Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells

Journal of Controlled Release

Volumn 167, Issue 2, 2013, Pages 157-166

  Andries, Oliwia ^a   Filette, Marina De ^a   De Smedt, Stefaan C ^a   Demeester, Jo ^a   Poucke, Mario Van ^a   Peelman, Luc ^a   Sanders, Niek N ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Genetic vaccination; Innate immunity; mRNA; mRNA based vaccine; Pulmonary vaccination; TLR3

Indexed keywords

GENETIC VACCINATION; INNATE IMMUNITY; MRNA; PULMONARY VACCINATION; TLR3;

CELL DEATH; CELL SIGNALING; IMMUNE SYSTEM; VACCINES;

MOLECULAR BIOLOGY;

BETA INTERFERON; DRUG CARRIER; INTERLEUKIN 12; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; LUNG ALVEOLUS EPITHELIUM; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSLATION INITIATION; UPREGULATION; VACCINATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYTOKINES; DNA; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LIPOSOMES; LUCIFERASES; LUNG; MICE; MICE, INBRED BALB C; RNA, MESSENGER; TOLL-LIKE RECEPTOR 3; TRANSFECTION;

EID: 84874397293     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.033     Document Type: Article

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