The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa

Journal of Biological Chemistry

Volumn 279, Issue 50, 2004, Pages 52593-52602

  Kimber, Matthew S ^a   Martin, Fernando ^a   Lu, Yingjie ^b   Houston, Simon ^a   Vedadi, Masoud ^a,c   Dharamsi, Akil ^a   Fiebig, Klaus M ^a   Schmid, Molly ^a   Rock, Charles O ^b  

^a Affinium Pharmaceuticals   (Canada)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOLOGICAL MEMBRANES; BIOSYNTHESIS; CATALYSIS; DEHYDRATION; DIMERS; DISEASES; FATTY ACIDS;

ELONGATION CYCLE; SUBSTRATE BINDING; TRIMERS;

ENZYMES;

3R HYDROXYACYL ACYL CARRIER PROTEIN; CARRIER PROTEIN; CIS 3 DECENOYL ACYL CARRIER PROTEIN; DIMER; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ARTICLE; CATALYSIS; DEHYDRATION; FATTY ACID SYNTHESIS; ISOMERIZATION; MEMBRANE FORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA, BACTERIAL; ELECTROSTATICS; ESCHERICHIA COLI; HYDRO-LYASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 10644295401     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M408105200     Document Type: Article

References (51)

1. Jackowski, S., and Rock, C. O. (2002) Biochem. Biophys. Res. Commun. 292, 1155-1166
2. Waller, R. F., Ralph, S. A., Reed, M. B., Su, V., Douglas, J. D., Minnikin, D. E., Cowman, A. F., Besra, G. S., and McFadden, G. I. (2003) Antimicrob. Agents Chemother. 47, 297-301
3. Harwood, J. L. (1996) Biochim. Biophys. Acta 1301, 7-56
4. Rock, C. O., and Cronan, J. E., Jr. (1996) Biochim. Biophys. Acta 1302, 1-16
5. Cronan, J. E., Jr., and Rock, C. O. (1996) in Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt, F. C., Curtis, R., Gross, C. A., Ingraham, J. L., Lin, E. C. C., Low, K. B., Magasanik, B., Reznikoff, W., Riley, M., Schaechter, M., and Umbarger, H. E., eds) pp. 612-636, American Society for Microbiology, Washington, D. C.
6. Smith, S., Witkowski, A., and Joshi, A. K. (2003) Prog. Lipid Res. 42, 289-317
7. Campbell, J. W., and Cronan, J. E., Jr. (2001) Annu. Rev. Microbiol. 55, 305-332
8. Heath, R. J., White, S. W., and Rock, C. O. (2001) Prog. Lipid Res. 40, 467-497
9. Price, A. C., Choi, K. H., Heath, R. J., Li, Z., Rock, C. O., and White, S. W. (2001) J. Biol Chem. 276, 6551-6559
10. Huang, W., Jia, J., Edwards, P., Dehesh, K., Schneider, G., and Lindqvist. Y. (1998) EMBO J. 17, 1183-1191
11. Price, A. C., Rock, C. O., and White, S. W. (2003) J. Bacteriol. 185, 4136-4143
12. Fisher, M., Kroon, J. T., Martindale, W., Stuitje, A. R., Slabas, A. R., and Rafferty, J. B. (2000) Structure 8, 339-347
13. Price, A. C., Zhang, Y.-M., Rock, C. O., and White, S. W. (2001) Biochemistry 40, 12772-12781
14. Price, A. C., Zhang, Y.-M., Rock, C. O., and White, S. W. (2004) Structure 12, 417-428
15. Leesong, M., Henderson, B. S., Gillig, J. R., Schwab, J. M., and Smith, J. L. (1996) Structure 4, 253-264
16. Baldock, C., Rafferty, J. B., Stuitje, A. R., Slabas, A. R., and Rice, D. W. (1998) J. Mol. Biol. 284, 1529-1546
17. Kass, L. R., and Bloch, K. (1967) Proc. Natl. Acad. Sci. U. S. A. 58, 1168-1173
18. Birge, C. H., Silbert, D. F., and Vagelos, P. R. (1967) Biochem. Biophys. Res. Commun. 26, 808-814
19. Kass, L. R., Brock, D. J. H., and Bloch, K. (1967) J. Biol. Chem. 242, 4418-4431
20. Silbert, D. F., and Vagelos, P. R. (1967) Proc. Natl. Acad. Sci. U. S. A. 58, 1579-1586
21. Rosenfeld, I. S., D'Agnolo, G., and Vagelos, P. R. (1973) J. Biol. Chem. 248, 2452-2460
