Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 597-604

  Gao, Rui ^a   Liao, Sha ^b   Zhang, Chen ^a   Zhu, Weilong ^a   Wang, Liyan ^b   Huang, Jin ^b   Zhao, Zhenjiang ^b   Li, Honglin ^b   Qian, Xuhong ^a   Xu, Yufang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Benzenesulfonamides; Carbonic anhydrase inhibitors; Molecular docking; Structure activity relationship

Indexed keywords

3 [[4 (3 METHOXYPHENYL)PHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 3 [[4 (4 [TRIFLUOROMETHYL)PHENYL]PHTHALAZIN 1 YL]AMINO)BENZENESULFONAMIDE; 3 [[4 (4 CHLOROPHENYL)PHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 3 [[4 (4 METHOXYPHENYL)PHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 3 [[4 PHENYLPHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 (3 METHOXYPHENYL)PHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 (4 CHLOROPHENYL)PHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [4 (TRIFLUOROMETHYL)PHENYL]PHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 PHENYLPHTHALAZIN 1 YL]AMINO]BENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONIC ANHYDRASE IX INHIBITOR; LEAD; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84874009090     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.030     Document Type: Article

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