Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain

European Journal of Pain (United Kingdom)

Volumn 16, Issue 10, 2012, Pages 1378-1388

  Wu, J X ^a,b   Xu, M Y ^b   Miao, X R ^a   Lu, Z J ^a   Yuan, X M ^b   Li, X Q ^a   Yu, W F ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; MESSENGER RNA; PURINERGIC P2X3 RECEPTOR;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; BONE CANCER; CANCER PAIN; CONTROLLED STUDY; FEMALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SPINAL GANGLION; TUMOR CELL; X RAY ANALYSIS;

ANIMALS; BEHAVIOR, ANIMAL; BONE AND BONES; BONE NEOPLASMS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GANGLIA, SPINAL; GENE EXPRESSION PROFILING; MUSCULOSKELETAL PAIN; PATCH-CLAMP TECHNIQUES; PHENOLS; POLYCYCLIC COMPOUNDS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2X3; RNA, MESSENGER; UP-REGULATION;

EID: 84873687657     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2012.00149.x     Document Type: Article

References (41)

1. Ambalavanar, R., Moritani, M., Dessem, D. (2005). Trigeminal P2X3 receptor expression differs from dorsal root ganglion and is modulated by deep tissue inflammation. Pain 117, 280-291.
2. Bennett, D.L. (2001). Neurotrophic factors: Important regulators of nociceptive function. Neuroscientist 7, 13-17.
3. Bradbury, E.J., Burnstock, G., McMahon, S.B. (1998). The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12, 256-268.
4. Brederson, J.D., Jarvis, M.F. (2008). Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons. Curr Opin Investig Drugs 9, 716-725.
5. Brigatte, P., Sampaio, S.C., Gutierrez, V.P., Guerra, J.L., Sinhorini, I.L., Curi, R., et al. (2007). Walker 256 tumorbearing rats as a model to study cancer pain. J Pain 8, 412-421.
6. Brown, D.A., Yule, D.I. (2007). Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation. Biochim Biophys Acta 1773, 166-175.
7. Burgard, E.C., Niforatos, W., van Biesen, T., Lynch, K.J., Touma, E., Metzger, R.E., et al. (1999). P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol 82, 1590-1598.
8. Burnstock, G. (1996). A unifying purinergic hypothesis for the initiation of pain. Lancet 347, 1604-1605.
9. Burnstock, G. (2000). P2X receptors in sensory neurones. Br J Anaesth 84, 476-488.
10. Cain, D.M., Wacnik, P.W., Turner, M., Wendelschafer-Crabb, G., Kennedy, W.R., Wilcox, G.L., et al. (2001). Functional interactions between tumor and peripheral nerve: Changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain. J Neurosci 21, 9367-9376.
11. Charlton, S.J., Brown, C.A., Weisman, G.A., Turner, J.T., Erb, L., Boarder, M.R. (1996). PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br J Pharmacol 118, 704-710.
12. Coleman, R.E., Rubens, R.D. (1987). The clinical course of bone metastases from breast cancer. Br J Cancer 55, 61-66.
13. Coutinho-Silva, R., Stahl, L., Cheung, K.K., de Campos, N.E., de Oliveira Souza, C., Ojcius, D.M., et al. (2005). P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: Effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol 288, G1024-G1035.
14. Ding, Y., Cesare, P., Drew, L., Nikitaki, D., Wood, J.N. (2000). ATP, P2X receptors and pain pathways. J Auton Nerv Syst 81, 289-294.
15. Dunn, P.M., Zhong, Y., Burnstock, G. (2001). P2X receptors in peripheral neurons. Prog Neurobiol 65, 107-134.
16. Egan, T.M., Cox, J.A., Voigt, M.M. (2004). Molecular structure of P2X receptors. Curr Top Med Chem 4, 821-829.
17. Fabbretti, E., Sokolova, E., Masten, L., D'Arco, M., Fabbro, A., Nistri, A., et al. (2004). Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites. J Biol Chem 279, 53109-53115.
