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Volumn 21, Issue 5, 2011, Pages 315-329

The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEPATITIS B VIRUS X PROTEIN; PROTEASOME; REGULATOR PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 80051925892     PISSN: 10529276     EISSN: 10991654     Source Type: Journal    
DOI: 10.1002/rmv.699     Document Type: Review
Times cited : (43)

References (142)
  • 1
    • 0034167525 scopus 로고    scopus 로고
    • Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B
    • Chisari FV. Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B. American Journal of Pathology 2000; 156: 1117-1132.
    • (2000) American Journal of Pathology , vol.156 , pp. 1117-1132
    • Chisari, F.V.1
  • 6
    • 0026493753 scopus 로고
    • The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis
    • Web of Science
    • Wang GH, Seeger C. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis. Cell 1992; 71: 663-670. Web of Science.
    • (1992) Cell , vol.71 , pp. 663-670
    • Wang, G.H.1    Seeger, C.2
  • 7
    • 0028300388 scopus 로고
    • Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription
    • Web of Science
    • Weber M, Bronsema V, Bartos H, et al. Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription. Journal of Virology 1994; 68: 2994-2999. Web of Science.
    • (1994) Journal of Virology , vol.68 , pp. 2994-2999
    • Weber, M.1    Bronsema, V.2    Bartos, H.3
  • 8
    • 0028091053 scopus 로고
    • Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase
    • Web of Science
    • Zoulim F, Seeger C. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. Journal of Virology 1994; 68: 6-13. Web of Science.
    • (1994) Journal of Virology , vol.68 , pp. 6-13
    • Zoulim, F.1    Seeger, C.2
  • 9
    • 0026706346 scopus 로고
    • Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome
    • Web of Science
    • Bartenschlager R, Schaller H. Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome. EMBO Journal 1992; 11: 3413-3420. Web of Science.
    • (1992) EMBO Journal , vol.11 , pp. 3413-3420
    • Bartenschlager, R.1    Schaller, H.2
  • 10
    • 6444242588 scopus 로고    scopus 로고
    • Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
    • Web of Science
    • Hsieh YH, Su IJ, Wang HC, et al. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 2004; 25: 2023-2032. Web of Science.
    • (2004) Carcinogenesis , vol.25 , pp. 2023-2032
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3
  • 11
    • 0032847032 scopus 로고    scopus 로고
    • Hepatitis B virus X protein: structure, function and biology
    • Web of Science
    • Murakami S. Hepatitis B virus X protein: structure, function and biology. Intervirology 1999; 42: 81-99. Web of Science.
    • (1999) Intervirology , vol.42 , pp. 81-99
    • Murakami, S.1
  • 12
    • 17644388427 scopus 로고    scopus 로고
    • Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues
    • Web of Science
    • Rui E, Moura PR, Goncalves K de A, et al. Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues. Journal of Virological Methods 2005; 126: 65-74. Web of Science.
    • (2005) Journal of Virological Methods , vol.126 , pp. 65-74
    • Rui, E.1    Moura, P.R.2    Goncalves, K.d.A.3
  • 15
    • 0028071822 scopus 로고
    • Three sites of the hepatitis B virus X protein cooperatively interact with cellular proteins
    • Web of Science
    • Takada S, Koike K. Three sites of the hepatitis B virus X protein cooperatively interact with cellular proteins. Virology 1994; 205: 503-510. Web of Science.
    • (1994) Virology , vol.205 , pp. 503-510
    • Takada, S.1    Koike, K.2
  • 16
    • 0028342986 scopus 로고
    • Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein
    • Web of Science
    • Murakami S, Cheong JH, Kaneko S. Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein. Journal of Biological Chemistry 1994; 269: 15118-15123. Web of Science.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 15118-15123
    • Murakami, S.1    Cheong, J.H.2    Kaneko, S.3
  • 17
    • 0026005668 scopus 로고
    • Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus
    • Web of Science
    • Schek N, Bartenschlager R, Kuhn C, et al. Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus. Oncogene 1991; 6: 1735-1744. Web of Science.
    • (1991) Oncogene , vol.6 , pp. 1735-1744
    • Schek, N.1    Bartenschlager, R.2    Kuhn, C.3
  • 18
    • 0029147911 scopus 로고
    • The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors
    • Web of Science
    • Doria M, Klein N, Lucito R, et al. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO Journal 1995; 14: 4747-4757. Web of Science.
    • (1995) EMBO Journal , vol.14 , pp. 4747-4757
    • Doria, M.1    Klein, N.2    Lucito, R.3
  • 19
    • 0035057205 scopus 로고    scopus 로고
    • Intracellular localization of the hepatitis B virus HBx protein
    • Web of Science
    • Henkler F, Hoare J, Waseem N, et al. Intracellular localization of the hepatitis B virus HBx protein. Journal of General Virology 2001; 82: 871-882. Web of Science.
    • (2001) Journal of General Virology , vol.82 , pp. 871-882
    • Henkler, F.1    Hoare, J.2    Waseem, N.3
  • 20
    • 0034964333 scopus 로고    scopus 로고
    • Subcellular localisation of the X protein in HBV infected hepatocytes
    • Web of Science
    • Hoare J, Henkler F, Dowling JJ, et al. Subcellular localisation of the X protein in HBV infected hepatocytes. Journal of Medical Virology 2001; 64: 419-426. Web of Science.
    • (2001) Journal of Medical Virology , vol.64 , pp. 419-426
    • Hoare, J.1    Henkler, F.2    Dowling, J.J.3
  • 21
    • 0032559971 scopus 로고    scopus 로고
    • Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome
    • Web of Science
    • Sirma H, Weil R, Rosmorduc O, et al. Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome. Oncogene 1998; 16: 2051-2063. Web of Science.
