Estrogen exerts a spatial and temporal influence on reactive oxygen species generation that precedes calcium uptake in high-capacity mitochondria: Implications for rapid nongenomic signaling of cell growth

Biochemistry

Volumn 45, Issue 9, 2006, Pages 2872-2881

  Parkash, Jai ^a   Felty, Quentin ^a   Roy, Deodutta ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CATALYSIS; CELLS; CHEMICAL REACTIONS; COMMUNICATION SYSTEMS; GENES; OXYGEN; RUTHENIUM; SIGNAL SYSTEMS;

BREAST CANCER; CREB; ESTROGEN ACTIONS; FUNCTIONAL HETEROGENEITY; MITOCHONDRIA; NONGENOMIC SIGNALING; SPECIES GENERATION;

BIODIVERSITY;

CALCIUM; CHELATING AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; CYCLOSPORIN; ESTRADIOL; ESTROGEN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; OLIGOMYCIN; REACTIVE OXYGEN METABOLITE; RUTHENIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CALCIUM TRANSPORT; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN ACTIVITY; GENE TARGETING; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; CALCIUM; CELL PROLIFERATION; ENZYME INHIBITORS; ESTROGENS; FEMALE; HUMANS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 33644692043     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051855x     Document Type: Article

References (44)

1. Benten, W. P., Stephan, C., Lieberherr, M., and Wunderlich, F. (2001) Estradiol signaling via sequestrable surface receptors, Endocrinology 142, 1669-1677.
2. Guo, Z., Krucken, J., Benten, W. P., and Wunderlich, F. (2002) Estradiol-induced nongenomic calcium signaling regulates genotropic signaling in macrophages, J. Biol. Chem. 277, 7044-7050.
3. Felty, Q., and Roy, D. (2005) Estrogen, mitochondria, and growth of cancer and non-cancer cells, J. Carcinog. 4, 1.
4. 0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling, Oncogene 24, 4883-4893.
5. Felty, Q., Xiong, W. C., Sun, D., Sarkar, S., Singh, K. P., Parkash, J., and Roy, D. (2005) Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers, Biochemistry 44, 6900-6909.
6. Lu, K. P., and Means, A. R. (1993) Regulation of the cell cycle by calcium and calmodulin, Endocr. Rev. 14, 40-58.
7. Montero, M., Lobaton, C. D., Hernandez-Sanmiguel, E., Santodomingo, J., Vay, L., Moreno, A., and Alvarez, J. (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids, Biochem. J. 384, 19-24.
8. Gunter, T. E., Buntinas, L., Sparagna, G., Eliseev, R., and Gunter, K. (2000) Mitochondrial calcium transport: Mechanisms and functions, Cell Calcium 28, 285-296.
9. Morkuniene, R., Jekabsone, A., and Borutaite, V. (2002) Estrogens prevent calcium-induced release of cytochrome c from heart mitochondria, FEBS Lett. 521, 53-56.
10. 2+ efflux from synaptosomal mitochondria, Gen. Physiol. Biophys. 19, 59-71.
11. Nilsen, J., and Diaz, B. R. (2003) Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression, Proc. Natl. Acad. Sci. U.S.A. 100, 2842-2847.
12. 2+ uptake by estrogen receptor agonists and antagonists, Br. J. Pharmacol. 145, 862-871.
13. Roy, D., Parkash, J., and Narayan, S. (2005) Genetics and Bioenergetics of Mitochondria Influencing the Etiology and Pharmacology of Steroidal Hormones, Curr. Pharmacogenomics 2, 379-390.
14. i resulting in enhanced spatial interactions with calbindin-D28k protein, Int. J. Mol. Med. 13, 3-11.
15. DuMond, J. W., Jr., Singh, K. P., and Roy, D. (2001) The biphasic stimulation of proliferation of Leydig cells by estrogen exposure, Int. J. Oncol. 18, 623-628.
16. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R. (1990) New colorimetric cytotoxicity assay for anticancer-drug screening, J. Natl. Cancer Inst. 82, 1107-1112.
17. Huang, S. G. (2002) Development of a high throughput screening assay for mitochondrial membrane potential in living cells, J. Biomol. Screening 7, 383-389.
18. Starkov, A. A., Chinopoulos, C., and Fiskum, G. (2004) Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury, Cell Calcium 36, 257-264.
