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Volumn 54, Issue 3, 2010, Pages 1374-1377

Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme A synthesis

Author keywords

[No Author keywords available]

Indexed keywords

ACPH ACYL CARRIER PROTEIN; ACYL CARRIER PROTEIN; ANTIINFECTIVE AGENT; COENZYME A; N PENTYLPANTOTHENAMIDE; PANTOTHENIC ACID DERIVATIVE; PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

EID: 77149152473     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01473-09     Document Type: Article
Times cited : (30)

References (23)
  • 1
    • 38849098884 scopus 로고    scopus 로고
    • Acyl carrier protein: Structure-function relationships in a conserved multifunctional protein family
    • Byers, D. M., and H. Gong. 2007. Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family. Biochem. Cell Biol. 85:649-662.
    • (2007) Biochem. Cell Biol , vol.85 , pp. 649-662
    • Byers, D.M.1    Gong, H.2
  • 2
    • 0014767905 scopus 로고
    • N′-(substituted) pantothenamides, antimetabolites of pantothenic acid
    • Clifton, G., S. R. Bryant, and C. G. Skinner. 1970. N′-(substituted) pantothenamides, antimetabolites of pantothenic acid. Arch. Biochem. Biophys. 137:523-528.
    • (1970) Arch. Biochem. Biophys , vol.137 , pp. 523-528
    • Clifton, G.1    Bryant, S.R.2    Skinner, C.G.3
  • 3
    • 32044460370 scopus 로고    scopus 로고
    • A family of arabinose-inducible Escherichia coli expression vectors having pBR322 copy control
    • Cronan, J. E. 2006. A family of arabinose-inducible Escherichia coli expression vectors having pBR322 copy control. Plasmid 55:152-157.
    • (2006) Plasmid , vol.55 , pp. 152-157
    • Cronan, J.E.1
  • 4
    • 0018838186 scopus 로고
    • β-Alanine synthesis in Escherichia coli
    • Cronan, J. E., Jr. 1980. β-Alanine synthesis in Escherichia coli. J. Bacteriol. 141:1291-1297.
    • (1980) J. Bacteriol , vol.141 , pp. 1291-1297
    • Cronan Jr., J.E.1
  • 5
    • 64049116611 scopus 로고    scopus 로고
    • Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways
    • Cronan, J. E., and J. Thomas. 2009. Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. Methods Enzymol. 459: 395-433.
    • (2009) Methods Enzymol , vol.459 , pp. 395-433
    • Cronan, J.E.1    Thomas, J.2
  • 6
    • 33644907784 scopus 로고    scopus 로고
    • Gene-specific random mutagenesis of Escherichia coli in vivo: Isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis
    • De Lay, N. R., and J. E. Cronan. 2006. Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. J. Bacteriol. 188:287-296.
    • (2006) J. Bacteriol , vol.188 , pp. 287-296
    • De Lay, N.R.1    Cronan, J.E.2
  • 7
    • 0033955033 scopus 로고    scopus 로고
    • Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli
    • Flugel, R. S., Y. Hwangbo, R. H. Lambalot, J. E. Cronan, Jr., and C. T. Walsh. 2000. Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. J. Biol. Chem. 275:959-968.
    • (2000) J. Biol. Chem , vol.275 , pp. 959-968
    • Flugel, R.S.1    Hwangbo, Y.2    Lambalot, R.H.3    Cronan Jr., J.E.4    Walsh, C.T.5
  • 8
    • 0029018327 scopus 로고
    • Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    • Guzman, L. M., D. Belin, M. J. Carson, and J. Beckwith. 1995. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J. Bacteriol. 177:4121-4130.
    • (1995) J. Bacteriol , vol.177 , pp. 4121-4130
    • Guzman, L.M.1    Belin, D.2    Carson, M.J.3    Beckwith, J.4
  • 9
    • 30744471966 scopus 로고    scopus 로고
    • The β-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent
    • Iram, S. H., and J. E. Cronan. 2006. The β-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent. J. Bacteriol. 188:599-608.
    • (2006) J. Bacteriol , vol.188 , pp. 599-608
    • Iram, S.H.1    Cronan, J.E.2
  • 10
    • 4143098353 scopus 로고    scopus 로고
    • The structure of the pantothenate kinase-ADP-pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
    • Ivey, R. A., Y. M. Zhang, K. G. Virga, K. Hevener, R. E. Lee, C. O. Rock, S. Jackowski, and H. W. Park. 2004. The structure of the pantothenate kinase-ADP-pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. J. Biol. Chem. 279:35622-35629.
    • (2004) J. Biol. Chem , vol.279 , pp. 35622-35629
    • Ivey, R.A.1    Zhang, Y.M.2    Virga, K.G.3    Hevener, K.4    Lee, R.E.5    Rock, C.O.6    Jackowski, S.7    Park, H.W.8
