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Volumn 2, Issue OCT, 2011, Pages

Neurosteroids as neuromodulators in the treatment of anxiety disorders

Author keywords

Anxiety; GABAA receptor; Neurosteroids; Serotonin transporter; Sigma 1 receptor; TSPO

Indexed keywords


EID: 84874364455     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2011.00055     Document Type: Review
Times cited : (42)

References (113)
  • 1
    • 0027488935 scopus 로고
    • Participation of mitochon-drial diazepam binding inhibitor receptors in the anticonflict, anti-neophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives
    • Auta, J., Romeo, E., Kozikowski, A., Ma, D., Costa, E., and Guidotti, A. (1993). Participation of mitochon-drial diazepam binding inhibitor receptors in the anticonflict, anti-neophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives. J. Pharmacol. Exp. Ther. 265, 649-656.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 649-656
    • Auta, J.1    Romeo, E.2    Kozikowski, A.3    Ma, D.4    Costa, E.5    Guidotti, A.6
  • 2
    • 79952269149 scopus 로고    scopus 로고
    • Pharmacological treatment of generalized anxiety disorder
    • Baldwin,D. S.,Ajel,K. I.,and Garner,M. (2010). Pharmacological treatment of generalized anxiety disorder. Curr. Top. Behav. Neurosci. 2, 453-467.
    • (2010) Curr. Top. Behav. Neurosci. , vol.2 , pp. 453-467
    • Baldwin, D.S.1    Ajel, K.I.2    Garner, M.3
  • 3
    • 22544438690 scopus 로고    scopus 로고
    • Escitalopram in the treatment of generalized anxiety disorder
    • Baldwin, D. S., and Nair, R. V. (2005). Escitalopram in the treatment of generalized anxiety disorder. Expert Rev. Neurother. 5, 443-449.
    • (2005) Expert Rev. Neurother. , vol.5 , pp. 443-449
    • Baldwin, D.S.1    Nair, R.V.2
  • 4
    • 54949154218 scopus 로고    scopus 로고
    • WFSBP Task Force on Treatment Guidelines for Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disoders
    • Zohar, J., Hollander, E., Kasper, S., Möller, H. J., Bandelow, B., Allgu-lander, C., Ayuso-Gutierrez, J., Bald-win, D. S., Buenvicius, R., Cassano, G., Fineberg, N., Gabriels, L., Hind-march, I., Kaiya, H., Klein, D. F., Lader, M., Lecrubier, Y., Lépine, J. P., Liebowitz, M. R., Lopez-Ibor, J. J., Marazziti,D.,Miguel,E. C.,Oh,K. S., Preter, M., Rupprecht, R., Sato, M., Starcevic,V.,Stein,D. J.,van Amerin-gen, M., and Vega, J
    • Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Möller, H. J., WFSBP Task Force on Treatment Guidelines for Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disoders, Zohar, J., Hollander, E., Kasper, S., Möller, H. J., Bandelow, B., Allgu-lander, C., Ayuso-Gutierrez, J., Bald-win, D. S., Buenvicius, R., Cassano, G., Fineberg, N., Gabriels, L., Hind-march, I., Kaiya, H., Klein, D. F., Lader, M., Lecrubier, Y., Lépine, J. P., Liebowitz, M. R., Lopez-Ibor, J. J., Marazziti,D.,Miguel,E. C.,Oh,K. S., Preter, M., Rupprecht, R., Sato, M., Starcevic,V.,Stein,D. J.,van Amerin-gen, M., and Vega, J. (2008). World Federation of Societies of Biologi-cal Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety,obsessive-compulsive and post-traumatic stress disorders -first revision. World J. Biol. Psychi-atry 9, 248-312.
    • (2008) World J. Biol. Psychi-atry , vol.9 , pp. 248-312
    • Bandelow, B.1    Zohar, J.2    Hollander, E.3    Kasper, S.4    Möller, H.J.5
  • 5
    • 0033404703 scopus 로고    scopus 로고
    • Trabuc-chi, M., Purdy, R. H., Colombo, G., and Gessa, G. L
    • Barbaccia, M. L., Affricano, D., Trabuc-chi, M., Purdy, R. H., Colombo, G., and Gessa, G. L. (1999). Ethanol markedly increases GABAergic neu-rosteroids in alcohol preferring rats. Eur. J. Pharmacol. 384, R1-R2.
    • (1999) Eur. J. Pharmacol. , vol.384
    • Barbaccia, M.L.1    Affricano, D.2
  • 7
    • 77955415606 scopus 로고    scopus 로고
    • Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states
    • Batarseh, A., and Papadopoulos, V. (2010). Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol. Cell. Endocrinol. 327, 1-12.
    • (2010) Mol. Cell. Endocrinol. , vol.327 , pp. 1-12
    • Batarseh, A.1    Papadopoulos, V.2
  • 8
    • 0025645557 scopus 로고
    • Neurosteroids: a new brain func-tion? J
    • Baulieu, E. E., and Robel, P. (1990). Neurosteroids: a new brain func-tion? J. Steroid Biochem. Mol. Biol. 37, 395-403.
    • (1990) Steroid Biochem. Mol. Biol. , vol.37 , pp. 395-403
    • Baulieu, E.E.1    Robel, P.2
  • 10
    • 0024357291 scopus 로고
    • 5 alpha-pregnan-3 alpha 20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneu-rosomes
    • Belelli, D., and Gee, K. W. (1989). 5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneu-rosomes. Eur. J. Pharmacol. 167, 173-176.
    • (1989) Eur. J. Pharmacol. , vol.167 , pp. 173-176
    • Belelli, D.1    Gee, K.W.2
  • 11
    • 0025161662 scopus 로고
    • Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore com-plex
    • Belelli, D., Lan, N. C., and Gee, K. W. (1990). Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore com-plex. Neurosci. Biobehav. Rev. 14, 315-322.
