MRNA induces RANTES production in trophoblast cells via TLR3 only when delivered intracellularly using lipid membrane encapsulation

Placenta

Volumn 32, Issue 7, 2011, Pages 500-505

  Nakada, E ^a,b   Nakada, T A ^a   Walley, K R ^a   McConechy, M ^a   McLaughlin, L ^a   Von Dadelszen, P ^c   Shozu, M ^b   Boyd, J H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Inflammation; RNA; Toll like receptor; Trophoblast

Indexed keywords

BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; MESSENGER RNA; RANTES; TOLL LIKE RECEPTOR 3;

ARTICLE; CELL LINE; CONTROLLED STUDY; ENCAPSULATION; ENZYME ACTIVITY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; PRIORITY JOURNAL; RNA CAPPING; SIGNAL TRANSDUCTION; TROPHOBLAST;

CELL LINE; CHEMOKINE CCL5; HUMANS; INTERFERON REGULATORY FACTORS; INTERFERON-BETA; LIPOSOMES; MALE; NF-KAPPA B; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TROPHOBLASTS;

EID: 79958178407     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2011.04.011     Document Type: Article

References (38)

1. I. Guleria, and J.W. Pollard The trophoblast is a component of the innate immune system during pregnancy Nat Med 6 5 2000 589 593 (Pubitemid 30305912)
2. S. Patni, L.P. Wynen, A.L. Seager, G. Morgan, J.O. White, and C.A. Thornton Expression and activity of Toll-like receptors 1-9 in the human term placenta and changes associated with labor at term Biol Reprod 80 2 2009 243 248
3. E. Nakada, K.R. Walley, T. Nakada, Y. Hu, P. von Dadelszen, and J.H. Boyd Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells Placenta 30 9 2009 774 779
4. V.M. Abrahams, and G. Mor Toll-like receptors and their role in the trophoblast Placenta 26 7 2005 540 547 (Pubitemid 40916306)
5. L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 Nature 413 6857 2001 732 738 (Pubitemid 33009951)
6. F. Brentano, O. Schorr, R.E. Gay, S. Gay, and D. Kyburz RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3 Arthritis Rheum 52 9 2005 2656 2665 (Pubitemid 41369093)
7. K.A. Cavassani, M. Ishii, H. Wen, M.A. Schaller, P.M. Lincoln, and N.W. Lukacs TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events J Exp Med 205 11 2008 2609 2621
8. K. Kariko, H. Ni, J. Capodici, M. Lamphier, and D. Weissman mRNA is an endogenous ligand for Toll-like receptor 3 J Biol Chem 279 13 2004 12542 12550 (Pubitemid 38445825)
9. K. Koga, I. Cardenas, P. Aldo, V.M. Abrahams, B. Peng, and S. Fill Activation of TLR3 in the trophoblast is associated with preterm delivery Am J Reprod Immunol 61 3 2009 196 212
10. J.H. Tinsley, V.L. Chiasson, A. Mahajan, K.J. Young, and B.M. Mitchell Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats Am J Hypertens 22 12 2009 1314 1319
11. A. Ablasser, F. Bauernfeind, G. Hartmann, E. Latz, K.A. Fitzgerald, and V. Hornung RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate Nat Immunol 10 10 2009 1065 1072
12. P.M. Barral, D. Sarkar, Z.Z. Su, G.N. Barber, R. DeSalle, and V.R. Racaniello Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity Pharmacol Ther 124 2 2009 219 234
13. C. Ding, and Y.M. Lo MALDI-TOF mass spectrometry for quantitative, specific, and sensitive analysis of DNA and RNA Ann N Y Acad Sci 1075 2006 282 287 (Pubitemid 44532795)
14. A. Farina, C.W. Chan, R.W. Chiu, N.B. Tsui, P. Carinci, and M. Concu Circulating corticotropin-releasing hormone mRNA in maternal plasma: relationship with gestational age and severity of preeclampsia Clin Chem 50 10 2004 1851 1854 (Pubitemid 39298025)
15. L.L. Poon, T.N. Leung, T.K. Lau, and Y.M. Lo Presence of fetal RNA in maternal plasma Clin Chem 46 11 2000 1832 1834
16. N.B. Tsui, S.S. Chim, R.W. Chiu, T.K. Lau, E.K. Ng, and T.N. Leung Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling J Med Genet 41 6 2004 461 467 (Pubitemid 38788044)
17. B.C. Wong, R.W. Chiu, N.B. Tsui, K.C. Chan, L.W. Chan, and T.K. Lau Circulating placental RNA in maternal plasma is associated with a preponderance of 5' mRNA fragments: implications for noninvasive prenatal diagnosis and monitoring Clin Chem 51 10 2005 1786 1795 (Pubitemid 41368168)
