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Volumn 3, Issue , 2013, Pages

Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; LIGAND; PROOPIOMELANOCORTIN; TOLL LIKE RECEPTOR 2;

EID: 84874337419     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01254     Document Type: Article
Times cited : (34)

References (53)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira, S. & Takeda, K. Toll-like receptor signalling. Nat Rev Immunol 4, 499-511 (2004).
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • Jiang, D. et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11, 1173-1179 (2005).
    • (2005) Nat Med , vol.11 , pp. 1173-1179
    • Jiang, D.1
  • 3
    • 21344449546 scopus 로고    scopus 로고
    • The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis
    • Andreakos, E., Sacre, S., Foxwell, B. M. & Feldmann, M. The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Front Biosci 10, 2478-2488 (2005).
    • (2005) Front Biosci , vol.10 , pp. 2478-2488
    • Andreakos, E.1    Sacre, S.2    Foxwell, B.M.3    Feldmann, M.4
  • 4
    • 45949106077 scopus 로고    scopus 로고
    • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
    • Richard, K. L., Filali, M., Prefontaine, P. & Rivest, S. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci 28, 5784-5793 (2008).
    • (2008) J Neurosci , vol.28 , pp. 5784-5793
    • Richard, K.L.1    Filali, M.2    Prefontaine, P.3    Rivest, S.4
  • 5
    • 84859449180 scopus 로고    scopus 로고
    • Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation
    • Eguchi, K. et al. Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation. Cell Metab 15, 518-533 (2012).
    • (2012) Cell Metab , vol.15 , pp. 518-533
    • Eguchi, K.1
  • 6
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H. et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116, 3015-3025 (2006).
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1
  • 7
    • 33846610092 scopus 로고    scopus 로고
    • High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance
    • Murakami, K., Bujo, H., Unoki, H. & Saito, Y. High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance. Biochem Biophys Res Commun 354, 727-734 (2007).
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 727-734
    • Murakami, K.1    Bujo, H.2    Unoki, H.3    Saito, Y.4
  • 8
    • 34250169823 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    • Kim, F. et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100, 1589-1596 (2007).
    • (2007) Circ Res , vol.100 , pp. 1589-1596
    • Kim, F.1
  • 9
    • 2342435824 scopus 로고    scopus 로고
    • Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    • Lee, J. Y. et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem 279, 16971-16979 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 16971-16979
    • Lee, J.Y.1
  • 10
    • 44449110675 scopus 로고    scopus 로고
    • Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    • Davis, J. E., Gabler, N. K., Walker-Daniels, J. & Spurlock, M. E. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16, 1248-1255 (2008).
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1248-1255
    • Davis, J.E.1    Gabler, N.K.2    Walker-Daniels, J.3    Spurlock, M.E.4
  • 11
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo, D. M. et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56, 1986-1998 (2007).
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1
  • 12
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn, J. J. Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem 281, 26865-26875 (2006).
    • (2006) J Biol Chem , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 13
    • 57449083385 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
    • Caricilli, A. M. et al. Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol 199, 399-406 (2008).
    • (2008) J Endocrinol , vol.199 , pp. 399-406
    • Caricilli, A.M.1
  • 14
    • 56149100877 scopus 로고    scopus 로고
    • Toll-like receptor 4 restricts retinal progenitor cell proliferation
    • Shechter, R. et al. Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol 183, 393-400 (2008).
    • (2008) J Cell Biol , vol.183 , pp. 393-400
    • Shechter, R.1
  • 15
    • 34548358816 scopus 로고    scopus 로고
    • Toll-like receptors modulate adult hippocampal neurogenesis
    • Rolls, A. et al. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 9, 1081-1088 (2007).
    • (2007) Nat Cell Biol , vol.9 , pp. 1081-1088
    • Rolls, A.1
  • 16
    • 34548358822 scopus 로고    scopus 로고
    • Neural stem cells: Guardians of the brain
    • Martino, G. & Pluchino, S. Neural stem cells: guardians of the brain. Nat Cell Biol 9, 1031-1034 (2007).
    • (2007) Nat Cell Biol , vol.9 , pp. 1031-1034
    • Martino, G.1    Pluchino, S.2
  • 17
    • 33750333015 scopus 로고    scopus 로고
    • Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    • Ma, Y. et al. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol 175, 209-215 (2006).
    • (2006) J Cell Biol , vol.175 , pp. 209-215
    • Ma, Y.1
  • 18
    • 35348860696 scopus 로고    scopus 로고
    • Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    • Tang, S. C. et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104, 13798-13803 (2007).
