메뉴 건너뛰기




Volumn 43, Issue 2, 2013, Pages 131-138

Cannabinoid 1 receptor in fatty liver

Author keywords

Cannabinoid receptor CB1; Fatty liver; Hepatic steatosis; Non alcoholic fatty liver disease; Sterol regulatory element binding protein 1c

Indexed keywords

ACETYL COENZYME A ACETYLTRANSFERASE; ACTIVATING TRANSCRIPTION FACTOR 6; ADENYLATE CYCLASE; CANNABINOID; CANNABINOID 1 RECEPTOR; CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FATTY ACID; GLUCAGON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; RIMONABANT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84873954007     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2012.01085.x     Document Type: Review
Times cited : (15)

References (78)
  • 1
    • 17444417085 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. CMAJ 2005; 172 (7): 899-905.
    • (2005) CMAJ , vol.172 , Issue.7 , pp. 899-905
    • Adams, L.A.1    Angulo, P.2    Lindor, K.D.3
  • 2
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346 (16): 1221-1231.
    • (2002) N Engl J Med , vol.346 , Issue.16 , pp. 1221-1231
    • Angulo, P.1
  • 3
    • 33645828659 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290 (5): G852-858.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , Issue.5
    • Reddy, J.K.1    Rao, M.S.2
  • 4
    • 28044446543 scopus 로고    scopus 로고
    • The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    • Hamaguchi M, Kojima T, Takeda N etal. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005; 143 (10): 722-728.
    • (2005) Ann Intern Med , vol.143 , Issue.10 , pp. 722-728
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 6
    • 84862500687 scopus 로고    scopus 로고
    • Hepatic steatosis in type 1 diabetes
    • Regnell SE, Lernmark A. Hepatic steatosis in type 1 diabetes. Rev Diabet Stud 2011; 8 (4): 454-467.
    • (2011) Rev Diabet Stud , vol.8 , Issue.4 , pp. 454-467
    • Regnell, S.E.1    Lernmark, A.2
  • 7
    • 11144225924 scopus 로고    scopus 로고
    • Hepatitis C and nonalcoholic fatty liver disease
    • Ramesh S, Sanyal AJ. Hepatitis C and nonalcoholic fatty liver disease. Semin Liver Dis 2004; 24 (4): 399-413.
    • (2004) Semin Liver Dis , vol.24 , Issue.4 , pp. 399-413
    • Ramesh, S.1    Sanyal, A.J.2
  • 8
    • 6944227798 scopus 로고    scopus 로고
    • Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults
    • Kim HJ, Kim HJ, Lee KE etal. Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. Arch Intern Med 2004; 164 (19): 2169-2175.
    • (2004) Arch Intern Med , vol.164 , Issue.19 , pp. 2169-2175
    • Kim, H.J.1    Kim, H.J.2    Lee, K.E.3
  • 9
    • 33645536593 scopus 로고    scopus 로고
    • Treatment of non-alcoholic fatty liver disease
    • Adams LA, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgrad Med J 2006; 82 (967): 315-322.
    • (2006) Postgrad Med J , vol.82 , Issue.967 , pp. 315-322
    • Adams, L.A.1    Angulo, P.2
  • 10
    • 57749119549 scopus 로고    scopus 로고
    • Endocannabinoids and the control of energy homeostasis
    • Kunos G, Osei-Hyiaman D, Liu J, Godlewski G, Bátkai S. Endocannabinoids and the control of energy homeostasis. J Biol Chem 2008; 283 (48): 33021-33025.
    • (2008) J Biol Chem , vol.283 , Issue.48 , pp. 33021-33025
    • Kunos, G.1    Osei-Hyiaman, D.2    Liu, J.3    Godlewski, G.4    Bátkai, S.5
  • 11
    • 38649131428 scopus 로고    scopus 로고
    • Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C
    • Hézode C, Zafrani ES, Roudot-Thoraval F etal. Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C. Gastroenterology 2008; 134 (2): 432-439.
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 432-439
    • Hézode, C.1    Zafrani, E.S.2    Roudot-Thoraval, F.3
  • 12
    • 84860109551 scopus 로고    scopus 로고
    • Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice
    • Liu J, Zhou L, Xiong K etal. Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology 2012; 142 (5): 1218-1228.