    • (1998) Oncogene , vol.16 , pp. 2051-2063
    • Sirma, H.1    Weil, R.2    Rosmorduc, O.3
  • 22
    • 0035013093 scopus 로고    scopus 로고
    • Phosphorylation of purified recombinant hepatitis B virus-X protein by mitogen-activated protein kinase and protein kinase C in vitro
    • Web of Science
    • Lee YI, Kim SO, Kwon HJ, et al. Phosphorylation of purified recombinant hepatitis B virus-X protein by mitogen-activated protein kinase and protein kinase C in vitro. Journal of Virological Methods 2001; 95: 1-10. Web of Science.
    • (2001) Journal of Virological Methods , vol.95 , pp. 1-10
    • Lee, Y.I.1    Kim, S.O.2    Kwon, H.J.3
  • 23
    • 0025319078 scopus 로고
    • Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA
    • Web of Science
    • Hohne M, Schaefer S, Seifer M, et al. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO Journal 1990; 9: 1137-1145. Web of Science.
    • (1990) EMBO Journal , vol.9 , pp. 1137-1145
    • Hohne, M.1    Schaefer, S.2    Seifer, M.3
  • 25
    • 65549130040 scopus 로고    scopus 로고
    • Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression
    • Web of Science
    • Cha MY, Ryu DK, Jung HS, et al. Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression. Journal of General Virology 2009; 90: 978-986. Web of Science.
    • (2009) Journal of General Virology , vol.90 , pp. 978-986
    • Cha, M.Y.1    Ryu, D.K.2    Jung, H.S.3
  • 26
    • 67649460609 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice
    • Web of Science
    • Keasler VV, Hodgson AJ, Madden CR, et al. Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology 2009; 390: 122-129. Web of Science.
    • (2009) Virology , vol.390 , pp. 122-129
    • Keasler, V.V.1    Hodgson, A.J.2    Madden, C.R.3
  • 27
    • 0035933725 scopus 로고    scopus 로고
    • Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway
    • Web of Science
    • Forgues M, Marrogi AJ, Spillare EA, et al. Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway. Journal of Biological Chemistry 2001; 276: 22797-22803. Web of Science.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 22797-22803
    • Forgues, M.1    Marrogi, A.J.2    Spillare, E.A.3
  • 28
    • 0032772369 scopus 로고    scopus 로고
    • Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha
    • Web of Science
    • Weil R, Sirma H, Giannini C, et al. Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. Molecular and Cellular Biology 1999; 19: 6345-6354. Web of Science.
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 6345-6354
    • Weil, R.1    Sirma, H.2    Giannini, C.3
  • 29
    • 17444430845 scopus 로고    scopus 로고
    • The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication
    • Web of Science
    • Tang H, Delgermaa L, Huang F, et al. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. Journal of Virology 2005; 79: 5548-5556. Web of Science.
    • (2005) Journal of Virology , vol.79 , pp. 5548-5556
    • Tang, H.1    Delgermaa, L.2    Huang, F.3
  • 30
    • 71149108706 scopus 로고    scopus 로고
    • Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis
    • Web of Science
    • Benhenda S, Cougot D, Buendia MA, et al. Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis. Advances in Cancer Research 2009; 103: 75-109. Web of Science.
    • (2009) Advances in Cancer Research , vol.103 , pp. 75-109
    • Benhenda, S.1    Cougot, D.2    Buendia, M.A.3
  • 31
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • Web of Science
    • Bouchard MJ, Schneider RJ. The enigmatic X gene of hepatitis B virus. Journal of Virology 2004; 78: 12725-12734. Web of Science.
    • (2004) Journal of Virology , vol.78 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 32
    • 0025372815 scopus 로고
    • The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax
    • Web of Science
    • Faktor O, Shaul Y. The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax. Oncogene 1990; 5: 867-872. Web of Science.
    • (1990) Oncogene , vol.5 , pp. 867-872
    • Faktor, O.1    Shaul, Y.2
  • 33
    • 0028878098 scopus 로고
    • Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation
    • Web of Science
    • Cheong JH, Yi M, Lin Y, et al. Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO Journal 1995; 14: 143-150. Web of Science.
    • (1995) EMBO Journal , vol.14 , pp. 143-150
    • Cheong, J.H.1    Yi, M.2    Lin, Y.3
  • 34
    • 0031932893 scopus 로고    scopus 로고
    • Hepatitis B virus pX targets TFIIB in transcription coactivation
    • Web of Science
    • Haviv I, Shamay M, Doitsh G, et al. Hepatitis B virus pX targets TFIIB in transcription coactivation. Molecular and Cellular Biology 1998; 18: 1562-1569. Web of Science.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 1562-1569
    • Haviv, I.1    Shamay, M.2    Doitsh, G.3
  • 35
    • 0033989897 scopus 로고    scopus 로고
    • Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression
    • Web of Science
    • Barnabas S, Andrisani OM. Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression. Journal of Virology 2000; 74: 83-90. Web of Science.
    • (2000) Journal of Virology , vol.74 , pp. 83-90
    • Barnabas, S.1    Andrisani, O.M.2
  • 36
    • 34247637220 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma
    • Web of Science
    • Kim KH, Shin HJ, Kim K, et al. Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterology 2007; 132: 1955-1967. Web of Science.