    • (1990) Neurosci. Biobehav. Rev. , vol.14 , pp. 315-322
    • Belelli, D.1    Lan, N.C.2    Gee, K.W.3
  • 12
    • 0031045750 scopus 로고    scopus 로고
    • Effects of low and high doses of selective sigma ligands: fur-ther evidence suggesting the exis-tence of different subtypes of sigma receptors
    • Bergeron, R., and Debonnel, G. (1997). Effects of low and high doses of selective sigma ligands: fur-ther evidence suggesting the exis-tence of different subtypes of sigma receptors. Psychopharmacol-ogy (Berl.) 129, 215-224.
    • (1997) Psychopharmacol-ogy (Berl. ) , vol.129 , pp. 215-224
    • Bergeron, R.1    Debonnel, G.2
  • 13
    • 0027979053 scopus 로고
    • The cell surface progesterone receptor which stimu-lates calcium influx in human sperm is unlike the A ring reduced steroid site on the GABAA receptor/chloride channel
    • Blackmore, P. F., Im, W. B., and Bleas-dale, J. E. (1994). The cell surface progesterone receptor which stimu-lates calcium influx in human sperm is unlike the A ring reduced steroid site on the GABAA receptor/chloride channel. Mol. Cell. Endocrinol. 104, 237-243.
    • (1994) Mol. Cell. Endocrinol. , vol.104 , pp. 237-243
    • Blackmore, P.F.1    Im, W.B.2    Bleas-Dale, J.E.3
  • 15
    • 0037247185 scopus 로고    scopus 로고
    • Chronic fluoxetine induces opposite changes in G pro-tein coupling at pre and postsynap-tic 5-HT1A receptors in rat brain
    • Castro, M. E., Diaz,A., del Olmo, E., and Pazos, A. (2003). Chronic fluoxetine induces opposite changes in G pro-tein coupling at pre and postsynap-tic 5-HT1A receptors in rat brain. Neuropharmacology 44, 93-101.
    • (2003) Neuropharmacology , vol.44 , pp. 93-101
    • Castro, M.E.1    Diaz, A.2    del Olmo, E.3    Pazos, A.4
  • 18
    • 0033953033 scopus 로고    scopus 로고
    • Neurosteroids: biosynthesis and function of these novel neuro-modulators
    • doi:10.1006/frne.1999.0188
    • Compagnone, N. A., and Mellon, S. H. (2000). Neurosteroids: biosynthesis and function of these novel neuro-modulators. Front. Neuroendocrinol. 21:1. doi:10.1006/frne.1999.0188
    • (2000) Front. Neuroendocrinol. , vol.21 , Issue.1
    • Compagnone, N.A.1    Mellon, S.H.2
  • 19
    • 0014150508 scopus 로고
    • The biochemistry of affective disorders
    • Coppen,A. (1967). The biochemistry of affective disorders. Br. J. Psychiatry 113, 1237-1264.
    • (1967) Br. J. Psychiatry , vol.113 , pp. 1237-1264
    • Coppen, A.1
  • 21
    • 0029884812 scopus 로고    scopus 로고
    • Ben-zodiazepines on trials: a research strategy for their rehabilitation
    • Costa, E., and Guidotti, A. (1996). Ben-zodiazepines on trials: a research strategy for their rehabilitation. Trends Pharmacol. Sci. 17, 192-200.
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 192-200
    • Costa, E.1    Guidotti, A.2
  • 22
    • 77956009908 scopus 로고    scopus 로고
    • Serotonin: a regulator of neuronal morphology and circuitry
    • Daubert, E. A., and Condron, B. G. (2010). Serotonin: a regulator of neuronal morphology and circuitry. Trends Neurosci. 33, 424-434.
    • (2010) Trends Neurosci , vol.33 , pp. 424-434
    • Daubert, E.A.1    Condron, B.G.2
  • 24
    • 0032550157 scopus 로고    scopus 로고
    • Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake
    • El-Etr, M., Akwa, Y., Robel, P., and Baulieu, E. E. (1998). Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake. Brain Res. 790, 334-338.
    • (1998) Brain Res , vol.790 , pp. 334-338
    • El-Etr, M.1    Akwa, Y.2    Robel, P.3    Baulieu, E.E.4
  • 25
    • 0025113134 scopus 로고
    • Decreased density of benzodiazepine receptors in lymphocytes of anxious patients: reversal after chronic diazepam treatment
    • Ferrarese, C., Appollonio, I., Frigo, M., Perego, M., Piolti, R., Trabucchi, M., and Frattola, L. (1990). Decreased density of benzodiazepine receptors in lymphocytes of anxious patients: reversal after chronic diazepam treatment. Acta Psychiatr. Scand. 82, 169-173.
    • (1990) Acta Psychiatr. Scand. , vol.82 , pp. 169-173
    • Ferrarese, C.1    Appollonio, I.2    Frigo, M.3    Perego, M.4    Piolti, R.5    Trabucchi, M.6    Frattola, L.7
  • 26
    • 0028954029 scopus 로고
    • Neuroactive steroid sen-sitivity in withdrawal seizure-prone and resistant mice
    • Finn, D. A., Roberts, A. J., and Crabbe, J. C. (1995). Neuroactive steroid sen-sitivity in withdrawal seizure-prone and resistant mice. Alcohol. Clin. Exp. Res. 19, 410-415.
