Inhibitors of pantothenate kinase: Novel antibiotics for staphylococcal infections

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 6, 2003, Pages 2051-2055

  Choudhry, Anthony E ^a   Mandichak, Tracy L ^a,c   Broskey, John P ^a   Egolf, Richard W ^a,c   Kinsland, Cynthia ^b   Begley, Tadhg P ^b   Seefeld, Mark A ^a   Ku, Thomas W ^a   Brown, James R ^a   Zalacain, Magdalena ^a   Ratnam, Kapila ^a  

^a GLAXOSMITHKLINE   (United States)

^b Department of Molecular Biology and Genetics   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; COENZYME A; PANTOTHENATE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM IDENTIFICATION; CONTROLLED STUDY; ENZYME INHIBITION; GENE IDENTIFICATION; GROWTH INHIBITION; IC 50; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STAPHYLOCOCCUS INFECTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; COENZYME A; DNA, BACTERIAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PANTOTHENIC ACID; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PHYLOGENY; SEQUENCE ALIGNMENT; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TUMOR CELLS, CULTURED;

EID: 0037764064     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.6.2051-2055.2003     Document Type: Article

References (27)

1. Abiko, Y. 1967. Investigations on pantothenic acid and its related compounds. IX. Biochemical studies. 4. Separation and substrate specificity of pantothenate kinase and phosphopantothenoylcysteine synthetase. J. Biochem. (Tokyo) 61:290-299.
2. Afshar, K., P. Gönczy, S. DiNardo, and S. A. Wasserman. 2001. fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Genetics 157:1267-1276.
3. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, and K. Struhl (ed.). 1987. Current protocols in molecular biology. Wiley, New York, N.Y.
5. Begley, T. P., C. Kinsland, and E. Strauss. 2001. The biosynthesis of coenzyme A in bacteria, p. 157-171. In G. Litwack and T. P. Begley (ed.), Vitamins and hormones, vol. 61. Academic Press, New York, N.Y.
6. 1-(substituted) pantothenamides, antimetabolites of pantothenic acid. Arch. Biochem. Biophys. 137:523-528.
7. Daugherty, M., B. Polanuyer, M. Farrell, M. Scholle, A. Lykidis, V. de Crecy-Lagard, and A. Osterman. 2002. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J. Biol. Chem. 277:21431-21439.
8. Daugherty, M., V. Vonstein, R. Overbeek, and A. Osterman. 2001. Archaeal shikimate kinase, a new member of the GHMP-kinase family. J. Bacteriol. 183:292-300.
9. Geerlof, A., A. Lewendon, and W. V. Shaw. 1999. Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli. J. Biol. Chem. 274:27105-27111.
10. Kupke, T., M. Uebele, D. Schmid, G. Jung, M. Blaesse, and S. Steinbacher. 2000. Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J. Biol. Chem. 275:31838-31846.
11. Kuroda, M., et al. 2001. Whole genome sequencing of methicillin-resistant Staphylococcus aureus. Lancet 357:1225-1240.
12. Martin, D. P., and D. G. Drueckhammer. 1993. Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase. Biochem. Biophys. Res. Commun. 192:1155-1161.
13. Mishra, P. K., P. K. Park, and D. G. Drueckhammer. 2001. Identification of yace (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12. J. Bacteriol. 183:2774-2778.
14. Payne, D. J., et al. 2002. Discovery of a novel and potent class of Fabldirected antibacterial agents. Antimicrob. Agents Chemother. 46:3118-3124.
15. Read, T. D., S. L. Salzberg, M. Pop, M. Shumway, L. Umayam, L. Jiang, E. Holtzapple, J. D. Busch, K. L. Smith, J. M. Schupp, D. Solomon, P. Keim, and C. M. Fraser. 2002. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis. Science 296:2028-2033.
16. Rock, C. O., R. B. Calder, M. A. Karim, and S. Jackowski. 2000. Pantothenate kinase regulation of the intracellular concentration of coenzyme A. J. Biol. Chem. 275:1377-1383.
17. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
18. Skrede, S., and O. Halvorsen. 1983. Mitochondrial pantetheinephosphate adenylyltransferase and dephospho-CoA kinase. Eur. J. Biochem. 131:57-63.
19. Song, W.-J., and S. Jackowski. 1992. Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli. J. Bacteriol. 174:6411-6417.
20. Song, W.-J., and S. Jackowski. 1994. Kinetics and regulation of pantothenate kinase from Escherichia coli. J. Biol. Chem. 269:27051-27058.
21. Strauss, E., C. Kinsland, Y. Ge, F. W. McLafferty, and T. P. Begley. 2001. Phosphopantothenoylcysteine synthase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. J. Biol. Chem. 276:13513-13516.
22. Strauss, E., and T. P. Begley. 2002. The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite. J. Biol. Chem. 277:48205-48209.
23. Strimmer, K., and A. von Haeseler. 1996. Quartet puzzling: a quartet maximum-likelihood method for reconstructing tree topologies. Mol. Biol. Evol. 13:964-969.
24. Suzuki, T., Y. Abiko, and M. Shimizu. 1967. Dephospho-CoA pyrophosphorylase and dephospho-CoA kinase as a possible bifunctional enzyme complex. J. Biochem. (Tokyo) 62:642-649.
25. Takami, H., Y. Takaki, and I. Uchiyama. 2002. Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments. Nucleic Acids Res. 30:3927-3935.
26. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
27. Worrall, D. M., and P. K. Tubbs. 1983. A bifunctional enzyme complex in coenzyme A biosynthesis: purification of pantetheine phosphate adenylyltransferase and dephospho-CoA kinase. Biochem. J. 215:153-157.