    • (2007) Gastroenterology , vol.132 , pp. 1955-1967
    • Kim, K.H.1    Shin, H.J.2    Kim, K.3
  • 37
    • 0032403765 scopus 로고    scopus 로고
    • The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway
    • Web of Science
    • Lara-Pezzi E, Armesilla AL, Majano PL, et al. The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. EMBO Journal 1998; 17: 7066-7077. Web of Science.
    • (1998) EMBO Journal , vol.17 , pp. 7066-7077
    • Lara-Pezzi, E.1    Armesilla, A.L.2    Majano, P.L.3
  • 38
    • 0035112148 scopus 로고    scopus 로고
    • The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis
    • Web of Science
    • Lee DK, Park SH, Yi Y, et al. The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. Genes & Development 2001; 15: 455-466. Web of Science.
    • (2001) Genes & Development , vol.15 , pp. 455-466
    • Lee, D.K.1    Park, S.H.2    Yi, Y.3
  • 39
    • 0025784335 scopus 로고
    • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
    • Web of Science
    • Maguire HF, Hoeffler JP, Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 1991; 252: 842-844. Web of Science.
    • (1991) Science , vol.252 , pp. 842-844
    • Maguire, H.F.1    Hoeffler, J.P.2    Siddiqui, A.3
  • 40
    • 0025176474 scopus 로고
    • Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors
    • Web of Science
    • Seto E, Mitchell PJ, Yen TS. Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 1990; 344: 72-74. Web of Science.
    • (1990) Nature , vol.344 , pp. 72-74
    • Seto, E.1    Mitchell, P.J.2    Yen, T.S.3
  • 41
    • 33947528120 scopus 로고    scopus 로고
    • The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription
    • Web of Science
    • Cougot D, Wu Y, Cairo S, et al. The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription. Journal of Biological Chemistry 2007; 282: 4277-4287. Web of Science.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 4277-4287
    • Cougot, D.1    Wu, Y.2    Cairo, S.3
  • 42
    • 1242293658 scopus 로고    scopus 로고
    • A pivotal role of cyclic AMP-responsive element binding protein in tumor progression
    • Web of Science
    • Abramovitch R, Tavor E, Jacob-Hirsch J, et al. A pivotal role of cyclic AMP-responsive element binding protein in tumor progression. Cancer Research 2004; 64: 1338-1346. Web of Science.
    • (2004) Cancer Research , vol.64 , pp. 1338-1346
    • Abramovitch, R.1    Tavor, E.2    Jacob-Hirsch, J.3
  • 43
    • 23944481332 scopus 로고    scopus 로고
    • CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter
    • Web of Science
    • Tacke F, Liedtke C, Bocklage S, et al. CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter. Gut 2005; 54: 1309-1317. Web of Science.
    • (2005) Gut , vol.54 , pp. 1309-1317
    • Tacke, F.1    Liedtke, C.2    Bocklage, S.3
  • 44
    • 0026526978 scopus 로고
    • Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C
    • Web of Science
    • Lucito R, Schneider RJ. Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. Journal of Virology 1992; 66: 983-991. Web of Science.
    • (1992) Journal of Virology , vol.66 , pp. 983-991
    • Lucito, R.1    Schneider, R.J.2
  • 45
    • 0028274952 scopus 로고
    • Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways
    • Web of Science
    • Murakami S, Cheong J, Ohno S, et al. Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways. Virology 1994; 199: 243-246. Web of Science.
    • (1994) Virology , vol.199 , pp. 243-246
    • Murakami, S.1    Cheong, J.2    Ohno, S.3
  • 46
    • 0029982621 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins
    • Web of Science
    • Su F, Schneider RJ. Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins. Journal of Virology 1996; 70: 4558-4566. Web of Science.
    • (1996) Journal of Virology , vol.70 , pp. 4558-4566
    • Su, F.1    Schneider, R.J.2
  • 47
    • 0029895723 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases
    • Web of Science
    • Benn J, Su F, Doria M, et al. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. Journal of Virology 1996; 70: 4978-4985. Web of Science.
    • (1996) Journal of Virology , vol.70 , pp. 4978-4985
    • Benn, J.1    Su, F.2    Doria, M.3
  • 48
    • 0035860752 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
    • Web of Science
    • Tarn C, Lee S, Hu Y, et al. Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. Journal of Biological Chemistry 2001; 276: 34671-34680. Web of Science.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 34671-34680
    • Tarn, C.1    Lee, S.2    Hu, Y.3
  • 49
    • 0036776554 scopus 로고    scopus 로고
    • Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes
    • Web of Science
    • Tarn C, Zou L, Hullinger RL, et al. Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. Journal of Virology 2002; 76: 9763-9772. Web of Science.
    • (2002) Journal of Virology , vol.76 , pp. 9763-9772
    • Tarn, C.1    Zou, L.2    Hullinger, R.L.3
  • 50
    • 0030764344 scopus 로고    scopus 로고
    • Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras
    • Web of Science
    • Klein NP, Schneider RJ. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Molecular and Cellular Biology 1997; 17: 6427-6436. Web of Science.
    • (1997) Molecular and Cellular Biology , vol.17 , pp. 6427-6436
    • Klein, N.P.1    Schneider, R.J.2
  • 51
    • 33646193810 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication
    • Web of Science
    • Bouchard MJ, Wang L, Schneider RJ. Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. Journal of Virology 2006; 80: 4406-4414. Web of Science.
    • (2006) Journal of Virology , vol.80 , pp. 4406-4414
    • Bouchard, M.J.1    Wang, L.2    Schneider, R.J.3
  • 52
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Web of Science
    • Bouchard MJ, Wang LH, Schneider RJ. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 2001; 294: 2376-2378. Web of Science.