    • (1995) Alcohol. Clin. Exp. Res. , vol.19 , pp. 410-415
    • Finn, D.A.1    Roberts, A.J.2    Crabbe, J.C.3
  • 27
    • 0034490999 scopus 로고    scopus 로고
    • Estrous cycle and sex differences in per-formance on anxiety tasks coin-cide with increases in hippocam-pal progesterone and 3alpha
    • Frye, C. A., Petralia, S. M., and Rhodes, M. E. (2000). Estrous cycle and sex differences in per-formance on anxiety tasks coin-cide with increases in hippocam-pal progesterone and 3alpha,5alpha-THP. Pharmacol. Biochem. Behav. 67, 587-596.
    • (2000) Biochem. Behav. , vol.67 , pp. 587-596
    • Frye, C.A.1    Petralia, S.M.2    Rhodes, M.E.3
  • 29
    • 0023681634 scopus 로고
    • Steroid modulation of the chloride ionophore in rat brain: structure-activity require-ments, regional dependence and mechanism of action
    • Gee, K. W., Bolger, M. B., Brinton, R. E., Coirini, H., and McEwen, B. S. (1988). Steroid modulation of the chloride ionophore in rat brain: structure-activity require-ments, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 246, 803-812.
    • (1988) J. Pharmacol. Exp. Ther. , vol.246 , pp. 803-812
    • Gee, K.W.1    Bolger, M.B.2    Brinton, R.E.3    Coirini, H.4    McEwen, B.S.5
  • 30
    • 0033539661 scopus 로고    scopus 로고
    • Selective serotonin reup-take inhibitors directly alter activ-ity of neurosteroidogenic enzymes
    • Griffin, L. D., and Mellon, S. H. (1999). Selective serotonin reup-take inhibitors directly alter activ-ity of neurosteroidogenic enzymes. Proc. Natl. Acad. Sci. U.S.A. 96, 13512-13517.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 13512-13517
    • Griffin, L.D.1    Mellon, S.H.2
  • 31
    • 0035663937 scopus 로고    scopus 로고
    • The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders
    • Guidotti, A., Dong, E., Matsumoto, K., Pinna, G., Rasmusson, A. M., and Costa, E. (2001). The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res. Brain Res. Rev. 37, 110-115.
    • (2001) Brain Res. Brain Res. Rev , vol.37 , pp. 110-115
    • Guidotti, A.1    Dong, E.2    Matsumoto, K.3    Pinna, G.4    Rasmusson, A.M.5    Costa, E.6
  • 32
    • 0037184708 scopus 로고    scopus 로고
    • Allopregnanolone modu-lates spontaneous GABA release via presynaptic Cl-permeability in rat preoptic nerve terminals
    • Haage, D., Druzin, M., and Johansson, S. (2002). Allopregnanolone modu-lates spontaneous GABA release via presynaptic Cl-permeability in rat preoptic nerve terminals. Brain Res. 958, 405-413.
    • (2002) Brain Res , vol.958 , pp. 405-413
    • Haage, D.1    Druzin, M.2    Johansson, S.3
  • 33
    • 0025180755 scopus 로고
    • A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower mole-cular weight suggest a different sigma receptor form from that of guinea pig brain
    • Hellewell, S. B., and Bowen, W. D. (1990). A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower mole-cular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res. 527, 244-253.
    • (1990) Brain Res , vol.527 , pp. 244-253
    • Hellewell, S.B.1    Bowen, W.D.2
  • 34
    • 0037469488 scopus 로고    scopus 로고
    • Regulation of 5-HT1A receptor function in brain following agonist or antidepres-sant administration
    • Hensler, J. G. (2003). Regulation of 5-HT1A receptor function in brain following agonist or antidepres-sant administration. Life Sci. 72, 1665-1682.
    • (2003) Life Sci , vol.72 , pp. 1665-1682
    • Hensler, J.G.1
  • 36
    • 0029867876 scopus 로고    scopus 로고
    • (+)-SKF-10 047 and dextromethorphan ameliorate conditioned fear stress through the activation of phenytoin-regulated sigma 1 sites
    • Kamei, H., Kameyama, T., and Nabeshima, T. (1996). (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress through the activation of phenytoin-regulated sigma 1 sites. Eur. J. Pharmacol. 299, 21-28.
    • (1996) Eur. J. Pharmacol. , vol.299 , pp. 21-28
    • Kamei, H.1    Kameyama, T.2    Nabeshima, T.3
  • 37
    • 22544452738 scopus 로고    scopus 로고
    • Rethinking the dura-tion requirement for generalized anxiety disorder: evidence from the National Comorbidity Sur-vey Replication
    • Kessler, R. C., Brandenburg, N., Lane, M., Roy-Byrne, P., Stang, P. D., Stein, D. J., and Wittchen, H. U. (2005). Rethinking the dura-tion requirement for generalized anxiety disorder: evidence from the National Comorbidity Sur-vey Replication. Psychol. Med. 35, 1073-1082.
    • (2005) Psychol. Med. , vol.35 , pp. 1073-1082
    • Kessler, R.C.1    Brandenburg, N.2    Lane, M.3    Roy-Byrne, P.4    Stang, P.D.5    Stein, D.J.6    Wittchen, H.U.7
  • 38
    • 0034447177 scopus 로고    scopus 로고
    • The augmen-tation hypothesis for improvement of antidepressant therapy: is pin-dolol a suitable candidate for testing the ability of 5HT1A receptor antag-onists to enhance SSRI efficacy and onset latency? Mol
    • Kinney, G. G., Taber, M. T., and Gribkoff, V. K. (2000). The augmen-tation hypothesis for improvement of antidepressant therapy: is pin-dolol a suitable candidate for testing the ability of 5HT1A receptor antag-onists to enhance SSRI efficacy and onset latency? Mol. Neurobiol. 21, 137-152.
    • (2000) Neurobiol , vol.21 , pp. 137-152
    • Kinney, G.G.1    Taber, M.T.2    Gribkoff, V.K.3
  • 39
    • 39149102505 scopus 로고    scopus 로고
    • Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
    • Kita, A., and Furukawa, K. (2008). Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice. Pharmacol. Biochem. Behav. 89, 171-178.
