The structure of the pantothenate kinase·ADP·pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites

Journal of Biological Chemistry

Volumn 279, Issue 34, 2004, Pages 35622-35629

  Ivey, Robert A ^a   Zhang, Yong Mei ^a   Virga, Kristopher G ^b   Hevener, Kirk ^b   Lee, Richard E ^b   Rock, Charles O ^a   Jackowski, Suzanne ^a   Park, Hee Won ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOCHEMISTRY; CATALYSIS; DISSOCIATION; FEEDBACK CONTROL; HYDROPHOBICITY;

INTRACELLULAR COENZYMES; PATHOTHENATE KINASE;

ENZYMES;

ADENOSINE DIPHOSPHATE; AMINO ACID; ARGININE; LIGAND; LYSINE; MAGNESIUM ION; PANTOTHENATE KINASE; PANTOTHENIC ACID; PHOSPHATE;

ARTICLE; BINDING SITE; CRYSTALLIZATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SYNTHESIS;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CATALYSIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PANTOTHENIC ACID; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 4143098353     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403152200     Document Type: Article

References (33)

1. Jackowski, S. (1996) in Escherichia coli and Salmonella typhimurium (Neidhardt, F. C., Curtiss, R., Gross, C. A., Ingraham, J. L., Lin, E. C., Low, K. B., Mgasanik, B., Reznikoff, W., Riley, M., Schaechter, M., and Umbarger, H. E., eds) pp. 687-694, American Society of Microbiology, Washington, D.C.
2. Begley, T. P., Kinsland, C., and Strauss, E. (2001) Vitam. Horm. 61, 157-171
3. Vallari, D. S., and Rock, C. O. (1985) J. Bacteriol. 162, 1156-1161
4. Jackowski, S., and Alix, J. H. (1990) J. Bacteriol. 172, 3842-3848
5. Song, W. J., and Jackowski, S. (1992) J. Bacteriol. 174, 6411-6417
6. Strauss, E., Kinsland, C., Ge, Y., McLafferty, F. W., and Begley, T. P. (2001) J. Biol. Chem. 276, 13513-13516
7. Geerlof, A., Lewendon, A., and Shaw, W. V. (1999) J. Biol. Chem. 274, 27105-27111
8. Izard, T., and Geerlof, A. (1999) EMBO J. 18, 2021-2030
9. Mishra, P., Park, P. K., and Drueckhammer, D. G. (2001) J. Bacteriol. 183, 2774-2778
10. Song, W. J., and Jackowski, S. (1994) J. Biol. Chem. 269, 27051-27058
11. Vallari, D. S., Jackowski, S., and Rock, C. O. (1987) J. Biol. Chem. 262, 2468-2471
12. Yun, M., Park, C. G., Kim, J. Y., Rock, C. O., Jackowski, S., and Park, H. W. (2000) J. Biol. Chem. 275, 28093-28099
13. Gerdes, S. Y., Scholle, M. D., D'Souza, M., Bernal, A., Baev, M. V., Farrell, M., Kurnasov, O. V., Daugherty, M. D., Mseeh, F., Polanuyer, B. M., Campbell, J. W., Anantha, S., Shatalin, K. Y., Chowdhury, S. A., Fonstein, M. Y., and Osterman, A. L. (2002) J. Bacteriol. 184, 4555-4572
14. Calder, R. B., Williams, R. S., Ramaswamy, G., Rock, C. O., Campbell, E., Unkles, S. E., Kinghorn, J. R., and Jackowski, S. (1999) J. Biol. Chem. 274, 2014-2020
15. Rock, C. O., Calder, R. B., Karim, M. A., and Jackowski, S. (2000) J. Biol. Chem. 275, 1377-1383
16. Rock, C. O., Karim, M. A., Zhang, Y. M., and Jackowski, S. (2002) Gene 291, 35-43
17. Osterman, A., and Overbeek, R. (2003) Curr. Opin. Chem. Biol. 7, 238-251
18. Mishra, P. K., and Drueckhammer, D. G. (2000) Chem. Rev. 100, 3283-3310
19. Clifton, G., Bryant, S. R., and Skinner, C. G. (1970) Arch. Biochem. Biophys. 137, 523-528
20. Strauss, E., and Begley, T. P. (2002) J. Biol. Chem. 277, 48205-48209
21. Matsumoto, M., Kuhara, T., Inoue, Y., Shinka, T., and Matsumoto, I. (1991) J. Chromatogr. 562, 139-145
22. Noda, S., Haratake, J., Sasaki, A., Ishii, N., Umezaki, H., and Horie, A. (1991) Liver 11, 134-142
23. Sasaki, T., Minagawa, M., Yamamoto, T., and Ichihashi, H. (1991) Brain Dev. 13, 52-55
24. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
25. Madhusudan, A., P., Xuong, N. H., and Taylor, S. S. (2002) Nat. Struct. Biol. 9, 273-277
26. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276A, 307-326
27. Collaborative, Computational Project (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
28. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D. Biol. Crystallogr. 54, Pt. 5, 905-921
29. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A. 47, Pt. 2, 110-119
30. Cleland, W. W., and Hengge, A. C. (1995) FASEB J. 9, 1585-1594
31. Mildvan, A. S. (1997) Proteins 29, 401-416
32. Pauling, L. (1960) in The Nature of the Chemical Bond (Pauling, L., ed) 3rd Ed., Cornell University Press, Ithaca, NY
33. Brown, I. D., and Altermatt, D. (1985) Acta Crystallogr. Sect. B Struct. Crystallogr. 41, 244-247