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.J.1    Wang, L.H.2    Schneider, R.J.3
  • 53
    • 0037744950 scopus 로고    scopus 로고
    • Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication
    • Web of Science
    • Bouchard MJ, Puro RJ, Wang L, et al. Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. Journal of Virology 2003; 77: 7713-7719. Web of Science.
    • (2003) Journal of Virology , vol.77 , pp. 7713-7719
    • Bouchard, M.J.1    Puro, R.J.2    Wang, L.3
  • 54
    • 47049100688 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    • Web of Science
    • Clippinger AJ, Bouchard MJ. Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. Journal of Virology 2008; 82: 6798-6811. Web of Science.
    • (2008) Journal of Virology , vol.82 , pp. 6798-6811
    • Clippinger, A.J.1    Bouchard, M.J.2
  • 55
    • 35448949218 scopus 로고    scopus 로고
    • Hepatitis B virus replication is associated with an HBx-dependent mitochondrion-regulated increase in cytosolic calcium levels
    • Web of Science
    • McClain SL, Clippinger AJ, Lizzano R, et al. Hepatitis B virus replication is associated with an HBx-dependent mitochondrion-regulated increase in cytosolic calcium levels. Journal of Virology 2007; 81: 12061-12065. Web of Science.
    • (2007) Journal of Virology , vol.81 , pp. 12061-12065
    • McClain, S.L.1    Clippinger, A.J.2    Lizzano, R.3
  • 56
    • 0038158319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential
    • Web of Science
    • Shirakata Y, Koike K. Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. Journal of Biological Chemistry 2003; 278: 22071-22078. Web of Science.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 22071-22078
    • Shirakata, Y.1    Koike, K.2
  • 57
    • 0035821645 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
    • Web of Science
    • Lara-Pezzi E, Roche S, Andrisani OM, et al. The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 2001; 20: 3323-3331. Web of Science.
    • (2001) Oncogene , vol.20 , pp. 3323-3331
    • Lara-Pezzi, E.1    Roche, S.2    Andrisani, O.M.3
  • 58
    • 33748288087 scopus 로고    scopus 로고
    • Molecular functions and biological roles of hepatitis B virus x protein
    • Web of Science
    • Tang H, Oishi N, Kaneko S, et al. Molecular functions and biological roles of hepatitis B virus x protein. Cancer Science 2006; 97: 977-983. Web of Science.
    • (2006) Cancer Science , vol.97 , pp. 977-983
    • Tang, H.1    Oishi, N.2    Kaneko, S.3
  • 59
    • 0026601861 scopus 로고
    • Hepatitis B virus X protein is not central to the viral life cycle in vitro
    • Web of Science
    • Blum HE, Zhang ZS, Galun E, et al. Hepatitis B virus X protein is not central to the viral life cycle in vitro. Journal of Virology 1992; 66: 1223-1227. Web of Science.
    • (1992) Journal of Virology , vol.66 , pp. 1223-1227
    • Blum, H.E.1    Zhang, Z.S.2    Galun, E.3
  • 61
    • 0027478980 scopus 로고
    • The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks
    • Chen HS, Kaneko S, Girones R, et al. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. Journal of Virology 1993; 67: 1218-1226.
    • (1993) Journal of Virology , vol.67 , pp. 1218-1226
    • Chen, H.S.1    Kaneko, S.2    Girones, R.3
  • 62
    • 0035178992 scopus 로고    scopus 로고
    • X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo
    • Zhang Z, Torii N, Hu Z, et al. X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo. The Journal of Clinical Investigation 2001; 108: 1523-1531.
    • (2001) The Journal of Clinical Investigation , vol.108 , pp. 1523-1531
    • Zhang, Z.1    Torii, N.2    Hu, Z.3
  • 63
    • 0036171745 scopus 로고    scopus 로고
    • Enhancement of hepatitis B virus replication by its X protein in transgenic mice
    • Xu Z, Yen TS, Wu L, et al. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. Journal of Virology 2002; 76: 2579-2584.
    • (2002) Journal of Virology , vol.76 , pp. 2579-2584
    • Xu, Z.1    Yen, T.S.2    Wu, L.3
  • 64
    • 77954162816 scopus 로고    scopus 로고
    • HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice
    • Tsuge M, Hiraga N, Akiyama R et al. HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice. Journal of General Virology 2010; 91: 1854-1864.
    • (2010) Journal of General Virology , vol.91 , pp. 1854-1864
    • Tsuge, M.1    Hiraga, N.2    Akiyama, R.3
  • 65
    • 79957614798 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
    • DOI: 10.1016/j.jhep.2011.02.015.
    • Lucifora J, Arzberger S, Durantel D, et al. Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. Journal of Hepatology 2011; DOI: 10.1016/j.jhep.2011.02.015.
    • (2011) Journal of Hepatology
    • Lucifora, J.1    Arzberger, S.2    Durantel, D.3
  • 67
    • 0035048023 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway
    • Bouchard M, Giannakopoulos S, Wang EH, et al. Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway. Journal of Virology 2001; 75: 4247-4257.
    • (2001) Journal of Virology , vol.75 , pp. 4247-4257
    • Bouchard, M.1    Giannakopoulos, S.2    Wang, E.H.3
  • 68
    • 34547593907 scopus 로고    scopus 로고
    • Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis
    • Chin R, Earnest-Silveira L, Koeberlein B, et al. Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis. Journal of Hepatology 2007; 47: 325-337.
    • (2007) Journal of Hepatology , vol.47 , pp. 325-337
    • Chin, R.1    Earnest-Silveira, L.2    Koeberlein, B.3
  • 69
    • 0037042205 scopus 로고    scopus 로고
    • Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein
    • Han HJ, Jung EY, Lee WJ, et al. Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein. FEBS Letters 2002; 518: 169-172.