    • (2008) Pharmacol. Biochem. Behav. , vol.89 , pp. 171-178
    • Kita, A.1    Furukawa, K.2
  • 40
    • 0028149787 scopus 로고
    • Anticonvul-sant activity of neurosteroids: cor-relation with g-aminobutyric acidis evoked chloride current potentia-tion
    • Kokate, T. G., Svensson, B. E., and Rogawski, M. A. (1994). Anticonvul-sant activity of neurosteroids: cor-relation with g-aminobutyric acidis evoked chloride current potentia-tion. J. Pharmacol. Exp. Ther. 270, 1223-1229.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 1223-1229
    • Kokate, T.G.1    Svensson, B.E.2    Rogawski, M.A.3
  • 41
    • 0025073860 scopus 로고
    • Peripheral-type benzodi-azepine receptors mediate translo-cation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells
    • Krueger, K. E., and Papadopoulos, V. (1990). Peripheral-type benzodi-azepine receptors mediate translo-cation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J. Biol. Chem. 265, 15015-15022.
    • (1990) J. Biol. Chem. , vol.265 , pp. 15015-15022
    • Krueger, K.E.1    Papadopoulos, V.2
  • 42
    • 67651033692 scopus 로고    scopus 로고
    • Sigma-1 receptors in major depres-sion and anxiety
    • Kulkarni, S. K., and Dhir, A. (2009). Sigma-1 receptors in major depres-sion and anxiety. Expert Rev. Neu-rother. 9, 91021-91034.
    • (2009) Expert Rev. Neu-rother. , vol.9 , pp. 91021-91034
    • Kulkarni, S.K.1    Dhir, A.2
  • 43
    • 66149161668 scopus 로고    scopus 로고
    • Pregnanolone sulfate pro-motes desensitization of activated NMDA receptors
    • Kussius, C. L., Kaur, N., and Popescu, G. K. (2009). Pregnanolone sulfate pro-motes desensitization of activated NMDA receptors. J. Neurosci. 29, 6819-6827.
    • (2009) J. Neurosci. , vol.29 , pp. 6819-6827
    • Kussius, C.L.1    Kaur, N.2    Popescu, G.K.3
  • 46
    • 0032706095 scopus 로고    scopus 로고
    • Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroen-docrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice
    • Li, Q., Wichems, C., Heils, A., Van De Kar, L. D., Lesch, K. P., and Mur-phy, D. L. (1999). Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroen-docrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. J. Pharmacol. Exp. Ther. 291, 999-1007.
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 999-1007
    • Li, Q.1    Wichems, C.2    Heils, A.3    Van De Kar, L.D.4    Lesch, K.P.5    Murphy, D.L.6
  • 47
    • 0037343950 scopus 로고    scopus 로고
    • Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice
    • Li, Q., Wichems, C. H., Ma, L., Van de Kar, L. D., Garcia, F., and Murphy, D. L. (2003). Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice. J. Neurochem. 84, 1256-1265.
    • (2003) J. Neurochem. , vol.84 , pp. 1256-1265
    • Li, Q.1    Wichems, C.H.2    Ma, L.3    Van de Kar, L.D.4    Garcia, F.5    Murphy, D.L.6
  • 48
    • 44649155158 scopus 로고    scopus 로고
    • Abuse and dependence lia-bility of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond
    • Licata, S. C., and Rowlett, J. K. (2008). Abuse and dependence lia-bility of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond. Pharmacol. Biochem. Behav. 90, 74-89.
    • (2008) Pharmacol. Biochem. Behav. , vol.90 , pp. 74-89
    • Licata, S.C.1    Rowlett, J.K.2
  • 49
    • 0037237412 scopus 로고    scopus 로고
    • The role of GABA in anxiety disorders
    • Lydiard, R. B. (2003). The role of GABA in anxiety disorders. J. Clin. Psychia-try 64, 21-27.
    • (2003) J. Clin. Psychia-try , vol.64 , pp. 21-27
    • Lydiard, R.B.1
  • 50
    • 0026509649 scopus 로고
    • Neurosteroids: endogenous bimodal modulators of GABA A receptors Mechanism of action and physiological signifi-cance
    • Majewska, M. D. (1992). Neurosteroids: endogenous bimodal modulators of GABA A receptors. Mechanism of action and physiological signifi-cance. Prog. Neurobiol. 38, 379-395.
    • (1992) Prog. Neurobiol. , vol.38 , pp. 379-395
    • Majewska, M.D.1
  • 51
    • 0022483382 scopus 로고
    • Steroid hor-mone metabolites are barbiturate-like modulators of the GABA recep-tor
    • Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., and Paul, S. M. (1986). Steroid hor-mone metabolites are barbiturate-like modulators of the GABA recep-tor. Science 232, 1004-1007.
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 53
    • 0017064976 scopus 로고
    • The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog
    • Martin, W. R., Eades, C. G., Thomp-son, J. A., Huppler, R. E., and Gilbert, P. E. (1976). The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197, 517-532.
    • (1976) J. Pharmacol. Exp. Ther. , vol.197 , pp. 517-532
    • Martin, W.R.1    Eades, C.G.2    Thomp-Son, J.A.3    Huppler, R.E.4    Gilbert, P.E.5
  • 54
    • 10344221595 scopus 로고    scopus 로고
    • Gene dose dependent alterations in extraneu-ronal serotonin but not dopamine in mice with reduced serotonin trans-porter expression
    • Mathews,T. A.,Fedele,D. E.,Coppelli,F. M., Avila, A. M., Murphy, D. L., and Andrews, A. M. (2004). Gene dose dependent alterations in extraneu-ronal serotonin but not dopamine in mice with reduced serotonin trans-porter expression. J. Neurosci. Meth-ods 140, 169-181.