    • (2012) Gastroenterology , vol.142 , Issue.5 , pp. 1218-1228
    • Liu, J.1    Zhou, L.2    Xiong, K.3
  • 13
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    • Gary-Bobo M, Elachouri G, Gallas JF etal. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology 2007; 46 (1): 122-129.
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3
  • 14
    • 79960316462 scopus 로고    scopus 로고
    • The case for peripheral CB1 receptor blockade in the treatment of visceral obesity and its cardiometabolic complications
    • Kunos G, Tam J. The case for peripheral CB1 receptor blockade in the treatment of visceral obesity and its cardiometabolic complications. Br J Pharmacol 2011; 163 (7): 1423-1431.
    • (2011) Br J Pharmacol , vol.163 , Issue.7 , pp. 1423-1431
    • Kunos, G.1    Tam, J.2
  • 16
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109 (9): 1125-1131.
    • (2002) J Clin Invest , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 17
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997; 89 (3): 331-340.
    • (1997) Cell , vol.89 , Issue.3 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 18
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 1997; 99 (5): 838-845.
    • (1997) J Clin Invest , vol.99 , Issue.5 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 19
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res 2009; 48 (1): 1-26.
    • (2009) Prog Lipid Res , vol.48 , Issue.1 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 20
    • 77951184370 scopus 로고    scopus 로고
    • CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice
    • Jourdan T, Djaouti L, Demizieux L, Gresti J, Vergès B, Degrace P. CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice. Diabetes 2010; 59 (4): 926-934.
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 926-934
    • Jourdan, T.1    Djaouti, L.2    Demizieux, L.3    Gresti, J.4    Vergès, B.5    Degrace, P.6
  • 21
    • 0036079706 scopus 로고    scopus 로고
    • Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status
    • Sone H, Shimano H, Sakakura Y etal. Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab 2002; 282 (1): E222-230.
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , Issue.1
    • Sone, H.1    Shimano, H.2    Sakakura, Y.3
  • 22
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114 (2): 147-152.
    • (2004) J Clin Invest , vol.114 , Issue.2 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 23
    • 77956253088 scopus 로고    scopus 로고
    • Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters
    • Zhao W, Fong O, Muise ES etal. Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters. Mol Pharmacol 2010; 78 (3): 350-359.
    • (2010) Mol Pharmacol , vol.78 , Issue.3 , pp. 350-359
    • Zhao, W.1    Fong, O.2    Muise, E.S.3
  • 24
    • 23844530704 scopus 로고    scopus 로고
    • Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
    • Sundqvist A, Bengoechea-Alonso MT, Ye X etal. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 2005; 1 (6): 379-391.
    • (2005) Cell Metab , vol.1 , Issue.6 , pp. 379-391
    • Sundqvist, A.1    Bengoechea-Alonso, M.T.2    Ye, X.3
  • 25
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • Repa JJ, Liang G, Ou J, Bashmakov Y etal. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000; 14 (22): 2819-2830.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3    Bashmakov, Y.4
  • 26
    • 80054789655 scopus 로고    scopus 로고
    • Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gαi/o inhibition
    • Wu HM, Yang YM, Kim SG. Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gαi/o inhibition. Mol Pharmacol 2011; 80 (5): 859-869.
    • (2011) Mol Pharmacol , vol.80 , Issue.5 , pp. 859-869
    • Wu, H.M.1    Yang, Y.M.2    Kim, S.G.3
  • 27
    • 34249721531 scopus 로고    scopus 로고
    • Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver
    • Yamamoto T, Shimano H, Inoue N etal. Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver. J Biol Chem 2007; 282 (16): 11687-11695.
    • (2007) J Biol Chem , vol.282 , Issue.16 , pp. 11687-11695
    • Yamamoto, T.1    Shimano, H.2    Inoue, N.3
  • 28
    • 0025753154 scopus 로고
    • cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase
    • Dash PK, Karl KA, Colicos MA, Prywes R, Kandel ER. cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 1991; 88 (11): 5061-5065.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.11 , pp. 5061-5065
    • Dash, P.K.1    Karl, K.A.2    Colicos, M.A.3    Prywes, R.4    Kandel, E.R.5
  • 29
    • 0029778985 scopus 로고    scopus 로고
    • Role of cyclic AMP in the actions of cannabinoid receptors
    • Childers SR, Deadwyler SA. Role of cyclic AMP in the actions of cannabinoid receptors. Biochem Pharmacol 1996; 52 (6): 819-827.