    • (2002) FEBS Letters , vol.518 , pp. 169-172
    • Han, H.J.1    Jung, E.Y.2    Lee, W.J.3
  • 70
    • 0038218567 scopus 로고    scopus 로고
    • Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3
    • Leach JK, Qiao L, Fang Y, et al. Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3. Journal of Gastroenterology and Hepatology 2003; 18: 376-385.
    • (2003) Journal of Gastroenterology and Hepatology , vol.18 , pp. 376-385
    • Leach, J.K.1    Qiao, L.2    Fang, Y.3
  • 71
    • 33846333916 scopus 로고    scopus 로고
    • HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1
    • Mukherji A, Janbandhu VC, Kumar V. HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1. Biochemical Journal 2007; 401: 247-256.
    • (2007) Biochemical Journal , vol.401 , pp. 247-256
    • Mukherji, A.1    Janbandhu, V.C.2    Kumar, V.3
  • 72
    • 33845995100 scopus 로고    scopus 로고
    • Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter
    • Park SG, Chung C, Kang H, et al. Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter. Journal of Biological Chemistry 2006; 281: 31770-31777.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 31770-31777
    • Park, S.G.1    Chung, C.2    Kang, H.3
  • 73
    • 0034761676 scopus 로고    scopus 로고
    • Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression
    • Qiao L, Leach K, McKinstry R, et al. Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression. Hepatology 2001; 34: 906-917.
    • (2001) Hepatology , vol.34 , pp. 906-917
    • Qiao, L.1    Leach, K.2    McKinstry, R.3
  • 74
    • 77649112712 scopus 로고    scopus 로고
    • The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication
    • Gearhart TL, Bouchard MJ. The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. Journal of Virology 2010; 84: 2675-2686.
    • (2010) Journal of Virology , vol.84 , pp. 2675-2686
    • Gearhart, T.L.1    Bouchard, M.J.2
  • 75
    • 57749106581 scopus 로고    scopus 로고
    • Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration
    • Hodgson AJ, Keasler VV, Slagle BL. Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Research 2008; 68: 10341-10348.
    • (2008) Cancer Research , vol.68 , pp. 10341-10348
    • Hodgson, A.J.1    Keasler, V.V.2    Slagle, B.L.3
  • 76
    • 33749481298 scopus 로고    scopus 로고
    • HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis
    • Fujii R, Zhu C, Wen Y, et al. HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis. Cancer Research 2006; 66: 9099-9107.
    • (2006) Cancer Research , vol.66 , pp. 9099-9107
    • Fujii, R.1    Zhu, C.2    Wen, Y.3
  • 77
    • 44449120297 scopus 로고    scopus 로고
    • HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint
    • Kim S, Park SY, Yong H, et al. HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint. Oncogene 2008; 27: 3457-3464.
    • (2008) Oncogene , vol.27 , pp. 3457-3464
    • Kim, S.1    Park, S.Y.2    Yong, H.3
  • 78
    • 57649116077 scopus 로고    scopus 로고
    • Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy
    • Rakotomalala L, Studach L, Wang WH, et al. Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. Journal of Biological Chemistry 2008; 283: 28729-28740.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 28729-28740
    • Rakotomalala, L.1    Studach, L.2    Wang, W.H.3
  • 79
    • 41449097647 scopus 로고    scopus 로고
    • Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation
    • Wen Y, Golubkov VS, Strongin AY, et al. Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation. Journal of Biological Chemistry 2008; 283: 2793-2803.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 2793-2803
    • Wen, Y.1    Golubkov, V.S.2    Strongin, A.Y.3
  • 80
    • 3543150890 scopus 로고    scopus 로고
    • Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway
    • Yun C, Cho H, Kim SJ, et al. Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. Molecular Cancer Research 2004; 2: 159-169.
    • (2004) Molecular Cancer Research , vol.2 , pp. 159-169
    • Yun, C.1    Cho, H.2    Kim, S.J.3
  • 81
    • 0035155733 scopus 로고    scopus 로고
    • Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B
    • Pan J, Duan LX, Sun BS, et al. Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. Journal of General Virology 2001; 82: 171-182.
    • (2001) Journal of General Virology , vol.82 , pp. 171-182
    • Pan, J.1    Duan, L.X.2    Sun, B.S.3
  • 82
    • 56149087784 scopus 로고    scopus 로고
    • Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1
    • Martin-Lluesma S, Schaeffer C, Robert EI, et al. Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1. Hepatology 2008; 48: 1467-1476.
    • (2008) Hepatology , vol.48 , pp. 1467-1476
    • Martin-Lluesma, S.1    Schaeffer, C.2    Robert, E.I.3
  • 83
    • 77950609088 scopus 로고    scopus 로고
    • Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation
    • Molina-Jimenez F, Benedicto I, Murata M, et al. Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation. Hepatology 2010; 51: 777-787.
    • (2010) Hepatology , vol.51 , pp. 777-787
    • Molina-Jimenez, F.1    Benedicto, I.2    Murata, M.3
  • 84
    • 0242468471 scopus 로고    scopus 로고
    • Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells
    • Yu R, Lu W, Chen J, et al. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology 2003; 144: 4991-4998.
