Ethanol markedly increases 'GABAergic' neurosteroids in alcohol-preferring rats

European Journal of Pharmacology

Volumn 384, Issue 2-3, 1999, Pages R1-

  Barbaccia, Maria Luisa ^a   Affricano, Daniela ^a   Trabucchi, Marco ^a   Purdy, Robert H ^b   Colombo, Giancarlo ^c   Agabio, Roberta ^d   Gessa, Gian Luigi ^c,d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c CNR   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Alcohol; Brain neurosteroid; Sardinian alcohol preferring (sP) and non preferring (sNP) rat

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; NEUROSTEROID;

ANIMAL MODEL; BRAIN CORTEX; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT SURVEY; STRAIN DIFFERENCE; TRANQUILIZING ACTIVITY;

EID: 0033404703     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00678-0     Document Type: Article

References (5)

1. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Concas A., Biggio G. The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations. Br. J. Pharmacol. 120:1997;1582-1588.
2. Colombo G. Ethanol drinking behaviour in Sardinian alcohol-preferring rats. Alcohol Alcohol. 32:1997;443-453.
3. Finn D.A., Phillips T.J., Okorn D.M., Chester J.A., Cunningham C.L. Rewarding effect of the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in mice. Pharmacol. Biochem. Behav. 56:1997;261-264.
4. A receptors in the acute and chronic effects of ethanol. Psychopharmacology. 139:1998;2-19.
5. A receptor function. Trends Pharmacol. Sci. 16:1995;295-303.