22. Garwin, J. L., Klages, A. L., and Cronan, J. E., Jr. (1980) J. Biol. Chem. 255, 11949-11956
23. Garwin, J. L., Hages, A. L., and Cronan, J. E., Jr. (1980) J. Biol. Chem. 255, 3263-3265
24. de Mendoza, D., and Cronan, J. E., Jr. (1983) Trends Biochem. Sci. 8, 49-52
25. Mohan, S., Kelly, T. M., Eveland, S. S., Raetz, C. R. H., and Anderson, M. S. (1994) J. Biol. Chem. 269, 32896-32903
26. Heath, R. J., and Rock, C. O. (1996) J. Biol. Chem. 271, 27795-27801
27. Sharma, S. K., Kapoor, M., Ramya, T. N., Kumar, S., Kumar, G., Modak, R., Sharma, S., Surolia, N., and Surolia, A. (2003) J. Biol. Chem. 278, 45661-45671
28. Hoang, T. T., and Schweizer, H. P. (1997) J. Bacteriol. 179, 5326-5332
29. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
30. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
31. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
32. Levitt, D. G. (2001) Acta Crystallogr. D Biol. Crystallogr. 57, 1013-1019
33. Adams, P. D., Pannu, N. S., Read, R. J., and Brunger, A. T. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5018-5023
34. Choi, K.-H., Heath, R. J., and Rock, C. O. (2000) J. Bacteriol. 182, 365-370
35. Marrakchi, H., Choi, K.-H., and Rock, C. O. (2002) J. Biol. Chem. 277, 44809-44816
36. Choi, K.-H., Kremer, L., Besra, G. S., and Rock, C. O. (2000) J. Biol. Chem. 275, 28201-28207
37. Heath, R. J., and Rock, C. O. (1995) J. Biol. Chem. 270, 26538-26542
38. Heath, R. J., and Rock, C. O. (1996) J. Biol. Chem. 271, 10996-11000
39. Schujman, G. E., Choi, K.-H., Altabe, S., Rock, C. O., and de Mendoza, D. (2001) J. Bacteriol. 183, 3032-3040
40. Case, D. A., Pearlman, D. A., Caldwell, J. W., Cheatham, T. E., Wang, J., Ross, W. S., Simmerling, L., Darden, T. A., Merz, K. M., Jr., Stanton, R. V., Cheng, A. L., Vincent, J. J., Crowley, M., Tsui, V., Gohlke, H., Radmer, R. J., Duan, Y., Pitera, J., Massova, I., Seibel, G. L., Singh, U. C., Weiner, P. K., and Kollman, P. A. (2002) AMBER 7, University of California, San Francisco, CA
41. Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz, K. M., Jr., Ferguson, D. M., Spellmeyer, D. C., Fox, T., Caldwell, J. W., and Kollman, P. A. (1995) J. Am. Chem. Soc. 117, 5179-5197
42. Benning, M. M., Wesenberg, G., Liu, R., Taylor, K. L., Dunaway-Mariano, D., and Holden, H. M. (1998) J. Biol. Chem. 273, 33572-33579
43. Li, J., Derewenda, U., Dauter, Z., Smith, S., and Derewenda, Z. S. (2000) Nat. Struct. Biol. 7, 555-559
44. Lakshmi Swarna, M. P., Kumar, S. S., Kapoor, M., Surolia, N., Surolia, A., and Suguna, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 120-121
45. Kaplan, W., and Littlejohn, T. G. (2001) Brief Bioinform. 2, 195-197
46. Zhang, Y.-M., Rao, M. S., Heath, R. J., Price, A. C., Olson, A. J., Rock, C. O., and White, S. W. (2001) J. Biol. Chem. 276, 8231-8238
47. Zhang, Y.-M., Marrakchi, H., White, S. W., and Rock, C. O. (2003) J. Lipid Res. 44, 1-10
48. Zhang, Y.-M., Wu, B., Zheng, J., and Rock, C. O. (2003) J. Biol. Chem. 278, 52935-52943
49. Annand, R. R., Kozlowski, J. F., Davisson, V. J., and Schwab, J. M. (1993) J. Am. Chem. Soc. 115, 1088-1094
50. Wang, H., and Cronan, J. E. (2004) J. Biol. Chem. 279, 34489-34495
51. Christopher, J. A. (1998) SPOCK: The Structural Properties Observation and Calculation Kit, Texas A&M University, The Center for Macromolecular Design, College Station, Texas