Loss of α-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia

Journal of Clinical Investigation

Volumn 114, Issue 10, 2004, Pages 1457-1466

  Kong, Yi ^a   Zhou, Suiping ^b   Kihm, Anthony J ^b,e   Katein, Anne M ^c   Yu, Xiang ^a   Gell, David A ^d   Mackay, Joel P ^d   Adachi, Kazuhiko ^b   Foster Brown, Linda ^c   Louden, Calvert S ^c   Gow, Andrew J ^b   Weiss, Mitchell J ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF SYDNEY   (Australia)

^e JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEMOGLOBIN STABILIZING PROTEIN; CELL PROTEIN; HEMOGLOBIN A; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; HEMOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BETA THALASSEMIA; BIOSYNTHESIS; CELL DAMAGE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DISEASE SEVERITY; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; HEMOGLOBIN SYNTHESIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRECIPITATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; ERYTHROCYTE; GENETICS; HEINZ BODY; HETEROZYGOTE; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BETA-THALASSEMIA; ERYTHROCYTES; ERYTHROPOIESIS; HEINZ BODIES; HEMOGLOBINS; HETEROZYGOTE; KINETICS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PROTEIN CONFORMATION; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS;

EID: 85047690518     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI21982     Document Type: Article

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