An abundant erythroid protein that stabilizes free α-haemoglobin

Nature

Volumn 417, Issue 6890, 2002, Pages 758-763

  Kihm, Anthony J ^a   Kong, Yi ^a   Hong, Wel ^a   Russell, J Eric ^a   Rouda, Susan ^a   Adachl, Kazuhiko ^a   Simon, M Celeste ^b   Blobel, Gerd A ^a   Weiss, Mitchell J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; MORPHOLOGY; PATHOLOGY; PRECIPITATION (CHEMICAL); PROTEINS; STABILIZERS (AGENTS); TOXIC MATERIALS;

HAEMOGLOBIN PRECIPITATION;

HEMOGLOBIN;

ALPHA HEMOGLOBIN STABILIZING PROTEIN; CHAPERONE; GLOBIN; HEMOGLOBIN A; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; OXYGEN; PROTEIN; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE STRUCTURE; ERYTHROPOIESIS; GENETIC SCREENING; HEMOGLOBIN SYNTHESIS; HUMAN; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN STABILITY; RETICULOCYTOSIS;

ANIMALS; BETA-THALASSEMIA; CELL LINE; COS CELLS; DNA-BINDING PROTEINS; ERYTHROCYTES; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GATA1 TRANSCRIPTION FACTOR; GENE DELETION; GENE EXPRESSION REGULATION; HEMOGLOBINS; HUMANS; MICE; MOLECULAR CHAPERONES; ORGAN SPECIFICITY; OXIDANTS; PRECIPITATION; PROTEIN BINDING; SOLUTIONS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037071860     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00803     Document Type: Article

References (29)

1. Chromosomal and cytoplasmic regulation of hyemoglobin synthesis
2. Thalassemia: The consequences of unbalanced hemoglobin synthesis
3. GATA transcription factors: Key regulators of hematopoiesis
4. ABCa novel mitochondrial transporter induced by GATA-1 during erythroid differentiation
5. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells
6. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
7. A novel erythroid-specific marker of transmissible spongiform encephalopathies
8. Influence of hemoglobin precipitation on erythrocyte metabolism in alpha and beta thalassemia
9. Erythrocyte membrane skeleton abnormalities in severe beta-thalassemia
10. The role of membrane skeletal-associated alpha-globin in the pathophysiology of beta-thalassemia
11. The instability of the membrane skeleton in thalassemic red blood cells
12. Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia)
13. A correlation of rythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in Thai patients with thalassemia
14. The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major
15. Studies on the stability of oxyhemoglobin A and its constituent chains and their derivatives
16. Ultrastructural studies of erythropoiesis in beta-thalassaemia trait
17. Mouse model of human beta zero thalassemia: Targeted deletion of the mouse beta maj- and beta min min-globin genes in embryonic stem cells
18. A mouse model for beta (O)-thalassemia
19. Evidence for soluble alpha-chains as intermediates in hemoglobin synthesis in the rabbit reticulocyte
20. The control of hemoglobin synthesis
21. Prion protein biology
22. Posttranslational quality control: Folding, refolding, and degrading proteins
23. Intracellular loss of free α chains in β-thalassaemia
24. Turnover of excess hemoglobin α chains in β-thalassemic cells is ATP-dependent
25. L expression
26. Denaturation of the normal and abnormal hemoglobin molecule