  • 11
    • 0022626960 scopus 로고
    • Consequences of reduced intracellular coenzyme A content in Escherichia coli
    • Jackowski, S., and C. O. Rock. 1986. Consequences of reduced intracellular coenzyme A content in Escherichia coli. J. Bacteriol. 166:866-871.
    • (1986) J. Bacteriol , vol.166 , pp. 866-871
    • Jackowski, S.1    Rock, C.O.2
  • 12
    • 0019812065 scopus 로고
    • Regulation of coenzyme A biosynthesis
    • Jackowski, S., and C. O. Rock. 1981. Regulation of coenzyme A biosynthesis. J. Bacteriol. 148:926-932.
    • (1981) J. Bacteriol , vol.148 , pp. 926-932
    • Jackowski, S.1    Rock, C.O.2
  • 13
    • 0029989316 scopus 로고    scopus 로고
    • Keating, D. H., Y. Zhang, and J. E. Cronan, Jr. 1996. The apparent coupling between synthesis and posttranslational modification of Escherichia coli acyl carrier protein is due to inhibition of amino acid biosynthesis. J. Bacteriol. 178:2662-2667.
    • Keating, D. H., Y. Zhang, and J. E. Cronan, Jr. 1996. The apparent coupling between synthesis and posttranslational modification of Escherichia coli acyl carrier protein is due to inhibition of amino acid biosynthesis. J. Bacteriol. 178:2662-2667.
  • 14
    • 33748776033 scopus 로고    scopus 로고
    • Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification
    • Meier, J. L., A. C. Mercer, H. Rivera, Jr., and M. D. Burkart. 2006. Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification. J. Am. Chem. Soc. 128:12174-12184.
    • (2006) J. Am. Chem. Soc , vol.128 , pp. 12174-12184
    • Meier, J.L.1    Mercer, A.C.2    Rivera Jr., H.3    Burkart, M.D.4
  • 15
    • 0019416792 scopus 로고    scopus 로고
    • Polacco, M. L., and J. E. Cronan, Jr. 1981. A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]. J. Biol. Chem. 256:5750-5754.
    • Polacco, M. L., and J. E. Cronan, Jr. 1981. A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]. J. Biol. Chem. 256:5750-5754.
  • 16
    • 0019345428 scopus 로고    scopus 로고
    • Rock, C. O., and J. E. Cronan, Jr. 1981. Acyl carrier protein from Escherichia coli. Methods Enzymol. 71(Pt C):341-351.
    • Rock, C. O., and J. E. Cronan, Jr. 1981. Acyl carrier protein from Escherichia coli. Methods Enzymol. 71(Pt C):341-351.
  • 18
    • 0037073693 scopus 로고    scopus 로고
    • The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite
    • Strauss, E., and T. P. Begley. 2002. The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite. J. Biol. Chem. 277:48205-48209.
    • (2002) J. Biol. Chem , vol.277 , pp. 48205-48209
    • Strauss, E.1    Begley, T.P.2
  • 19
    • 27144441544 scopus 로고    scopus 로고
    • The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: Genetic and enzymological characterization
    • Thomas, J., and J. E. Cronan. 2005. The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. J. Biol. Chem. 280:34675-34683.
    • (2005) J. Biol. Chem , vol.280 , pp. 34675-34683
    • Thomas, J.1    Cronan, J.E.2
  • 20
    • 0014216564 scopus 로고
    • Acyl carrier protein. IX. Acyl carrier protein hydrolase
    • Vagelos, P. R., and A. R. Larrabee. 1967. Acyl carrier protein. IX. Acyl carrier protein hydrolase. J. Biol. Chem. 242:1776-1781.
    • (1967) J. Biol. Chem , vol.242 , pp. 1776-1781
    • Vagelos, P.R.1    Larrabee, A.R.2
  • 22
    • 0018696728 scopus 로고
    • Purification and properties of L-aspartate-alpha-decarboxylase, an enzyme that catalyzes the formation of β-alanine in Escherichia coli
    • Williamson, J. M., and G. M. Brown. 1979. Purification and properties of L-aspartate-alpha-decarboxylase, an enzyme that catalyzes the formation of β-alanine in Escherichia coli. J. Biol. Chem. 254:8074-8082.
    • (1979) J. Biol. Chem , vol.254 , pp. 8074-8082
    • Williamson, J.M.1    Brown, G.M.2
  • 23
    • 10944262320 scopus 로고    scopus 로고
    • Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites
    • Zhang, Y. M., M. W. Frank, K. G. Virga, R. E. Lee, C. O. Rock, and S. Jackowski. 2004. Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J. Biol. Chem. 279:50969-50975.
    • (2004) J. Biol. Chem , vol.279 , pp. 50969-50975
    • Zhang, Y.M.1    Frank, M.W.2    Virga, K.G.3    Lee, R.E.4    Rock, C.O.5    Jackowski, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.