-
1
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. & Takeda, K. Toll-like receptor signalling. Nat Rev Immunol 4, 499-511 (2004).
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
2
-
-
30744462300
-
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
-
Jiang, D. et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11, 1173-1179 (2005).
-
(2005)
Nat Med
, vol.11
, pp. 1173-1179
-
-
Jiang, D.1
-
3
-
-
21344449546
-
The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis
-
Andreakos, E., Sacre, S., Foxwell, B. M. & Feldmann, M. The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Front Biosci 10, 2478-2488 (2005).
-
(2005)
Front Biosci
, vol.10
, pp. 2478-2488
-
-
Andreakos, E.1
Sacre, S.2
Foxwell, B.M.3
Feldmann, M.4
-
4
-
-
45949106077
-
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
-
Richard, K. L., Filali, M., Prefontaine, P. & Rivest, S. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci 28, 5784-5793 (2008).
-
(2008)
J Neurosci
, vol.28
, pp. 5784-5793
-
-
Richard, K.L.1
Filali, M.2
Prefontaine, P.3
Rivest, S.4
-
5
-
-
84859449180
-
Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation
-
Eguchi, K. et al. Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation. Cell Metab 15, 518-533 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 518-533
-
-
Eguchi, K.1
-
6
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi, H. et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116, 3015-3025 (2006).
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
-
7
-
-
33846610092
-
High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance
-
Murakami, K., Bujo, H., Unoki, H. & Saito, Y. High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance. Biochem Biophys Res Commun 354, 727-734 (2007).
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 727-734
-
-
Murakami, K.1
Bujo, H.2
Unoki, H.3
Saito, Y.4
-
8
-
-
34250169823
-
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
-
Kim, F. et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100, 1589-1596 (2007).
-
(2007)
Circ Res
, vol.100
, pp. 1589-1596
-
-
Kim, F.1
-
9
-
-
2342435824
-
Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
-
Lee, J. Y. et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem 279, 16971-16979 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 16971-16979
-
-
Lee, J.Y.1
-
10
-
-
44449110675
-
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
-
Davis, J. E., Gabler, N. K., Walker-Daniels, J. & Spurlock, M. E. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16, 1248-1255 (2008).
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 1248-1255
-
-
Davis, J.E.1
Gabler, N.K.2
Walker-Daniels, J.3
Spurlock, M.E.4
-
11
-
-
34547602916
-
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo, D. M. et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56, 1986-1998 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
-
12
-
-
33748755008
-
Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
-
Senn, J. J. Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem 281, 26865-26875 (2006).
-
(2006)
J Biol Chem
, vol.281
, pp. 26865-26875
-
-
Senn, J.J.1
-
13
-
-
57449083385
-
Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
-
Caricilli, A. M. et al. Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol 199, 399-406 (2008).
-
(2008)
J Endocrinol
, vol.199
, pp. 399-406
-
-
Caricilli, A.M.1
-
14
-
-
56149100877
-
Toll-like receptor 4 restricts retinal progenitor cell proliferation
-
Shechter, R. et al. Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol 183, 393-400 (2008).
-
(2008)
J Cell Biol
, vol.183
, pp. 393-400
-
-
Shechter, R.1
-
15
-
-
34548358816
-
Toll-like receptors modulate adult hippocampal neurogenesis
-
Rolls, A. et al. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 9, 1081-1088 (2007).
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1081-1088
-
-
Rolls, A.1
-
16
-
-
34548358822
-
Neural stem cells: Guardians of the brain
-
Martino, G. & Pluchino, S. Neural stem cells: guardians of the brain. Nat Cell Biol 9, 1031-1034 (2007).
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1031-1034
-
-
Martino, G.1
Pluchino, S.2
-
17
-
-
33750333015
-
Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
-
Ma, Y. et al. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol 175, 209-215 (2006).
-
(2006)
J Cell Biol
, vol.175
, pp. 209-215
-
-
Ma, Y.1
-
18
-
-
35348860696
-
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
-
Tang, S. C. et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104, 13798-13803 (2007).
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 13798-13803
-
-
Tang, S.C.1
-
19
-
-
78650205054
-
Toll-like receptor 7 mediates pruritus
-
Liu, T., Xu, Z. Z., Park, C. K., Berta, T. & Ji, R. R. Toll-like receptor 7 mediates pruritus. Nat Neurosci 13, 1460-1462 (2010).
