Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Spry, Christina ^a,f   Macuamule, Cristiano ^b   Lin, Zhiyang ^a   Virga, Kristopher G ^c,d   Lee, Richard E ^d,e   Strauss, Erick ^b   Saliba, Kevin J ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c PRESBYTERIAN COLLEGE   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ENZYME; PANTETHEINASE; PANTOTHENAMIDE; PANTOTHENATE KINASE; PANTOTHENIC ACID; UNCLASSIFIED DRUG; AMIDASE; AMIDE; COENZYME A; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; PHOSPHOTRANSFERASE; RECOMBINANT PROTEIN;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DETERMINATION; DRUG EFFECT; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; IN VITRO STUDY; NONHUMAN; PARASITE IDENTIFICATION; PLASMODIUM FALCIPARUM; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; ERYTHROCYTE; MALARIA, FALCIPARUM; METABOLISM; PARASITOLOGY; PHOSPHORYLATION;

AMIDES; AMIDOHYDROLASES; ANTIMALARIALS; CELLS, CULTURED; COENZYME A; ERYTHROCYTES; GPI-LINKED PROTEINS; HUMANS; MALARIA, FALCIPARUM; PANTOTHENIC ACID; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLASMODIUM FALCIPARUM; RECOMBINANT PROTEINS;

EID: 84873558652     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054974     Document Type: Article

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