    • (2004) J. Neurosci. Meth-ods , vol.140 , pp. 169-181
    • Mathews, T.A.1    Fedele, D.E.2    Coppelli, F.M.3    Avila, A.M.4    Murphy, D.L.5    Andrews, A.M.6
  • 55
    • 77149179753 scopus 로고    scopus 로고
    • Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibi-tion of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms
    • Mato, S., Vidal, R., Castro, E., Díaz, A., Pazos, A., and Valdizán, E. M. (2010). Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibi-tion of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms. Mol. Phar-macol. 77, 424-434.
    • (2010) Mol. Phar-macol. , vol.77 , pp. 424-434
    • Mato, S.1    Vidal, R.2    Castro, E.3    Díaz, A.4    Pazos, A.5    Valdizán, E.M.6
  • 56
    • 0030986689 scopus 로고    scopus 로고
    • SA4503, a novel cognitive enhancer with sigma1 receptor agonist prop-erties, facilitates NMDA receptor-dependent learning in mice
    • Maurice, T., and Privat, A. (1997). SA4503, a novel cognitive enhancer with sigma1 receptor agonist prop-erties, facilitates NMDA receptor-dependent learning in mice. Eur. J. Pharmacol. 328, 9-18.
    • (1997) Eur. J. Pharmacol. , vol.328 , pp. 9-18
    • Maurice, T.1    Privat, A.2
  • 57
    • 0027971029 scopus 로고
    • Pregnenolone and preg-nenolone sulfate, alone and with ethanol, in mice on the plus-maze
    • Melchior, C. L., and Ritzmann, R. F. (1994). Pregnenolone and preg-nenolone sulfate, alone and with ethanol, in mice on the plus-maze. Pharmacol. Biochem. Behav. 48, 893-897.
    • (1994) Pharmacol. Biochem. Behav. , vol.48 , pp. 893-897
    • Melchior, C.L.1    Ritzmann, R.F.2
  • 58
    • 0029007089 scopus 로고
    • Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus
    • Monnet, F. P., Mahé, V., Robel, P., and Baulieu, E. E. (1995). Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc. Natl. Acad. Sci. U.S.A. 92, 3774-3778.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 3774-3778
    • Monnet, F.P.1    Mahé, V.2    Robel, P.3    Baulieu, E.E.4
  • 59
    • 33244462381 scopus 로고    scopus 로고
    • The sigma1 protein as a tar-get for the non-genomic effects of neuro(active)steroids: molecu-lar, physiological, and behavioral aspects
    • Monnet, F. P., and Maurice, T. (2006). The sigma1 protein as a tar-get for the non-genomic effects of neuro(active)steroids: molecu-lar, physiological, and behavioral aspects. J. Pharmacol. Sci. 100, 93-118.
    • (2006) J. Pharmacol. Sci. , vol.100 , pp. 93-118
    • Monnet, F.P.1    Maurice, T.2
  • 60
    • 0141680728 scopus 로고    scopus 로고
    • A presynaptic action of the neu-rosteroid pregnenolone sulfate on GABAergic synaptic transmission
    • Mtchedlishvili, Z., and Kapur, J. (2003). A presynaptic action of the neu-rosteroid pregnenolone sulfate on GABAergic synaptic transmission. Mol. Pharmacol. 64, 857-864.
    • (2003) Mol. Pharmacol. , vol.64 , pp. 857-864
    • Mtchedlishvili, Z.1    Kapur, J.2
  • 61
    • 36048991556 scopus 로고    scopus 로고
    • Neu-roactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats
    • Naert, G., Maurice, T., Tapia-Arancibia, L., and Givalois, L. (2007). Neu-roactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats. Psychoneu-roendocrinology 32, 1062-1078.
    • (2007) Psychoneu-roendocrinology , vol.32 , pp. 1062-1078
    • Naert, G.1    Maurice, T.2    Tapia-Arancibia, L.3    Givalois, L.4
  • 62
    • 4644336231 scopus 로고    scopus 로고
    • The role of GABA in the pathophysiology and treatment of anxiety disorders
    • Nemeroff, C. B. (2003). The role of GABA in the pathophysiology and treatment of anxiety disorders. Psy-chopharmacol. Bull. 37, 133-146.
    • (2003) Psy-chopharmacol. Bull. , vol.37 , pp. 133-146
    • Nemeroff, C.B.1
  • 63
    • 77955060200 scopus 로고    scopus 로고
    • Cortical GABA, striatal dopamine and mid-brain serotonin as the key play-ers in compulsive and anxiety dis-orders -results from in vivo imaging studies
    • Nikolaus, S., Antke, C., Beu, M., and Müller, H. W. (2010). Cortical GABA, striatal dopamine and mid-brain serotonin as the key play-ers in compulsive and anxiety dis-orders -results from in vivo imaging studies. Rev. Neurosci. 21, 119-139.
    • (2010) Rev. Neurosci , vol.21 , pp. 119-139
    • Nikolaus, S.1    Antke, C.2    Beu, M.3    Müller, H.W.4
  • 64
    • 0034284671 scopus 로고    scopus 로고
    • Neurosteroids amelio-rate conditioned fear stress: an association with sigma receptors
    • Noda, Y., Kamei, H., Kamei, Y., Nagai, T., Nishida, M., and Nabeshima, T. (2000). Neurosteroids amelio-rate conditioned fear stress: an association with sigma receptors. Neuropsychopharmacology 23, 276-284.