-
(2010)
Nat Neurosci
, vol.13
, pp. 1460-1462
-
-
Liu, T.1
Xu, Z.Z.2
Park, C.K.3
Berta, T.4
Ji, R.R.5
-
20
-
-
36348955676
-
Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals
-
Cameron, J. S. et al. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci 27, 13033-13041 (2007).
-
(2007)
J Neurosci
, vol.27
, pp. 13033-13041
-
-
Cameron, J.S.1
-
21
-
-
80052315340
-
Toll-like receptors in health and disease in the brain: Mechanisms and therapeutic potential
-
Hanke, M. L. & Kielian, T. Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond) 121, 367-387 (2011).
-
(2011)
Clin Sci (Lond)
, vol.121
, pp. 367-387
-
-
Hanke, M.L.1
Kielian, T.2
-
22
-
-
77649234691
-
Overview of toll-like receptors in the CNS
-
Kielian, T. Overview of toll-like receptors in the CNS. Curr Top Microbiol Immunol 336, 1-14 (2009).
-
(2009)
Curr Top Microbiol Immunol
, vol.336
, pp. 1-14
-
-
Kielian, T.1
-
23
-
-
52949096557
-
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang, X. et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73 (2008).
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
-
24
-
-
79960117277
-
Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB
-
Purkayastha, S., Zhang, G. & Cai, D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB. Nat Med 17, 883-887 (2011).
-
(2011)
Nat Med
, vol.17
, pp. 883-887
-
-
Purkayastha, S.1
Zhang, G.2
Cai, D.3
-
25
-
-
70349484212
-
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
-
Kleinridders, A. et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10, 249-259 (2009).
-
(2009)
Cell Metab
, vol.10
, pp. 249-259
-
-
Kleinridders, A.1
-
26
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820 (2011).
-
(2011)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
28
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz, M. W., Woods, S. C., Porte, D. Jr., Seeley, R. J. & Baskin, D. G. Central nervous system control of food intake. Nature 404, 661-671 (2000).
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte, Jr.D.3
Seeley, R.J.4
Baskin, D.G.5
-
29
-
-
33747813597
-
Coordinate regulation of neuropeptide y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons
-
Titolo, D., Cai, F. & Belsham, D. D. Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons. Mol Endocrinol 20, 2080-2092 (2006).
-
(2006)
Mol Endocrinol
, vol.20
, pp. 2080-2092
-
-
Titolo, D.1
Cai, F.2
Belsham, D.D.3
-
30
-
-
34547204416
-
Adipokine gene expression in a novel hypothalamic neuronal cell line: Resistin-dependent regulation of fasting-induced adipose factor and SOCS-3
-
Brown, R., Imran, S. A., Belsham, D. D., Ur, E. & Wilkinson, M. Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3. Neuroendocrinology 85, 232-241 (2007).
-
(2007)
Neuroendocrinology
, vol.85
, pp. 232-241
-
-
Brown, R.1
Imran, S.A.2
Belsham, D.D.3
Ur, E.4
Wilkinson, M.5
-
31
-
-
27844478786
-
Regulation of lipid metabolism via angiopoietin-like proteins
-
Kersten, S. Regulation of lipid metabolism via angiopoietin-like proteins. Biochem Soc Trans 33, 1059-1062 (2005).
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 1059-1062
-
-
Kersten, S.1
-
32
-
-
20944447890
-
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
-
Xu, A. et al. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci U S A 102, 6086-6091 (2005).
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6086-6091
-
-
Xu, A.1
-
33
-
-
78049283381
-
Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight
-
Kim, H. K. et al. Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes 59, 2772-2780 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 2772-2780
-
-
Kim, H.K.1
-
34
-
-
0022189558
-
Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product
-
Anderson, K. V., Bokla, L. & Nusslein-Volhard, C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42, 791-798 (1985).
-
(1985)
Cell
, vol.42
, pp. 791-798
-
-
Anderson, K.V.1
Bokla, L.2
Nusslein-Volhard, C.3
-
35
-
-
0030983153
-
Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila
-
Rose, D. et al. Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila. Development 124, 1561-1571 (1997).
-
(1997)
Development
, vol.124
, pp. 1561-1571
-
-
Rose, D.1
-
36
-
-
33645322938
-
Toll-like receptors in central nervous system glial inflammation and homeostasis
-
Kielian, T. Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res 83, 711-730 (2006).
