Marked decrease of plasma neuroactive steroids during alcohol withdrawal

Clinical Neuropharmacology

Volumn 19, Issue 4, 1996, Pages 366-369

  Romeo, E ^a   Brancati, A ^a   De Lorenzo, A ^a   Fucci, P ^a   Furnari, C ^a   Pompili, E ^a   Sasso, G F ^b   Spalletta, G ^a   Troisi, A ^a   Pasini, A ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Alcohol; Anxiety; Depression; Steroids; Withdrawal

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; ALLOTETRAHYDRODEOXYCORTICOSTERONE; STEROID; TETRAHYDRODEOXYCORTICOSTERONE; UNCLASSIFIED DRUG;

ADULT; ALCOHOL WITHDRAWAL; ANXIETY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; HUMAN; MALE; PRIORITY JOURNAL; STEROID BLOOD LEVEL;

EID: 9344232788     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-199619040-00011     Document Type: Article

References (11)

1. Liskow BI, Ooodwin DW. Pharmacological treatment of alcohol intoxication, withdrawal and dependence: a critical review. J Stud Alcohol 1987;48:356-70.
2. A receptor subunit mRNAs in the rat cerebral cortex. Mol Phurmacol 1991;39:157-63.
3. Baulieu EE, Robel RJ. Neurosteroids: a new brain function? J Steroid Biochem Mol Biol 1990;37:395-403.
4. Paul SM, Purdy RH. Neuroactive steroids. FASEB J 1992;6:2311-22.
5. A receptors. Neuron 1990:4:759-65,
6. Romeo E, Cheney DL, Zivkovic I, Costa E, Guidotti A. Mitochondrial DBI receptor complex (MDRC) agonists antagonize dizocilpine amnesia: putative role for allopregnanolone. J Pharmacol Exp Ther 1994;270:89-96.
7. Campbell JS, Karavolas HJ. The kinetic mechanism of the hypothalamic progesterone 5α-reductase. J Steroid Biochem 1989;32:283-9.
8. Adinoff B, Martin PR, Bone GHA, et al. Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch Gen Psychiatry 1990;47:325-30.
9. Cronholm T, Borg S, Viestam-Rains M, Sjovall J. Metabolic profiles of steroids in urine of alcoholics after withdrawal. J Steroid Biochem Mol Biol 1994;49:101-5.
10. Freeman EW, Purdy RH, Coutifaris C, Rickels K, Paul SM. Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers. Neuroendocrinology 1993;58:478-84.
11. Devaud LL, Purdy RH, Morrow AL. The neurosteroid, 3-alpha-hydroxy-5-alpha-pregnan-20-one, protects against bicuculline-indiced seizures during ethanol withdrawal in rats. Alcohol Clin Exp Res 1995;19:350-5.