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Volumn 331, Issue 1, 2013, Pages 76-83

C-terminal region of HBx is crucial for mitochondrial DNA damage

Author keywords

8 oxoG; 8 Oxoguanine; C terminal truncated HBx; HBx; MtDNA damage

Indexed keywords

8 HYDROXYGUANINE; BIOLOGICAL MARKER; HEPATITIS B VIRUS X PROTEIN; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

EID: 84873522428     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.12.004     Document Type: Article
Times cited : (55)

References (47)
  • 1
    • 80052411388 scopus 로고    scopus 로고
    • Hepatitis B virus X gene and hepatocarcinogenesis
    • Ng S.A., Lee C. Hepatitis B virus X gene and hepatocarcinogenesis. J. Gastroenterol. 2011, 46:974-990.
    • (2011) J. Gastroenterol. , vol.46 , pp. 974-990
    • Ng, S.A.1    Lee, C.2
  • 2
    • 0034954277 scopus 로고    scopus 로고
    • X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis
    • Diao J., Garces R., Richardson C.D. X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Factor Rev. 2001, 12:189-205.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 189-205
    • Diao, J.1    Garces, R.2    Richardson, C.D.3
  • 4
    • 78650769017 scopus 로고    scopus 로고
    • Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma
    • Kew M.C. Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2011, 26(Suppl 1):144-152.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , Issue.SUPPL. 1 , pp. 144-152
    • Kew, M.C.1
  • 6
  • 7
    • 77951254206 scopus 로고    scopus 로고
    • HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression
    • Lim W., Kwon S.H., Cho H., Kim S., Lee S., Ryu W.S., Cho H. HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression. J. Mol. Med. (Berl) 2010, 88:359-369.
    • (2010) J. Mol. Med. (Berl) , vol.88 , pp. 359-369
    • Lim, W.1    Kwon, S.H.2    Cho, H.3    Kim, S.4    Lee, S.5    Ryu, W.S.6    Cho, H.7
  • 8
    • 79956196320 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) - induced genetic and epigenetic alterations in human carcinogenesis
    • Ziech D., Franco R., Pappa A., Panayiotidis M.I. Reactive oxygen species (ROS) - induced genetic and epigenetic alterations in human carcinogenesis. Mutat. Res. 2011, 711:167-173.
    • (2011) Mutat. Res. , vol.711 , pp. 167-173
    • Ziech, D.1    Franco, R.2    Pappa, A.3    Panayiotidis, M.I.4
  • 9
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes F.M., Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad Sci. USA 1997, 94:514-519.
    • (1997) Proc. Natl. Acad Sci. USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 10
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • Richter C., Park J.W., Ames B.N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad Sci. USA 1988, 85:6465-6467.
    • (1988) Proc. Natl. Acad Sci. USA , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 11
    • 25144507232 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA mutation with colorectal carcinogenesis in ulcerative colitis
    • Nishikawa M., Oshitani N., Matsumoto T., Nishigami T., Arakawa T., Inoue M. Accumulation of mitochondrial DNA mutation with colorectal carcinogenesis in ulcerative colitis. Brit. J. Cancer 2005, 93:331-337.
    • (2005) Brit. J. Cancer , vol.93 , pp. 331-337
    • Nishikawa, M.1    Oshitani, N.2    Matsumoto, T.3    Nishigami, T.4    Arakawa, T.5    Inoue, M.6
  • 13
    • 0036570012 scopus 로고    scopus 로고
    • Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells
    • Bohr V.A. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radical Biol. Med. 2002, 32:804-812.
    • (2002) Free Radical Biol. Med. , vol.32 , pp. 804-812
    • Bohr, V.A.1
  • 14
    • 79959697571 scopus 로고    scopus 로고
    • Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG
    • Lee S.F., Pervaiz S. Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG. Method. Cell Biol. 2011, 103:99-113.
    • (2011) Method. Cell Biol. , vol.103 , pp. 99-113
    • Lee, S.F.1    Pervaiz, S.2
  • 17
    • 58149291663 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha
    • Kim K., Kim K.H., Kim H.H., Cheong J. Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. Biochem. J. 2008, 416:219-230.
    • (2008) Biochem. J. , vol.416 , pp. 219-230
    • Kim, K.1    Kim, K.H.2    Kim, H.H.3    Cheong, J.4
  • 18
    • 33744805811 scopus 로고    scopus 로고
    • Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells
    • Cao J., Jia L., Zhou H.M., Liu Y., Zhong L.F. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol. Sci. 2006, 91:476-483.
    • (2006) Toxicol. Sci. , vol.91 , pp. 476-483
    • Cao, J.1    Jia, L.2    Zhou, H.M.3    Liu, Y.4    Zhong, L.F.5
  • 19
    • 78651082584 scopus 로고    scopus 로고
    • Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells
    • Wang W., Osenbroch P., Skinnes R., Esbensen Y., Bjoras M., Eide L. Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells. Stem Cells 2010, 28:2195-2204.
    • (2010) Stem Cells , vol.28 , pp. 2195-2204
    • Wang, W.1    Osenbroch, P.2    Skinnes, R.3    Esbensen, Y.4    Bjoras, M.5    Eide, L.6
  • 21
    • 10244247903 scopus 로고    scopus 로고
    • Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma
    • Tamori A., Nishiguchi S., Nishikawa M., Kubo S., Koh N., Hirohashi K., Shiomi S., Inoue M. Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma. J. Gastroenterol. 2004, 39:1063-1068.
    • (2004) J. Gastroenterol. , vol.39 , pp. 1063-1068
    • Tamori, A.1    Nishiguchi, S.2    Nishikawa, M.3    Kubo, S.4    Koh, N.5    Hirohashi, K.6    Shiomi, S.7    Inoue, M.8
  • 22
    • 0036187963 scopus 로고    scopus 로고
    • Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma
    • Nomoto S., Yamashita K., Koshikawa K., Nakao A., Sidransky D. Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma. Clin. Cancer Res. 2002, 8:481-487.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 481-487
    • Nomoto, S.1    Yamashita, K.2    Koshikawa, K.3    Nakao, A.4    Sidransky, D.5
  • 23
    • 62849083222 scopus 로고    scopus 로고
    • The emerging role of nuclear architecture in DNA repair and genome maintenance
    • Misteli T., Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat. Rev. Mol. Cell Biol. 2009, 10:243-254.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 243-254
    • Misteli, T.1    Soutoglou, E.2
  • 24
    • 77950961695 scopus 로고    scopus 로고
    • GammaH2AX: a sensitive molecular marker of DNA damage and repair
    • Mah L.J., El-Osta A., Karagiannis T.C. GammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 2010, 24:679-686.
    • (2010) Leukemia , vol.24 , pp. 679-686
    • Mah, L.J.1    El-Osta, A.2    Karagiannis, T.C.3
  • 26
    • 41549120029 scopus 로고    scopus 로고
    • Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation
    • Zhang H., Shan C.L., Li N., Zhang X., Zhang X.Z., Xu F.Q., Zhang S., Qiu L.Y., Ye L.H., Zhang X.D. Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol. Sin. 2008, 29:473-480.
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 473-480
    • Zhang, H.1    Shan, C.L.2    Li, N.3    Zhang, X.4    Zhang, X.Z.5    Xu, F.Q.6    Zhang, S.7    Qiu, L.Y.8    Ye, L.H.9    Zhang, X.D.10
  • 27
    • 77952076065 scopus 로고    scopus 로고
    • A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase
    • Zhang X., Ye L.H., Zhang X.D. A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase. Acta Pharmacol. Sin. 2010, 31:593-600.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 593-600
    • Zhang, X.1    Ye, L.H.2    Zhang, X.D.3
  • 29
    • 37449003586 scopus 로고    scopus 로고
    • Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma
    • Xu R., Zhang X., Zhang W., Fang Y., Zheng S., Yu X.F. Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma. Hepatology 2007, 46:1810-1820.
    • (2007) Hepatology , vol.46 , pp. 1810-1820
    • Xu, R.1    Zhang, X.2    Zhang, W.3    Fang, Y.4    Zheng, S.5    Yu, X.F.6
  • 30
    • 60249085506 scopus 로고    scopus 로고
    • Quantification of mitochondrial DNA (mtDNA) damage and error rates by real-time QPCR
    • Edwards J.G. Quantification of mitochondrial DNA (mtDNA) damage and error rates by real-time QPCR. Mitochondrion 2009, 9:31-35.
    • (2009) Mitochondrion , vol.9 , pp. 31-35
    • Edwards, J.G.1
  • 31
    • 78049519873 scopus 로고    scopus 로고
    • HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway
    • Ha H.L., Yu D.Y. HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway. World J. Gastroenterol. 2010, 16:4932-4937.
    • (2010) World J. Gastroenterol. , vol.16 , pp. 4932-4937
    • Ha, H.L.1    Yu, D.Y.2
  • 32
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 2006, 6:674-687.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 33
    • 79961058215 scopus 로고    scopus 로고
    • The role of hepatitis B virus X protein is related to its differential intracellular localization
    • Ma J., Sun T., Park S., Shen G., Liu J. The role of hepatitis B virus X protein is related to its differential intracellular localization. Acta Biochim. Biophys. Sin. (Shanghai) 2011, 43:583-588.
    • (2011) Acta Biochim. Biophys. Sin. (Shanghai) , vol.43 , pp. 583-588
    • Ma, J.1    Sun, T.2    Park, S.3    Shen, G.4    Liu, J.5
  • 34
    • 38549153790 scopus 로고    scopus 로고
    • Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs
    • Oka S., Ohno M., Tsuchimoto D., Sakumi K., Furuichi M., Nakabeppu Y. Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. Embo J. 2008, 27:421-432.
    • (2008) Embo J. , vol.27 , pp. 421-432
