Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem

Nature

Volumn 435, Issue 7042, 2005, Pages 697-701

  Feng, Liang ^a   Zhou, Suiping ^b   Gu, Lichuan ^a   Gell, David A ^c   Mackay, Joel P ^c   Weiss, Mitchell J ^b   Gow, Andrew J ^b   Shi, Yigong ^a  

^a PRINCETON UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; IRON; OXIDATION; OXYGEN; PRECIPITATION (CHEMICAL); REDOX REACTIONS; STRESS ANALYSIS; STRUCTURE (COMPOSITION); SYNTHESIS (CHEMICAL);

CHEMICAL REACTIVITY; FERRIC BIHISTIDINE; OXIDANT STRESS; STRUCTURAL CHANGES;

HEMOGLOBIN;

ALPHA HEMOGLOBIN STABILIZING PROTEIN; BINDING PROTEIN; FERRIC ION; FERROUS ION; HEME; HEMOGLOBIN A; HISTIDINE; OXIDIZED HEMOGLOBIN A; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CHAPERONE; OXYHEMOGLOBIN; PLASMA PROTEIN;

MEDICINE;

ALPHA HELIX; ARTICLE; CHEMOREACTIVITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; ERYTHROCYTE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

BLOOD PROTEINS; CRYSTALLOGRAPHY, X-RAY; HEME; HEMOGLOBIN A; MODELS, MOLECULAR; MOLECULAR CHAPERONES; OXIDATION-REDUCTION; OXYHEMOGLOBINS; PROTEIN BINDING; PROTEIN CONFORMATION; REACTIVE OXYGEN SPECIES;

EID: 20444445134     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03609     Document Type: Article

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