    • (2000) Neuropsychopharmacology , vol.23 , pp. 276-284
    • Noda, Y.1    Kamei, H.2    Kamei, Y.3    Nagai, T.4    Nishida, M.5    Nabeshima, T.6
  • 65
    • 77749330369 scopus 로고    scopus 로고
    • Serotonin, genetic variability, behav-iour, and psychiatric disorders -a review
    • Nordquist, N., and Oreland, L. (2010). Serotonin, genetic variability, behav-iour, and psychiatric disorders -a review. Ups. J. Med. Sci. 115, 2-10.
    • (2010) Ups. J. Med. Sci. , vol.115 , pp. 2-10
    • Nordquist, N.1    Oreland, L.2
  • 66
    • 84055191672 scopus 로고    scopus 로고
    • TSPO (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile
    • doi: 10.1111/j.1365-2826.2011.02166.x [Epub ahead of print]
    • Nothdurfter, C., Rammes, G., Baghai, T. C., Schüle, C., Schumacher, M., Papadopoulos, V., and Rupprecht, R. (2011). TSPO (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile. J. Neu-roendocrinol. doi: 10.1111/j.1365-2826.2011.02166.x [Epub ahead of print].
    • (2011) J. Neu-roendocrinol.
    • Nothdurfter, C.1    Rammes, G.2    Baghai, T.C.3    Schüle, C.4    Schumacher, M.5    Papadopoulos, V.6    Rupprecht, R.7
  • 67
    • 0036903920 scopus 로고    scopus 로고
    • Gener-alized anxiety disorder: comorbid-ity, comparative biology and treat-ment
    • Nutt, D. J., Ballenger, J. C., Sheehan, D., and Wittchen, H. U. (2002). Gener-alized anxiety disorder: comorbid-ity, comparative biology and treat-ment. Int. J. Neuropsychopharmacol. 5, 315-325.
    • (2002) Int. J. Neuropsychopharmacol. , vol.5 , pp. 315-325
    • Nutt, D.J.1    Ballenger, J.C.2    Sheehan, D.3    Wittchen, H.U.4
  • 68
    • 0026579057 scopus 로고
    • Neuroactive steroids
    • Paul, S. M., and Purdy, R. H. (1992). Neuroactive steroids. FASEB J. 6, 2311-2322.
    • (1992) FASEB J , vol.6 , pp. 2311-2322
    • Paul, S.M.1    Purdy, R.H.2
  • 69
    • 0032969123 scopus 로고    scopus 로고
    • Modula-tion of steroidal levels by adrena-lectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice
    • Phan, V. L., Su, T. P., Privat, A., and Maurice, T. (1999). Modula-tion of steroidal levels by adrena-lectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice. Eur. J. Neurosci. 11, 2385-2396.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 2385-2396
    • Phan, V.L.1    Su, T.P.2    Privat, A.3    Maurice, T.4
  • 70
    • 1942501614 scopus 로고    scopus 로고
    • Fluoxetine and norfluoxe-tine stereospecifically facilitate pen-tobarbital sedation by increasing neurosteroids
    • Pinna, G., Costa, E., and Guidotti, A. (2004). Fluoxetine and norfluoxe-tine stereospecifically facilitate pen-tobarbital sedation by increasing neurosteroids. Proc. Natl. Acad. Sci. U.S.A. 101, 6222-6225.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 6222-6225
    • Pinna, G.1    Costa, E.2    Guidotti, A.3
  • 71
    • 33744504184 scopus 로고    scopus 로고
    • Fluoxetine and norfluoxe-tine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake
    • Pinna, G., Costa, E., and Guidotti, A. (2006). Fluoxetine and norfluoxe-tine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl.) 186, 362-372.
    • (2006) Psychopharmacology (Berl. ) , vol.186 , pp. 362-372
    • Pinna, G.1    Costa, E.2    Guidotti, A.3
  • 75
    • 77955302215 scopus 로고    scopus 로고
    • The pharmacologic treat-ment of anxiety disorders: a review of progress
    • Ravindran, L. N., and Stein, M. B. (2010). The pharmacologic treat-ment of anxiety disorders: a review of progress. J. Clin. Psychiatry 71, 839-854.
    • (2010) J. Clin. Psychiatry , vol.71 , pp. 839-854
    • Ravindran, L.N.1    Stein, M.B.2
  • 77
    • 78649361562 scopus 로고    scopus 로고
    • Neurosteroids: endogenous role in the human brain and therapeutic potentials. Prog
    • Reddy, D. S. (2010). Neurosteroids: endogenous role in the human brain and therapeutic potentials. Prog. Brain Res. 186, 113-137.
    • (2010) Brain Res , vol.186 , pp. 113-137
    • Reddy, D.S.1
  • 78
    • 0030896347 scopus 로고    scopus 로고
    • Differential anxiolytic effects of neu-rosteroids in the mirrored chamber behaviour test in mice
    • Reddy, D. S., and Kulkarni, S. K. (1997). Differential anxiolytic effects of neu-rosteroids in the mirrored chamber behaviour test in mice. Brain Res. 752, 61-71.
    • (1997) Brain Res , vol.752 , pp. 61-71
    • Reddy, D.S.1    Kulkarni, S.K.2
  • 79
    • 0033765025 scopus 로고    scopus 로고
    • Role of serotonergic and noradren-ergic systems in the pathophysiology of depression and anxiety disorders
    • Ressler,K. J.,and Nemeroff,C. B. (2000). Role of serotonergic and noradren-ergic systems in the pathophysiology of depression and anxiety disorders. Depress. Anxiety 12, 2-19.
    • (2000) Depress. Anxiety , vol.12 , pp. 2-19
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 81
    • 0026806389 scopus 로고
    • 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)
    • Romeo, E., Auta, J., Kozikowski, A. P., Ma, D., Papadopoulos, V., Puia, G., Costa, E., and Guidotti, A. (1992). 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J. Pharmacol. Exp. Ther. 262, 971-978.