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13798-13803
    • Tang, S.C.1
  • 19
    • 78650205054 scopus 로고    scopus 로고
    • Toll-like receptor 7 mediates pruritus
    • Liu, T., Xu, Z. Z., Park, C. K., Berta, T. & Ji, R. R. Toll-like receptor 7 mediates pruritus. Nat Neurosci 13, 1460-1462 (2010).
    • (2010) Nat Neurosci , vol.13 , pp. 1460-1462
    • Liu, T.1    Xu, Z.Z.2    Park, C.K.3    Berta, T.4    Ji, R.R.5
  • 20
    • 36348955676 scopus 로고    scopus 로고
    • Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals
    • Cameron, J. S. et al. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci 27, 13033-13041 (2007).
    • (2007) J Neurosci , vol.27 , pp. 13033-13041
    • Cameron, J.S.1
  • 21
    • 80052315340 scopus 로고    scopus 로고
    • Toll-like receptors in health and disease in the brain: Mechanisms and therapeutic potential
    • Hanke, M. L. & Kielian, T. Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond) 121, 367-387 (2011).
    • (2011) Clin Sci (Lond) , vol.121 , pp. 367-387
    • Hanke, M.L.1    Kielian, T.2
  • 22
    • 77649234691 scopus 로고    scopus 로고
    • Overview of toll-like receptors in the CNS
    • Kielian, T. Overview of toll-like receptors in the CNS. Curr Top Microbiol Immunol 336, 1-14 (2009).
    • (2009) Curr Top Microbiol Immunol , vol.336 , pp. 1-14
    • Kielian, T.1
  • 23
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang, X. et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73 (2008).
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 24
    • 79960117277 scopus 로고    scopus 로고
    • Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB
    • Purkayastha, S., Zhang, G. & Cai, D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB. Nat Med 17, 883-887 (2011).
    • (2011) Nat Med , vol.17 , pp. 883-887
    • Purkayastha, S.1    Zhang, G.2    Cai, D.3
  • 25
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • Kleinridders, A. et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10, 249-259 (2009).
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1
  • 26
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820 (2011).
    • (2011) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 27
    • 78650472774 scopus 로고    scopus 로고
    • Toll-like receptors: Linking inflammation to metabolism
    • Konner, A. C. & Bruning, J. C. Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol Metab (2011).
    • (2011) Trends Endocrinol Metab
    • Konner, A.C.1    Bruning, J.C.2
  • 29
    • 33747813597 scopus 로고    scopus 로고
    • Coordinate regulation of neuropeptide y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons
    • Titolo, D., Cai, F. & Belsham, D. D. Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons. Mol Endocrinol 20, 2080-2092 (2006).
    • (2006) Mol Endocrinol , vol.20 , pp. 2080-2092
    • Titolo, D.1    Cai, F.2    Belsham, D.D.3
  • 30
    • 34547204416 scopus 로고    scopus 로고
    • Adipokine gene expression in a novel hypothalamic neuronal cell line: Resistin-dependent regulation of fasting-induced adipose factor and SOCS-3
    • Brown, R., Imran, S. A., Belsham, D. D., Ur, E. & Wilkinson, M. Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3. Neuroendocrinology 85, 232-241 (2007).
    • (2007) Neuroendocrinology , vol.85 , pp. 232-241
    • Brown, R.1    Imran, S.A.2    Belsham, D.D.3    Ur, E.4    Wilkinson, M.5
  • 31
    • 27844478786 scopus 로고    scopus 로고
    • Regulation of lipid metabolism via angiopoietin-like proteins
    • Kersten, S. Regulation of lipid metabolism via angiopoietin-like proteins. Biochem Soc Trans 33, 1059-1062 (2005).
    • (2005) Biochem Soc Trans , vol.33 , pp. 1059-1062
    • Kersten, S.1
  • 32
    • 20944447890 scopus 로고    scopus 로고
    • Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    • Xu, A. et al. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci U S A 102, 6086-6091 (2005).
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6086-6091
    • Xu, A.1
  • 33
    • 78049283381 scopus 로고    scopus 로고
    • Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight
    • Kim, H. K. et al. Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes 59, 2772-2780 (2010).
    • (2010) Diabetes , vol.59 , pp. 2772-2780
    • Kim, H.K.1
  • 34
    • 0022189558 scopus 로고
    • Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product
    • Anderson, K. V., Bokla, L. & Nusslein-Volhard, C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42, 791-798 (1985).
    • (1985) Cell , vol.42 , pp. 791-798
    • Anderson, K.V.1    Bokla, L.2    Nusslein-Volhard, C.3
  • 35
    • 0030983153 scopus 로고    scopus 로고
    • Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila
    • Rose, D. et al. Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila. Development 124, 1561-1571 (1997).
