Antiplasmodial activity of naphthoquinones related to lapachol and β-lapachone

Chemistry and Biodiversity

Volumn 2, Issue 2, 2005, Pages 264-274

  Pérez Sacau, Elisa ^a,b   Estévez Braun, Ana ^a,b   Ravelo, Ángel G ^a,b   Gutiérrez Yapu, David ^c   Giménez Turba, Alberto ^c  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b Facultad de Ciencias Farmacéuticas y Bioquímicas   (Spain)

^c UNIVERSIDAD MAYOR DE SAN ANDRÉS   (Bolivia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3,4,9 TETRAHYDRO 4,9 DIOXONAPHTHO[2,3 B]FURAN 2 YL) 1 METHYLETHYL NITRATE; 1,4 DIHYDRO 3 (3 METHYLBUT 2 EN 1 YL) 1,4 DIOXONAPHTHALEN 2 YL 3,4,5 TRIMETHOXYBENZOATE; 2 (METHOXYMETHOXY) 3 (3 METHYLBUT 2 EN 1 YL)NAPHTHALENE 1,4 DIONE; 2 [[(TERT BUTYL)(DIMETHYLSILYL)]OXY] 3 (3 METHYLBUT 2 EN 1 YL)NAPHTHALENE 1,4 DIONE; 2 ETHOXY 3,4 DIHYDRO 2H NAPHTHO[1,2 B]PYRAN 5,6 DIONE; 2,3 DIHYDRO 2 (1 HYDROXY 1 METHYLETHYL) 5 NITRONAPHTHO[1,2 B]FURAN 4 OL; 2,3 DIHYDRO 2 (1 HYDROXY 1 METHYLETHYL)NAPHTHO[1,2 B]FURAN 4,5 DIONE; 2,3,10,11,12,13 HEXAHYDRO 3,3 DIMETHYL 1H BENZO[A]PYRANO[2,3 C]PHENAZINE; 3 BROMO 3,4 DIHYDRO 2,2 DIMETHYL 2H NAPHTHO[1,2 B]PYRAN 5,6 DIONE; 7A,8,9,10,11,11A HEXAHYDRO 6 (3 METHYLBUT 2 EN 1 YL)BENZO[A]PHENAZIN 5(7H) ONE; ANTIMALARIAL AGENT; ANTISPOROZOAL AGENT; BETA LAPACHONE; DEHYDRO BETA LAPACHONE; LAPACHOL; NAPHTHOQUINONE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CULTURE TECHNIQUE; DRUG MECHANISM; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; MOLECULAR STRUCTURE; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 16844370826     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200590009     Document Type: Article

References (12)

1. P. Olliaro, Pharmacol Ther. 2001, 89, 207.
2. G. Yamey, Br. Med. J. 2001, 322, 1191.
3. R. Caniato, L. Puricelli, Crit. Rev. Plant Sci. 2003 22, 79.
4. S. Schwikkard, F. Van Heerden, Nat. Prod. Rep. 2002 19, 675.
5. P. J. Brien, Chem.-Biol. Interact. 1991, 80 1.
6. A. G. Ravelo, A. Estévez-Braun, E. Pérez-Sacau. Stud. Nat. Prod. Chem. 2003, 29, 719.
7. E. Pérez-Sacau, A. Estévez-Braun, A. G. Ravelo, E. A Ferro, H. Tozuda, H. Nishino, Bioorg. Med. Chem. 2003, 11 483.
8. V. Nair, P. M. Treesa, Tetrahedron Lett. 2001, 42, 4549.
9. K. Inoue, C. Chen, H. Inouye, K. Kuriyama, J. Chem. Soc., Perkin Trans 1 1981, 11, 2764.
10. J. R. Villegas, S. Amato, I. Castro, O. Castro, U. Jacobson, Fitoterapia 1995, 66, 281.
11. M. Girard, J. C. Ethier, D. Kindack, B. A Dawson, D. V. Awang, J. Nat. Prod. 1987, 50, 1149.
12. W. Trager, J. B. Jensen, Science 1976, 193, 673.