    • (1992) J. Pharmacol. Exp. Ther , vol.262 , pp. 971-978
    • Romeo, E.1    Auta, J.2    Kozikowski, A.P.3    Ma, D.4    Papadopoulos, V.5    Puia, G.6    Costa, E.7    Guidotti, A.8
  • 85
    • 30844456191 scopus 로고    scopus 로고
    • GABA-based therapeu-tic approaches: GABAA receptor subtype functions
    • Rudolph, U., and Möhler, H. (2006). GABA-based therapeu-tic approaches: GABAA receptor subtype functions. Curr. Opin. Pharmacol. 6, 18-23.
    • (2006) Curr. Opin. Pharmacol. , vol.6 , pp. 18-23
    • Rudolph, U.1    Möhler, H.2
  • 86
    • 0033198566 scopus 로고    scopus 로고
    • Neuroactive steroids: mechanisms of action and neuropsychopharmaco-logical perspectives
    • Rupprecht, R., and Holsboer, F. (1999). Neuroactive steroids: mechanisms of action and neuropsychopharmaco-logical perspectives. Trends Neurosci. 22, 410-416.
    • (1999) Trends Neurosci , vol.22 , pp. 410-416
    • Rupprecht, R.1    Holsboer, F.2
  • 87
    • 0035225999 scopus 로고    scopus 로고
    • Neuroactive steroids in neuropsy-chopharmacology
    • Rupprecht, R., and Holsboer, F. (2001). Neuroactive steroids in neuropsy-chopharmacology. Int. Rev. Neuro-biol. 46, 461-477.
    • (2001) Int. Rev. Neuro-biol. , vol.46 , pp. 461-477
    • Rupprecht, R.1    Holsboer, F.2
  • 90
    • 0032800583 scopus 로고    scopus 로고
    • The dexamethasone/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness
    • Rybakowski, J. K., and Twar-dowska, K. (1999). The dexamethasone/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness. J. Psychiatr. Res. 33, 363-370.
    • (1999) J. Psychiatr. Res. , vol.33 , pp. 363-370
    • Rybakowski, J.K.1    Twar-Dowska, K.2
  • 91
    • 34247858960 scopus 로고    scopus 로고
    • GABA: homeostatic and pharmacological aspects. Prog
    • Schousboe, A., and Waagepetersen, H. S. (2007). GABA: homeostatic and pharmacological aspects. Prog. Brain Res. 160, 9-19.
    • (2007) Brain Res , vol.160 , pp. 9-19
    • Schousboe, A.1    Waagepetersen, H.S.2
  • 92
    • 0032908756 scopus 로고    scopus 로고
    • 2-Phenyl-imidazo[1 2-a]pyridine derivatives as ligands for peripheral benzodiazepine recep-tors: stimulation of neurosteroid synthesis and anticonflict action in rats
    • Serra, M., Madau, P., Chessa, M. F., Caddeo, M., Sanna, E., Trapani, G., Franco, M., Liso, G., Purdy, R. H., Barbaccia, M. L., and Biggio, G. (1999). 2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine recep-tors: stimulation of neurosteroid synthesis and anticonflict action in rats. Br. J. Pharmacol. 127, 177-187.
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 177-187
    • Serra, M.1    Madau, P.2    Chessa, M.F.3    Caddeo, M.4    Sanna, E.5    Trapani, G.6    Franco, M.7    Liso, G.8    Purdy, R.H.9    Barbaccia, M.L.10    Biggio, G.11
  • 93
    • 0032433519 scopus 로고    scopus 로고
    • Treatment of adjustment disorder with anxiety: efficacy and tolerance of etifoxine in a double-blind controlled study
    • Servant, D., Graziani, P. L., Moyse, D., and Parquet, P. J. (1998). Treatment of adjustment disorder with anxiety: efficacy and tolerance of etifoxine in a double-blind controlled study. Encephale 24, 569-574.
    • (1998) Encephale , vol.24 , pp. 569-574
    • Servant, D.1    Graziani, P.L.2    Moyse, D.3    Parquet, P.J.4
  • 94
    • 0026052215 scopus 로고
    • The clinical use of barbiturates in neurological disorders
    • Smith, M. C., and Riskin, B. J. (1991). The clinical use of barbiturates in neurological disorders. Drugs 42, 365-378.
    • (1991) Drugs , vol.42 , pp. 365-378
    • Smith, M.C.1    Riskin, B.J.2
  • 95
    • 0036231790 scopus 로고    scopus 로고
    • Withdrawal proper-ties of a neuroactive steroid: impli-cations for GABA(A) receptor gene regulation in the brain and anxiety behavior
    • Smith, S. S. (2002). Withdrawal proper-ties of a neuroactive steroid: impli-cations for GABA(A) receptor gene regulation in the brain and anxiety behavior. Steroids 67, 519-528.
    • (2002) Steroids , vol.67 , pp. 519-528
    • Smith, S.S.1
  • 96
    • 0029002285 scopus 로고
    • Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group
    • Steiner, M., Steinberg, S., Stewart, D., Carter, D., Berger, C., Reid, R., Grover, D., and Streiner, D. (1995). Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group. N. Engl. J. Med. 332, 1529-1534.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1529-1534
    • Steiner, M.1    Steinberg, S.2    Stewart, D.3    Carter, D.4    Berger, C.5    Reid, R.6    Grover, D.7    Streiner, D.8
  • 97
    • 0036357699 scopus 로고    scopus 로고
    • GABA A receptor modulatory neu-roactive steroid composition in panic disorder and during paroxe-tine treatment
    • Strohle, A., Romeo, E., di Michele, F., Pasini, A., Yassouridis, A., Hols-boer, F., and Rupprecht, R. (2002). GABA A receptor modulatory neu-roactive steroid composition in panic disorder and during paroxe-tine treatment. Am. J. Psychiatry 159, 145-147.
