Functional up-regulation of P2X3 receptors in the chronically compressed dorsal root ganglion

Pain

Volumn 140, Issue 1, 2008, Pages 23-34

  Xiang, Zhenghua ^a   Xiong, Yuanchang ^b   Yan, Ni ^a   Li, Xiaohan ^a   Mao, Yanfei ^b   Ni, Xin ^a   He, Cheng ^a   LaMotte, Robert H ^c   Burnstock, Geoffrey ^d   Sun, Jihu ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Dorsal root ganglion; ERK; Nerve injury; Neuropathic pain; P2X receptor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINERGIC P2X3 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HYPERALGESIA; IMMUNOREACTIVITY; NERVE COMPRESSION; NERVE POTENTIAL; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION; UPREGULATION;

ANIMALS; FEMALE; GANGLIA, SPINAL; NERVE COMPRESSION SYNDROMES; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SPINAL CORD COMPRESSION; UP-REGULATION;

EID: 54249155951     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.07.006     Document Type: Article

References (62)

1. Abe Y., Akeda K., An H.S., Aoki Y., Pichika R., Muehleman C., et al. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 32 (2007) 635-642
2. Barclay J., Patel S., Dorn G., Wotherspoon G., Moffatt S., Eunson L., et al. Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22 (2002) 8139-8147
3. Bean B.P. ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. J Neurosci 10 (1990) 1-10
4. 3 purinoreceptors in sensory neurons: effects of axotomy and glial derived neurotrophic factor. Mol Cell Neurosci 12 (1998) 256-268
5. Bron R., Klesse L.J., Shah K., Parada L.F., and Winter J. Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci 22 (2003) 118-132
6. Burgard E.C., Niforatos W., van Biesen T., Lynch K.J., Touma E., Metzger R.E., et al. P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol 82 (1999) 1590-1598
7. Burnstock G., and Wood J.N. Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol 6 (1996) 526-532
8. Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87 (2007) 659-797
9. Burnstock G. A unifying purinergic hypothesis for the initiation of pain. Lancet 347 (1996) 1604-1605
10. Burnstock G. Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22 (2001) 182-188
11. Chen C.C., Akopian A.N., Sivilotti L., Colquhoun D., Burnstock G., and Wood J.N. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 77 (1995) 428-431
12. Chen Y., Li G.W., Wang C., Gu Y., and Huang L.M. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain 119 (2005) 38-48
13. Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407 (2000) 1011-1015
14. Cook S.P., and McCleskey E.W. Cell damage excites nociceptors through release of cytosolic ATP. Pain 95 (2002) 41-47
15. Dai Y., Fukuoka T., Wang H., Yamanaka H., Obata K., Tokunaga A., et al. Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons. Pain 108 (2004) 258-266
16. Dai Y., Iwata K., Fukuoka T., Kondo E., Tokunaga A., Yamanaka H., et al. Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 22 (2002) 7737-7745
17. 3 receptors of nociceptive trigeminal ganglion neurons. J Neurosci 27 (2007) 8190-8201
18. Dorn G., Patel S., Wotherspoon G., Hemmings-Mieszczak M., Barclay J., Natt F.J., et al. SiRNA relieves chronic neuropathic pain. Nucleic Acids Res 32 (2004) e49
19. Genzen J.R., Van Cleve W., and McGehee D.S. Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes. J Neurophysiol 86 (2001) 1773-1782
20. Grubb B.D., and Evans R.J. Characterization of cultured dorsal root ganglion neuron P2X receptors. Eur J Neurosci 11 (1999) 149-154
21. Gu J.G., and MacDermott A.B. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389 (1997) 749-753
22. Guo A., Vulchanova L., Wang J., Li X., and Elde R. Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11 (1999) 946-958
23. Hamilton S.G., McMahon S.B., and Lewin G.R. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J Physiol 534 (2001) 437-445
24. Hamilton S.G., Wade A., and McMahon S.B. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol 126 (1999) 326-332
25. Honore P., Kage K., Mikusa J., Watt A.T., Johnston J.F., Wyatt J.R., et al. Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 99 (2002) 11-19
26. Hu S.J., and Xing J.L. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 77 (1998) 15-23
27. 2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA 99 (2002) 17179-17184
