Metabolic specialization of mouse embryonic stem cells

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 76, Issue , 2011, Pages 183-193

  Wang, J ^a   Alexander, P ^a   McKnight, S L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; GLUCOSE 6 PHOSPHATE; HYDROXYSTEROID DEHYDROGENASE; LACTATE DEHYDROGENASE; TISSUE CULTURE MEDIUM; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A; CARBON; GLYCINE; OXIDOREDUCTASE; QUINAZOLINE DERIVATIVE; QUINAZOLINECARBOXAMIDE; RADICAL; THREONINE; THREONINE DEHYDROGENASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CARBON METABOLISM; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL METABOLISM; CELL SPECIFICITY; CONCENTRATION (PARAMETERS); DNA SYNTHESIS; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; GENE EXPRESSION; HELA CELL; HIGH THROUGHPUT SCREENING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PURINE SYNTHESIS; ANIMAL CELL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; EMBRYOID BODY; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; METABOLITE; MOUSE; MOUSE EMBRYONIC STEM CELL; NUTRITIONAL STATUS;

ACETYL COENZYME A; ALCOHOL OXIDOREDUCTASES; AMINO ACIDS; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYOID BODIES; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; HELA CELLS; HUMANS; MICE; NIH 3T3 CELLS; RIBONUCLEOTIDES; THREONINE;

EID: 84867414365     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2011.76.010835     Document Type: Article

References (14)

1. Alexander P, Wang J, McKnight SL. 2011. Targeted killing of a cell based upon its specialized metabolic state. Proc Natl Acad Sci 108: 15828-15833.
2. Almaas E, Kovacs B, Vicsek T, Oltvai ZN, Barabasi AL. 2004. Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 427: 839-843.
3. Dale RA. 1978. Catabolism of threonine in mammals by coupling of L-threonine 3-dehydrogenase with 2-amino-3-oxobutyrate-CoA ligase. Biochim Biophys Acta 544: 496-503.
4. Dulbecco R, Freeman G. 1959. Plaque production by the polyoma virus. Virology 8: 396-397.
5. Edgar AJ. 2002. The human L-threonine 3-dehydrogenase gene is an expressed pseudogene. BMC Genet 3: 18.
6. Evans MJ, Kaufman MH. 1981. Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154-156.
7. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr. 2001. HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 292: 464-468.
8. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
9. Li CM, Klevecz RR. 2006. A rapid genome-scale response of the transcriptional oscillator to perturbation reveals a perioddoubling path to phenotypic change. Proc Natl Acad Sci 103: 16254-16259.
10. Martin GR. 1981. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci 78: 7634-7638.
11. Tu BP, Kudlicki A, Rowicka M, McKnight SL. 2005. Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes. Science 310: 1152-1158.
12. Tu BP, Mohler RE, Liu JC, Dombek KM, Young ET, Synovec RE, McKnight SL. 2007. Cyclic changes in metabolic state during the life of a yeast cell. Proc Natl Acad Sci 104: 16886-16891.
13. Wang GL, Jiang BH, Rue EA, Semenza GL. 1995. Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci 92: 5510-5514.
14. Wang J, Alexander P, Wu L, Hammer R, Cleaver O, McKnight SL. 2009. Dependence of mouse embryonic stem cells on threonine catabolism. Science 325: 435-439.