Potent elastase inhibitors from cyanobacteria: Structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 1276-1290

  Salvador, Lilibeth A ^a   Taori, Kanchan ^a   Biggs, Jason S ^b   Jakoncic, Jean ^c   Ostrov, David A ^d   Paul, Valerie J ^e   Luesch, Hendrik ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF GUAM MARINE LABORATORY   (Guam)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e SMITHSONIAN MARINE STATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DOLASTATIN 13; ELASTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; LYNGBYASTATIN 4; LYNGBYASTATIN 7; LYNGBYASTATIN 8; LYNGBYASTATIN 9; SIVELESTAT; SYMPLOSTATIN 10; SYMPLOSTATIN 5; SYMPLOSTATIN 6; SYMPLOSTATIN 7; SYMPLOSTATIN 8; SYMPLOSTATIN 9; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS EPITHELIUM CELL; CELL DEATH; CELL PROTECTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYANOBACTERIUM; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; RECEPTOR UPREGULATION; RESPIRATORY TRACT INFLAMMATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRANSCRIPTOMICS;

ANTI-INFLAMMATORY AGENTS; BRONCHI; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYANOBACTERIA; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PANCREATIC ELASTASE; REAL-TIME POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84873928009     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3017305     Document Type: Article

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