Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Okoh, Victor O ^a   Felty, Quentin ^a   Parkash, Jai ^a   Poppiti, Robert ^b   Roy, Deodutta ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYESTRADIOL; BMI1 PROTEIN; CATALASE; CATECHOL; CYCLIN DEPENDENT KINASE 1; CYCLINE; ESTRADIOL; NUCLEAR RESPIRATORY FACTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; 4-HYDROXYESTRADIOL; CATECHOL DERIVATIVE; CATECHOL ESTROGEN; CELL CYCLE PROTEIN; COLLAGEN; EBSELEN; FULVESTRANT; ORGANOSELENIUM DERIVATIVE; PYRROLE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER INVASION; CDC2 GENE; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MALIGNANT TRANSFORMATION; METABOLITE; MOUSE; NONHUMAN; NUCLEAR RESPIRATORY FACTOR 1 GENE; OXIDATION REDUCTION REACTION; PCNA GENE; PRC1 GENE; PROTEIN EXPRESSION; RNA INTERFERENCE; TUMOR VOLUME; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; CELL PROLIFERATION; CELL TRANSFORMATION; CFU COUNTING; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; MAMMARY GLAND; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; TUMOR INVASION;

ANIMALS; AZOLES; CATALASE; CATECHOLS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLLAGEN; COLONY-FORMING UNITS ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ESTRADIOL; ESTROGENS, CATECHOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY GLANDS, HUMAN; MICE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; ORGANOSELENIUM COMPOUNDS; OXIDATION-REDUCTION; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR;

EID: 84874340856     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054206     Document Type: Article

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