Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 2, 2012, Pages 633-640

  Haedke, Ute ^a   Götz, Markus ^a   Baer, Philipp ^a   Verhelst, Steven H L ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Activity based probes; Click chemistry; Functional proteomics; Isocoumarins; Serine proteases

Indexed keywords

3 (2 BROMOETHOXY) 4 CHLORO 7 (4 PENTYNOYLAMINO)ISOCOUMARIN; 3 (3 BUTYNOXY)4 CHLORO 7 [GUANIDINOACETYL]AMINO ISOCOUMARIN; 3 (3 BUTYNOXY)4 CHLORO 7 GLYCYLAMINO ISOCOUMARIN; 3 (3 BUTYNOXY)4 CHLORO 7 NITRO ISOCOUMARIN; 3 (3 BUTYNOXY)4 CHLORO ISOCOUMARIN; 3 ALKOXY 4 CHLORO ISOCOUMARIN DERIVATIVE; 4 CHLORO 3 (2 BROMOETHOXY) 7 NITRO ISOCOUMARIN; 4 CHLORO 3 (2 PHENYLETHOXY) 7 NITRO ISOCOUMARIN; 4 CHLORO 3 METHOXY 7 (4 PENTYNOYLAMINO)ISOCOUMARIN; 4 CHLORO 3 METHOXY ISOCOUMARIN; 4 CHLORO 7 (4 PENTYNOYLAMINO) 3 (2 ISOTHIOUREIDOETHOXY)ISOCOUMARIN; 4 CHLORO 7 (4 PENTYNOYLAMINO) 3 (2 PHENYLETHOXY)ISOCOUMARIN; 7 ACETYLAMINO 3 (3 BUTYNOXY)4 CHLORO ISOCOUMARIN; 7 AMINO 3 (2 BROMOETHOXY) 4 CHLORO ISOCOUMARIN; 7 AMINO 3 (3 BUTYNOXY)4 CHLORO ISOCOUMARIN; 7 AMINO 4 CHLORO 3 (2 PHENYLETHOXY) ISOCOUMARIN; 7 AMINO 4 CHLORO 3 METHOXY ISOCOUMARIN; 7 BENZOYLAMINO 3 (3 BUTYNOXY)4 CHLORO ISOCOUMARIN; ALKENE DERIVATIVE; ISOCOUMARIN DERIVATIVE; PROTEOME; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ACTIVITY BASED PROBE; ANIMAL CELL; ARTICLE; CHEMICAL LABELING; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROPHILICITY; ENZYME SUBSTRATE COMPLEX; FUNCTIONAL PROTEOMICS; MOLECULAR PROBE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANIMALS; CATALYSIS; CLICK CHEMISTRY; COPPER; ISOCOUMARINS; LIVER; PROTEOME; RATS; SERINE PROTEASES; SERINE PROTEINASE INHIBITORS;

EID: 84855811087     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.014     Document Type: Article

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