , vol.348 , pp. 33-42
    • Zoidis, E.1    Ghirlanda-Keller, C.2    Schmid, C.3


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