Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites

Journal of Biological Chemistry

Volumn 279, Issue 49, 2004, Pages 50969-50975

  Zhang, Yong Mei ^a   Frank, Matthew W ^a   Virga, Kristopher G ^b   Lee, Richard E ^b   Rock, Charles O ^a   Jackowski, Suzanne ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; CATALYSIS; COENZYMES; ELECTROPHORESIS; ENZYME INHIBITION; ESCHERICHIA COLI; FATTY ACIDS; HYDROLYSIS; SYNTHESIS (CHEMICAL); TOXICITY;

MEMBRANE LIPIDS; PANTOTHENAMIDES; PHOSPHORYLATION; TIME-OF-FLIGHT MASS SPECTROMETRY;

PROTEINS;

ACYL CARRIER PROTEIN; ANTIMETABOLITE; APOPROTEIN; BACTERIAL PROTEIN; COENZYME A; MEMBRANE LIPID; PANTOTHENIC ACID; PANTOTHENIC ACID 4' PHOSPHATE; THIOL GROUP;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; GEL ELECTROPHORESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; TARGET CELL;

ACETATES; ACYL CARRIER PROTEIN; ANTIMETABOLITES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; COENZYME A; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FATTY ACIDS; HYDROLYSIS; LIPID METABOLISM; LIPIDS; MASS SPECTROMETRY; MODELS, CHEMICAL; PANTOTHENIC ACID; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STREPTOCOCCUS PNEUMONIAE; SUBSTRATE SPECIFICITY; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 10944262320     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409607200     Document Type: Article

References (33)

1. Jackowski, S. (1996) in Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt, F. C., Curtiss, R., Gross, C. A., Ingraham, J. L., Lin, E. C. C., Low, K. B., Magasanik, B., Reznikoff, W., Riley, M., Schaechter, M., and Umbarger, H. E., eds) Vol. 1, pp. 687-694, American Society for Microbiology Press, Washington, D. C.
2. Strauss, E., Kinsland, C., Ge, Y., McLafferty, F. W., and Begley, T. P. (2001) J. Biol. Chem. 276, 13513-13516
3. Geerlof, A., Lewendon, A., and Shaw, W. V. (1999) J. Biol. Chem. 274, 27105-27111
4. Izard, T., and Geerlof, A. (1999) EMBO J. 18, 2021-2030
5. Mishra, P., Park, P. K., and Drueckhammer, D. G. (2001) J. Bacteriol. 183, 2774-2778
6. Vallari, D. S., and Rock, C. O. (1985) J. Bacteriol. 164, 136-142
7. Vallari, D. S., and Rock, C. O. (1985) J. Bacteriol. 162, 1156-1161
8. Jackowski, S., and Alix, J.-H. (1990) J. Bacteriol. 172, 3842-3848
9. Polacco, M. L., and Cronan, J. E., Jr. (1981) J. Biol. Chem. 256, 5750-5754
10. Flugel, R. S., Hwangbo, Y., Lambalot, R. H., Cronan, J. E., Jr., and Walsh, C. T. (2000) J. Biol. Chem. 275, 959-968
11. Fischl, A. S., and Kennedy, E. P. (1990) J. Bacteriol. 172, 5445-5449
12. Nakanishi, M., Yatome, C., Ishida, N., and Kitade, Y. (2001) J. Biol. Chem. 276, 46394-46399
13. Powell, G. L., Elovson, J., and Vagelos, P. R. (1969) J. Biol. Chem. 211, 5610-5624
14. Jackowski, S., and Rock, C. O. (1984) J. Biol. Chem. 259, 1891-1895
15. Clifton, G., Bryant, S. R., and Skinner, C. G. (1970) Arch. Biochem. Biophys. 137, 523-528
16. Strauss, E., and Begley, T. P. (2002) J. Biol. Chem. 277, 48205-48209
17. Buchanan, S. K. (2001) Trends Biochem. Sci. 26, 3-6
18. Jackowski, S., and Rock, C. O. (1981) J. Bacteriol. 148, 926-932
19. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917
20. Lacks, S., and Hotchkiss, R. D. (1960) Biochim. Biophys. Acta 39, 508-518
21. Jackowski, S., and Rock, C. O. (1983) J. Biol. Chem. 258, 15186-15191
22. Ferrige, A. G., Seddon, M. J., Green, B. N., Jarvis, S. A., and Skilling, J. (1992) Rapid Commun. Mass Spectrom. 6, 707-711
23. Rock, C. O., Cronan, J. E., Jr., and Armitage, I. M. (1981) J. Biol. Chem. 256, 2669-2674
24. Ivey, R. A., Zhang, Y.-M., Virga, K. G., Hevener, K., Lee, R. E., Rock, C. O., Jackowski, S., and Park, H.-W. (2004) J. Biol. Chem. 279, 35622-35629
25. Heath, R. J., and Rock, C. O. (1995) J. Biol. Chem. 270, 26538-26542
26. Jackowski, S., and Rock, C. O. (1986) J. Bacteriol. 166, 866-871
27. Keating, D. H., Zhang, Y., and Cronan, J. E., Jr. (1996) J. Bacteriol. 178, 2662-2667
28. Vallari, D. S., and Jackowski, S. (1988) J. Bacteriol. 170, 3961-3966
29. Keating, D. H., Carey, M. R., and Cronan, J. E., Jr. (1995) J. Biol. Chem. 270, 22229-22235
30. Gehring, A. M., Lambalot, R. H., Vogel, K. W., Drueckhammer, D. G., and Walsh, C. T. (1997) Chem. Biol. 4, 17-24
31. Choudhry, A. E., Mandichak, T. L., Broskey, J. P., Egolf, R. W., Kinsland, C., Begley, T. P., Seefeld, M. A., Ku, T. W., Brown, J. R., Zalacain, M., and Ratnam, K. (2003) Antimicrob. Agents Chemother. 47, 2051-2055
32. Gerdes, S. Y., Scholle, M. D., D'Souza, M., Bernal, A., Baev, M. V., Farrell, M., Kurnasov, O. V., Daugherty, M. D., Mseeh, F., Polanuyer, B. M., Campbell, J. W., Anantha, S., Shatalin, K. Y., Chowdhury, S. A., Fonstein, M. Y., and Osterman, A. L. (2002) J. Bacteriol. 184, 4555-4572
33. Osterman, A., and Overbeek, R. (2003) Curr. Opin. Chem. Biol. 7, 238-251