Characterization of the mitochondrial association of hepatitis B virus X protein, HBx

Mitochondrion

Volumn 1, Issue 4, 2002, Pages 349-359

  Huh, Kyung Won ^a,b   Siddiqui, Aleem ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

HBx; Mitochondria; Mitochondrial targeting

Indexed keywords

AMINO ACID; BASE; PROTEIN X; TRYPSIN; VIRUS PROTEIN;

ALPHA HELIX; ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER DISEASE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; OUTER MEMBRANE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TARGETING;

HEPATITIS B VIRUS;

EID: 0036208949     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-7249(01)00040-X     Document Type: Article

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5. Hepatitis B virus HBx deregulates cell cycle checkpoint controls
6. Heptitis B virus HBx induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases
7. The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines
8. RGS4 binds to membranes through an amphipathic α-helix
9. Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases
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12. Human RPB5, a subunit shared by eukaryotic nuclear polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation
13. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activators of transcription factors
14. Interaction of the Hepatitis B virus X protein with the Crm1-dependent nuclear export pathway
15. Regulated targeting of BAX to mitochondria
16. Intracellular localization of the hepatitis B virus HBx protein
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18. Characterization of the signal that directs Tom20 to the mitochondrial outer membrane
19. X-gene product of hepatitis B virus induces apoptosis in liver cells
20. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signalling to Ras
21. Src kinases involved in hepatitis B virus replication
22. A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function
23. The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway
24. The Hepatitis B virus X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
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27. Protein import into mitochondria
28. Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1)
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30. In vivo mitochondrial import
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33. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
34. Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function
35. Mitochondria, aging and longevity
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38. Import and insertion of proteins into the mitochondrial outer membrane
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41. Alteration of a mitochondrial outer membrane signal anchor sequence that permits its insertion into the inner membrane
42. Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
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44. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
45. Abrogation of p53-induced apoptosis by hepatitis B virus X gene
46. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kB via oxidative stress
47. Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor Ikappa B alpha
48. Membrane protein anchors and polytopic determinants
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