Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB 1-induced hepatocellular carcinoma

Gene

Volumn 490, Issue 1-2, 2011, Pages 54-59

  Kumar, Manoj ^a   Verma, Vinod ^b   Nagpal, Ravinder ^c   Kumar, Ashok ^d   Gautam, Sanjeev K ^e   Behare, Pradip V ^f   Grover, Chand R ^a   Aggarwal, Praveen K ^a  

^a NATIONAL DAIRY RESEARCH INSTITUTE   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c JMIT Institute of Engineering and Technology   (India)

^d Department of Botany   (India)

^e KURUKSHETRA UNIVERSITY   (India)

^f PVNRTVU   (India)

Author keywords

Aflatoxins; Fermented milk; Genotoxicity; Liver cancer; Probiotics

Indexed keywords

AFLATOXIN B1; CHLOROPHYLL; CYCLIN D1; PROBIOTIC AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG POTENTIATION; GENE; GENE EXPRESSION; GENOTOXICITY; LACTOBACILLUS CASEI; LACTOBACILLUS RHAMNOSUS; LIVER CELL; LIVER CELL CARCINOMA; MALE; MILK; NONHUMAN; PRIORITY JOURNAL; PROBIOTIC FERMENTED MILK; RASP21 GENE; RAT;

AFLATOXIN B1; ANIMALS; CARCINOMA, HEPATOCELLULAR; CHLOROPHYLLIDES; COMET ASSAY; CULTURED MILK PRODUCTS; DNA DAMAGE; GENE EXPRESSION; LIVER NEOPLASMS; MALE; MUTAGENS; PROBIOTICS; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 80055027947     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.09.003     Document Type: Article

References (42)