    • Oka, S.1    Ohno, M.2    Tsuchimoto, D.3    Sakumi, K.4    Furuichi, M.5    Nakabeppu, Y.6
  • 35
    • 34250900982 scopus 로고    scopus 로고
    • Base-excision repair of oxidative DNA damage
    • David S.S., O'Shea V.L., Kundu S. Base-excision repair of oxidative DNA damage. Nature 2007, 447:941-950.
    • (2007) Nature , vol.447 , pp. 941-950
    • David, S.S.1    O'Shea, V.L.2    Kundu, S.3
  • 36
    • 0036208949 scopus 로고    scopus 로고
    • Characterization of the mitochondrial association of hepatitis B virus X protein, HBx
    • Huh K.W., Siddiqui A. Characterization of the mitochondrial association of hepatitis B virus X protein, HBx. Mitochondrion 2002, 1:349-359.
    • (2002) Mitochondrion , vol.1 , pp. 349-359
    • Huh, K.W.1    Siddiqui, A.2
  • 37
    • 0033604446 scopus 로고    scopus 로고
    • Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
    • Takada S., Shirakata Y., Kaneniwa N., Koike K. Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death. Oncogene 1999, 18:6965-6973.
    • (1999) Oncogene , vol.18 , pp. 6965-6973
    • Takada, S.1    Shirakata, Y.2    Kaneniwa, N.3    Koike, K.4
  • 38
    • 0038158319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential
    • Shirakata Y., Koike K. Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. J. Biol. Chem. 2003, 278:22071-22078.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22071-22078
    • Shirakata, Y.1    Koike, K.2
  • 39
    • 47049100688 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    • Clippinger A.J., Bouchard M.J. Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J. Virol. 2008, 82:6798-6811.
    • (2008) J. Virol. , vol.82 , pp. 6798-6811
    • Clippinger, A.J.1    Bouchard, M.J.2
  • 40
    • 34547118616 scopus 로고    scopus 로고
    • BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis
    • Tembe V., Henderson B.R. BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis. J. Biol. Chem. 2007, 282:20513-20522.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20513-20522
    • Tembe, V.1    Henderson, B.R.2
  • 41
    • 48849116019 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria
    • Kim H.J., Kim S.Y., Kim J., Lee H., Choi M., Kim J.K., Ahn J.K. Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria. IUBMB Life 2008, 60:473-480.
    • (2008) IUBMB Life , vol.60 , pp. 473-480
    • Kim, H.J.1    Kim, S.Y.2    Kim, J.3    Lee, H.4    Choi, M.5    Kim, J.K.6    Ahn, J.K.7
  • 42
    • 0342905085 scopus 로고    scopus 로고
    • Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
    • Rahmani Z., Huh K.W., Lasher R., Siddiqui A. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J. Virol. 2000, 74:2840-2846.
    • (2000) J. Virol. , vol.74 , pp. 2840-2846
    • Rahmani, Z.1    Huh, K.W.2    Lasher, R.3    Siddiqui, A.4
  • 43
    • 84870728349 scopus 로고    scopus 로고
    • C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun/MMP10 activation in hepatocellular carcinoma
    • Sze K.M., Chu G.K., Lee J.M., Ng I.O. C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun/MMP10 activation in hepatocellular carcinoma. Hepatology 2012.
    • (2012) Hepatology
    • Sze, K.M.1    Chu, G.K.2    Lee, J.M.3    Ng, I.O.4
  • 44
    • 25844447771 scopus 로고    scopus 로고
    • The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage
    • Lee A.T., Ren J., Wong E.T., Ban K.H., Lee L.A., Lee C.G. The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage. J. Biol. Chem. 2005, 280:33525-33535.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33525-33535
    • Lee, A.T.1    Ren, J.2    Wong, E.T.3    Ban, K.H.4    Lee, L.A.5    Lee, C.G.6
  • 45
    • 27444447839 scopus 로고    scopus 로고
    • Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression
    • Kim S.Y., Kim J.K., Kim H.J., Ahn J.K. Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression. IUBMB Life 2005, 57:651-658.
    • (2005) IUBMB Life , vol.57 , pp. 651-658
    • Kim, S.Y.1    Kim, J.K.2    Kim, H.J.3    Ahn, J.K.4
  • 46
    • 0030787584 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha
    • Su F., Schneider R.J. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc. Natl. Acad Sci. USA 1997, 94:8744-8749.
    • (1997) Proc. Natl. Acad Sci. USA , vol.94 , pp. 8744-8749
    • Su, F.1    Schneider, R.J.2
  • 47
    • 33644976369 scopus 로고    scopus 로고
    • Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism
    • Kim W.H., Hong F., Jaruga B., Zhang Z.S., Fan S.J., Liang T.J., Gao B. Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism. Cell. Mol. Immunol. 2005, 2:40-48.
    • (2005) Cell. Mol. Immunol. , vol.2 , pp. 40-48
    • Kim, W.H.1    Hong, F.2    Jaruga, B.3    Zhang, Z.S.4    Fan, S.J.5    Liang, T.J.6    Gao, B.7


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