18. N.B. Tsui, E.K. Ng, and Y.M. Lo Stability of endogenous and added RNA in blood specimens, serum, and plasma Clin Chem 48 10 2002 1647 1653
19. J.M. Garcia, V. Garcia, C. Pena, G. Dominguez, J. Silva, and R. Diaz Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched RNA 14 7 2008 1424 1432 (Pubitemid 351872198)
20. V.M. Abrahams, I. Visintin, P.B. Aldo, S. Guller, R. Romero, and G. Mor A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells J Immunol 175 12 2005 8096 8104 (Pubitemid 41798372)
21. C.H. Graham, T.S. Hawley, R.G. Hawley, J.R. MacDougall, R.S. Kerbel, and N. Khoo Establishment and characterization of first trimester human trophoblast cells with extended lifespan Exp Cell Res 206 2 1993 204 211 (Pubitemid 23212937)
22. S. Akira, K. Takeda, and T. Kaisho Toll-like receptors: critical proteins linking innate and acquired immunity Nat Immunol 2 8 2001 675 680 (Pubitemid 32747155)
23. V.M. Abrahams, T.M. Schaefer, J.V. Fahey, I. Visintin, J.A. Wright, and P.B. Aldo Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I: C) Hum Reprod 21 9 2006 2432 2439 (Pubitemid 44530624)
24. M.M. Heung, N.B. Tsui, T.Y. Leung, T.K. Lau, Y.M. Lo, and R.W. Chiu Development of extraction protocols to improve the yield for fetal RNA in maternal plasma Prenat Diagn 29 3 2009 277 279
25. X. Cao New DNA-sensing pathway feeds RIG-I with RNA Nat Immunol 10 10 2009 1049 1051
26. M. Garcia, Z. Dogusan, F. Moore, S. Sato, G. Hartmann, and D.L. Eizirik Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells Biochim Biophys Acta 1793 11 2009 1768 1775
27. S. Hahn, and W. Holzgreve Fetal cells and cell-free fetal DNA in maternal blood: new insights into pre-eclampsia Hum Reprod Update 8 6 2002 501 508 (Pubitemid 35452777)
28. E.K. Ng, N.B. Tsui, T.K. Lau, T.N. Leung, R.W. Chiu, and N.S. Panesar mRNA of placental origin is readily detectable in maternal plasma Proc Natl Acad Sci U S A 100 8 2003 4748 4753 (Pubitemid 36457801)
29. C.W. Redman, and I.L. Sargent Placental debris, oxidative stress and pre-eclampsia Placenta 21 7 2000 597 602
30. M. Knight, C.W. Redman, E.A. Linton, and I.L. Sargent Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies Br J Obstet Gynaecol 105 6 1998 632 640 (Pubitemid 28293481)
31. X.Y. Zhong, S. Gebhardt, R. Hillermann, K.C. Tofa, W. Holzgreve, and S. Hahn Parallel assessment of circulatory fetal DNA and corticotropin-releasing hormone mRNA in early- and late-onset preeclampsia Clin Chem 51 9 2005 1730 1733 (Pubitemid 41233115)
32. Y. Purwosunu, A. Sekizawa, K. Koide, A. Farina, N. Wibowo, and G.H. Wiknjosastro Cell-free mRNA concentrations of plasminogen activator inhibitor-1 and tissue-type plasminogen activator are increased in the plasma of pregnant women with preeclampsia Clin Chem 53 3 2007 399 404 (Pubitemid 46447935)
33. Y. Purwosunu, A. Sekizawa, A. Farina, N. Wibowo, K. Koide, and S. Okazaki Evaluation of physiological alterations of the placenta through analysis of cell-free messenger ribonucleic acid concentrations of angiogenic factors Am J Obstet Gynecol 198 1 2008 124 e1-7
34. Y. Purwosunu, A. Sekizawa, S. Okazaki, A. Farina, N. Wibowo, and M. Nakamura Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasma Am J Obstet Gynecol 200 4 2009 386 e1-7
35. H.D. Halicka, E. Bedner, and Z. Darzynkiewicz Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis Exp Cell Res 260 2 2000 248 256
36. L. Myatt Role of placenta in preeclampsia Endocrine 19 1 2002 103 111 (Pubitemid 36106256)
37. C. Rusterholz, S. Hahn, and W. Holzgreve Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia Semin Immunopathol 29 2 2007 151 162 (Pubitemid 47596394)
38. K. Naruse, B.A. Innes, J.N. Bulmer, S.C. Robson, R.F. Searle, and G.E. Lash Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy J Reprod Immunol 86 2 2010 148 150