28. 3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res 147 (2002) 511-519
29. Kennedy C., Assis T.S., Currie A.J., and Rowan E.G. Crossing the pain barrier. P2 receptors as targets for noveal analgesics. J Physiol (London) 3 (2003) 683-694
30. Khakh B.S., and North R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442 (2006) 527-532
31. Kobayashi K., Fukuoka T., Yamanaka H., Dai Y., Obata K., Tokunaga A., et al. Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat. J Comp Neurol 481 (2005) 377-390
32. Krishtal O.A., Marchenko S.M., and Obukhov A.G. Cationic channels activated by extracellular ATP in rat sensory neurons. Neuroscience 27 (1988) 995-1000
33. LaMotte R.H. Spontaneous ectopia. In: Schmidt R.F., and Willis W.D. (Eds). Encyclopedia of pain (2006), Springer, Berlin
34. 3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377 (1995) 432-435
35. Ma C., Greenquist K.W., and Lamotte R.H. Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons. J Neurophysiol 95 (2006) 2098-2107
36. Maruo K., Yamamoto H., Yamamoto S., Nagata T., Fujikawa H., Kanno T., et al. Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury. Pain 120 (2006) 106-112
37. Nakatsuka T., and Gu J.G. ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 21 (2001) 6522-6531
38. North R.A., and Verkhratsky A. Purinergic transmission in the central nervous system. Pflugers Arch 452 (2006) 479-485
39. North R.A. Molecular physiology of P2X receptors. Physiol Rev 82 (2002) 1013-1067
40. 3 receptors and peripheral pain mechanisms. J Physiol (London) 2 (2003) 301-308
41. 3 purinoreceptors in sensory neurons in naive rats and following neuropathic injury. Pain 80 (1999) 273-282
42. Obata K., Yamanaka H., Dai Y., Tachibana T., Fukuoka T., Tokunaga A., et al. Differential activation of extracellular signal regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci (2003) 4117-4126
43. Obata K., Yamanaka H., Kobayashi K., Dai Y., Mizushima T., Katsura H., et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci (2004) 10211-10222
44. 3 subunit. J Biol Chem 276 (2001) 21077-21082
45. Ramer M.S., Bradbury E.J., and McMahon S.B. Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem 77 (2001) 864-875
46. Seino D., Tokunaga A., Tachibana T., Yoshiya S., Dai Y., Obata K., et al. The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain 123 (2006) 193-203
47. Song X.J., Hu S.J., Greenquist K.W., Zhang J.M., and LaMotte R.H. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol 82 (1999) 3347-3358
48. 3 receptors. Nature 407 (2000) 1015-1017
49. Stevens B., and Fields R.D. Response of Schwann cells to action potentials in development. Science 287 (2000) 2267-2271
50. Sun J.H., Yang B., Donnelly D.F., Ma C., and Lamotte R.H. MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J Neurophysiol 96 (2006) 2189-2199
51. 2/3 receptors. Mol Pharmacol 53 (1998) 969-973
52. 3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10 (1998) 3470-3478
53. 3 receptor currents in inflamed rats. J Physiol 584 (2007) 191-203
54. 3 receptor mediated currents in dorsal root ganglion neurons. Mol Pain 3 (2007) 22
55. White F.A., Sun J.H., Waters S.M., Ma C., Ren D.J., Ripsch M., et al. Excitatory MCP-1/CCR2 chemokine signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc Natl Acad Sci USA 102 (2005) 14092-14097
56. 3 receptors by ecto-protein kinase C. J Neurosci 25 (2005) 7734-7742
57. Woodall A.J., Richards M.A., Turner D.J., and Fitzgerald E.M. Growth factors differentially regulate neuronal Ca (v) channels via ERK-dependent signalling. Cell Calcium 43 (2008) 562-575
58. Xiang Z., Bo X., and Burnstock G. Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia. Neurosci Lett 256 (1998) 105-108
59. Xie W.R., Deng H., Li H., Bowen T.L., Strong J.A., and Zhang J.M. Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia. Neuroscience 142 (2006) 809-822
60. 2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors. Proc Natl Acad Sci USA 101 (2004) 11868-11873
61. Zhang X., Chen Y., Wang C., and Huang L.Y. Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc Natl Acad Sci USA 104 (2007) 9864-9869
62. Zhang Y., Cai G., Ni X., and Sun J. The role of ERK activation in the neuronal excitability in the chronically compressed dorsal root ganglia. Neurosci Lett 419 (2007) 153-157