α-hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of a-subunits of human HbA with hydrogen peroxide

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 4288-4298

  Mollan, Todd L ^a   Banerjee, Sambuddha ^b   Wu, Gang ^c   Parker Siburt, Claire J ^b   Tsai, Ah Lim ^c   Olson, John S ^d   Weiss, Mitchell J ^e   Crumbliss, Alvin L ^b   Alayash, Abdu I ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b DUKE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d RICE UNIVERSITY   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME IRON; HEXACOORDINATION; HUMAN HEMOGLOBIN A; MOLECULAR CHAPERONES; OXIDATION STATE; OXIDATIVE REACTION; PH VALUE; REDOX MECHANISM; REDOX POTENTIALS;

AMINO ACIDS; HEMOGLOBIN; HYDROGEN PEROXIDE; OXIDATION; PEROXIDES; PORPHYRINS; PROTEINS; REDOX REACTIONS; SECONDARY BATTERIES;

IRON COMPOUNDS;

ALPHA HEMOGLOBIN STABILIZING PROTEIN; BINDING PROTEIN; FERRIC ION; FERRYL HEME; GLYCINE; HEME; HEMOGLOBIN A; HEMOGLOBIN BETA CHAIN; HYDROGEN PEROXIDE; RADICAL; UNCLASSIFIED DRUG;

ARTICLE; AUTOOXIDATION; BINDING AFFINITY; IRON METABOLISM; METABOLIC RATE; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; TEMPERATURE;

BLOOD PROTEINS; HEMOGLOBIN A; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; METHEMOGLOBIN; MOLECULAR CHAPERONES; MULTIPROTEIN COMPLEXES; OXIDANTS; OXIDATION-REDUCTION;

EID: 84873668645     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.412064     Document Type: Article

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