    • (1996) Biochem Pharmacol , vol.52 , Issue.6 , pp. 819-827
    • Childers, S.R.1    Deadwyler, S.A.2
  • 30
    • 0034283596 scopus 로고    scopus 로고
    • Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
    • Azzout-Marniche D, Bécard D, Guichard C, Foretz M, Ferré P, Foufelle F. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem J 2000; 350 (Pt 2): 389-393.
    • (2000) Biochem J , vol.350 , Issue.PART 2 , pp. 389-393
    • Azzout-Marniche, D.1    Bécard, D.2    Guichard, C.3    Foretz, M.4    Ferré, P.5    Foufelle, F.6
  • 31
    • 20044388364 scopus 로고    scopus 로고
    • Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes
    • Im SS, Kang SY, Kim SY etal. Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes. Diabetes 2005; 54 (6): 1684-1691.
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1684-1691
    • Im, S.S.1    Kang, S.Y.2    Kim, S.Y.3
  • 32
    • 0032933626 scopus 로고    scopus 로고
    • ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
    • Foretz M, Pacot C, Dugail I etal. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol 1999; 19 (5): 3760-3768.
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3760-3768
    • Foretz, M.1    Pacot, C.2    Dugail, I.3
  • 33
    • 80755148711 scopus 로고    scopus 로고
    • Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver
    • Berglund ED, Lustig DG, Baheza RA etal. Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver. Diabetes 2011; 60 (11): 2720-2729.
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2720-2729
    • Berglund, E.D.1    Lustig, D.G.2    Baheza, R.A.3
  • 34
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N etal. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428 (6982): 569-574.
    • (2004) Nature , vol.428 , Issue.6982 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3
  • 35
    • 44449103256 scopus 로고    scopus 로고
    • Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    • Huang X, Wullschleger S, Shpiro N etal. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 2008; 412 (2): 211-221.
    • (2008) Biochem J , vol.412 , Issue.2 , pp. 211-221
    • Huang, X.1    Wullschleger, S.2    Shpiro, N.3
  • 36
    • 0034141636 scopus 로고    scopus 로고
    • LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
    • Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 2000; 345 (Pt 3): 673-680.
    • (2000) Biochem J , vol.345 , Issue.PART 3 , pp. 673-680
    • Collins, S.P.1    Reoma, J.L.2    Gamm, D.M.3    Uhler, M.D.4
  • 37
    • 51349153318 scopus 로고    scopus 로고
    • Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    • Osei-Hyiaman D, Liu J, Zhou L, Godlewski G etal. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 2008; 118: 3160-3169.
    • (2008) J Clin Invest , vol.118 , pp. 3160-3169
    • Osei-Hyiaman, D.1    Liu, J.2    Zhou, L.3    Godlewski, G.4
  • 38
    • 38649114788 scopus 로고    scopus 로고
    • Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    • Jeong WI, Osei-Hyiaman D, Park O etal. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab 2008; 7 (3): 227-235.
    • (2008) Cell Metab , vol.7 , Issue.3 , pp. 227-235
    • Jeong, W.I.1    Osei-Hyiaman, D.2    Park, O.3
  • 39
    • 12744267804 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins
    • You M, Crabb DW. Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol 2004; 34 (1): 39-43.
    • (2004) Alcohol , vol.34 , Issue.1 , pp. 39-43
    • You, M.1    Crabb, D.W.2
  • 40
    • 38949104356 scopus 로고    scopus 로고
    • Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
    • García-Villafranca J, Guillén A, Castro J. Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver. Biochimie 2008; 90 (3): 460-466.
    • (2008) Biochimie , vol.90 , Issue.3 , pp. 460-466
    • García-Villafranca, J.1    Guillén, A.2    Castro, J.3
  • 41
    • 34250679654 scopus 로고    scopus 로고
    • S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet
    • Esfandiari F, You M, Villanueva JA, Wong DH, French SW, Halsted CH. S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin Exp Res 2007; 31 (7): 1231-1239.
    • (2007) Alcohol Clin Exp Res , vol.31 , Issue.7 , pp. 1231-1239
    • Esfandiari, F.1    You, M.2    Villanueva, J.A.3    Wong, D.H.4    French, S.W.5    Halsted, C.H.6
  • 42
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y etal. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108 (8): 1167-1174.