    • (1997) Development , vol.124 , pp. 1561-1571
    • Rose, D.1
  • 36
    • 33645322938 scopus 로고    scopus 로고
    • Toll-like receptors in central nervous system glial inflammation and homeostasis
    • Kielian, T. Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res 83, 711-730 (2006).
    • (2006) J Neurosci Res , vol.83 , pp. 711-730
    • Kielian, T.1
  • 37
    • 58149380109 scopus 로고    scopus 로고
    • Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation
    • Lathia, J. D. et al. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci 28, 13978-13984 (2008).
    • (2008) J Neurosci , vol.28 , pp. 13978-13984
    • Lathia, J.D.1
  • 38
    • 84855174006 scopus 로고    scopus 로고
    • Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
    • Caricilli, A. M. et al. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol 9, e1001212 (2011).
    • (2011) PLoS Biol , vol.9
    • Caricilli, A.M.1
  • 39
    • 77952315676 scopus 로고    scopus 로고
    • Tlr2 is critical for diet-induced metabolic syndrome in a murine model
    • Himes, R. W. & Smith, C. W. Tlr2 is critical for diet-induced metabolic syndrome in a murine model. Faseb J 24, 731-739 (2010).
    • (2010) Faseb J , vol.24 , pp. 731-739
    • Himes, R.W.1    Smith, C.W.2
  • 40
    • 77955492173 scopus 로고    scopus 로고
    • Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
    • Ehses, J. A. et al. Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet. Diabetologia 53, 1795-1806 (2010).
    • (2010) Diabetologia , vol.53 , pp. 1795-1806
    • Ehses, J.A.1
  • 41
    • 0036152683 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop mature-onset obesity
    • Wallenius, V. et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8, 75-79 (2002).
    • (2002) Nat Med , vol.8 , pp. 75-79
    • Wallenius, V.1
  • 42
    • 33745009509 scopus 로고    scopus 로고
    • Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    • Netea, M. G. et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 12, 650-656 (2006).
    • (2006) Nat Med , vol.12 , pp. 650-656
    • Netea, M.G.1
  • 43
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • De Souza, C. T. et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146, 4192-4199 (2005).
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1
  • 44
    • 17844379953 scopus 로고    scopus 로고
    • Hypothalamic sensing of fatty acids
    • Lam, T. K., Schwartz, G. J. & Rossetti, L. Hypothalamic sensing of fatty acids. Nat Neurosci 8, 579-584 (2005).
    • (2005) Nat Neurosci , vol.8 , pp. 579-584
    • Lam, T.K.1    Schwartz, G.J.2    Rossetti, L.3
  • 45
    • 45749151055 scopus 로고    scopus 로고
    • Brain foods: The effects of nutrients on brain function
    • Gomez-Pinilla, F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 9, 568-578 (2008).
    • (2008) Nat Rev Neurosci , vol.9 , pp. 568-578
    • Gomez-Pinilla, F.1
  • 46
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin, M. S. et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082 (2007).
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1
  • 47
    • 79953304038 scopus 로고    scopus 로고
    • Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2
    • Ahangarani, R. R. et al. Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2. Mol Ther 19, 711-722 (2011).
    • (2011) Mol Ther , vol.19 , pp. 711-722
    • Ahangarani, R.R.1
  • 48
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-kappaB signaling pathways
    • Oeckinghaus, A., Hayden, M. S. & Ghosh, S. Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12, 695-708 (2011).
    • (2011) Nat Immunol , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 49
    • 10744224022 scopus 로고    scopus 로고
    • Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses
    • von Aulock, S. et al. Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun 72, 1828-1831 (2004).
    • (2004) Infect Immun , vol.72 , pp. 1828-1831
    • Von Aulock, S.1
  • 50
    • 0034891984 scopus 로고    scopus 로고
    • Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
    • Kang, T. J. & Chae, G. T. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol 31, 53-58 (2001).
    • (2001) FEMS Immunol Med Microbiol , vol.31 , pp. 53-58
    • Kang, T.J.1    Chae, G.T.2
  • 51
    • 84870057394 scopus 로고    scopus 로고
    • Elevated expression of the toll like receptors 2 and 4 in obese individuals: Its significance for obesity-induced inflammation
    • Ahmad, R. et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond) 9, 48 (2012).
    • (2012) J Inflamm (Lond) , vol.9 , pp. 48
    • Ahmad, R.1
  • 52
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung, S. et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20, 4106-4114 (2000).
    • (2000) Mol Cell Biol , vol.20 , pp. 4106-4114
    • Jung, S.1
  • 53
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • Shechter, R. et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 6, e1000113 (2009).
    • (2009) PLoS Med , vol.6
    • Shechter, R.1


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