    • (2002) Am. J. Psychiatry , vol.159 , pp. 145-147
    • Strohle, A.1    Romeo, E.2    di Michele, F.3    Pasini, A.4    Yassouridis, A.5    Hols-Boer, F.6    Rupprecht, R.7
  • 98
    • 0037317122 scopus 로고    scopus 로고
    • Induced panic attacks shift GABA A type receptor modulatory neuroactive steroid composition in patients with panic disorder; preliminary results
    • Strohle, A., Romeo, E., di Michele, F., Pasini, A., Yassouridis, A., Hols-boer, F., and Rupprecht, R. (2003). Induced panic attacks shift GABA A type receptor modulatory neuroac-tive steroid composition in patients with panic disorder; preliminary results. Arch. Gen. Psychiatry 60, 161-168.
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 161-168
    • Strohle, A.1    Romeo, E.2    di Michele, F.3    Pasini, A.4    Yassouridis, A.5    Holsboer, F.6    Rupprecht, R.7
  • 99
    • 0034780517 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance
    • Strüder, H. K., and Weicker, H. (2001a). Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part I. Int. J. Sports Med. 22, 467-481.
    • (2001) Part I. Int. J. Sports Med. , vol.22 , pp. 467-481
    • Strüder, H.K.1    Weicker, H.2
  • 100
    • 0034779474 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the serotonergic system and its implications on mental and physi-cal performance
    • Strüder, H. K., and Weicker, H. (2001b). Physiology and pathophysiology of the serotonergic system and its implications on mental and physi-cal performance. Part II. Int. J. Sports Med. 22, 482-497.
    • (2001) Part II. Int. J. Sports Med. , vol.22 , pp. 482-497
    • Strüder, H.K.1    Weicker, H.2
  • 101
    • 0024281403 scopus 로고
    • Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems
    • Su, T. P., London, E. D., and Jaffe, J. H. (1988). Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science 240, 219-221.
    • (1988) Science , vol.240 , pp. 219-221
    • Su, T.P.1    London, E.D.2    Jaffe, J.H.3
  • 104
    • 70450214705 scopus 로고    scopus 로고
    • Translocator protein ligands as promising therapeutic tools for anxiety disorders
    • Taliani, S., Da Settimo, F., Da Pozzo, E., Chelli, B., and Martini, C. (2009). Translocator protein ligands as promising therapeutic tools for anxiety disorders. Curr. Med. Chem. 16, 3359-3380.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 3359-3380
    • Taliani, S.1    Da Settimo, F.2    Da Pozzo, E.3    Chelli, B.4    Martini, C.5
  • 105
    • 0037470175 scopus 로고    scopus 로고
    • 5-HT1A receptor knockout mouse as a genetic model of anxiety
    • Toth, M. (2003). 5-HT1A receptor knockout mouse as a genetic model of anxiety. Eur J Pharmacol. 463, 177-184.
    • (2003) Eur J Pharmacol , vol.463 , pp. 177-184
    • Toth, M.1
  • 106
    • 0029970863 scopus 로고    scopus 로고
    • Fluoxetine-elicited changes in brain neuros-teroid content measured by neg-ative ion mass fragmentography
    • Uzunov, D. P., Cooper, T. B., Costa, E., and Guidotti, A. (1996). Fluoxetine-elicited changes in brain neuros-teroid content measured by neg-ative ion mass fragmentography. Proc. Natl. Acad. Sci. U.S.A. 93, 12599-12604.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 12599-12604
    • Uzunov, D.P.1    Cooper, T.B.2    Costa, E.3    Guidotti, A.4
  • 107
    • 0032539862 scopus 로고    scopus 로고
    • Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxam-ine
    • Uzunova, V., Sheline, Y., Davis, J. M., Rasmusson, A., Uzunov, D. P., Costa, E., and Guidotti, A. (1998). Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxam-ine. Proc. Natl. Acad. Sci. U.S.A. 95, 3239-3244.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 3239-3244
    • Uzunova, V.1    Sheline, Y.2    Davis, J.M.3    Rasmusson, A.4    Uzunov, D.P.5    Costa, E.6    Guidotti, A.7
  • 109
    • 0037453204 scopus 로고    scopus 로고
    • 5-HT2A and 5-HT2C receptors and their atypi-cal regulation properties
    • van Oekelen, D., Luyten, W. H., and Leysen, J. E. (2003). 5-HT2A and 5-HT2C receptors and their atypi-cal regulation properties. Life Sci. 72, 2429-2449.
    • (2003) Life Sci , vol.72 , pp. 2429-2449
    • van Oekelen, D.1    Luyten, W.H.2    Leysen, J.E.3
  • 111
    • 4644254282 scopus 로고    scopus 로고
    • Effects of etifoxine on stress-induced hyperthermia, freezing behavior and colonic motor activation in rats
    • Verleye, M., and Gillardin, J. M. (2004). Effects of etifoxine on stress-induced hyperthermia, freezing behavior and colonic motor activation in rats. Physiol. Behav. 82, 891-897.
    • (2004) Physiol. Behav. , vol.82 , pp. 891-897
    • Verleye, M.1    Gillardin, J.M.2
  • 112
    • 67649807652 scopus 로고    scopus 로고
    • Recent advances in understanding and treating social anxiety disorder
    • Westenberg, H. G. (2009). Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 14, 24-33.
    • (2009) CNS Spectr , vol.14 , pp. 24-33
    • Westenberg, H.G.1
  • 113
    • 0027460680 scopus 로고
    • Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
    • Whitnall, M. H. (1993). Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Prog. Neurobiol. 40, 573-629.
    • (1993) Prog. Neurobiol. , vol.40 , pp. 573-629
    • Whitnall, M.H.1


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