    • (2003) Endocrinology , vol.144 , pp. 4991-4998
    • Yu, R.1    Lu, W.2    Chen, J.3
  • 85
    • 0035896631 scopus 로고    scopus 로고
    • X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
    • Diao J, Khine AA, Sarangi F, et al. X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. Journal of Biological Chemistry 2001; 276: 8328-8340.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 8328-8340
    • Diao, J.1    Khine, A.A.2    Sarangi, F.3
  • 86
    • 0034682769 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
    • Shih WL, Kuo ML, Chuang SE, et al. Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. Journal of Biological Chemistry 2000; 275: 25858-25864.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 25858-25864
    • Shih, W.L.1    Kuo, M.L.2    Chuang, S.E.3
  • 88
    • 0035927496 scopus 로고    scopus 로고
    • Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis
    • Huo TI, Wang XW, Forgues M, et al. Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis. Oncogene 2001; 20: 3620-3628.
    • (2001) Oncogene , vol.20 , pp. 3620-3628
    • Huo, T.I.1    Wang, X.W.2    Forgues, M.3
  • 89
    • 0032509550 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein inhibits caspase 3 activity
    • Gottlob K, Fulco M, Levrero M, et al. The hepatitis B virus HBx protein inhibits caspase 3 activity. Journal of Biological Chemistry 1998; 273: 33347-33353.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 33347-33353
    • Gottlob, K.1    Fulco, M.2    Levrero, M.3
  • 90
    • 0038182537 scopus 로고    scopus 로고
    • HBXIP functions as a cofactor of survivin in apoptosis suppression
    • Marusawa H, Matsuzawa S, Welsh K, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO Journal 2003; 22: 2729-2740.
    • (2003) EMBO Journal , vol.22 , pp. 2729-2740
    • Marusawa, H.1    Matsuzawa, S.2    Welsh, K.3
  • 91
    • 2442452762 scopus 로고    scopus 로고
    • Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells
    • Lee YI, Hwang JM, Im JH, et al. Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells. Journal of Biological Chemistry 2004; 279: 15460-15471.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 15460-15471
    • Lee, Y.I.1    Hwang, J.M.2    Im, J.H.3
  • 92
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
    • Waris G, Huh KW, Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Molecular and Cellular Biology 2001; 21: 7721-7730.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.W.2    Siddiqui, A.3
  • 93
    • 33846783316 scopus 로고    scopus 로고
    • Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners
    • Kim S, Kim HY, Lee S, et al. Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners. Journal of Virology 2007; 81: 1714-1726.
    • (2007) Journal of Virology , vol.81 , pp. 1714-1726
    • Kim, S.1    Kim, H.Y.2    Lee, S.3
  • 94
    • 78049519873 scopus 로고    scopus 로고
    • HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway
    • Ha HL, Yu DY. HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway. World Journal of Gastroenterology 2010; 16: 4932-4937.
    • (2010) World Journal of Gastroenterology , vol.16 , pp. 4932-4937
    • Ha, H.L.1    Yu, D.Y.2
  • 97
    • 54449091313 scopus 로고    scopus 로고
    • Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis
    • Wang WH, Hullinger RL, Andrisani OM. Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. Journal of Biological Chemistry 2008; 283: 25455-25467.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 25455-25467
    • Wang, W.H.1    Hullinger, R.L.2    Andrisani, O.M.3
  • 98
    • 0032558845 scopus 로고    scopus 로고
    • p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro
    • Terradillos O, Pollicino T, Lecoeur H, et al. p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro. Oncogene 1998; 17: 2115-2123.
    • (1998) Oncogene , vol.17 , pp. 2115-2123
    • Terradillos, O.1    Pollicino, T.2    Lecoeur, H.3
  • 99
    • 0034022192 scopus 로고    scopus 로고
    • Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice
    • Madden CR, Finegold MJ, Slagle BL. Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice. Journal of Virology 2000; 74: 5266-5272.
    • (2000) Journal of Virology , vol.74 , pp. 5266-5272
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 100
    • 33744808242 scopus 로고    scopus 로고
    • The immune response during hepatitis B virus infection
    • Bertoletti A, Gehring AJ. The immune response during hepatitis B virus infection. Journal of General Virology 2006; 87: 1439-1449.
    • (2006) Journal of General Virology , vol.87 , pp. 1439-1449
    • Bertoletti, A.1    Gehring, A.J.2
  • 101
    • 0031702780 scopus 로고    scopus 로고
    • The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes
    • Lara-Pezzi E, Majano PL, Gomez-Gonzalo M, et al. The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes. Hepatology 1998; 28: 1013-1021.
    • (1998) Hepatology , vol.28 , pp. 1013-1021
    • Lara-Pezzi, E.1    Majano, P.L.2    Gomez-Gonzalo, M.3
  • 102
    • 0035184889 scopus 로고    scopus 로고
    • Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation
    • Majano P, Lara-Pezzi E, Lopez-Cabrera M, et al. Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation. Hepatology 2001; 34: 1218-1224.
    • (2001) Hepatology , vol.34 , pp. 1218-1224
    • Majano, P.1    Lara-Pezzi, E.2    Lopez-Cabrera, M.3
  • 103
    • 0034127757 scopus 로고    scopus 로고
    • Cytokine regulation of liver injury and repair
    • Diehl AM. Cytokine regulation of liver injury and repair. Immunology Reviews 2000; 174: 160-171.
    • (2000) Immunology Reviews , vol.174 , pp. 160-171
    • Diehl, A.M.1
  • 104
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolytic control of viral infections by the innate and adaptive immune response
    • Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annual Review of Immunology 2001; 19: 65-91.
    • (2001) Annual Review of Immunology , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 105
    • 77955496554 scopus 로고    scopus 로고
    • The hepatitis B virus X protein disrupts innate immunity by downregulation mitochondrial antiviral signalling protein
    • Wei C, Ni C, Song T, et al. The hepatitis B virus X protein disrupts innate immunity by downregulation mitochondrial antiviral signalling protein. Journal of Immunology 2010; 185: 1158-1168.