18. Fields, R.D., Burnstock, G. (2006). Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 7, 423-436.
19. Ford, K.K., Matchett, M., Krause, J.E., Yu, W. (2005). The P2X3 antagonist P1, P5-di[inosine-5′] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 315, 405-413.
20. Fox, A., Medhurst, S., Courade, J.P., Glatt, M., Dawson, J., Urban, L., et al. (2004). Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. Pain 107, 33-40.
21. Gerevich, Z., Zadori, Z.S., Koles, L., Kopp, L., Milius, D., Wirkner, K., et al. (2007). Dual effect of acid pH on purinergic P2X3 receptors depends on the histidine 206 residue. J Biol Chem 282, 33949-33957.
22. Gilchrist, L.S., Cain, D.M., Harding-Rose, C., Kov, A.N., Wendelschafer-Crabb, G., Kennedy, W.R., et al. (2005). Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain. Brain Res 1044, 197-205.
23. Gu, J.G., MacDermott, A.B. (1997). Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389, 749-753.
24. Guo, A., Vulchanova, L., Wang, J., Li, X., Elde, R. (1999). Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11, 946-958.
25. Honore, P., Rogers, S.D., Schwei, M.J., Salak-Johnson, J.L., Luger, N.M., Sabino, M.C., et al. (2000). Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience 98, 585-598.
26. Jarvis, M.F., Burgard, E.C., McGaraughty, S., Honore, P., Lynch, K., Brennan, T.J., et al. (2002). A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A 99, 17179-17184.
27. Koles, L., Furst, S., Illes, P. (2007). Purine ionotropic (P2X) receptors. Curr Pharm Des 13, 2368-2384.
28. Maehara, Y., Kusumoto, H., Anai, H., Kusumoto, T., Sugimachi, K. (1987). Human tumor tissues have higher ATP contents than normal tissues. Clin Chim Acta 169, 341-343.
29. Mao-Ying, Q.L., Zhao, J., Dong, Z.Q., Wang, J., Yu, J., Yan, M.F., et al. (2006). A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells. Biochem Biophys Res Commun 345, 1292-1298.
30. Medhurst, S.J., Walker, K., Bowes, M., Kidd, B.L., Glatt, M., Muller, M., et al. (2002). A rat model of bone cancer pain. Pain 96, 129-140.
31. de Oliveira Fusaro, M.C., Pelegrini-Da-Silva, A., Araldi, D., Parada, C.A., Tambeli, C.H. (2010). P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE or dopamine. Eur J Pharmacol 649, 177-182.
32. Shir, Y., Seltzer, Z. (1990). A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neurosci Lett 115, 62-67.
33. Siems, W.G., Grune, T., Schmidt, H., Tikhonov, Y.V., Pimenov, A.M. (1993). Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor. Cancer Res 53, 5143-5147.
34. Storkson, R.V., Kjorsvik, A., Tjolsen, A., Hole, K. (1996). Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods 65, 167-172.
35. Ueno, S., Tsuda, M., Iwanaga, T., Inoue, K. (1999). Cell typespecific ATP-activated responses in rat dorsal root ganglion neurons. Br J Pharmacol 126, 429-436.
36. Volonte, C., Amadio, S., D'Ambrosi, N., Colpi, M., Burnstock, G. (2006). P2 receptor web: Complexity and fine-tuning. Pharmacol Ther 112, 264-280.
37. Vulchanova, L., Riedl, M.S., Shuster, S.J., Stone, L.S., Hargreaves, K.M., Buell, G., et al. (1998). P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10, 3470-3478.
38. Wang, C., Li, G.W., Huang, L.Y. (2007). Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons. Mol Pain 3, 22.
39. Wirkner, K., Sperlagh, B., Illes, P. (2007). P2X3 receptor involvement in pain states. Mol Neurobiol 36, 165-183.
40. Xiang, Z., Xiong, Y., Yan, N., Li, X., Mao, Y., Ni, X., et al. (2008). Functional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion. Pain 140, 23-34.
41. Zhang, R.X., Liu, B., Wang, L., Ren, K., Qiao, J.T., Berman, B.M., et al. (2005). Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain 118, 125-136.