Evidence that nitric oxide mediates the blood pressure lowering effect of a polyphenol-rich cocoa powder in spontaneously hypertensive rats

Pharmacological Research

Volumn 64, Issue 5, 2011, Pages 478-481

  Quinones M ^a   Muguerza, B ^b   Miguel, M ^c   Aleixandre, A ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Natraceutical Group   (Spain)

^c INSTITUTE OF FOOD SCIENCE RESEARCH CIAL   (Spain)

Author keywords

Cocoa; Nitric oxide; Polyphenols; Spontaneously hypertensive rats

Indexed keywords

ANTIHYPERTENSIVE AGENT; COCOANOX; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POLYPHENOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CACAO; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ESSENTIAL HYPERTENSION; IN VIVO STUDY; MALE; NONHUMAN; POWDER; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE;

EID: 80055020879     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.06.005     Document Type: Article

References (35)

1. JNC-7 Guidelines. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003;42:1206.
2. Mancia G, Bombelli M, Lanzarotti A, Grassi G, Cesana G, Zanchetti A, et al. Systolic vs. diastolic blood pressure control in the hypertensive patients of the PAMELA population. Arch Intern Med 2002;162:582-6. (Pubitemid 34193546)
3. Galleano M, Pechanova O, Fraga CG. Hypertension, nitric oxide, oxidants, and dietary plant polyphenols. Curr Pharm Biotechnol 2010;11:837-48.
4. Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T. Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv Pharmacol 2010;60:133-75.
5. Perez-Vizcaino F, Duarte J. Flavonols and cardiovascular disease. Mol Aspects Med 2010;3:478-94.
6. Gu L, House SE, Wu X, Ou B, Prior RL. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products. J Agric Food Chem 2006;54:4057-61. (Pubitemid 44030590)
7. Cienfuegos-Jovellanos E, Pasamar MA, Fritz J, Arcos J, Ramón D, Castilla Y. Method for obtaining polyphenol-rich cocoa powder with a low fat content and cocoa thus obtained. Patent Cooperation Treaty (PCT) 2007. WO 2007/096449A1, Natraceutical Industrial, España.
8. Schinella G, Mosca S, Cienfuegos-Jovellanos E, Pasamar MA, Muguerza B, Ramón D, et al. Antioxidant properties of polyphenol-rich cocoa products industrially processed. Food Res Int 2010;43:1614-23.
9. Cienfuegos-Jovellanos E, Quiñones M, Muguerza B, Moulay L, Miguel M, Aleixandre A. Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans. J Agric Food Chem 2009;57:6156-62.
10. Quiñones M, Sánchez D, Muguerza B, Moulay L, Miguel M, Aleixandre A. Long-term intake of CocoanOX attenuates the development of hypertension in spontaneously hypertensive rats. Food Chem 2010;122:1013-9.
11. Emura K, Yokomizo A, Toyoshi T, Moriwaki M. Effect of enzymatically modified isoquercetin in spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 2007;1:68-74. (Pubitemid 46623921)
12. Yamamoto M, Suzuki A, Hase T. Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. J Nutr Sci Vitaminol 2008;1:95-8. (Pubitemid 351413109)
13. Ichimura T, Yamanaka A, Ichiba T, Toyokawa T, Kamada Y, Tamamura T, et al. Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats. Biosci Biotechnol Biochem 2006;3:718-21.
14. Mukai Y, Sato S. Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutr Metab Cardiovasc Dis 2009;19:491-7.
15. Li JX, Xue B, Chai Q, Liu ZX, Zhao AP, Chen LB. Antihypertensive effect of total flavonoid fraction of Astragalus complanatus in hipertensive rats. Chin J Physiol 2005;2:101-6. (Pubitemid 40867528)
16. Liu JC, Hsu FL, Tsa JC, Chan P, Liu JY, Thomas GN, et al. Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiotensin converting enzyme. Life Sci 2003;12:1543-55. (Pubitemid 36831138)
17. Duarte J, Perez-Palencia R, Vargas F, Ocete MA, Pérez-Vizcaino F, Zarzuelo A, et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol 2001;1:117-24. (Pubitemid 32500458)
18. Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr 2004;134:38-42. (Pubitemid 38057420)
19. Villar IC, Jiménez R, Galisteo M, Garcia-Saura MF, Zarzuelo A, Duarte J. Effects of chronic chrysin treatment in spontaneously hypertensive rats. Planta Med 2002;9:847-50. (Pubitemid 35177638)
20. Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 2005;3: 771-5.
21. Quiñones M, Sánchez D, Muguerza B, Miguel M, Aleixandre A. Mechanisms for antihypertensive effect of CocoanOX, a polyphenol-rich cocoa powder, in spontaneously hypertensive rats. Food Res Int 2011;44:1203-8.
22. Buñag RD. Validation in awake rats of a tail-cuff method for measuring systolic pressure. J Appl Physiol 1973;34:279-82.
23. López-Fandiño R, Otte J, van Camp J. Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. Int Dairy J 2006;11:1277-93. (Pubitemid 44331581)
24. Furchgott RF, Zawadzki JV. The obligatory role of the endothelium in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6. (Pubitemid 11169009)
25. Moncada S, Herman AG, Vanhoutte P. Endothelium-derived relaxing factor identified as nitric oxide. Trends Pharmacol Sci 1987;8:365-8.
26. Moncada S, Radomski MW, Palmer RMJ. Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol 1988;37:2495-501.
27. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 1998;333:664-6.
28. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-42.
29. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990;101:746-52. (Pubitemid 20357206)
30. Furchgott RF, Khan MT, Jothianandan D. Comparison of properties of nitric oxide and endothelium-derived relaxing factor: some cautionary findings. In: Rubanyi GM, Vanhoutte PM, editors. Endothelium-Derived Relaxing Factors. Karger: Basel; 1990. p. 8-21.
31. Vane JR, Greglewski RJ, Botting RM. The endothelial cells as a metabolic and endocrine organ. Trends Pharmacol Sci 1987;8:491-6.
32. Kumar KV, Das UN. Are free radicals involved in the pathology of human essential hypertension? Free Radic Res Commun 1993;19:59-66. (Pubitemid 23310628)
33. Sekiguchi F, Yanamoto A, Sunano S. Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta. J Smooth Muscle Res 2004;40:65-74. (Pubitemid 39106855)
34. Jameson M, Dai FX, Lüscher T, Skopec J, Dierderich A, Diederich D. Endothelium-derived contracting factors in resistance arteries of young spontenaeously hypertensive rats before development of overt hypertension. Hypertension 1993;21:280-8. (Pubitemid 23065165)
35. Félétou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 2006;291:H985-1002. (Pubitemid 44343640)