    • (2010) Journal of Immunology , vol.185 , pp. 1158-1168
    • Wei, C.1    Ni, C.2    Song, T.3
  • 106
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrosis
    • Friedman SL. Mechanisms of hepatic fibrosis. Gastroenterology 2008; 134: 1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 108
    • 46249101267 scopus 로고    scopus 로고
    • The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells
    • Martin-Vilchez S, Sanz-Cameno P, Rodriguez-Munoz Y, et al. The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells. Hepatology 2008; 47: 1872-1883.
    • (2008) Hepatology , vol.47 , pp. 1872-1883
    • Martin-Vilchez, S.1    Sanz-Cameno, P.2    Rodriguez-Munoz, Y.3
  • 109
    • 33744538682 scopus 로고    scopus 로고
    • Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    • Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. Journal of Cellular and Molecular Medicine 2006; 10: 76-99.
    • (2006) Journal of Cellular and Molecular Medicine , vol.10 , pp. 76-99
    • Gressner, A.M.1    Weiskirchen, R.2
  • 110
    • 7744229935 scopus 로고    scopus 로고
    • Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    • Chung TW, Lee YC, Kim CH. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. The FASEB Journal 2004; 18: 1123-1125.
    • (2004) The FASEB Journal , vol.18 , pp. 1123-1125
    • Chung, T.W.1    Lee, Y.C.2    Kim, C.H.3
  • 111
    • 70350136670 scopus 로고    scopus 로고
    • Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease
    • Feitelson MA, Reis HM, Tufan NL, et al. Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease. Cancer Letters 2009; 286: 69-79.
    • (2009) Cancer Letters , vol.286 , pp. 69-79
    • Feitelson, M.A.1    Reis, H.M.2    Tufan, N.L.3
  • 112
    • 7544220200 scopus 로고    scopus 로고
    • The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha
    • Yoo YG, Cho S, Park S, et al. The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha. FEBS Letters 2004; 577: 121-126.
    • (2004) FEBS Letters , vol.577 , pp. 121-126
    • Yoo, Y.G.1    Cho, S.2    Park, S.3
  • 113
    • 0141532010 scopus 로고    scopus 로고
    • Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway
    • Yoo YG, Oh SH, Park ES, et al. Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway. Journal of Biological Chemistry 2003; 278: 39076-39084.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 39076-39084
    • Yoo, Y.G.1    Oh, S.H.2    Park, E.S.3
  • 115
    • 44449114668 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells
    • Yoo YG, Na TY, Seo HW, et al. Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene 2008; 27: 3405-3413.
    • (2008) Oncogene , vol.27 , pp. 3405-3413
    • Yoo, Y.G.1    Na, T.Y.2    Seo, H.W.3
  • 116
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nature Reviews Cancer 2002; 2: 161-174.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 117
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010; 141: 52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 118
    • 33748500218 scopus 로고    scopus 로고
    • Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally
    • Ou DP, Tao YM, Chang ZG, et al. Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally. Digestive and Liver Disease 2006; 38: 262-267.
    • (2006) Digestive and Liver Disease , vol.38 , pp. 262-267
    • Ou, D.P.1    Tao, Y.M.2    Chang, Z.G.3
  • 119
    • 14844307045 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3
    • Yu FL, Liu HJ, Lee JW, et al. Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. Journal of Hepatology 2005; 42: 520-527.
    • (2005) Journal of Hepatology , vol.42 , pp. 520-527
    • Yu, F.L.1    Liu, H.J.2    Lee, J.W.3
  • 120
    • 37549064123 scopus 로고    scopus 로고
    • Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein
    • Sanz-Cameno P, Martin-Vilchez S, Lara-Pezzi E, et al. Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein. American Journal of Pathology 2006; 169: 1215-1222.
    • (2006) American Journal of Pathology , vol.169 , pp. 1215-1222
    • Sanz-Cameno, P.1    Martin-Vilchez, S.2    Lara-Pezzi, E.3
  • 121
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • Feitelson MA, Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Letters 2007; 252: 157-170.
    • (2007) Cancer Letters , vol.252 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 122
    • 52649139395 scopus 로고    scopus 로고
    • COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis
    • Ma NF, Lau SH, Hu L, et al. COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clinical Cancer Research 2008; 14: 5061-5068.
    • (2008) Clinical Cancer Research , vol.14 , pp. 5061-5068
    • Ma, N.F.1    Lau, S.H.2    Hu, L.3
  • 123
    • 0035502957 scopus 로고    scopus 로고
    • Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues
    • Tu H, Bonura C, Giannini C, et al. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Research 2001; 61: 7803-7810.
    • (2001) Cancer Research , vol.61 , pp. 7803-7810
    • Tu, H.1    Bonura, C.2    Giannini, C.3
  • 124
    • 0942289920 scopus 로고    scopus 로고
    • Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis
    • Wang Y, Lau SH, Sham JS, et al. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis. Oncogene 2004; 23: 142-148.
    • (2004) Oncogene , vol.23 , pp. 142-148
    • Wang, Y.1    Lau, S.H.2    Sham, J.S.3
  • 125
    • 0032529463 scopus 로고    scopus 로고
    • Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation
    • Gottlob K, Pagano S, Levrero M, et al. Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation. Cancer Research 1998; 58: 3566-3570.