    • (2001) J Clin Invest , vol.108 , Issue.8 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 43
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM, Zheng B etal. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011; 13 (4): 376-388.
    • (2011) Cell Metab , vol.13 , Issue.4 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4
  • 44
    • 66349099340 scopus 로고    scopus 로고
    • Fatty acid metabolism: target for metabolic syndrome
    • Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res 2009; 50: S138-143.
    • (2009) J Lipid Res , vol.50
    • Wakil, S.J.1    Abu-Elheiga, L.A.2
  • 45
    • 68949091995 scopus 로고    scopus 로고
    • Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
    • Hwahng SH, Ki SH, Bae EJ, Kim HE, Kim SG. Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology 2009; 49 (6): 1913-1925.
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1913-1925
    • Hwahng, S.H.1    Ki, S.H.2    Bae, E.J.3    Kim, H.E.4    Kim, S.G.5
  • 46
    • 56449117024 scopus 로고    scopus 로고
    • AMPK: a metabolic gauge regulating whole-body energy homeostasis
    • Lage R, Diéguez C, Vidal-Puig A, López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 2008; 14 (12): 539-549.
    • (2008) Trends Mol Med , vol.14 , Issue.12 , pp. 539-549
    • Lage, R.1    Diéguez, C.2    Vidal-Puig, A.3    López, M.4
  • 47
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry JD, Brown NF. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 1997; 244 (1): 1-14.
    • (1997) Eur J Biochem , vol.244 , Issue.1 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 51
    • 0346880507 scopus 로고    scopus 로고
    • Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation
    • Moller DE, Berger JP. Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord 2003; 27 (Suppl 3): S17-21.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.SUPPL. 3
    • Moller, D.E.1    Berger, J.P.2
  • 52
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B, Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 2005; 54 (8): 2460-2470.
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 53
    • 0035958960 scopus 로고    scopus 로고
    • Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells
    • Hsu MH, Savas U, Griffin KJ, Johnson EF. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem 2001; 276 (30): 27950-27958.
    • (2001) J Biol Chem , vol.276 , Issue.30 , pp. 27950-27958
    • Hsu, M.H.1    Savas, U.2    Griffin, K.J.3    Johnson, E.F.4
  • 54
    • 0033559336 scopus 로고    scopus 로고
    • Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
    • Hegardt FG. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem J 1999; 338 (Pt 3): 569-582.
    • (1999) Biochem J , vol.338 , Issue.PART 3 , pp. 569-582
    • Hegardt, F.G.1
  • 55
    • 79958793890 scopus 로고    scopus 로고
    • AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway
    • eal.. ; (): -.
    • Meng R, Pei Z, Zhang A eal. AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway. Arch Biochem Biophys 2011; 511 (1-2): 1-7.
    • (2011) Arch Biochem Biophys , vol.511 , Issue.1-2 , pp. 1-7
    • Meng, R.1    Pei, Z.2    Zhang, A.3
  • 56
    • 34547484379 scopus 로고    scopus 로고
    • Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
    • Ozaita A, Puighermanal E, Maldonado R. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 2007; 102 (4): 1105-1114.
    • (2007) J Neurochem , vol.102 , Issue.4 , pp. 1105-1114
    • Ozaita, A.1    Puighermanal, E.2    Maldonado, R.3
  • 57
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129 (7): 1261-1274.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 58
    • 77649251207 scopus 로고    scopus 로고
    • mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
    • Laplante M, Sabatini DM. mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc Natl Acad Sci U S A 2010; 107 (8): 3281-3282.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.8 , pp. 3281-3282
    • Laplante, M.1    Sabatini, D.M.2
  • 60
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
    • Pearson G, Robinson F, Beers Gibson T etal. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001; 22 (2): 153-183.
    • (2001) Endocr Rev , vol.22 , Issue.2 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Beers Gibson, T.3
  • 61
    • 33745003240 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis
    • Teixeira-Clerc F, Julien B, Grenard P etal. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med 2006; 12 (6): 671-676.
    • (2006) Nat Med , vol.12 , Issue.6 , pp. 671-676
    • Teixeira-Clerc, F.1    Julien, B.2    Grenard, P.3
  • 62
    • 46749113793 scopus 로고    scopus 로고
    • Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3
    • Rozenfeld R, Devi LA. Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J 2008; 22 (7): 2311-2322.
