Non-peptidic inhibitors of human neutrophil elastase: The design and synthesis of sulfonanilide-containing inhibitors

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 12, 1996, Pages 2115-2134

  Imaki, Katsuhiro ^a   Okada, Takanori ^a   Nakayama, Yoshisuke ^a   Nagao, Yuuki ^a   Kobayashi, Kaoru ^a   Sakai, Yasuhiro ^a   Mohri, Tetsuya ^a   Amino, Takaaki ^a   Nakai, Hisao ^a   Kawamura, Masanori ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; ELASTASE INHIBITOR; LEUKOCYTE ELASTASE; SIVELESTAT; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PLASMA; SKIN PERMEABILITY;

ANILINE COMPOUNDS; ANIMALS; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLYCINE; GUINEA PIGS; HUMANS; LEUKOCYTE ELASTASE; MALE; NEUTROPHILS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFONAMIDES;

EID: 0030454964     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00216-7     Document Type: Article

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