-
(2006)
J Neurosci Res
, vol.83
, pp. 711-730
-
-
Kielian, T.1
-
37
-
-
58149380109
-
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation
-
Lathia, J. D. et al. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci 28, 13978-13984 (2008).
-
(2008)
J Neurosci
, vol.28
, pp. 13978-13984
-
-
Lathia, J.D.1
-
38
-
-
84855174006
-
Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
-
Caricilli, A. M. et al. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol 9, e1001212 (2011).
-
(2011)
PLoS Biol
, vol.9
-
-
Caricilli, A.M.1
-
39
-
-
77952315676
-
Tlr2 is critical for diet-induced metabolic syndrome in a murine model
-
Himes, R. W. & Smith, C. W. Tlr2 is critical for diet-induced metabolic syndrome in a murine model. Faseb J 24, 731-739 (2010).
-
(2010)
Faseb J
, vol.24
, pp. 731-739
-
-
Himes, R.W.1
Smith, C.W.2
-
40
-
-
77955492173
-
Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
-
Ehses, J. A. et al. Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet. Diabetologia 53, 1795-1806 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 1795-1806
-
-
Ehses, J.A.1
-
41
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius, V. et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8, 75-79 (2002).
-
(2002)
Nat Med
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
-
42
-
-
33745009509
-
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
-
Netea, M. G. et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 12, 650-656 (2006).
-
(2006)
Nat Med
, vol.12
, pp. 650-656
-
-
Netea, M.G.1
-
43
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
De Souza, C. T. et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146, 4192-4199 (2005).
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
De Souza, C.T.1
-
44
-
-
17844379953
-
Hypothalamic sensing of fatty acids
-
Lam, T. K., Schwartz, G. J. & Rossetti, L. Hypothalamic sensing of fatty acids. Nat Neurosci 8, 579-584 (2005).
-
(2005)
Nat Neurosci
, vol.8
, pp. 579-584
-
-
Lam, T.K.1
Schwartz, G.J.2
Rossetti, L.3
-
45
-
-
45749151055
-
Brain foods: The effects of nutrients on brain function
-
Gomez-Pinilla, F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 9, 568-578 (2008).
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 568-578
-
-
Gomez-Pinilla, F.1
-
46
-
-
34548608447
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
-
Jin, M. S. et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082 (2007).
-
(2007)
Cell
, vol.130
, pp. 1071-1082
-
-
Jin, M.S.1
-
47
-
-
79953304038
-
Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2
-
Ahangarani, R. R. et al. Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2. Mol Ther 19, 711-722 (2011).
-
(2011)
Mol Ther
, vol.19
, pp. 711-722
-
-
Ahangarani, R.R.1
-
48
-
-
80051987703
-
Crosstalk in NF-kappaB signaling pathways
-
Oeckinghaus, A., Hayden, M. S. & Ghosh, S. Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12, 695-708 (2011).
-
(2011)
Nat Immunol
, vol.12
, pp. 695-708
-
-
Oeckinghaus, A.1
Hayden, M.S.2
Ghosh, S.3
-
49
-
-
10744224022
-
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses
-
von Aulock, S. et al. Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun 72, 1828-1831 (2004).
-
(2004)
Infect Immun
, vol.72
, pp. 1828-1831
-
-
Von Aulock, S.1
-
50
-
-
0034891984
-
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
-
Kang, T. J. & Chae, G. T. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol 31, 53-58 (2001).
-
(2001)
FEMS Immunol Med Microbiol
, vol.31
, pp. 53-58
-
-
Kang, T.J.1
Chae, G.T.2
-
51
-
-
84870057394
-
Elevated expression of the toll like receptors 2 and 4 in obese individuals: Its significance for obesity-induced inflammation
-
Ahmad, R. et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond) 9, 48 (2012).
-
(2012)
J Inflamm (Lond)
, vol.9
, pp. 48
-
-
Ahmad, R.1
-
52
-
-
0034028817
-
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
-
Jung, S. et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20, 4106-4114 (2000).
-
(2000)
Mol Cell Biol
, vol.20
, pp. 4106-4114
-
-
Jung, S.1
-
53
-
-
68049143269
-
Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
-
Shechter, R. et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 6, e1000113 (2009).
-
(2009)
PLoS Med
, vol.6
-
-
Shechter, R.1
|