    • (2008) FASEB J , vol.22 , Issue.7 , pp. 2311-2322
    • Rozenfeld, R.1    Devi, L.A.2
  • 63
    • 0034721772 scopus 로고    scopus 로고
    • MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro
    • Roth G, Kotzka J, Kremer L etal. MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. J Biol Chem 2000; 275 (43): 33302-33307.
    • (2000) J Biol Chem , vol.275 , Issue.43 , pp. 33302-33307
    • Roth, G.1    Kotzka, J.2    Kremer, L.3
  • 64
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: master regulators of lipid homeostasis
    • Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 2004; 86 (11): 839-848.
    • (2004) Biochimie , vol.86 , Issue.11 , pp. 839-848
    • Eberlé, D.1    Hegarty, B.2    Bossard, P.3    Ferré, P.4    Foufelle, F.5
  • 65
    • 42149148782 scopus 로고    scopus 로고
    • IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway
    • Smith TM, Gilliland K, Clawson GA, Thiboutot D. IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol 2008; 128 (5): 1286-1293.
    • (2008) J Invest Dermatol , vol.128 , Issue.5 , pp. 1286-1293
    • Smith, T.M.1    Gilliland, K.2    Clawson, G.A.3    Thiboutot, D.4
  • 66
    • 25644448266 scopus 로고    scopus 로고
    • Fat in the liver and insulin resistance
    • Yki-Järvinen H. Fat in the liver and insulin resistance. Ann Med 2005; 37 (5): 347-356.
    • (2005) Ann Med , vol.37 , Issue.5 , pp. 347-356
    • Yki-Järvinen, H.1
  • 67
    • 33645774428 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis (NASH) with diabetes: predictors of liver fibrosis
    • Amarapurka DN, Amarapurkar AD, Patel ND etal. Nonalcoholic steatohepatitis (NASH) with diabetes: predictors of liver fibrosis. Ann Hepatol 2006; 5 (1): 30-33.
    • (2006) Ann Hepatol , vol.5 , Issue.1 , pp. 30-33
    • Amarapurka, D.N.1    Amarapurkar, A.D.2    Patel, N.D.3
  • 68
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
    • RIO-Diabetes Study Group.
    • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF, RIO-Diabetes Study Group. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 2006; 368 (9548): 1660-1672.
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 69
    • 84861161242 scopus 로고    scopus 로고
    • CB1 antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs
    • Kim SP, Woolcott OO, Hsu IR etal. CB1 antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs. Am J Physiol Endocrinol Metab 2012; 302 (10): E1261-1268.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , Issue.10
    • Kim, S.P.1    Woolcott, O.O.2    Hsu, I.R.3
  • 71
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang D, Wei Y, Pagliassotti MJ. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 2006; 147 (2): 943-951.
    • (2006) Endocrinology , vol.147 , Issue.2 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 72
    • 0035014266 scopus 로고    scopus 로고
    • Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
    • Werstuck GH, Lentz SR, Dayal S etal. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest 2001; 107 (10): 1263-1273.
    • (2001) J Clin Invest , vol.107 , Issue.10 , pp. 1263-1273
    • Werstuck, G.H.1    Lentz, S.R.2    Dayal, S.3
  • 73
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • Puri P, Mirshahi F, Cheung O etal. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008; 134 (2): 568-576.
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3
  • 74
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 2005; 74: 739-789.
    • (2005) Annu Rev Biochem , vol.74 , pp. 739-789
    • Schröder, M.1    Kaufman, R.J.2
  • 75
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2000; 2 (6): 326-332.
    • (2000) Nat Cell Biol , vol.2 , Issue.6 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 76
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999; 397 (6716): 271-274.
    • (1999) Nature , vol.397 , Issue.6716 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 77
    • 33748495984 scopus 로고    scopus 로고
    • Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress
    • Bloch-Damti A, Potashnik R, Gual P etal. Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia 2006; 49 (10): 2463-2473.
    • (2006) Diabetologia , vol.49 , Issue.10 , pp. 2463-2473
    • Bloch-Damti, A.1    Potashnik, R.2    Gual, P.3
  • 78
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18 (1): 13-24.
    • (2005) Mol Cell , vol.18 , Issue.1 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.