    • (1998) Cancer Research , vol.58 , pp. 3566-3570
    • Gottlob, K.1    Pagano, S.2    Levrero, M.3
  • 126
    • 0026338610 scopus 로고
    • In vitro tumorigenicity of hepatitis B virus DNA and HBx protein
    • Seifer M, Hohne M, Schaefer S, et al. In vitro tumorigenicity of hepatitis B virus DNA and HBx protein. Journal of Hepatology 1991; 13(Suppl 4): S61-S65.
    • (1991) Journal of Hepatology , vol.13 , Issue.SUPPL. 4
    • Seifer, M.1    Hohne, M.2    Schaefer, S.3
  • 127
    • 0035804226 scopus 로고    scopus 로고
    • Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis
    • Kim YC, Song KS, Yoon G, et al. Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis. Oncogene 2001; 20: 16-23.
    • (2001) Oncogene , vol.20 , pp. 16-23
    • Kim, Y.C.1    Song, K.S.2    Yoon, G.3
  • 128
    • 34548182610 scopus 로고    scopus 로고
    • Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells
    • Oishi N, Shilagardi K, Nakamoto Y, et al. Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Cancer Science 2007; 98: 1540-1548.
    • (2007) Cancer Science , vol.98 , pp. 1540-1548
    • Oishi, N.1    Shilagardi, K.2    Nakamoto, Y.3
  • 129
    • 0029957571 scopus 로고    scopus 로고
    • Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249
    • Oguey D, Dumenco LL, Pierce RH, et al. Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249. Hepatology 1996; 24: 1024-1033.
    • (1996) Hepatology , vol.24 , pp. 1024-1033
    • Oguey, D.1    Dumenco, L.L.2    Pierce, R.H.3
  • 130
    • 0031972604 scopus 로고    scopus 로고
    • X-gene product of hepatitis B virus induces apoptosis in liver cells
    • Kim H, Lee H, Yun Y. X-gene product of hepatitis B virus induces apoptosis in liver cells. Journal of Biological Chemistry 1998; 273: 381-385.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 381-385
    • Kim, H.1    Lee, H.2    Yun, Y.3
  • 131
    • 0034708234 scopus 로고    scopus 로고
    • Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts
    • Schuster R, Gerlich WH, Schaefer S. Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts. Oncogene 2000; 19: 1173-1180.
    • (2000) Oncogene , vol.19 , pp. 1173-1180
    • Schuster, R.1    Gerlich, W.H.2    Schaefer, S.3
  • 133
    • 0033058294 scopus 로고    scopus 로고
    • Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein
    • Jul
    • Yu DY, Moon HB, Son JK, et al. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. Journal of Hepatology 1999 Jul; 31(1): 123-132.
    • (1999) Journal of Hepatology , vol.31 , Issue.1 , pp. 123-132
    • Yu, D.Y.1    Moon, H.B.2    Son, J.K.3
  • 134
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim CM, Koike K, Saito I, et al. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 1991; 351: 317-320.
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.M.1    Koike, K.2    Saito, I.3
  • 135
    • 0028230728 scopus 로고
    • High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice
    • Koike K, Moriya K, Iino S, et al. High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice. Hepatology 1994; 19: 810-819.
    • (1994) Hepatology , vol.19 , pp. 810-819
    • Koike, K.1    Moriya, K.2    Iino, S.3
  • 136
    • 0036252485 scopus 로고    scopus 로고
    • Virus replication and virion export in X-deficient hepatitis B virus transgenic mice
    • Kurt Reifenberg, Petra Nusser, Jürgen Löhler, et al. Virus replication and virion export in X-deficient hepatitis B virus transgenic mice. Journal of General Virology 2002; 83: 991-996.
    • (2002) Journal of General Virology , vol.83 , pp. 991-996
    • Reifenberg, K.1    Nusser, P.2    Löhler, J.3
  • 137
    • 0025222293 scopus 로고
    • Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice
    • Dec
    • Lee TH, Finegold MJ, Shen RF, et al. Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. Journal of Virology 1990 Dec; 64: 5939-5947.
    • (1990) Journal of Virology , vol.64 , pp. 5939-5947
    • Lee, T.H.1    Finegold, M.J.2    Shen, R.F.3
  • 138
    • 0035084167 scopus 로고    scopus 로고
    • Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions
    • Madden CR, Finegold MJ, Slagle BL. Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. Journal of Virology 2001; 75: 3851-3858.
    • (2001) Journal of Virology , vol.75 , pp. 3851-3858
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 139
    • 0036828029 scopus 로고    scopus 로고
    • Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein
    • Madden CR, Finegold MJ, Slagle BL. Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. Journal of Virology 2002; 76: 11770-11774.
    • (2002) Journal of Virology , vol.76 , pp. 11770-11774
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 140
    • 0031035764 scopus 로고    scopus 로고
    • The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice
    • Terradillos O, Billet O, Renard CA, et al. The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene 1997; 14: 395-404.
    • (1997) Oncogene , vol.14 , pp. 395-404
    • Terradillos, O.1    Billet, O.2    Renard, C.A.3
  • 141
    • 10744224746 scopus 로고    scopus 로고
    • HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice
    • Wang Y, Cui F, Lv Y, et al. HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology 2004; 39: 318-324.
    • (2004) Hepatology , vol.39 , pp. 318-324
    • Wang, Y.1    Cui, F.2    Lv, Y.3
  • 142
    • 79952217191 scopus 로고    scopus 로고
    • Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system
    • Mar
    • Keng VW, Tschida BR, Bell JB, Largaespada DA. Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system. Hepatology 2011 Mar; 53: 781-790.
    • (2011) Hepatology , vol.53 , pp. 781-790
    • Keng, V.W.1    Tschida, B.R.2    Bell, J.B.3    Largaespada, D.A.4


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