1. Ahotupa M., Saxelin M., Korpela R. Antioxidant properties of Lactobacillus GG. Nutr. Today 1996, 31(Suppl.):51-52.
2. Anderson D., Yu T.W., Phillips B.J., Schemezer P. The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay. Mutat. Res. 1994, 307:261-271.
3. Arimoto S., Negishi T., Hayatsu H. Inhibitory effect of hemin on the mutagenic activities of carcinogens. Cancer Lett. 1980, 11:29-33.
4. Bennett J.W., Klich M. Mycotoxins. Clin. Microbiol. 2003, 3:497-516.
5. Dashwood R.H., Breinholt V., Bailey G.S. Chemoprotective properties of chlorophyllin: inhibition of aflatoxin-B, (AFB,)-DNA binding in vivo and antimutagenic activity against AFB, and two heterocyclic amines in the salmonella mutagenicity assay. Carcinogenesis 1991, 12:939-942.
6. Dashwood R., Negishi T., Hayatsu H., Breinholt V., Hendricks J., Bailey G. Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of antimutagenicity and anticarcinogenecity data in rainbow trout. Mutat. Res. 1998, 399:245-253.
7. El-Nezami H.S., et al. Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from southern China. Am. J. Clin. Nutr. 2006, 83:1199-1203.
8. Feig D.I., Reid T.M., Loeb L.A. Reactive oxygen species in tumorigenesis. Cancer Res. 1994, 54:1890s-1894s.
9. Foster P.L., Eisenstadt E., Miller J.H. Base substitution 291 mutations induced by metabolically activated aflatoxin B1. Proc. Natl. Acad. Sci. U.S.A. 1983, 80:2695-2698.
10. Fuller R. Probiotics in man and animals. J. Appl. Bacteriol. 1989, 66:365-378.
11. Goldin B.R., Gualtieri L.J., Moore R.P. The effect of Lactobacillus GG on the initiation and promotion of DMH induced intestinal tumors in the rat. Nutr. Cancer 1996, 25:197-204.
12. Gratz S., et al. Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B(1) in rats. Appl. Environ. Microbiol. 2006, 72:7398-7400.
13. IARC IARC monographs on the evaluation of carcinogenic risks to humans: some traditional herbal medicines, some mycotoxinsm naphtalene and styrene. IARC Monogr. 2002, 82:171.
14. John P.A. The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention Mol. Cancer 2007, 6:1-16.
15. Kensler T.W., et al. Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Gastroenterology 2004, 127:S310-S318.
16. Kumar A., Singh N.K., Sinha P.R., Kumar R. Intervention of acidophilus-casei dahi and wheat bran against molecular alteration in colon carcinogenesis. Mol. Biol. Rep. 2010, 37:621-627.
17. Kumar M., et al. Cancer-preventing attributes of probiotics: an update. Int. J. Food Sci. Nutr. 2010, 61:473-496.
18. Kumar M., Verma V., Nagpal R., Kumar A., Behare P.V., Singh B., Aggarwal P.K. Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B1 induced liver carcinogenesis in rats. Brit. J. Nutr. 2011, [Epub ahead of print].
19. Larson P.S., McMahon G., Wogan G.N. Modulation of c-myc gene expression in rat livers by aflatoxin B1 exposure and age. Fundam. Appl. Toxicol. 1993, 203:316-324.
20. Levy D., Groopman J., Lim S., Seidman M., Kraemer K. Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells. Cancer Res. 1992, 52:5668-5673.
21. Lin M.Y., Chang F.J. Antioxidative effect of intestinal bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356. Dig. Dis. Sci. 2000, 5:1617-1622.
22. Miglio De M.R., et al. Correlation of c-myc over-expression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain. Mol. Carcinog. 1999, 25:21-29.
23. Mitsuoka T. Bifidobacteria and their role in human health. J. Ind. Microbiol. 1990, 6:263-268.
24. Negishi T., Rai H., Hayatsu H. Antigenotoxic activity of natural chlorophylls. Mutat. Res. 1997, 376:97-100.
25. Nishida N., et al. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res. 1994, 54:3107-3110.
26. Nita, M.E. 2000. Role of apoptosis related proteins in digestive tract cancer (thesis). Tokyo: The University of Tokyo.
27. Nita M.E., et al. p21Waf1/Cip1 expression is a prognostic marker in curatively resected esophageal squamous cell carcinoma, but not p27Kip1, p53, or Rb. Ann. Surg. Oncol. 1999, 6:481-488.
28. Ozturk M. Genetic aspects of hepatocellular carcinogenesis. Semin. Liver Dis. 1999, 19:235-242.
29. Paget V., Sichel F., Garon D., Lechevrel M. Aflatoxin B(1)-induced TP53 mutational pattern in normal human cells using the FASAY (functional analysis of separated alleles in yeast). Mutat. Res. 2008, 656:55-61.
30. Pascale R.M., et al. cmyc amplification in pre-malignant and malignant lesions induced rat liver by the resistant hepatocyte model. Int. J. Cancer 1996, 68:136-142.
31. Patricia A., Egner A.M., Thomas W.K. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mut. Res./ Fund. Mol. Mech. Mutagen. 2003, 524:209-216.
32. Prives C., Hall P.A. The p53 pathway. J. Pathol. 1999, 187:112-126.
33. Rao D.R., Pulasani S.R., Chawan C.B. Natural inhibitors of carcinogenesis: fermented milk products. A Critical Evaluation 1986, vol. 2:63-75. CRC press, Boca Raton. B.S. Reddy, L.A. Cohen (Eds.).
34. Reddy B.S., Rivenson A. Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo(4,5-f)quinoline, a food mutagen. Cancer Res. 1993, 53:3914-3918.
35. Reddy G.V., Shahani K.M., Benerjee M.R. Inhibitory effect of yogurt on Ehrich ascites tumor-cell proliferation. J. Natl. Cancer Inst. 1973, 50:815-817.
36. Romert L., Curvali M., Jenssen D. Chlorophyllin is both a positive and negative modifier of mutagenicity. Mutagenesis 1992, 7:349-355.
37. Singh J., Rivenson A., Tomita M., Shimamura S., Ishibashi N., Reddy B.S. Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis 1997, 18:833-841.
38. Storz G., Polla B.S. Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes. Exper. Suppl. Basel. 1996, 77:239-254.
39. Suchy R.K., Sarafoff M., Kerler R., Rabi H.M. Amplifications, rearrangements, and enhanced expression of c-myc in chemically induced rat livers in vivo and in vitro. Cancer Res. 1989, 49:6781-6787.
40. Tavan E., Cayuela C., Antoine J., Trugnan G. Effects of dairy products on heterocyclic aromatic amine induced rat colon carcinogenesis. Carcinogenesis 2002, 23:477-483.
41. Terahara M., Meguro S., Kaneko T. Effects of lactic acid bacteria on binding and absorption of mutagenic heterocyclic amines. Biosci. Biotechnol. Biochem. 1998, 62:197-200.
42. Zsivkovits M., et al. Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different Lactobacillus strains. Carcinogenesis 2003, 24:1913-1918.