19. Minta, A., Kao, J. P., and Tsien, R. Y. (1989) Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores, J. Biol. Chem. 264, 8171-8178.
20. 2+ waves in rat cortical astrocytes, J. Cell Biol. 145, 795-808.
21. 2+ uptake by estrogen receptor agonists and antagonists, Br. J. Pharmacol. 145, 862-871.
22. 2+] in human breast cancer cells, Anticancer Res. 17, 1167-1174.
23. Zhang, W., Couldwell, W. T., Song, H., Takano, T., Lin, J. H., and Nedergaard, M. (2000) Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells, Cancer Res. 60, 5395-5400.
24. Schiff, R., Reddy, P., Ahotupa, M., Coronado-Heinsohn, E., Grim, M., Hilsenbeck, S. G., Lawrence, R., Deneke, S., Herrera, R., Chamness, G. C., Fuqua, S. A., Brown, P. H., and Osborne, C. K. (2000) Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo, J. Natl. Cancer Inst. 92, 1926-1934.
25. 2+ uptake by estrogen receptor agonists and antagonists, Br. J. Pharmacol.
26. Arteaga, E., Villaseca, P., Bianchi, M., Rojas, A., and Marshall, G. (2003) Raloxifene is a better antioxidant of low-density lipoprotein than estradiol or tamoxifen in postmenopausal women in vitro, Menopause 10, 142-146.
27. Hermenegildo, C., Garcia-Martinez, M. C., Tarin, J. J., and Cano, A. (2002) Inhibition of low-density lipoprotein oxidation by the pure antiestrogens ICI 182780 and EM-652 (SCH 57068), Menopause 9, 430-435.
28. Budd, S. L., and Nicholls, D. G. (1996) Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells, J. Neurochem. 67, 2282-2291.
29. Gear, A. R. (1974) Rhodamine 6G. A potent inhibitor of mitochondrial oxidative phosphorylation, J. Biol. Chem. 249, 3628-3637.
30. 2+ uptake by cyclosporin A, Br. J. Pharmacol. 141, 263-268.
31. Swift, L. M., and Sarvazyan, N. (2000) Localization of dichlorofluorescin in cardiac myocytes: Implications for assessment of oxidative stress, Am. J. Physiol. 278, H982-H990.
32. Pani, G., Colavitti, R., Bedogni, B., Anzevino, R., Borrello, S., and Galeotti, T. (2000) A redox signaling mechanism for density-dependent inhibition of cell growth, J. Biol. Chem. 275, 38891-38899.
33. 2+ signals, J. Biol. Chem. 276, 26411-26420.
34. Collins, T. J., Berridge, M. J., Lipp, P., and Bootman, M. D. (2002) Mitochondria are morphologically and functionally heterogeneous within cells, EMBO J. 21, 1616-1627.
35. 2+ dynamics in individual mitochondria in situ, Am. J. Physiol. 276, C1193-C1204.
36. 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria, Science 262, 744-747.
37. Renard, D. C., Seitz, M. B., and Thomas, A. P. (1992) Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes, Biochem. J. 284 (Part 2), 507-512.
38. 2+-ATPase, J. Biol. Chem. 271, 29205-29210.
39. Livingston, F. R., Lui, E. M., Loeb, G. A., and Forman, H. J. (1992) Sublethal oxidant stress induces a reversible increase in intracellular calcium dependent on NAD(P)H oxidation in rat alveolar macrophages, Arch. Biochem. Biophys. 299, 83-91.
40. DuMond, J. W., Jr., Singh, K. P., and Roy, D. (2001) Regulation of the growth of mouse Leydig cells by the inactive stereoisomer, 17α-estradiol: Lack of correlation between the elevated expression of ERα and difference in sensitivity to estradiol isomers, Oncol. Rep. 8, 899-902.
41. Welshons, W. V., Thayer, K. A., Judy, B. M., Taylor, J. A., Curran, E. M., and Vom Saal, F. S. (2003) Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity, Environ. Health Perspect. 111, 994-1006.
42. Roy, D., and Cai, Q. (2002) Estrogen, immunoactivation, gene damage, and development of breast, endometrial, ovarian, prostate, and testicular cancers, Recent Res. Dev. Steroid Biochem. Mol. Biol. 3, 1-32.
43. 2+ uptake by estrogen receptor agonists and antagonists, Br. J. Pharmacol.
44. Barbieri, R. L. (1992) Hormone treatment of endometriosis: The estrogen threshold hypothesis, Am. J. Obstet. Gynecol. 166, 740-745.